FOLR1 (folate receptor 1 (adult))

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Keyword

Gene: FOLR1 (folate receptor 1 (adult)) Homo sapiens

Symbol:

FOLR1

Name:

folate receptor 1 (adult)

Description:

The protein encoded by this gene is a member of the folate receptor family. Members of this gene family bind folic acid and its reduced derivatives, and transport 5-methyltetrahydrofolate into cells. This gene product is a secreted protein that either anchors to membranes via a glycosyl-phosphatidylinositol linkage or exists in a soluble form. Mutations in this gene have been associated with neurodegeneration due to cerebral folate transport deficiency. Due to the presence of two promoters, multiple transcription start sites, and alternative splicing, multiple transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Oct 2009]

Type:

protein-coding

RefSeq Status:

REVIEWED

Also known as:

adult folate-binding protein; FBP; folate binding protein; folate receptor alpha; folate receptor, adult; FOLR; FR-alpha; FR-alpha; KB cells FBP; MOv18; OTTHUMP00000237140; OTTHUMP00000237141; OTTHUMP00000237142; OTTHUMP00000237143; ovarian tumor-associated antigen MOv18

Orthologs:

Mus musculus : Folr1 (folate receptor 1 (adult)) MGI
Rattus norvegicus : Folr1 (folate receptor 1 (adult))

Related Pseudogenes:

FOLR1P1

Latest Assembly:

Human Genome Assembly GRCh37

Position:

Map	Chr	Position	Strand	Source
Human Alternate Assembly CHM1_1	11	71,764,206 - 71,770,971	+	NCBI
Human Genome Assembly HuRef	11	68,193,609 - 68,200,378	+	NCBI
Human Genome Assembly GRCh37	11	71,900,602 - 71,907,367	+	NCBI
Human Genome Assembly Build 36	11	71,578,250 - 71,585,014	+	NCBI
Human Cytogenetic Map	11	q13.3-q14.1		NCBI
Human Genome Assembly	11	71,580,855 - 71,585,014		NCBI