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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3694
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Slc18a2
Name: solute carrier family 18 member A2
Acc ID: CHEBI:18243
Term: dopamine
Definition: Catechol in which the hydrogen at position 4 is substituted by a 2-aminoethyl group.
Chemical ID: MESH:D004298
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Slc18a2decreases abundanceEXP 6480464CTDSLC18A2 results in decreased abundance of DopaminePMID:19409267
Slc18a2multiple interactionsEXP 6480464CTDDopamine inhibits the reaction [SLC18A2 protein results in increased uptake of Serotonin]PMID:1438304
Slc18a2affects bindingISOSLC18A2 (Homo sapiens)6480464CTDDopamine binds to SLC18A2 proteinPMID:7912402
Slc18a2decreases activityISOSLC18A2 (Homo sapiens)6480464CTDDopamine results in decreased activity of SLC18A2 proteinPMID:15475732
Slc18a2increases uptakeISOSlc18a2 (Mus musculus)6480464CTDSLC18A2 protein results in increased uptake of DopaminePMID:18533268
Slc18a2increases uptakeISOSLC18A2 (Homo sapiens)6480464CTDSLC18A2 protein results in increased uptake of DopaminePMID:29908239
Slc18a2multiple interactionsISOSlc18a2 (Mus musculus)6480464CTDDDT inhibits the reaction [SLC18A2 protein results in increased uptake of Dopamine]; Dichlorodiphenyldichloroethane inhibits the reaction [SLC18A2 protein results in increased uptake of Dopamine]; SLC18A2 protein affects the transport of and affects the abundance of DopaminePMID:18533268 PMID:27287315
Slc18a2multiple interactionsISOSLC18A2 (Homo sapiens)6480464CTDHeptachlor Epoxide inhibits the reaction [SLC18A2 protein results in increased uptake of Dopamine]; N-Methyl-3,4-methylenedioxyamphetamine inhibits the reaction [SLC18A2 protein results in increased uptake of Dopamine]; para-methyl-4-methylaminorex inhibits the reaction [SLC18A2 protein results in increased uptake of Dopamine]; Reserpine inhibits the reaction [SLC18A2 protein results in increased uptake of Dopamine]PMID:10499361 PMID:29908239
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