Folr1 (folate receptor alpha) - Rat Genome Database

Name: Folr1
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

Gene: Folr1 (folate receptor alpha) Rattus norvegicus

Analyze

Symbol:

Folr1

Name:

folate receptor alpha

RGD ID:

71032

Description:

Predicted to enable folic acid binding activity; folic acid receptor activity; and signaling receptor activity. Predicted to be involved in several processes, including circulatory system development; nervous system development; and regulation of signal transduction. Predicted to act upstream of or within folic acid metabolic process. Located in brush border membrane. Human ortholog(s) of this gene implicated in cerebral folate receptor alpha deficiency. Orthologous to human FOLR1 (folate receptor alpha); PARTICIPATES IN altered folate cycle metabolic pathway; folate cycle metabolic pathway; endocytosis pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 3-chloropropane-1,2-diol.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

Fbp1; folate binding protein 1; folate receptor 1; folate receptor 1 (adult)

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	FOLR1 (folate receptor alpha)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Mus musculus (house mouse):	Folr1 (folate receptor alpha)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Folr1 (folate receptor alpha)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	LOC100994139 (folate receptor alpha)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	LOC609612 (folate receptor alpha)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Folr1 (folate receptor alpha)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	FOLR1 (folate receptor alpha)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	FOLR1 (folate receptor alpha)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Folr1 (folate receptor alpha)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	FOLR2 (folate receptor beta)	HGNC	OrthoDB, Treefam
Homo sapiens (human):	FOLR3 (folate receptor gamma)	HGNC	OrthoDB
Homo sapiens (human):	SEC14L5 (SEC14 like lipid binding 5)	HGNC	OMA
Alliance orthologs ³
Mus musculus (house mouse):	Folr1 (folate receptor alpha)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	FOLR1 (folate receptor alpha)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	folr (folate receptor)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	folr1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	1	165,631,462 - 165,650,430 (-)	NCBI		GRCr8
mRatBN7.2	1	156,219,460 - 156,238,436 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	1	156,219,460 - 156,230,667 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	1	164,209,769 - 164,220,975 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	1	171,389,863 - 171,401,069 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	1	164,267,520 - 164,278,567 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	1	166,934,457 - 166,945,864 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	166,934,460 - 166,943,592 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	1	173,124,242 - 173,135,651 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	1	159,315,191 - 159,324,141 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	1	159,394,208 - 159,403,158 (-)	NCBI
Celera	1	154,298,870 - 154,310,077 (-)	NCBI		Celera
Cytogenetic Map	1	q32	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

3-methylglutaconic aciduria type 7b (ISO)

cerebral folate receptor alpha deficiency (ISO)

Colonic Neoplasms (ISO)

Congenital Abnormalities (ISO)

congenital heart disease (ISO)

Craniofacial Abnormalities (ISO)

epilepsy (ISO)

gastrointestinal stromal tumor (ISO)

Generalized Epilepsy (ISO)

genetic disease (ISO)

intellectual disability (ISO)

Metabolic Brain Diseases, Inborn (ISO)

movement disease (ISO)

neural tube defect (ISO)

osteosarcoma (ISO)

Ovarian Neoplasms (ISO)

Psychomotor Disorders (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(S)-nicotine (ISO)

1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane (ISO)

1,2-dichloroethane (ISO)

1,2-dimethylhydrazine (ISO)

14-Deoxy-11,12-didehydroandrographolide (ISO)

17alpha-ethynylestradiol (EXP)

17beta-estradiol (ISO)

2,2',4,4',5,5'-hexachlorobiphenyl (ISO)

2,2',5,5'-tetrachlorobiphenyl (ISO)

2,3',4,4',5-Pentachlorobiphenyl (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

3-chloropropane-1,2-diol (EXP)

4,4'-sulfonyldiphenol (ISO)

5-fluorouracil (ISO)

5-formyltetrahydrofolic acid (ISO)

5-methyltetrahydrofolic acid (ISO)

6-propyl-2-thiouracil (ISO)

acrylamide (ISO)

aldehydo-D-glucose (ISO)

aldrin (ISO)

all-trans-retinoic acid (ISO)

ammonium chloride (EXP)

aristolochic acid A (ISO)

atrazine (ISO)

belinostat (ISO)

benzo[a]pyrene (ISO)

biochanin A (ISO)

bis(2-chloroethyl) sulfide (ISO)

bisphenol A (EXP,ISO)

bisphenol F (ISO)

bortezomib (ISO)

C60 fullerene (EXP)

cadmium atom (ISO)

cadmium dichloride (ISO)

CGP 52608 (ISO)

chloroethene (ISO)

chlorpyrifos (ISO)

ciguatoxin CTX1B (ISO)

copper atom (ISO)

copper(0) (ISO)

Cuprizon (EXP)

cyclosporin A (ISO)

D-glucose (ISO)

diallyl trisulfide (ISO)

diazinon (EXP)

dibutyl phthalate (EXP)

diethylstilbestrol (ISO)

diiodine (ISO)

diquat (ISO)

dorsomorphin (ISO)

doxorubicin (ISO)

ethanol (EXP,ISO)

flavonoids (EXP)

flurbiprofen (ISO)

folic acid (EXP,ISO)

gallic acid (ISO)

genistein (ISO)

glucose (ISO)

glycidol (EXP)

glycidyl methacrylate (ISO)

hydrogen peroxide (ISO)

ICI D1694 (ISO)

lead diacetate (EXP)

methylmercury chloride (ISO)

mono(2-ethylhexyl) phthalate (ISO)

N-methyl-N'-nitro-N-nitrosoguanidine (ISO)

nickel atom (ISO)

nicotine (ISO)

paracetamol (EXP,ISO)

PCB138 (ISO)

pentanal (ISO)

perfluorooctane-1-sulfonic acid (EXP)

perfluorooctanoic acid (ISO)

progesterone (ISO)

SB 431542 (ISO)

silicon dioxide (ISO)

sirolimus (ISO)

sodium arsenite (ISO)

sulforaphane (ISO)

tert-butyl hydroperoxide (ISO)

tetrachloromethane (ISO)

theophylline (ISO)

thimerosal (ISO)

titanium dioxide (ISO)

trichloroethene (EXP,ISO)

urethane (ISO)

valproic acid (ISO)

zearalenone (ISO)

zoledronic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

anterior neural tube closure (ISO)

axon regeneration (ISO)

cardiac neural crest cell migration involved in outflow tract morphogenesis (ISO)

cell adhesion (IBA)

cellular response to folic acid (ISO)

folic acid metabolic process (ISO)

folic acid transport (ISO)

fusion of sperm to egg plasma membrane involved in single fertilization (IBA)

heart looping (ISO)

neural crest cell migration involved in heart formation (ISO)

pharyngeal arch artery morphogenesis (ISO)

regulation of canonical Wnt signaling pathway (ISO)

regulation of transforming growth factor beta receptor signaling pathway (ISO)

response to axon injury (ISO)

sperm-egg recognition (IBA)

Cellular Component

apical plasma membrane (ISO)

basolateral plasma membrane (ISO)

brush border membrane (IDA)

external side of plasma membrane (IBA,ISO)

nucleus (ISO)

Molecular Function

folic acid binding (ISO)

folic acid receptor activity (ISO)

protein binding (ISO)

signaling receptor activity (IBA)

Molecular Pathway Annotations Click to see Annotation Detail View

altered folate cycle metabolic pathway (ISO)

endocytosis pathway (IEA)

folate cycle metabolic pathway (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Internalization and intracellular transport of folate-binding protein in rat kidney proximal tubule.	Birn H, etal., Am J Physiol. 1993 Feb;264(2 Pt 1):C302-10.
2.	Normalization and subtraction: two approaches to facilitate gene discovery.	Bonaldo MF, etal., Genome Res 1996 Sep;6(9):791-806.
3.	Folate deficiency reduces the GPI-anchored folate-binding protein in rat renal tubules.	da Costa M, etal., Am J Physiol Cell Physiol 2000 Apr;278(4):C812-21.
4.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5.	Gene Data Set	MGD Curation, June 12, 2002
6.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
7.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
8.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline
9.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
10.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
11.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
12.	Coding sequence, genomic organization and expression of a folate binding protein gene in the rat.	Sadasivan E, etal., Gene 2000 Aug 22;254(1-2):219-28.
13.	Folate-regulated changes in gene expression in the anterior neural tube of folate binding protein-1 (Folbp1)-deficient murine embryos.	Spiegelstein O, etal., Neurochem Res 2004 Jun;29(6):1105-12.
14.	Update and new concepts in vitamin responsive disorders of folate transport and metabolism.	Watkins D and Rosenblatt DS, J Inherit Metab Dis. 2012 Jul;35(4):665-70. doi: 10.1007/s10545-011-9418-1. Epub 2011 Nov 23.

Additional References at PubMed

PMID:2527252	PMID:8033114	PMID:10787414	PMID:12477932	PMID:12854656	PMID:14722620	PMID:17286298	PMID:19116913	PMID:19199708	PMID:19581412	PMID:20424322	PMID:21649587
PMID:23243496	PMID:23376485	PMID:23533145	PMID:23851396	PMID:26667416	PMID:27011008	PMID:30113208	PMID:36675153

Genomics

Comparative Map Data

Folr1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	1	165,631,462 - 165,650,430 (-)	NCBI		GRCr8
mRatBN7.2	1	156,219,460 - 156,238,436 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	1	156,219,460 - 156,230,667 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	1	164,209,769 - 164,220,975 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	1	171,389,863 - 171,401,069 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	1	164,267,520 - 164,278,567 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	1	166,934,457 - 166,945,864 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	166,934,460 - 166,943,592 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	1	173,124,242 - 173,135,651 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	1	159,315,191 - 159,324,141 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	1	159,394,208 - 159,403,158 (-)	NCBI
Celera	1	154,298,870 - 154,310,077 (-)	NCBI		Celera
Cytogenetic Map	1	q32	NCBI

FOLR1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	11	72,189,709 - 72,196,323 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	11	72,189,558 - 72,196,323 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	11	71,900,753 - 71,907,367 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	11	71,578,250 - 71,585,014 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	11	71,580,855 - 71,585,014	NCBI
Celera	11	69,202,176 - 69,208,941 (+)	NCBI		Celera
Cytogenetic Map	11	q13.4	NCBI
HuRef	11	68,193,609 - 68,200,378 (+)	NCBI		HuRef
CHM1_1	11	71,784,063 - 71,790,828 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	11	72,116,250 - 72,122,864 (+)	NCBI		T2T-CHM13v2.0

Folr1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	7	101,507,551 - 101,519,974 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	7	101,507,538 - 101,519,995 (-)	Ensembl		GRCm39 Ensembl
GRCm38	7	101,858,331 - 101,870,788 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	7	101,858,331 - 101,870,788 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	7	109,006,845 - 109,019,197 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	7	101,732,152 - 101,744,504 (-)	NCBI		MGSCv36	mm8
Celera	7	102,230,147 - 102,242,481 (-)	NCBI		Celera
Cytogenetic Map	7	E2	NCBI
cM Map	7	54.67	NCBI

Folr1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955414	19,187,388 - 19,197,728 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955414	19,188,830 - 19,197,728 (-)	NCBI	ChiLan1.0	ChiLan1.0

LOC100994139
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	9	73,138,207 - 73,144,766 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	11	74,180,529 - 74,188,172 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	11	67,268,721 - 67,275,498 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	11	70,492,039 - 70,498,665 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	11	70,492,039 - 70,498,665 (+)	Ensembl	panpan1.1		panPan2

LOC609612
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	21	25,944,350 - 25,951,010 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
Dog10K_Boxer_Tasha	21	25,714,017 - 25,720,656 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	21	26,153,187 - 26,159,847 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	21	26,153,297 - 26,159,800 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	21	25,944,449 - 25,951,109 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	21	26,160,593 - 26,167,256 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	21	26,062,191 - 26,068,851 (-)	NCBI		UU_Cfam_GSD_1.0

Folr1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404947	59,892,012 - 59,897,666 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936498	1,491,547 - 1,497,226 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936498	1,489,916 - 1,497,200 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

FOLR1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	9	6,757,040 - 6,760,402 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	9	6,753,513 - 6,760,433 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	9	7,515,002 - 7,521,923 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

FOLR1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	1	63,405,513 - 63,413,372 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	1	63,406,597 - 63,413,352 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666043	62,470,494 - 62,476,997 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Folr1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624817	4,820,163 - 4,851,339 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624817	4,830,164 - 4,850,565 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Folr1
94 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	95
Count of miRNA genes:	83
Interacting mature miRNAs:	85
Transcripts:	ENSRNOT00000026962
Prediction methods:	Microtar, Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
70225	Bp58	Blood pressure QTL 58	3.3		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	32356093	162846471	Rat
10059597	Bp377	Blood pressure QTL 377	3.42	0.025	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	32737458	199368955	Rat
1578654	Bss10	Bone structure and strength QTL 10	4		femur morphology trait (VT:0000559)	femoral neck cortical cross-sectional area (CMO:0001702)	1	49393172	159356837	Rat
634314	Niddm44	Non-insulin dependent diabetes mellitus QTL 44			blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	1	49393289	199050459	Rat
1578780	Cm52	Cardiac mass QTL 52	3.3	0.0001	heart mass (VT:0007028)	heart wet weight (CMO:0000069)	1	81591954	219808434	Rat
724521	Uae1	Urinary albumin excretion QTL 1	3.8	0.0001	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	1	90508614	173018436	Rat
1358902	Bw47	Body weight QTL 47	1.67		body mass (VT:0001259)	body weight (CMO:0000012)	1	90508614	180359386	Rat
1331793	Bp200	Blood pressure QTL 200	3.71601		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	94494440	172949803	Rat
1331751	Bp199	Blood pressure QTL 199	3.60022		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	1	94494440	181830018	Rat
1331749	Hrtrt11	Heart rate QTL 11	2.973		heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	1	94494440	198211706	Rat
70209	Niddm23	Non-insulin dependent diabetes mellitus QTL 23	2.82		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	1	94494440	198324465	Rat
731168	Bp154	Blood pressure QTL 154	3.4		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	94642644	214537671	Rat
8655649	Arrd1	Age-related retinal degeneration QTL 1	4.89		retinal layer morphology trait (VT:0003727)	percentage of study population developing retinopathy during a period of time (CMO:0002453)	1	100357752	183970443	Rat
1354591	Cm36	Cardiac mass QTL 36	4.1		heart left ventricle mass (VT:0007031)	calculated heart weight (CMO:0000073)	1	102813953	201278233	Rat
1354615	Cm32	Cardiac mass QTL 32	5.2		heart left ventricle mass (VT:0007031)	heart left ventricle wet weight (CMO:0000071)	1	102813953	201278233	Rat
1354606	Bp246	Blood pressure QTL 246	3.6		arterial blood pressure trait (VT:2000000)	pulse pressure (CMO:0000292)	1	102813953	218753816	Rat
1300158	Bp173	Blood pressure QTL 173	3.48		arterial blood pressure trait (VT:2000000)	blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)	1	115540693	185145286	Rat
7794788	Mcs32	Mammary carcinoma susceptibility QTL 32	2.61		mammary gland integrity trait (VT:0010552)	mammary tumor incidence/prevalence measurement (CMO:0000946)	1	115540693	238914717	Rat
631199	Cm23	Cardiac mass QTL 23	4.6	0.0004	heart left ventricle mass (VT:0007031)	heart left ventricle wet weight (CMO:0000071)	1	115585465	172949803	Rat
7421630	Bp362	Blood pressure QTL 362		0.001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	1	118608292	241799120	Rat
2313060	Bss71	Bone structure and strength QTL 71	2.6	0.0001	long bone metaphysis morphology trait (VT:0000133)	tibia midshaft total cross-sectional area (CMO:0001715)	1	118944747	163944747	Rat
631205	Bp196	Blood pressure QTL 196	4	0.0001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	1	118944897	199050459	Rat
1598850	Bp297	Blood pressure QTL 297	2.1		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	121006655	166006655	Rat
1598866	Bp287	Blood pressure QTL 287	5.1		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	121006655	166006655	Rat
61442	Strs1	Sensitivity to stroke QTL 1	7.4		cerebrum integrity trait (VT:0010549)	post-insult time to onset of cerebrovascular lesion (CMO:0002343)	1	121767634	166767634	Rat
2293140	Bp313	Blood pressure QTL 313			arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	121833674	166833674	Rat
631544	Bp84	Blood pressure QTL 84	5.6		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	123350408	181759564	Rat
1358189	Cstrr1	Cold stress response QTL 1		0.0001	catecholamine amount (VT:0010543)	urine norepinephrine level (CMO:0001629)	1	123350408	182418476	Rat
1641895	Bp298	Blood pressure QTL 298			arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	1	123350408	182418476	Rat
1578770	Stresp23	Stress response QTL 23			kidney sympathetic nerve activity (VT:0004050)	stimulated renal sympathetic nerve activity to basal renal sympathetic nerve activity ratio (CMO:0001786)	1	123350408	182418476	Rat
631549	Bp89	Blood pressure QTL 89	5.7		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	123350581	201284552	Rat
634348	Bp138	Blood pressure QTL 138			arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	125611501	168883176	Rat
9685799	Bp375	Blood pressure QTL 375			arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	125611501	170611501	Rat
631654	Bp107	Blood pressure QTL 107			arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	125611501	170611501	Rat
9685802	Bp376	Blood pressure QTL 376			arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	126540680	171540680	Rat
738006	Anxrr14	Anxiety related response QTL 14	4	0.00035	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	1	130636910	175636910	Rat
738028	Anxrr12	Anxiety related response QTL 12	4.9	0.00001	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	1	130636910	175636910	Rat
631202	Gluco13	Glucose level QTL 13		0.0001	blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	1	131763437	159756369	Rat
6893347	Bw98	Body weight QTL 98	0.2	0.53	body mass (VT:0001259)	body weight (CMO:0000012)	1	133680936	178680936	Rat
6893361	Bw104	Body weight QTL 104	0.59	0.27	body mass (VT:0001259)	body weight (CMO:0000012)	1	133680936	178680936	Rat
1558645	Bw55	Body weight QTL 55	3.2	0.004	body mass (VT:0001259)	body weight (CMO:0000012)	1	133680936	178680936	Rat
631206	Niddm40	Non-insulin dependent diabetes mellitus QTL 40			blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	1	136745990	163747690	Rat
71118	Thym1	Thymus enlargement QTL 1	10.17	0.001	thymus mass (VT:0004954)	thymus weight to body weight ratio (CMO:0000612)	1	136829932	181829932	Rat
724550	Thym3	Thymus enlargement QTL 3	7.82	0.001	thymus mass (VT:0004954)	thymus weight to body weight ratio (CMO:0000612)	1	136829932	181829932	Rat
631519	Pia11	Pristane induced arthritis QTL 11	5.3		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	1	136830018	181830018	Rat
1598853	Memor3	Memory QTL 3	4.5		exploratory behavior trait (VT:0010471)	total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)	1	143506580	212458660	Rat
61348	Bp30	Blood pressure QTL 30	2.4		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	144017057	197814409	Rat
70160	Bw18	Body weight QTL 18	5.7		body mass (VT:0001259)	body weight (CMO:0000012)	1	144267353	196383668	Rat
737828	Hcas3	Hepatocarcinoma susceptibility QTL 3	4.9		liver integrity trait (VT:0010547)	liver tumorous lesion volume to total liver volume ratio (CMO:0001082)	1	144267353	222987745	Rat
2302378	Insul11	Insulin level QTL 11	3.25		blood insulin amount (VT:0001560)	serum insulin level (CMO:0000358)	1	144267353	251128347	Rat
634315	Niddm45	Non-insulin dependent diabetes mellitus QTL 45	7.16		blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	1	144267916	172949660	Rat
61379	Bp44	Blood pressure QTL 44	19.2		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	144267916	174133260	Rat
7771612	Cm80	Cardiac mass QTL 80	8.4		heart left ventricle mass (VT:0007031)	heart left ventricle weight (CMO:0000776)	1	149448574	221264292	Rat
724531	Uae5	Urinary albumin excretion QTL 5	4		urine albumin amount (VT:0002871)	urine albumin level (CMO:0000130)	1	150700142	252085212	Rat
1578759	Uae30	Urinary albumin excretion QTL 30	3.3	0.003	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	1	150700247	252085048	Rat
1578778	Pur4	Proteinuria QTL 4	3.3	0.003	urine total protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	1	150700247	252085048	Rat
1354602	Bw35	Body weight QTL 35	12.2		body mass (VT:0001259)	body weight (CMO:0000012)	1	151162512	201278233	Rat
1354620	Kidm19	Kidney mass QTL 19	4		kidney mass (VT:0002707)	calculated kidney weight (CMO:0000160)	1	151162512	201278233	Rat
1354634	Kidm12	Kidney mass QTL 12	3.9		kidney mass (VT:0002707)	right kidney wet weight (CMO:0000082)	1	151162512	201278233	Rat
1354636	Lmblg1	Limb length QTL 1	6.4		tibia length (VT:0004357)	tibia length (CMO:0000450)	1	151162512	201278233	Rat
1354610	Bw34	Body weight QTL 34	4.1		body mass (VT:0001259)	body weight (CMO:0000012)	1	151162512	256448636	Rat
1354646	Kidm18	Kidney mass QTL 18	5.7		kidney mass (VT:0002707)	calculated kidney weight (CMO:0000160)	1	151162512	256448636	Rat
1354661	Bw33	Body weight QTL 33	5.2		body mass (VT:0001259)	body weight (CMO:0000012)	1	151162512	256448636	Rat
1358886	Bp260	Blood pressure QTL 260	3.67		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	1	151162766	225824951	Rat
61343	Bp28	Blood pressure QTL 28			arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	151646613	196646613	Rat
1549837	Hcar15	Hepatocarcinoma resistance QTL 15		0.05	liver integrity trait (VT:0010547)	liver tumorous lesion number (CMO:0001068)	1	153136852	260522016	Rat
2303622	Vencon6	Ventilatory control QTL 6		0.001	respiration trait (VT:0001943)	respiration rate (CMO:0000289)	1	154561505	199561505	Rat
1582204	Livw1	Liver weight QTL 1	3.6	0.0003	liver mass (VT:0003402)	liver weight to body weight ratio (CMO:0000633)	1	155422851	172949803	Rat
4889419	Cstrr2	Cold stress response QTL 2		0.05	urine catecholamine amount (VT:0010502)	absolute change in urine norepinephrine level (CMO:0001634)	1	155866514	158592016	Rat
4889428	Stresp24	Stress response QTL 24		0.05	heart pumping trait (VT:2000009)	absolute change in electrocardiographic low frequency R-R spectral component to high frequency R-R spectral component ratio (CMO:0002162)	1	155866514	200866514	Rat

Markers in Region

D1Bda29

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	1	156,220,011 - 156,220,359 (+)	MAPPER	mRatBN7.2
Rnor_6.0	1	166,935,009 - 166,935,356	NCBI	Rnor6.0
Rnor_5.0	1	173,124,794 - 173,125,141	UniSTS	Rnor5.0
RGSC_v3.4	1	159,315,739 - 159,316,086	UniSTS	RGSC3.4
Celera	1	154,299,422 - 154,299,769	UniSTS
Cytogenetic Map	1	q32	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium			17	14		14			23	35	32
Low	3	14	23	10	19	10	8	11	47		9	11	8
Below cutoff		25	12	12		12			4

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_133527	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006229842	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017588710	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017588711	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017588712	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017588713	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039085665	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039085707	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039085757	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063273293	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063273361	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063273405	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AF219904	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AF219905	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AF219906	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC157811	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473956	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FM059473	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FM060472	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000001	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	KU095827	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSRNOT00000026962 ⟹ ENSRNOP00000026962

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	1	156,219,460 - 156,230,667 (-)	Ensembl
Rnor_6.0 Ensembl	1	166,934,462 - 166,943,592 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000079675 ⟹ ENSRNOP00000071311

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	1	166,934,460 - 166,939,541 (-)	Ensembl

RefSeq Acc Id:

NM_133527 ⟹ NP_598211

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	165,631,462 - 165,642,669 (-)	NCBI
mRatBN7.2	1	156,219,460 - 156,230,667 (-)	NCBI
Rnor_6.0	1	166,934,457 - 166,945,845 (-)	NCBI
Rnor_5.0	1	173,124,242 - 173,135,651 (-)	NCBI
RGSC_v3.4	1	159,315,191 - 159,324,141 (-)	RGD
Celera	1	154,298,870 - 154,310,077 (-)	NCBI

Sequence:

show sequence

TCTTCCCCAATCAGCAGGCTGATCTGGAAGCATAAACAAGAACTGAAGCTGAAGGCTCTAGGGG
TTCCCAACCTGTGATCTCCAGCAGACACTCCTGGTGTGTCACCGGATTCAGGCTCCTGGGATAA
AGAAAGCAAAGGAAGTCTGGAGTGGAGACGAAGAAACCCCAGGCACTCTGAGAGCTGCTACCTT
TTCCATGTGTGCTGCCAGACACTTCTCGTCAGGGACCAAATACCCCAAGGGAGTGGAGAGAGGC
CTGGGCTGGGCCAGACTTCCTGGGCTTTAACCTGTGCTCCAAGTAGGTGGGTCACATTTTCCCC
AGCGGGAGTTGAAGAGTCACCTGGTGCTTCAACGGGACTGATTTCCTGGGCCTGGAGTTGGAGA
TCAGAGGTCTGACATGGCTCACCTGATGGCTGGGCAGTGGTTGCTCCTGCTGATGTGGATGGCC
GAATGTGCCCAGTCCAGAGCTACTCGGGCCAGGACCGAACTTCTCAATGTCTGCATGGATGCCA
AGCACCACAAAGAAAAGCCAGGCCCAGAGGACAAGTTACACGACCAGTGCAGCCCCTGGAAGAC
GAATGCCTGCTGCTCCACCAACACAAGCCAGGAAGCACATAAGGACATTTCCTACCTGTACCGA
TTCAACTGGAATCACTGTGGAACTATGACCCCGGAGTGCAAACGTCACTTTATCCAAGACACCT
GCCTCTATGAGTGTTCCCCGAACTTGGGACCCTGGATCCAGCAGGTGGACCAGAGCTGGCGCAA
AGAGCGGATCCTTGATGTTCCCCTGTGCAAAGAAGACTGTGTGCTGTGGTGGGAGGACTGCAAG
AGCTCTTTTACCTGCAAGAGCAACTGGCACAAGGGATGGAACTGGACCTCGGGGCATAATGAGT
GCCCTGTGGGAGCCTCCTGCCATCCCTTCACTTTCTACTTCCCTACACCTGCTGTTCTGTGTGA
GAAAATCTGGAGTCACTCCTACAAGCTCAGCAACTACAGCCGAGGGAGCGGCCGCTGCATCCAG
ATGTGGTTCGACCCAGCCCAAGGCAACCCCAACGAGGAAGTGGCGAGGTTCTATGCCGAGGTCA
TGAGTGGAGCTGGGCTTCGCGAGGCCTGGCTGCTGGTGTGCAGCCTGTCCTTAGTGCTGTTCTG
GGTGCTCAGCTGAGTTCCTGTTACTCCTTGTCTGGAGCTCCACCCTGCCCGGCTTAGCCTCCCA
GCTCCCAGCCTCCTTTGTGGTGGGGCTCTGACAGCCTGTTTAGTAAACCAGACATTCTACATG

hide sequence

RefSeq Acc Id:

XM_006229842 ⟹ XP_006229904

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	165,631,466 - 165,639,634 (-)	NCBI
mRatBN7.2	1	156,219,574 - 156,227,508 (-)	NCBI
Rnor_6.0	1	166,934,457 - 166,942,684 (-)	NCBI
Rnor_5.0	1	173,124,242 - 173,135,651 (-)	NCBI

Sequence:

show sequence

AATTGGTTCTGTCTGCTTTTGCTGGGGTTAACGGTGTGCTCTGCCGTACCCAGCTGGACAGAAG
TTTTAAGGGAAATACGGTAATCCGGAGACAAGGGTAGGTGTGTGAGCTGGGAAGTCCAGACTGA
AGACGCGACCACTTCAAGGGTCTGACATGGCTCACCTGATGGCTGGGCAGTGGTTGCTCCTGCT
GATGTGGATGGCCGAATGTGCCCAGTCCAGAGCTACTCGGGCCAGGACCGAACTTCTCAATGTC
TGCATGGATGCCAAGCACCACAAAGAAAAGCCAGGCCCAGAGGACAAGTTACACGACCAGTGCA
GCCCCTGGAAGACGAATGCCTGCTGCTCCACCAACACAAGCCAGGAAGCACATAAGGACATTTC
CTACCTGTACCGATTCAACTGGAATCACTGTGGAACTATGACCCCGGAGTGCAAACGTCACTTT
ATCCAAGACACCTGCCTCTATGAGTGTTCCCCGAACTTGGGACCCTGGATCCAGCAGGTGGACC
AGAGCTGGCGCAAAGAGCGGATCCTTGATGTTCCCCTGTGCAAAGAAGACTGTGTGCTGTGGTG
GGAGGACTGCAAGAGCTCTTTTACCTGCAAGAGCAACTGGCACAAGGGATGGAACTGGACCTCG
GGGCATAATGAGTGCCCTGTGGGAGCCTCCTGCCATCCCTTCACTTTCTACTTCCCTACACCTG
CTGTTCTGTGTGAGAAAATCTGGAGTCACTCCTACAAGCTCAGCAACTACAGCCGAGGGAGCGG
CCGCTGCATCCAGATGTGGTTCGACCCAGCCCAAGGCAACCCCAACGAGGAAGTGGCGAGGTTC
TATGCCGAGGTCATGAGTGGAGCTGGGCTTCGCGAGGCCTGGCTGCTGGTGTGCAGCCTGTCCT
TAGTGCTGTTCTGGGTGCTCAGCTGAGTTCCTGTTACTCCTTGTCTGGAGCTCCACCCTGCCCG
GCTTAGCCTCCCAGCTCCCAGCCTCCTTTGTGGTGGGGCTCTGACAGCCTGTTTAGTAAACCAG
ACATTCTACATG

hide sequence

RefSeq Acc Id:

XM_017588710 ⟹ XP_017444199

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	165,631,466 - 165,641,291 (-)	NCBI
mRatBN7.2	1	156,219,464 - 156,229,294 (-)	NCBI
Rnor_6.0	1	166,934,457 - 166,944,455 (-)	NCBI

Sequence:

show sequence

AAACCTCAACAGGCTCCTGGGATAAAGAAAGCAAAGGAAGTCTGGAGTGGAGACGAAGAAACCC
CAGGCACTCTGAGAGCTGCTACCTTTTCCATGTGTGCTGCCAGACACTTCTCGTCAGGGACCAA
ATACCCCAAGGGAGTGGAGAGAGGCCTGGGCTGGGCCAGACTTCCTGGGCTTTAACCTGTGCTC
CAAGTAGGTGGGTCACATTTTCCCCAGCGGGAGTTGAAGAGTCACCTGGTGCTTCAACGGGACT
GATTTCCTGGGCCTGGAGTTGGAGATCAGAGGTCTGACATGGCTCACCTGATGGCTGGGCAGTG
GTTGCTCCTGCTGATGTGGATGGCCGAATGTGCCCAGTCCAGAGCTACTCGGGCCAGGACCGAA
CTTCTCAATGTCTGCATGGATGCCAAGCACCACAAAGAAAAGCCAGGCCCAGAGGACAAGTTAC
ACGACCAGTGCAGCCCCTGGAAGACGAATGCCTGCTGCTCCACCAACACAAGCCAGGAAGCACA
TAAGGACATTTCCTACCTGTACCGATTCAACTGGAATCACTGTGGAACTATGACCCCGGAGTGC
AAACGTCACTTTATCCAAGACACCTGCCTCTATGAGTGTTCCCCGAACTTGGGACCCTGGATCC
AGCAGGTGGACCAGAGCTGGCGCAAAGAGCGGATCCTTGATGTTCCCCTGTGCAAAGAAGACTG
TGTGCTGTGGTGGGAGGACTGCAAGAGCTCTTTTACCTGCAAGAGCAACTGGCACAAGGGATGG
AACTGGACCTCGGGGCATAATGAGTGCCCTGTGGGAGCCTCCTGCCATCCCTTCACTTTCTACT
TCCCTACACCTGCTGTTCTGTGTGAGAAAATCTGGAGTCACTCCTACAAGCTCAGCAACTACAG
CCGAGGGAGCGGCCGCTGCATCCAGATGTGGTTCGACCCAGCCCAAGGCAACCCCAACGAGGAA
GTGGCGAGGTTCTATGCCGAGGTCATGAGTGGAGCTGGGCTTCGCGAGGCCTGGCTGCTGGTGT
GCAGCCTGTCCTTAGTGCTGTTCTGGGTGCTCAGCTGAGTTCCTGTTACTCCTTGTCTGGAGCT
CCACCCTGCCCGGCTTAGCCTCCCAGCTCCCAGCCTCCTTTGTGGTGGGGCTCTGACAGCCTGT
TTAGTAAACCAGACATTCTACATG

hide sequence

RefSeq Acc Id:

XM_017588711 ⟹ XP_017444200

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	165,631,466 - 165,641,288 (-)	NCBI
mRatBN7.2	1	156,219,464 - 156,229,293 (-)	NCBI
Rnor_6.0	1	166,934,457 - 166,945,864 (-)	NCBI

Sequence:

show sequence

TGATAGATACCTGGCCCACTCTTCCCCAATCAGCAGGCTGATCTGGAAGCATAAACAAGAACTG
AAGCTGAAGGCTCTAGGGGTTCCCAACCTGTGATCTCCAGCAGACACTCCTGGTGTGTCACCGG
ATTCAGGCTCCTGGGATAAAGAAAGCAAAGGAAGTCTGGAGTGGAGACGAAGAAACCCCAGGCA
CTCTGAGAGCTGCTACCTTTTCCATGTGTGCTGCCAGACACTTCTCGTCAGGGACCAAATACCC
CAAGCAGGGAGTGGAGAGAGGCCTGGGCTGGGCCAGACTTCCTGGGCTTTAACCTGTGCTCCAA
GTAGGTGGGTCACATTTTCCCCAGCGGGAGTTGAAGAGTCACCTGGTGCTTCAACGGGACTGAT
TTCCTGGGCCTGGAGTTGGAGATCAGAGGTCTGACATGGCTCACCTGATGGCTGGGCAGTGGTT
GCTCCTGCTGATGTGGATGGCCGAATGTGCCCAGTCCAGAGCTACTCGGGCCAGGACCGAACTT
CTCAATGTCTGCATGGATGCCAAGCACCACAAAGAAAAGCCAGGCCCAGAGGACAAGTTACACG
ACCAGTGCAGCCCCTGGAAGACGAATGCCTGCTGCTCCACCAACACAAGCCAGGAAGCACATAA
GGACATTTCCTACCTGTACCGATTCAACTGGAATCACTGTGGAACTATGACCCCGGAGTGCAAA
CGTCACTTTATCCAAGACACCTGCCTCTATGAGTGTTCCCCGAACTTGGGACCCTGGATCCAGC
AGGTGGACCAGAGCTGGCGCAAAGAGCGGATCCTTGATGTTCCCCTGTGCAAAGAAGACTGTGT
GCTGTGGTGGGAGGACTGCAAGAGCTCTTTTACCTGCAAGAGCAACTGGCACAAGGGATGGAAC
TGGACCTCGGGGCATAATGAGTGCCCTGTGGGAGCCTCCTGCCATCCCTTCACTTTCTACTTCC
CTACACCTGCTGTTCTGTGTGAGAAAATCTGGAGTCACTCCTACAAGCTCAGCAACTACAGCCG
AGGGAGCGGCCGCTGCATCCAGATGTGGTTCGACCCAGCCCAAGGCAACCCCAACGAGGAAGTG
GCGAGGTTCTATGCCGAGGTCATGAGTGGAGCTGGGCTTCGCGAGGCCTGGCTGCTGGTGTGCA
GCCTGTCCTTAGTGCTGTTCTGGGTGCTCAGCTGAGTTCCTGTTACTCCTTGTCTGGAGCTCCA
CCCTGCCCGGCTTAGCCTCCCAGCTCCCAGCCTCCTTTGTGGTGGGGCTCTGACAGCCTGTTTA
GTAAACCAGACATTCTACATG

hide sequence

RefSeq Acc Id:

XM_039085665 ⟹ XP_038941593

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	165,631,466 - 165,650,430 (-)	NCBI
mRatBN7.2	1	156,219,460 - 156,238,435 (-)	NCBI

RefSeq Acc Id:

XM_039085707 ⟹ XP_038941635

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	165,631,466 - 165,650,430 (-)	NCBI
mRatBN7.2	1	156,219,574 - 156,238,436 (-)	NCBI

RefSeq Acc Id:

XM_039085757 ⟹ XP_038941685

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	165,631,466 - 165,650,428 (-)	NCBI
mRatBN7.2	1	156,219,464 - 156,238,434 (-)	NCBI

RefSeq Acc Id:

XM_063273293 ⟹ XP_063129363

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	165,631,466 - 165,639,566 (-)	NCBI

RefSeq Acc Id:

XM_063273361 ⟹ XP_063129431

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	165,631,466 - 165,650,428 (-)	NCBI

RefSeq Acc Id:

XM_063273405 ⟹ XP_063129475

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	165,631,466 - 165,642,650 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_598211	(Get FASTA)	NCBI Sequence Viewer
	XP_006229904	(Get FASTA)	NCBI Sequence Viewer
	XP_017444199	(Get FASTA)	NCBI Sequence Viewer
	XP_017444200	(Get FASTA)	NCBI Sequence Viewer
	XP_038941593	(Get FASTA)	NCBI Sequence Viewer
	XP_038941635	(Get FASTA)	NCBI Sequence Viewer
	XP_038941685	(Get FASTA)	NCBI Sequence Viewer
	XP_063129363	(Get FASTA)	NCBI Sequence Viewer
	XP_063129431	(Get FASTA)	NCBI Sequence Viewer
	XP_063129475	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAF66225	(Get FASTA)	NCBI Sequence Viewer
	AAI57812	(Get FASTA)	NCBI Sequence Viewer
	EDM18254	(Get FASTA)	NCBI Sequence Viewer
	EDM18255	(Get FASTA)	NCBI Sequence Viewer
	EDM18256	(Get FASTA)	NCBI Sequence Viewer
	EDM18257	(Get FASTA)	NCBI Sequence Viewer
	EDM18258	(Get FASTA)	NCBI Sequence Viewer
	EDM18259	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000026962
	ENSRNOP00000026962.3

RefSeq Acc Id:	NP_598211 ⟸ NM_133527
- Peptide Label:	precursor
- UniProtKB:	G3V8M6 (UniProtKB/TrEMBL), A6I6X2 (UniProtKB/TrEMBL), Q9JL02 (UniProtKB/TrEMBL)
- Sequence:	show sequence MAHLMAGQWLLLLMWMAECAQSRATRARTELLNVCMDAKHHKEKPGPEDKLHDQCSPWKTNACC STNTSQEAHKDISYLYRFNWNHCGTMTPECKRHFIQDTCLYECSPNLGPWIQQVDQSWRKERIL DVPLCKEDCVLWWEDCKSSFTCKSNWHKGWNWTSGHNECPVGASCHPFTFYFPTPAVLCEKIWS HSYKLSNYSRGSGRCIQMWFDPAQGNPNEEVARFYAEVMSGAGLREAWLLVCSLSLVLFWVLS hide sequence

RefSeq Acc Id:	XP_006229904 ⟸ XM_006229842
- Peptide Label:	isoform X1
- UniProtKB:	G3V8M6 (UniProtKB/TrEMBL), A6I6X2 (UniProtKB/TrEMBL), Q9JL02 (UniProtKB/TrEMBL)
- Sequence:	show sequence MAHLMAGQWLLLLMWMAECAQSRATRARTELLNVCMDAKHHKEKPGPEDKLHDQCSPWKTNACC STNTSQEAHKDISYLYRFNWNHCGTMTPECKRHFIQDTCLYECSPNLGPWIQQVDQSWRKERIL DVPLCKEDCVLWWEDCKSSFTCKSNWHKGWNWTSGHNECPVGASCHPFTFYFPTPAVLCEKIWS HSYKLSNYSRGSGRCIQMWFDPAQGNPNEEVARFYAEVMSGAGLREAWLLVCSLSLVLFWVLS hide sequence

RefSeq Acc Id:	XP_017444200 ⟸ XM_017588711
- Peptide Label:	isoform X1
- UniProtKB:	G3V8M6 (UniProtKB/TrEMBL), A6I6X2 (UniProtKB/TrEMBL), Q9JL02 (UniProtKB/TrEMBL)
- Sequence:	show sequence MAHLMAGQWLLLLMWMAECAQSRATRARTELLNVCMDAKHHKEKPGPEDKLHDQCSPWKTNACC STNTSQEAHKDISYLYRFNWNHCGTMTPECKRHFIQDTCLYECSPNLGPWIQQVDQSWRKERIL DVPLCKEDCVLWWEDCKSSFTCKSNWHKGWNWTSGHNECPVGASCHPFTFYFPTPAVLCEKIWS HSYKLSNYSRGSGRCIQMWFDPAQGNPNEEVARFYAEVMSGAGLREAWLLVCSLSLVLFWVLS hide sequence

RefSeq Acc Id:	XP_017444199 ⟸ XM_017588710
- Peptide Label:	isoform X1
- UniProtKB:	G3V8M6 (UniProtKB/TrEMBL), A6I6X2 (UniProtKB/TrEMBL), Q9JL02 (UniProtKB/TrEMBL)
- Sequence:	show sequence MAHLMAGQWLLLLMWMAECAQSRATRARTELLNVCMDAKHHKEKPGPEDKLHDQCSPWKTNACC STNTSQEAHKDISYLYRFNWNHCGTMTPECKRHFIQDTCLYECSPNLGPWIQQVDQSWRKERIL DVPLCKEDCVLWWEDCKSSFTCKSNWHKGWNWTSGHNECPVGASCHPFTFYFPTPAVLCEKIWS HSYKLSNYSRGSGRCIQMWFDPAQGNPNEEVARFYAEVMSGAGLREAWLLVCSLSLVLFWVLS hide sequence

RefSeq Acc Id:

ENSRNOP00000071311 ⟸ ENSRNOT00000079675

RefSeq Acc Id:

ENSRNOP00000026962 ⟸ ENSRNOT00000026962

RefSeq Acc Id:	XP_038941593 ⟸ XM_039085665
- Peptide Label:	isoform X1
- UniProtKB:	G3V8M6 (UniProtKB/TrEMBL), A6I6X2 (UniProtKB/TrEMBL), Q9JL02 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038941685 ⟸ XM_039085757
- Peptide Label:	isoform X1
- UniProtKB:	G3V8M6 (UniProtKB/TrEMBL), A6I6X2 (UniProtKB/TrEMBL), Q9JL02 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038941635 ⟸ XM_039085707
- Peptide Label:	isoform X1
- UniProtKB:	G3V8M6 (UniProtKB/TrEMBL), A6I6X2 (UniProtKB/TrEMBL), Q9JL02 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063129431 ⟸ XM_063273361
- Peptide Label:	isoform X1
- UniProtKB:	A6I6X2 (UniProtKB/TrEMBL), G3V8M6 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063129475 ⟸ XM_063273405
- Peptide Label:	isoform X1
- UniProtKB:	A6I6X2 (UniProtKB/TrEMBL), G3V8M6 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063129363 ⟸ XM_063273293
- Peptide Label:	isoform X2

Protein Domains

Folate receptor-like

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-G3V8M6-F1-model_v2	AlphaFold	G3V8M6	1-255	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13690263

Promoter ID:

EPDNEW_R786

Type:

multiple initiation site

Name:

Folr1_1

Description:

folate receptor 1

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	1	166,943,650 - 166,943,710	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:71032	AgrOrtholog
BioCyc Gene	G2FUF-58272	BioCyc
Ensembl Genes	ENSRNOG00000019902	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000026962	ENTREZGENE
	ENSRNOT00000026962.5	UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:9088301	IMAGE-MGC_LOAD
InterPro	Folate_rcpt	UniProtKB/TrEMBL
	Folate_rcpt-like	UniProtKB/TrEMBL
KEGG Report	rno:171049	UniProtKB/TrEMBL
MGC_CLONE	MGC:187337	IMAGE-MGC_LOAD
NCBI Gene	171049	ENTREZGENE
PANTHER	Folt_rcpt	UniProtKB/TrEMBL
	PTHR10517:SF15	UniProtKB/TrEMBL
Pfam	Folate_rec	UniProtKB/TrEMBL
PhenoGen	Folr1	PhenoGen
RatGTEx	ENSRNOG00000019902	RatGTEx
UniProt	A6I6X2	ENTREZGENE, UniProtKB/TrEMBL
	A6I6X6_RAT	UniProtKB/TrEMBL
	A9UMV5_RAT	UniProtKB/TrEMBL
	G3V8M6	ENTREZGENE, UniProtKB/TrEMBL
	Q9JL02	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2019-05-23	Folr1	folate receptor alpha	Folr1	folate receptor 1	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2016-06-29	Folr1	folate receptor 1	Folr1	folate receptor 1 (adult)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2002-07-09	Folr1	folate receptor 1 (adult)			Symbol and Name updated to reflect Human and Mouse nomenclature	70877	APPROVED

RGD Curation Notes

Note Type	Note	Reference
gene_cellular_localization	protein found on the brush borders of kidney tubules	1358236
gene_function	reabsorbs folate from the renal tubular fluid	1358236
gene_homology	72-92% homology with Folr1 cDNAs from mouse, human and pig; high amino acid sequence homology among known members of the folate receptor family	70742
gene_regulation	the shorter of the two mRNA species in the kidney may be transcribed from a second promoter immediately upstream of exon 3, possibly located within the second intron	70742
gene_regulation	protein levels increase in tissue culture cells under conditions of low folate concentration	1358236
gene_regulation	in vivo under conditions of low folate concentration, levels of Folr1 protein but not mRNA are decreased in kidney, apparently due to the proteolysis of unsaturated receptor resulting from decreased levels of folate in the glomerular filtrate; levels of protein in liver and brain are essentially unaffected under the same conditions	1358236
gene_transcript	approximately 10 kb in size and has 7 exons and 6 introns	70742
gene_transcript	kidney expresses two transcripts which differ in the length of their 5' untranslated regions by 311 nucleotides; the mRNA expressed in brain is intermediate in length between the two kidney transcripts	70742

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

RGD Manual Annotations

Imported Annotations - KEGG (archival)

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Imported Disease Annotations - ClinVar

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RGD Manual Annotations

Imported Annotations - KEGG (archival)