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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 71032
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Folr1
Name: folate receptor alpha
Acc ID: CHEBI:39867
Term: valproic acid
Definition: A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
Chemical ID: MESH:D014635
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Folr1affects expressionISOFOLR1 (Homo sapiens)6480464CTDValproic Acid affects the expression of FOLR1 mRNAPMID:25979313 PMID:34742744
Folr1affects expressionISOFolr1 (Mus musculus)6480464CTDValproic Acid affects the expression of FOLR1 mRNAPMID:9188671
Folr1decreases expressionISOFOLR1 (Homo sapiens)6480464CTDValproic Acid results in decreased expression of FOLR1 mRNAPMID:23179753
Folr1decreases expressionISOFolr1 (Mus musculus)6480464CTDValproic Acid results in decreased expression of FOLR1 mRNAPMID:19136453 PMID:20546886 PMID:21427059
Folr1increases expressionISOFOLR1 (Homo sapiens)6480464CTDValproic Acid results in increased expression of FOLR1 mRNAPMID:23179753 PMID:26272509 PMID:29223574
Folr1increases methylationISOFOLR1 (Homo sapiens)6480464CTDValproic Acid results in increased methylation of FOLR1 genePMID:29154799
Folr1multiple interactionsISOFOLR1 (Homo sapiens)6480464CTD[NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FOLR1 mRNAPMID:27188386
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