DOPAMINE BIOSYNTHETIC PATHWAY (PW:0000802)

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Description

The synthesis and release of catecholamines epinephrine, norepinephrine and dopamine are triggered by various but distinct conditions and stresses. Dopamine (DA) acts a neurotransmitter and neuromodulator in the brain and peripherally, as an autocrine/paracrine hormone. Dopamine exerts its major role in the nervous system where is involved in motor control and action selection, reward and motivation, behavior, memory and cognition. The five G protein-coupled (GPCR) DA receptors are subdivided in

Pathway Diagram:

Elsevier Inc. L-DOPA dopamine tyrosine BH2 BH4 Ddc Th Qdpr dopamine signaling pathway dopamine --+> dopamine signaling pathway Slc18a2 ---> dopamine Slc18a2 Ddc ---- Slc18a2 Slc18a2 ---- Th diet L-Phe hydroxylation BH4 ---> BH2 L-DOPA ---> dopamine tyrosine ---> L-DOPA diet ---> tyrosine L-Phe hydroxylation ---> tyrosine BH2 ---> BH4
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Genes in Pathway:

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dopamine biosynthetic pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ddc dopa decarboxylase JBrowse link 14 91,905,919 91,996,816 RGD:4139904
G Qdpr quinoid dihydropteridine reductase JBrowse link 14 70,164,682 70,178,284 RGD:4139904
G Slc18a2 solute carrier family 18 member A2 JBrowse link 1 280,397,831 280,457,968 RGD:5128868
G Th tyrosine hydroxylase JBrowse link 1 216,073,034 216,080,287 RGD:4139904

Additional Elements in Pathway:

(includes Gene Groups, Small Molecules, Other Pathways..etc.)
Object TypePathway ObjectPathway Object Description
Small MoleculeBH2dihydrobiopterin
Small MoleculeL-DOPALevodopa
Small MoleculeBH4tetrahydrobiopterin

Pathway Gene Annotations

Disease Annotations Associated with Genes in the dopamine biosynthetic pathway
Pathway Annotations Associated with Genes in the dopamine biosynthetic pathway

References Associated with the dopamine biosynthetic pathway:

Ontology Path Diagram:

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