Wnt2 (Wnt family member 2) - Rat Genome Database

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Gene: Wnt2 (Wnt family member 2) Rattus norvegicus
Analyze
Symbol: Wnt2
Name: Wnt family member 2
RGD ID: 621346
Description: Predicted to enable cytokine activity and frizzled binding activity. Involved in lung development and positive regulation of endothelial cell proliferation. Predicted to be located in collagen-containing extracellular matrix; cytoplasm; and extracellular region. Predicted to be active in extracellular space. Biomarker of visual epilepsy. Human ortholog(s) of this gene implicated in breast carcinoma; hepatocellular carcinoma; and urinary system cancer. Orthologous to human WNT2 (Wnt family member 2); PARTICIPATES IN Wnt signaling pathway; Wnt signaling, canonical pathway; basal cell carcinoma pathway; INTERACTS WITH 1,3-dinitrobenzene; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: protein Wnt-2; wingless-related MMTV integration site 2; wingless-type MMTV integration site 2; wingless-type MMTV integration site family member 2; Wnt
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8447,294,300 - 47,340,284 (-)NCBIGRCr8
mRatBN7.2446,328,408 - 46,374,673 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl446,333,998 - 46,374,402 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.0445,286,845 - 45,332,899 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl445,292,437 - 45,332,420 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0445,892,395 - 45,936,605 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4443,649,783 - 43,689,596 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1443,857,074 - 43,859,488 (-)NCBI
Celera441,596,263 - 41,642,309 (-)NCBICelera
Cytogenetic Map4q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
1,3-dinitrobenzene  (EXP)
1-nitropyrene  (ISO)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-amino-2,6-dinitrotoluene  (EXP)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
afimoxifene  (ISO)
all-trans-retinoic acid  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
arsenite(3-)  (ISO)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
cadmium dichloride  (ISO)
carbon nanotube  (ISO)
chloroprene  (EXP,ISO)
chlorpyrifos  (EXP)
clotrimazole  (EXP)
cocaine  (EXP)
Cuprizon  (EXP)
deguelin  (ISO)
dextran sulfate  (ISO)
diazinon  (EXP)
dichromium trioxide  (ISO)
dieldrin  (EXP)
dioxygen  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
entinostat  (ISO)
ethanol  (ISO)
ethylparaben  (ISO)
finasteride  (EXP)
fulvestrant  (ISO)
glufosinate  (ISO)
lead diacetate  (ISO)
lipopolysaccharide  (ISO)
methimazole  (EXP)
methoxychlor  (EXP)
N(gamma)-nitro-L-arginine methyl ester  (ISO)
N-methyl-4-phenylpyridinium  (EXP)
N-methyl-N'-nitro-N-nitrosoguanidine  (ISO)
N-nitrosodiethylamine  (ISO)
nickel atom  (EXP)
nickel subsulfide  (EXP)
nitrofen  (EXP,ISO)
oxaliplatin  (EXP)
ozone  (ISO)
paracetamol  (ISO)
paraquat  (EXP)
perfluorooctane-1-sulfonic acid  (ISO)
phenobarbital  (ISO)
resveratrol  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
titanium dioxide  (ISO)
topotecan  (EXP)
triclosan  (ISO)
triphenyl phosphate  (EXP)
valproic acid  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Expression and hormone regulation of Wnt2, 3, 4, 5a, 7a, 7b and 10b in normal human endometrium and endometrial carcinoma. Bui TD, etal., Br J Cancer. 1997;75(8):1131-6.
2. Differential expression of Wnt genes in normal and flat variants of PC12 cells, a cell line responsive to ectopic Wnt1 expression. Erdreich-Epstein A and Shackleford GM, Growth Factors 1998;15(2):149-58.
3. Long-term feeding of various fat diets modulates azoxymethane-induced colon carcinogenesis through Wnt/beta-catenin signaling in rats. Fujise T, etal., Am J Physiol Gastrointest Liver Physiol. 2007 Apr;292(4):G1150-6. Epub 2006 Dec 28.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
6. Oncogene amplification in urothelial cancers with p53 gene mutation or MDM2 amplification. Habuchi T, etal., J Natl Cancer Inst. 1994 Sep 7;86(17):1331-5.
7. Differential expression of human Wnt genes 2, 3, 4, and 7B in human breast cell lines and normal and disease states of human breast tissue. Huguet EL, etal., Cancer Res. 1994 May 15;54(10):2615-21.
8. Frizzled-9 is activated by Wnt-2 and functions in Wnt/beta -catenin signaling. Karasawa T, etal., J Biol Chem 2002 Oct 4;277(40):37479-86.
9. Wnt2 acts as a cell type-specific, autocrine growth factor in rat hepatic sinusoidal endothelial cells cross-stimulating the VEGF pathway. Klein D, etal., Hepatology. 2008 Mar;47(3):1018-31.
10. Growth and developmental regulation of wnt-2 (irp) gene in mesenchymal cells of fetal lung. Levay-Young BK and Navre M, Am J Physiol. 1992 Jun;262(6 Pt 1):L672-83.
11. Influence of polymorphisms in the Wnt/β-catenin pathway genes on hepatocellular carcinoma risk in a Chinese Han population. Li QM, etal., Medicine (Baltimore). 2017 Mar;96(12):e6127. doi: 10.1097/MD.0000000000006127.
12. Chronic electroconvulsive seizure up-regulates beta-catenin expression in rat hippocampus: role in adult neurogenesis. Madsen TM, etal., Biol Psychiatry. 2003 Nov 15;54(10):1006-14.
13. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
14. Analysis of genetic alterations related to the development and progression of breast carcinoma. Nagayama K and Watatani M, Jpn J Cancer Res. 1993 Nov;84(11):1159-64.
15. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
16. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
17. GOA pipeline RGD automated data pipeline
18. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
19. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
20. Comprehensive gene review and curation RGD comprehensive gene curation
21. Wnt signaling in the ovary: identification and compartmentalized expression of wnt-2, wnt-2b, and frizzled-4 mRNAs. Ricken A, etal., Endocrinology 2002 Jul;143(7):2741-9.
22. The Wnt Homepage Roel Nusse - Howard Hughes Medical Institute and the Department of Developmental Biology at Stanford University, California, USA
23. Transformation by Wnt family proteins correlates with regulation of beta-catenin. Shimizu H, etal., Cell Growth Differ. 1997 Dec;8(12):1349-58.
24. Alternative wnt signaling is initiated by distinct receptors. van Amerongen R, etal., Sci Signal. 2008 Sep 2;1(35):re9.
25. Independent amplification of two gene clusters on chromosome 4 in rat endometrial cancer: identification and molecular characterization. Walentinsson A, etal., Cancer Res 2001 Nov 15;61(22):8263-73.
26. A dual-color FISH gene map of the proximal region of rat Chromosome 4 and comparative analysis in human and mouse. Walentinsson A, etal., Mamm Genome 2001 Dec;12(12):900-8.
27. Expression of twist and wnt in human breast cancer. Watanabe O, etal., Anticancer Res. 2004 Nov-Dec;24(6):3851-6.
28. WIF1, a component of the Wnt pathway, is down-regulated in prostate, breast, lung, and bladder cancer. Wissmann C, etal., J Pathol 2003 Oct;201(2):204-12.
29. Differential transformation of mammary epithelial cells by Wnt genes. Wong GT, etal., Mol Cell Biol. 1994 Sep;14(9):6278-86.
Additional References at PubMed
PMID:8951051   PMID:9652750   PMID:10347172   PMID:10557084   PMID:11092808   PMID:15040835   PMID:15474371   PMID:15507471   PMID:16772171   PMID:16806007   PMID:16949068   PMID:17948129  
PMID:19038973   PMID:19239325   PMID:19686689   PMID:19734317   PMID:20018874   PMID:20159597   PMID:22517624   PMID:23124852   PMID:23271279   PMID:23610556   PMID:26541456   PMID:28887537  
PMID:33927285   PMID:35177206  


Genomics

Comparative Map Data
Wnt2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8447,294,300 - 47,340,284 (-)NCBIGRCr8
mRatBN7.2446,328,408 - 46,374,673 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl446,333,998 - 46,374,402 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.0445,286,845 - 45,332,899 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl445,292,437 - 45,332,420 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0445,892,395 - 45,936,605 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4443,649,783 - 43,689,596 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1443,857,074 - 43,859,488 (-)NCBI
Celera441,596,263 - 41,642,309 (-)NCBICelera
Cytogenetic Map4q22NCBI
WNT2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh387117,275,451 - 117,323,058 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl7117,275,451 - 117,323,152 (-)EnsemblGRCh38hg38GRCh38
GRCh377116,915,505 - 116,963,112 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 367116,704,518 - 116,750,579 (-)NCBINCBI36Build 36hg18NCBI36
Build 347116,511,232 - 116,557,294NCBI
Celera7111,724,862 - 111,771,525 (-)NCBICelera
Cytogenetic Map7q31.2NCBI
HuRef7111,282,485 - 111,328,966 (-)NCBIHuRef
CHM1_17116,850,055 - 116,896,705 (-)NCBICHM1_1
T2T-CHM13v2.07118,590,786 - 118,638,396 (-)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v27116,312,120 - 116,358,781 (-)NCBI
Wnt2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39617,988,939 - 18,032,771 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl617,988,939 - 18,030,584 (-)EnsemblGRCm39 Ensembl
GRCm38617,985,474 - 18,032,772 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl617,988,940 - 18,030,585 (-)EnsemblGRCm38mm10GRCm38
MGSCv37617,938,940 - 17,980,445 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36617,938,940 - 17,980,356 (-)NCBIMGSCv36mm8
Celera618,070,129 - 18,111,436 (-)NCBICelera
Cytogenetic Map6A2NCBI
cM Map68.08NCBI
Wnt2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543222,984,170 - 23,027,705 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495543222,988,208 - 23,024,530 (-)NCBIChiLan1.0ChiLan1.0
WNT2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v26154,101,025 - 154,151,405 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan176,111,284 - 6,161,665 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v07109,244,772 - 109,291,472 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.17121,939,254 - 121,985,862 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl7121,936,031 - 121,985,862 (-)Ensemblpanpan1.1panPan2
WNT2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11456,123,735 - 56,172,113 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1456,129,248 - 56,172,069 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1455,519,061 - 55,567,484 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01456,163,101 - 56,211,441 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1456,166,256 - 56,213,190 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11456,195,055 - 56,243,473 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01455,884,128 - 55,931,047 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01456,253,933 - 56,302,214 (-)NCBIUU_Cfam_GSD_1.0
Wnt2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440511844,819,573 - 44,865,128 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365891,825,209 - 1,866,889 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365891,825,209 - 1,866,898 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
WNT2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1828,946,326 - 28,993,961 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11828,945,825 - 28,993,969 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21830,790,071 - 30,838,269 (-)NCBISscrofa10.2Sscrofa10.2susScr3
WNT2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12185,955,517 - 86,005,664 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2185,955,145 - 86,001,730 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604217,730,443 - 17,777,632 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Wnt2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248272,045,595 - 2,089,442 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248272,045,733 - 2,088,284 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Wnt2
190 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:111
Count of miRNA genes:92
Interacting mature miRNAs:99
Transcripts:ENSRNOT00000010427
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
619616Bp79Blood pressure QTL 790.0292arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)4521460278882945Rat
2303168Bp330Blood pressure QTL 3304.250.017arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)45214602146446691Rat
2302371Stl22Serum triglyceride level QTL 225.15blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)4521829457114705Rat
1358203Stl19Serum triglyceride level QTL 192.80.002blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)4521829465958103Rat
631642Stl2Serum triglyceride level QTL 23.3blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)4521917856647776Rat
6478724Anxrr35Anxiety related response QTL 350.00449defecation behavior trait (VT:0010462)defecation measurement (CMO:0000997)41008408955084089Rat
6478766Anxrr47Anxiety related response QTL 470.09637locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)41008408955084089Rat
6478769Anxrr48Anxiety related response QTL 480.02514locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)41008408955084089Rat
8694374Bw155Body weight QTL 1553.390.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)41008408955084089Rat
9590304Scort17Serum corticosterone level QTL 174.960.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)41008408955084089Rat
8552906Pigfal3Plasma insulin-like growth factor 1 level QTL 3blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)41008408955084089Rat
631261Tcas3Tongue tumor susceptibility QTL 36.88tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)41081417091360527Rat
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)411320076180699135Rat
2303585Bw86Body weight QTL 864body mass (VT:0001259)body weight (CMO:0000012)41467806559678065Rat
2313401Anxrr27Anxiety related response QTL 27aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)41793350862933508Rat
61412Pia2Pristane induced arthritis QTL 23.9joint integrity trait (VT:0010548)post-insult time to onset of experimental arthritis (CMO:0001450)42133334362278020Rat
6909122Insul22Insulin level QTL 224.63blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)42690728575585128Rat
6909128Pancm4Pancreatic morphology QTL 411.35pancreas mass (VT:0010144)pancreas wet weight (CMO:0000626)42690728575585128Rat
8655906Rf60Renal function QTL 603.8blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)42949419581006281Rat
12798520Anxrr55Anxiety related response QTL 554.450.01locomotor behavior trait (VT:0001392)number of rearing movements with lid-pushing in an experimental apparatus (CMO:0002715)432583980114627242Rat
11530004Niddm71Non-insulin dependent diabetes mellitus QTL 710.001blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)43258419952754138Rat
8552782Vie1Viral induced encephalitis QTL 126.4brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)43443048482490359Rat
8552801Bw143Body weight QTL 1437.3body mass (VT:0001259)change in body weight to body weight ratio (CMO:0002216)43443048482490359Rat
8552809Vie5Viral induced encephalitis QTL 525.3brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)43443048482490359Rat
8655961Kidm43Kidney mass QTL 4318kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)436303261103194984Rat
1358352Srcrt3Stress Responsive Cort QTL 32.29blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)438465774146803430Rat
61475Aia2Adjuvant induced arthritis QTL 25.8joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)43950527573892441Rat
1331807Rf31Renal function QTL 312.988urine potassium amount (VT:0010539)urine potassium level (CMO:0000128)43952426474726312Rat
1300139Hrtrt6Heart rate QTL 62.85heart pumping trait (VT:2000009)heart rate (CMO:0000002)439524264116179656Rat
61445Strs3Sensitivity to stroke QTL 33cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)44043338885433388Rat
8694439Bw168Body weight QTL 1689.570.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)44043341485433414Rat
6893678Bw108Body weight QTL 1082.60.006body mass (VT:0001259)body weight (CMO:0000012)44345797688457976Rat
1576305Emca6Estrogen-induced mammary cancer QTL 65.8mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)444463720155883716Rat
1354612Foco1Food consumption QTL 18.87eating behavior trait (VT:0001431)food intake rate (CMO:0000427)444463908148090542Rat
1354660Salc1Saline consumption QTL 111.26drinking behavior trait (VT:0001422)saline drink intake rate (CMO:0001627)444463908148090542Rat
2312567Glom19Glomerulus QTL 191.90.006kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)445456990146803430Rat

Markers in Region
RH141342  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2446,365,759 - 46,365,947 (+)MAPPERmRatBN7.2
Rnor_6.0445,323,804 - 45,323,991NCBIRnor6.0
Rnor_5.0445,927,743 - 45,927,930UniSTSRnor5.0
RGSC_v3.4443,680,955 - 43,681,142UniSTSRGSC3.4
Celera441,633,214 - 41,633,401UniSTS
RH 3.4 Map4281.51UniSTS
Cytogenetic Map4q21-q22UniSTS
RH130031  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2446,334,021 - 46,334,214 (+)MAPPERmRatBN7.2
Rnor_6.0445,292,068 - 45,292,260NCBIRnor6.0
Rnor_5.0445,896,007 - 45,896,199UniSTSRnor5.0
RGSC_v3.4443,649,219 - 43,649,411UniSTSRGSC3.4
Celera441,601,486 - 41,601,678UniSTS
RH 3.4 Map4284.1UniSTS
Cytogenetic Map4q21-q22UniSTS
REN63976  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2446,368,043 - 46,368,267 (+)MAPPERmRatBN7.2
Rnor_6.0445,326,088 - 45,326,311NCBIRnor6.0
Rnor_5.0445,930,027 - 45,930,250UniSTSRnor5.0
RGSC_v3.4443,683,239 - 43,683,462UniSTSRGSC3.4
Celera441,635,498 - 41,635,721UniSTS
Cytogenetic Map4q21-q22UniSTS
Wnt2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2446,366,948 - 46,367,198 (+)MAPPERmRatBN7.2
Rnor_6.0445,324,993 - 45,325,242NCBIRnor6.0
Rnor_5.0445,928,932 - 45,929,181UniSTSRnor5.0
RGSC_v3.4443,682,144 - 43,682,393UniSTSRGSC3.4
Celera441,634,403 - 41,634,652UniSTS
Cytogenetic Map4q21-q22UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 10 2 5 9
Low 2 26 51 41 14 41 6 6 52 35 35 2 6
Below cutoff 6 6 5 2 5 20 1 2

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000083039   ⟹   ENSRNOP00000071025
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl446,333,998 - 46,374,402 (-)Ensembl
Rnor_6.0 Ensembl445,292,437 - 45,332,420 (-)Ensembl
RefSeq Acc Id: NM_053695   ⟹   NP_446147
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8447,294,300 - 47,340,284 (-)NCBI
Protein Sequences
Protein RefSeqs NP_446147 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAK32712 (Get FASTA)   NCBI Sequence Viewer  
  AAK32713 (Get FASTA)   NCBI Sequence Viewer  
  AAR16313 (Get FASTA)   NCBI Sequence Viewer  
  EDM15125 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000071025.1
Reference Protein Sequences
RefSeq Acc Id: ENSRNOP00000071025   ⟸   ENSRNOT00000083039
RefSeq Acc Id: NP_446147   ⟸   NM_053695
- Peptide Label: precursor
- UniProtKB: A0A0G2JZF4 (UniProtKB/TrEMBL),   A6IE38 (UniProtKB/TrEMBL),   Q2IBD1 (UniProtKB/TrEMBL)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q2IBD1-F1-model_v2 AlphaFold Q2IBD1 1-360 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621346 AgrOrtholog
BioCyc Gene G2FUF-45543 BioCyc
Ensembl Genes ENSRNOG00000051905 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000083039.2 UniProtKB/TrEMBL
Gene3D-CATH 3.30.2460.20 UniProtKB/TrEMBL
InterPro Wnt2 UniProtKB/TrEMBL
  Wnt_C UniProtKB/TrEMBL
  Wnt_CS UniProtKB/TrEMBL
  Wnt_SF UniProtKB/TrEMBL
KEGG Report rno:114487 UniProtKB/TrEMBL
NCBI Gene 114487 ENTREZGENE
PANTHER PROTEIN WNT-2 UniProtKB/TrEMBL
  Wnt UniProtKB/TrEMBL
Pfam wnt UniProtKB/TrEMBL
PhenoGen Wnt2 PhenoGen
PRINTS WNT2PROTEIN UniProtKB/TrEMBL
  WNTPROTEIN UniProtKB/TrEMBL
PROSITE WNT1 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000051905 RatGTEx
SMART WNT1 UniProtKB/TrEMBL
UniProt A0A0G2JZF4 ENTREZGENE, UniProtKB/TrEMBL
  A6IE38 ENTREZGENE, UniProtKB/TrEMBL
  Q2IBD1 ENTREZGENE
  Q99MC1_RAT UniProtKB/TrEMBL
  Q99MC2_RAT UniProtKB/TrEMBL
UniProt Secondary Q2IBD1 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-03-29 Wnt2  Wnt family member 2  Wnt2  wingless-type MMTV integration site family member 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-11-14 Wnt2  wingless-type MMTV integration site family member 2  Wnt2  wingless-related MMTV integration site 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2003-04-09 Wnt2  wingless-related MMTV integration site 2      Symbol and Name updated 629477 APPROVED
2003-03-12 Wnt2  wingless-related MMTV integration site 2  Wnt    Data merged from RGD:619763 628472 PROVISIONAL
2002-08-07 Wnt2        Symbol and Name status set to provisional 70820 PROVISIONAL
2002-08-07 Wnt        Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in uterus 70557
gene_process upregulated in uterine tumors 70557