Slc18a2 (solute carrier family 18 member A2) - Rat Genome Database

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Gene: Slc18a2 (solute carrier family 18 member A2) Rattus norvegicus
Analyze
Symbol: Slc18a2
Name: solute carrier family 18 member A2
RGD ID: 3694
Description: Enables several functions, including amine transmembrane transporter activity; heat shock protein binding activity; and monoamine:proton antiporter activity. Involved in several processes, including aminergic neurotransmitter loading into synaptic vesicle; neurotransmitter uptake; and signal release. Located in several cellular components, including neuronal cell body; secretory vesicle; and terminal bouton. Is active in dopaminergic synapse; postsynapse; and secretory vesicle. Used to study Parkinson's disease and type 1 diabetes mellitus. Biomarker of Machado-Joseph disease; Parkinson's disease; substance-related disorder; and toxic encephalopathy. Human ortholog(s) of this gene implicated in Parkinson's disease and infantile parkinsonism-dystonia 2. Orthologous to human SLC18A2 (solute carrier family 18 member A2); PARTICIPATES IN dopamine biosynthetic pathway; epinephrine biosynthetic pathway; norepinephrine biosynthetic pathway; INTERACTS WITH (R)-noradrenaline; 17alpha-ethynylestradiol; 2,2',4,4'-Tetrabromodiphenyl ether.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: MNAT; monoamine transporter; solute carrier family 18 (vesicular monoamine transporter), member 2; solute carrier family 18 (vesicular monoamine), member 2; Solute carrier family 18 A2 (vesicular monoamine transporter 2); solute carrier family 18 member 2; solute carrier family 18, member 2; synaptic vesicular amine transporter; VAT2; vesicular amine transporter 2; VMAT-2; VMAT2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81268,399,815 - 268,435,229 (+)NCBIGRCr8
mRatBN7.21258,413,748 - 258,449,143 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1258,413,959 - 258,448,325 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1266,619,517 - 266,653,852 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01273,325,530 - 273,359,877 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01265,966,700 - 266,001,038 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01280,397,831 - 280,457,968 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1280,423,079 - 280,457,148 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01287,782,713 - 287,818,452 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41265,789,917 - 265,824,551 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11266,000,961 - 266,035,596 (+)NCBI
Celera1254,067,617 - 254,102,150 (+)NCBICelera
RH 3.4 Map11709.1RGD
Cytogenetic Map1q55NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
(R)-noradrenaline  (EXP,ISO)
(S)-amphetamine  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
3,4-methylenedioxymethamphetamine  (EXP,ISO)
4,4'-sulfonyldiphenol  (ISO)
6-propyl-2-thiouracil  (EXP)
9,10-dimethoxy-3-isobutyl-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-one  (EXP,ISO)
acrylamide  (EXP)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
aldehydo-D-glucose  (ISO)
alendronic acid  (EXP)
amitrole  (EXP)
ammonium chloride  (EXP)
amphetamine  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
antimycin A  (ISO)
arsenite(3-)  (ISO)
Asiaticoside  (EXP)
atrazine  (EXP)
b-Dihydrotetrabenazine  (EXP)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
calcitriol  (ISO)
carbamazepine  (ISO)
carbonyl cyanide p-trifluoromethoxyphenylhydrazone  (EXP)
CGP 52608  (ISO)
chlordecone  (ISO)
chlorpyrifos  (EXP)
choline  (ISO)
clozapine  (EXP)
cocaine  (EXP,ISO)
curcumin  (EXP)
cyhalothrin  (EXP)
cypermethrin  (EXP)
D-glucose  (ISO)
dabigatran  (EXP)
DDD  (ISO)
DDT  (ISO)
decabromodiphenyl ether  (EXP)
dexamethasone  (ISO)
diazinon  (EXP)
dieldrin  (ISO)
dopamine  (EXP,ISO)
dorsomorphin  (ISO)
entinostat  (ISO)
estrone  (ISO)
folic acid  (ISO)
formaldehyde  (EXP)
fucoxanthin  (ISO)
fulvestrant  (ISO)
ganglioside GM1  (EXP)
genistein  (ISO)
geraniol  (ISO)
glucose  (ISO)
haloperidol  (ISO)
heptachlor  (ISO)
Heptachlor epoxide  (ISO)
herbicide  (EXP)
histamine  (EXP,ISO)
hydroquinone O-beta-D-glucopyranoside  (ISO)
ketoconazole  (ISO)
L-methionine  (ISO)
lead diacetate  (ISO)
leflunomide  (ISO)
maneb  (ISO)
manganese atom  (EXP)
manganese(0)  (EXP)
Mazindol  (ISO)
melatonin  (ISO)
mercury atom  (ISO)
mercury dibromide  (ISO)
mercury(0)  (ISO)
methamphetamine  (EXP,ISO)
methimazole  (EXP)
methoxychlor  (EXP,ISO)
methylphenidate  (ISO)
N-methyl-4-phenylpyridinium  (EXP,ISO)
nomifensine  (ISO)
oxaliplatin  (EXP)
oxidopamine  (EXP,ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
PCB138  (ISO)
phenylmercury acetate  (ISO)
pirinixic acid  (ISO)
probenecid  (ISO)
pyrroloquinoline quinone  (EXP)
quinpirole  (ISO)
rabeprazole  (EXP)
raloxifene  (EXP)
reserpine  (EXP,ISO)
resveratrol  (EXP)
rotenone  (EXP,ISO)
rottlerin  (ISO)
S-methyl-L-thiocitrulline  (EXP)
SB 431542  (ISO)
SCH 23390  (ISO)
serotonin  (EXP,ISO)
silver atom  (ISO)
silver(0)  (ISO)
simazine  (EXP,ISO)
sodium arsenite  (EXP,ISO)
sulfadimethoxine  (EXP)
sulpiride  (ISO)
telmisartan  (ISO)
tetrabenazine  (EXP,ISO)
topotecan  (EXP)
tributylstannane  (EXP)
trichloroethene  (EXP)
trichostatin A  (ISO)
triphenyl phosphate  (EXP)
trovafloxacin  (ISO)
valinomycin  (EXP)
valproic acid  (ISO)
vanoxerine dihydrochloride  (ISO)
zinc atom  (EXP)
zinc sulfate  (EXP)
zinc(0)  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Striatal and nigral pathology in a lentiviral rat model of Machado-Joseph disease. Alves S, etal., Hum Mol Genet. 2008 Jul 15;17(14):2071-83. Epub 2008 Apr 1.
2. Positron emission tomography of monoaminergic vesicular binding in aging and Parkinson disease. Bohnen NI, etal., J Cereb Blood Flow Metab. 2006 Sep;26(9):1198-212. Epub 2006 Jan 18.
3. The first luminal domain of vesicular monoamine transporters mediates G-protein-dependent regulation of transmitter uptake. Brunk I, etal., J Biol Chem. 2006 Nov 3;281(44):33373-85. Epub 2006 Aug 22.
4. Ca2+-dependent activator proteins of secretion promote vesicular monoamine uptake. Brunk I, etal., J Biol Chem. 2009 Jan 9;284(2):1050-6. Epub 2008 Nov 13.
5. A biochemical and functional protein complex involving dopamine synthesis and transport into synaptic vesicles. Cartier EA, etal., J Biol Chem. 2010 Jan 15;285(3):1957-66. Epub 2009 Nov 10.
6. Deglycosylation and subcellular redistribution of VMAT2 in the mesostriatal system during normal aging. Cruz-Muros I, etal., Neurobiol Aging. 2008 Nov;29(11):1702-11. Epub 2007 Jun 19.
7. Reserpine- and tetrabenazine-sensitive transport of (3)H-histamine by the neuronal isoform of the vesicular monoamine transporter. Erickson JD, etal., J Mol Neurosci. 1995;6(4):277-87. doi: 10.1007/BF02736786.
8. Expression cloning of a reserpine-sensitive vesicular monoamine transporter. Erickson JD, etal., Proc Natl Acad Sci U S A 1992 Nov 15;89(22):10993-7.
9. A rapid oxidation and persistent decrease in the vesicular monoamine transporter 2 after methamphetamine. Eyerman DJ and Yamamoto BK, J Neurochem. 2007 Nov;103(3):1219-27. Epub 2007 Aug 7.
10. Cocaine alters vesicular dopamine sequestration and potassium-stimulated dopamine release: the role of D2 receptor activation. Farnsworth SJ, etal., J Pharmacol Exp Ther. 2009 Mar;328(3):807-12. Epub 2008 Nov 26.
11. Vmat2 heterozygous mutant mice display a depressive-like phenotype. Fukui M, etal., J Neurosci. 2007 Sep 26;27(39):10520-9.
12. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
13. Gain-of-function haplotypes in the vesicular monoamine transporter promoter are protective for Parkinson disease in women. Glatt CE, etal., Hum Mol Genet. 2006 Jan 15;15(2):299-305. Epub 2005 Dec 8.
14. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
15. 11C-dihydrotetrabenazine PET of the pancreas in subjects with long-standing type 1 diabetes and in healthy controls. Goland R, etal., J Nucl Med. 2009 Mar;50(3):382-9. Epub 2009 Feb 17.
16. Directed evolution reveals hidden properties of VMAT, a neurotransmitter transporter. Gros Y and Schuldiner S, J Biol Chem. 2010 Feb 12;285(7):5076-84. Epub 2009 Dec 10.
17. Parietal cell activation by arborization of ECL cell cytoplasmic projections is likely the mechanism for histamine induced secretion of hydrochloric acid. Gustafsson BI, etal., Scand J Gastroenterol. 2011 May;46(5):531-7. Epub 2011 Feb 23.
18. Identification of a mammalian vesicular polyamine transporter. Hiasa M, etal., Sci Rep. 2014 Oct 30;4:6836. doi: 10.1038/srep06836.
19. Effect of zinc and paraquat co-exposure on neurodegeneration: Modulation of oxidative stress and expression of metallothioneins, toxicant responsive and transporter genes in rats. Kumar A, etal., Free Radic Res. 2010 Aug;44(8):950-65.
20. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
21. Fasting-induced changes in ECL cell gene expression. Lambrecht NW, etal., Physiol Genomics. 2007 Oct 22;31(2):183-92. Epub 2007 May 29.
22. Vesicular monoamine transporter-2 and aromatic L-amino acid decarboxylase gene therapy prevents development of motor complications in parkinsonian rats after chronic intermittent L-3,4-dihydroxyphenylalanine administration. Lee WY, etal., Exp Neurol. 2006 Jan;197(1):215-24. Epub 2005 Nov 2.
23. Sorting of vesicular monoamine transporter 2 to the regulated secretory pathway confers the somatodendritic exocytosis of monoamines. Li H, etal.
24. Protective effect of Zhen-Wu-Tang (ZWT) through keeping DA stable and VMAT 2/DAT mRNA in balance in rats with striatal lesions induced by MPTP. Li XM, etal., J Ethnopharmacol. 2011 Apr 12;134(3):768-74. Epub 2011 Feb 1.
25. A cDNA that suppresses MPP+ toxicity encodes a vesicular amine transporter. Liu Y, etal., Cell 1992 Aug 21;70(4):539-51.
26. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
27. Profound changes in dopaminergic neurotransmission in the prefrontal cortex in response to flattening of the diurnal glucocorticoid rhythm: implications for bipolar disorder. Minton GO, etal., Neuropsychopharmacology. 2009 Sep;34(10):2265-74. Epub 2009 Jun 3.
28. Mice with very low expression of the vesicular monoamine transporter 2 gene survive into adulthood: potential mouse model for parkinsonism. Mooslehner KA, etal., Mol Cell Biol. 2001 Aug;21(16):5321-31.
29. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
30. Ultrastructural localization of the vesicular monoamine transporter-2 in midbrain dopaminergic neurons: potential sites for somatodendritic storage and release of dopamine. Nirenberg MJ, etal., J Neurosci. 1996 Jul 1;16(13):4135-45.
31. The vesicular monoamine transporter 2 is present in small synaptic vesicles and preferentially localizes to large dense core vesicles in rat solitary tract nuclei. Nirenberg MJ, etal., Proc Natl Acad Sci U S A. 1995 Sep 12;92(19):8773-7.
32. Regulation of glutamate release by alpha7 nicotinic receptors: differential role in methamphetamine-induced damage to dopaminergic and serotonergic terminals. Northrop NA, etal., J Pharmacol Exp Ther. 2011 Mar;336(3):900-7. Epub 2010 Dec 15.
33. Vesicular monoamine and glutamate transporters select distinct synaptic vesicle recycling pathways. Onoa B, etal., J Neurosci. 2010 Jun 9;30(23):7917-27.
34. The chromaffin granule and synaptic vesicle amine transporters differ in substrate recognition and sensitivity to inhibitors. Peter D, etal., J Biol Chem. 1994 Mar 11;269(10):7231-7.
35. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
36. Role of vesicular monoamine transporter type 2 in rodent insulin secretion and glucose metabolism revealed by its specific antagonist tetrabenazine. Raffo A, etal., J Endocrinol. 2008 Jul;198(1):41-9.
37. The molecular chaperone Hsc70 interacts with the vesicular monoamine transporter-2. Requena DF, etal., J Neurochem. 2009 Jul;110(2):581-94. Epub 2009 Apr 30.
38. GOA pipeline RGD automated data pipeline
39. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
40. Enzymatic-nonenzymatic cellular antioxidant defense systems response and immunohistochemical detection of MDMA, VMAT2, HSP70, and apoptosis as biomarkers for MDMA (Ecstasy) neurotoxicity. Riezzo I, etal., J Neurosci Res. 2010 Mar;88(4):905-16.
41. C1 neurons in the rat rostral ventrolateral medulla differentially express vesicular monoamine transporter 2 in soma and axonal compartments. Sevigny CP, etal., Eur J Neurosci. 2008 Oct;28(8):1536-44.
42. Longitudinal noninvasive PET-based beta cell mass estimates in a spontaneous diabetes rat model. Souza F, etal., J Clin Invest. 2006 Jun;116(6):1506-13. Epub 2006 May 18.
43. Dopaminergic neurotoxicity following pulmonary exposure to manganese-containing welding fumes. Sriram K, etal., Arch Toxicol. 2010 Jul;84(7):521-40. Epub 2010 Mar 12.
44. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
45. Method development and validation of an in vitro model of the effects of methylphenidate on membrane-associated synaptic vesicles. Volz TJ, etal., J Neurosci Methods. 2009 Feb 15;177(1):177-82. Epub 2008 Oct 17.
Additional References at PubMed
PMID:8745292   PMID:9045708   PMID:9275230   PMID:9427251   PMID:12591135   PMID:15246838   PMID:15695065   PMID:16677634   PMID:16897727   PMID:17156758   PMID:17244889   PMID:18287335  
PMID:19021208   PMID:19429089   PMID:21046458   PMID:21705944   PMID:22570010   PMID:23160224   PMID:23404442   PMID:23504951   PMID:23530208   PMID:24062308   PMID:24161354   PMID:24239562  
PMID:24316448   PMID:24480406   PMID:25370842   PMID:25496994   PMID:25943760   PMID:26956479   PMID:27821772   PMID:31955909  


Genomics

Comparative Map Data
Slc18a2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81268,399,815 - 268,435,229 (+)NCBIGRCr8
mRatBN7.21258,413,748 - 258,449,143 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1258,413,959 - 258,448,325 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1266,619,517 - 266,653,852 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01273,325,530 - 273,359,877 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01265,966,700 - 266,001,038 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01280,397,831 - 280,457,968 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1280,423,079 - 280,457,148 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01287,782,713 - 287,818,452 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41265,789,917 - 265,824,551 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11266,000,961 - 266,035,596 (+)NCBI
Celera1254,067,617 - 254,102,150 (+)NCBICelera
RH 3.4 Map11709.1RGD
Cytogenetic Map1q55NCBI
SLC18A2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3810117,241,114 - 117,279,430 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl10117,241,093 - 117,279,430 (+)EnsemblGRCh38hg38GRCh38
GRCh3710119,000,625 - 119,038,941 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3610118,990,706 - 119,027,085 (+)NCBINCBI36Build 36hg18NCBI36
Build 3410118,991,172 - 119,027,085NCBI
Celera10112,730,694 - 112,769,064 (+)NCBICelera
Cytogenetic Map10q25.3NCBI
HuRef10112,628,076 - 112,666,635 (+)NCBIHuRef
CHM1_110119,284,792 - 119,323,133 (+)NCBICHM1_1
T2T-CHM13v2.010118,135,601 - 118,173,927 (+)NCBIT2T-CHM13v2.0
Slc18a2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391959,249,310 - 59,284,444 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1959,249,328 - 59,284,444 (+)EnsemblGRCm39 Ensembl
GRCm381959,260,878 - 59,296,012 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1959,260,896 - 59,296,012 (+)EnsemblGRCm38mm10GRCm38
MGSCv371959,335,368 - 59,370,502 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361959,314,177 - 59,348,927 (+)NCBIMGSCv36mm8
Celera1961,459,915 - 61,496,491 (+)NCBICelera
Cytogenetic Map19D3NCBI
cM Map1954.64NCBI
Slc18a2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543121,949,576 - 21,979,679 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495543121,949,553 - 21,979,679 (+)NCBIChiLan1.0ChiLan1.0
SLC18A2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v28129,110,470 - 129,149,927 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan110129,115,814 - 129,155,265 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v010113,823,005 - 113,862,451 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.110117,250,639 - 117,290,064 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl10117,250,639 - 117,290,064 (+)Ensemblpanpan1.1panPan2
SLC18A2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12827,731,709 - 27,809,341 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2827,731,004 - 27,767,993 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2827,875,180 - 27,989,296 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02828,261,416 - 28,375,583 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2828,261,774 - 28,298,038 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12827,822,412 - 27,937,317 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02827,836,195 - 27,950,801 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02828,030,658 - 28,145,734 (+)NCBIUU_Cfam_GSD_1.0
Slc18a2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721318,450,220 - 18,486,469 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364867,075,358 - 7,109,637 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364867,075,373 - 7,108,984 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SLC18A2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl14127,357,555 - 127,396,533 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.114127,357,605 - 127,394,242 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.214138,758,819 - 138,800,217 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SLC18A2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.19110,039,783 - 110,078,822 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl9110,040,391 - 110,076,647 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604871,296,614 - 71,335,781 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Slc18a2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473729,358,696 - 29,387,808 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473729,356,590 - 29,388,099 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

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Variants in Slc18a2
212 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:184
Count of miRNA genes:113
Interacting mature miRNAs:153
Transcripts:ENSRNOT00000011983
Prediction methods:Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1549837Hcar15Hepatocarcinoma resistance QTL 150.05liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1153136852260522016Rat
1578763Kidm29Kidney mass QTL 293.30.0001kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1179567751260522016Rat
634313Niddm43Non-insulin dependent diabetes mellitus QTL 43blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1199050459259647894Rat
1358890Bp259Blood pressure QTL 2593.06arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1210702053260522016Rat
734768Niddm59Non-insulin dependent diabetes mellitus QTL 59body mass (VT:0001259)body weight (CMO:0000012)1213843987258843987Rat
70211Niddm24Non-insulin dependent diabetes mellitus QTL 243.79blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1214647894259647894Rat
1549910Bw54Body weight QTL 540.05body mass (VT:0001259)body weight (CMO:0000012)1214647894259647894Rat
61327Eae7Experimental allergic encephalomyelitis QTL 75.6body mass (VT:0001259)change in body weight (CMO:0002045)1216255568260522016Rat
2302040Pia35Pristane induced arthritis QTL 353.80.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)1216255568260522016Rat
731175Uae20Urinary albumin excretion QTL 203.50.0018urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1221264111259647894Rat
10053715Scort24Serum corticosterone level QTL 242.130.0088blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1221414816260522016Rat
724552Glom2Glomerulus QTL 23.30.0001kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli directly contacting the kidney surface (CMO:0001001)1222363780260522016Rat
1600392Bw123Body weight QTL 1230.001body mass (VT:0001259)body weight (CMO:0000012)1223201027260522016Rat
734767Niddm57Non-insulin dependent diabetes mellitus QTL 57body mass (VT:0001259)body weight (CMO:0000012)1224054293260122809Rat
631843Bw116Body weight QTL 1164.10.016abdominal adipose amount (VT:1000220)abdominal fat pad weight (CMO:0000088)1224054293260122809Rat
734769Niddm58Non-insulin dependent diabetes mellitus QTL 58body mass (VT:0001259)body weight (CMO:0000012)1224569538260122809Rat
631215Stl8Serum triglyceride level QTL 89.270.0001blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)1225126575260522016Rat
1300108Rf8Renal function QTL 83.75renal blood flow trait (VT:2000006)absolute change in renal vascular resistance (CMO:0001900)1228581588259647894Rat
1581544Rf52Renal function QTL 520.05urine total protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)1232156370259647894Rat
631669Iddm9Insulin dependent diabetes mellitus QTL 92.80.039blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1233190394258625266Rat
631536Lnnr2Liver neoplastic nodule remodeling QTL 22.90.0005liver integrity trait (VT:0010547)liver remodeling tumorous lesion number to liver total tumorous lesion number ratio (CMO:0001705)1233948574260522016Rat
631690Scl5Serum cholesterol level QTL 52.1blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)1236125214260522016Rat
631836Stl31Serum triglyceride level QTL 314.640.00000487blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)1237147813260522016Rat
631837Niddm35Non-insulin dependent diabetes mellitus QTL 350.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1238699859259647894Rat

Markers in Region
RH94742  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21258,447,675 - 258,447,802 (+)MAPPERmRatBN7.2
Rnor_6.01280,456,499 - 280,456,625NCBIRnor6.0
Rnor_5.01287,816,983 - 287,817,109UniSTSRnor5.0
RGSC_v3.41265,823,902 - 265,824,028UniSTSRGSC3.4
Celera1254,101,501 - 254,101,627UniSTS
RH 3.4 Map11709.1UniSTS
Cytogenetic Map1q55UniSTS
D1Bda65  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21258,447,817 - 258,448,251 (+)MAPPERmRatBN7.2
Rnor_6.01280,456,641 - 280,457,074NCBIRnor6.0
Rnor_5.01287,817,125 - 287,817,558UniSTSRnor5.0
RGSC_v3.41265,824,044 - 265,824,477UniSTSRGSC3.4
Celera1254,101,643 - 254,102,076UniSTS
Cytogenetic Map1q55UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 1 4 31 1
Low 3 28 48 33 15 33 8 10 41 17 24 11 8
Below cutoff 13 2 2 2 1 2 12 13

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000011983   ⟹   ENSRNOP00000011983
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1258,413,959 - 258,448,325 (+)Ensembl
Rnor_6.0 Ensembl1280,423,079 - 280,457,148 (+)Ensembl
RefSeq Acc Id: NM_013031   ⟹   NP_037163
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81268,400,021 - 268,434,411 (+)NCBI
mRatBN7.21258,413,959 - 258,448,325 (+)NCBI
Rnor_6.01280,423,079 - 280,457,148 (+)NCBI
Rnor_5.01287,782,713 - 287,818,452 (+)NCBI
RGSC_v3.41265,789,917 - 265,824,551 (+)RGD
Celera1254,067,617 - 254,102,150 (+)RGD
Sequence:
RefSeq Acc Id: XM_006231664   ⟹   XP_006231726
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81268,399,815 - 268,435,229 (+)NCBI
mRatBN7.21258,413,748 - 258,449,143 (+)NCBI
Rnor_6.01280,397,831 - 280,457,968 (+)NCBI
Rnor_5.01287,782,713 - 287,818,452 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_037163 (Get FASTA)   NCBI Sequence Viewer  
  XP_006231726 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA41627 (Get FASTA)   NCBI Sequence Viewer  
  AAA42190 (Get FASTA)   NCBI Sequence Viewer  
  EDL94556 (Get FASTA)   NCBI Sequence Viewer  
  EDL94557 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000011983
  ENSRNOP00000011983.1
GenBank Protein Q01827 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: NP_037163   ⟸   NM_013031
- UniProtKB: Q9QVP1 (UniProtKB/Swiss-Prot),   Q01827 (UniProtKB/Swiss-Prot),   A0A0G2JSJ6 (UniProtKB/TrEMBL),   A6JI82 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006231726   ⟸   XM_006231664
- Peptide Label: isoform X1
- UniProtKB: Q9QVP1 (UniProtKB/Swiss-Prot),   Q01827 (UniProtKB/Swiss-Prot),   A0A0G2JSJ6 (UniProtKB/TrEMBL),   A6JI82 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000011983   ⟸   ENSRNOT00000011983
Protein Domains
Major facilitator superfamily (MFS) profile

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q01827-F1-model_v2 AlphaFold Q01827 1-515 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3694 AgrOrtholog
BioCyc Gene G2FUF-55254 BioCyc
Ensembl Genes ENSRNOG00000008890 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000011983 ENTREZGENE
  ENSRNOT00000011983.3 UniProtKB/TrEMBL
Gene3D-CATH 1.20.1250.20 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro MFS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MFS_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MFS_trans_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Multidrug-R UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25549 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 25549 ENTREZGENE
PANTHER PTHR23506 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SYNAPTIC VESICULAR AMINE TRANSPORTER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam MFS_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB SLC18A2 RGD
PhenoGen Slc18a2 PhenoGen
PROSITE MFS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000008890 RatGTEx
Superfamily-SCOP SSF103473 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC206310
UniProt A0A0G2JSJ6 ENTREZGENE, UniProtKB/TrEMBL
  A6JI82 ENTREZGENE, UniProtKB/TrEMBL
  Q01827 ENTREZGENE
  Q9QVP1 ENTREZGENE
  VMAT2_RAT UniProtKB/Swiss-Prot
UniProt Secondary Q9QVP1 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-01 Slc18a2  solute carrier family 18 member A2  Slc18a2  solute carrier family 18 member 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2016-02-25 Slc18a2  solute carrier family 18 member 2  Slc18a2  solute carrier family 18 (vesicular monoamine transporter), member 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-08-02 Slc18a2  solute carrier family 18 (vesicular monoamine transporter), member 2  Slc18a2  solute carrier family 18 (vesicular monoamine), member 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Slc18a2  solute carrier family 18 (vesicular monoamine), member 2    solute carrier family 18, member 2  Name updated 1299863 APPROVED
2003-04-09 Slc18a2  solute carrier family 18, member 2    Solute carrier family 18 A2 (vesicular monoamine transporter 2)  Name updated 629478 APPROVED
2002-06-10 Slc18a2  Solute carrier family 18 A2 (vesicular monoamine transporter 2)      Symbol and Name status set to approved 70586 APPROVED