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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 71032
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Folr1
Name: folate receptor alpha
Acc ID: CHEBI:27470
Term: folic acid
Definition: An N-acyl-amino acid that is a form of the water-soluble vitamin B9. Its biologically active forms (tetrahydrofolate and others) are essential for nucleotide biosynthesis and homocysteine remethylation.
Chemical ID: MESH:D005492
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Folr1decreases expressionEXP 6480464CTDFolic Acid results in decreased expression of FOLR1 proteinPMID:17482424
Folr1affects abundanceISOFolr1 (Mus musculus)6480464CTDFOLR1 protein affects the abundance of Folic AcidPMID:15705887
Folr1affects bindingISOFOLR1 (Homo sapiens)6480464CTDFolic Acid binds to FOLR1 proteinPMID:21879757
Folr1affects expressionISOFOLR1 (Homo sapiens)6480464CTDFolic Acid affects the expression of FOLR1 mRNAPMID:17311948
Folr1decreases abundanceISOFOLR1 (Homo sapiens)6480464CTDFOLR1 gene mutant form results in decreased abundance of Folic AcidPMID:19732866
Folr1decreases expressionISOFOLR1 (Homo sapiens)6480464CTDFolic Acid deficiency results in decreased expression of FOLR1 mRNA; Folic Acid results in decreased expression of FOLR1 mRNAPMID:17616776 PMID:20465997
Folr1decreases methylationISOFOLR1 (Homo sapiens)6480464CTDFolic Acid results in decreased methylation of FOLR1 promoterPMID:29644877
Folr1increases transportISOFOLR1 (Homo sapiens)6480464CTDFOLR1 protein results in increased transport of Folic AcidPMID:19732866
Folr1increases uptakeISOFolr1 (Mus musculus)6480464CTDFOLR1 protein results in increased uptake of Folic AcidPMID:14581169
Folr1multiple interactionsISOFOLR1 (Homo sapiens)6480464CTDFolic Acid inhibits the reaction [FOLR1 protein results in increased susceptibility to N-((5-((2-amino-4-oxo-4,7-dihydro-3H-pyrrolo(2,3-d)pyrimidin-6-yl)propyl)thiophen-2-yl)carbonyl)glutamic acid]; FOLR1 protein affects the reaction [Folic Acid results in increased expression of CADM1 mRNA]; FOLR1 protein affects the reaction [Folic Acid results in increased expression of CADM1 protein]; FOLR1 protein affects the reaction [Folic Acid results in increased expression of CDKN1A protein]; FOLR1 protein affects the reaction [Folic Acid results in increased expression of CDKN1B protein]; FOLR1 protein affects the reaction [Folic Acid results in increased expression of TP53 protein]; FOLR1 protein affects the reaction [Folic Acid results in increased phosphorylation of MAPK1 protein]; FOLR1 protein affects the reaction [Folic Acid results in increased phosphorylation of MAPK3 protein]; FOLR1 protein affects the reaction [Folic Acid results in increased phosphorylation of SRC protein]; FOLR1 protein affects the reaction [Folic Acid results in increased phosphorylation of STAT3 protein]; N-((5-((2-amino-4-oxo-4,7-dihydro-3H-pyrrolo(2,3-d)pyrimidin-6-yl)propyl)thiophen-2-yl)carbonyl)glutamic acid inhibits the reaction [Folic Acid binds to FOLR1 protein]PMID:21879757 PMID:25841994 PMID:26056802 PMID:29070520
Folr1multiple interactionsISOFolr1 (Mus musculus)6480464CTDRFC1 protein mutant form promotes the reaction [FOLR1 protein mutant form results in decreased abundance of Folic Acid]PMID:18926688
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