Apobec1 (apolipoprotein B mRNA editing enzyme catalytic subunit 1) - Rat Genome Database

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Gene: Apobec1 (apolipoprotein B mRNA editing enzyme catalytic subunit 1) Rattus norvegicus
Analyze
Symbol: Apobec1
Name: apolipoprotein B mRNA editing enzyme catalytic subunit 1
RGD ID: 2133
Description: Enables several functions, including deaminase activity; enzyme activator activity; and ribonucleoprotein complex binding activity. Involved in several processes, including DNA cytosine deamination; RNA modification; and positive regulation of mRNA modification. Predicted to be part of apolipoprotein B mRNA editing enzyme complex. Predicted to be active in cytoplasm and nucleus. Used to study familial hyperlipidemia and liver benign neoplasm. Biomarker of colon cancer and obesity. Orthologous to human APOBEC1 (apolipoprotein B mRNA editing enzyme catalytic subunit 1); PARTICIPATES IN lipoprotein metabolic pathway; INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 17beta-estradiol 3-benzoate.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: apobec-1; apolipoprotein B editing complex 1; Apolipoprotein B editing protein; apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1; apolipoprotein B mRNA-editing enzyme 1; C->U-editing enzyme APOBEC-1; mRNA(cytosine(6666)) deaminase 1; REPR
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84157,472,879 - 157,500,496 (-)NCBIGRCr8
mRatBN7.24155,800,030 - 155,828,515 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4155,800,887 - 155,827,390 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4162,064,076 - 162,078,798 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04157,847,296 - 157,862,008 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04156,493,855 - 156,508,527 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.04155,386,367 - 155,414,034 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4155,386,711 - 155,401,480 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04222,409,798 - 222,438,051 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44159,033,170 - 159,048,108 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14159,278,107 - 159,293,044 (-)NCBI
Celera4144,620,263 - 144,634,783 (-)NCBICelera
Cytogenetic Map4q42NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
apolipoprotein B mRNA editing enzyme complex  (IEA,ISO)
cytoplasm  (IBA,IEA,ISO,ISS)
nucleus  (IBA,IEA,ISO,NAS)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Apobec-1 transcription in rat colon cancer: decreased apobec-1 protein production through alterations in polysome distribution and mRNA translation associated with upstream AUGs. Anant S, etal., Biochim Biophys Acta 2002 May 3;1575(1-3):54-62.
2. Cytidine deamination of retroviral DNA by diverse APOBEC proteins. Bishop KN, etal., Curr Biol. 2004 Aug 10;14(15):1392-6.
3. Calcium increases apolipoprotein B mRNA editing. Chen Z, etal., Biochem Biophys Res Commun. 2000 Oct 14;277(1):221-7.
4. SINGLE NUCLEOTIDE POLYMORPHISMS THAT INFLUENCE LIPID METABOLISM: Interaction with Dietary Factors. Corella D and Ordovas JM, Annu Rev Nutr. 2005;25:341-90.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
7. Inhibition of the apolipoprotein B mRNA editing enzyme-complex by hnRNP C1 protein and 40S hnRNP complexes. Greeve J, etal., Biol Chem. 1998 Aug-Sep;379(8-9):1063-73.
8. Purification and molecular cloning of a novel essential component of the apolipoprotein B mRNA editing enzyme-complex. Lellek H, etal., J Biol Chem. 2000 Jun 30;275(26):19848-56.
9. Acute modulation of the extent of apoB mRNA editing and the relative rates of syntheses of apoB48 and apoB100 in cultured rat hepatocytes by osmotic and other stress stimuli. McCahill A, etal., Mol Cell Biochem. 2000 May;208(1-2):77-87.
10. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
11. Activation-induced cytidine deaminase deaminates 5-methylcytosine in DNA and is expressed in pluripotent tissues: implications for epigenetic reprogramming. Morgan HD, etal., J Biol Chem. 2004 Dec 10;279(50):52353-60. Epub 2004 Sep 24.
12. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
13. In vitro deamination of cytosine to uracil in single-stranded DNA by apolipoprotein B editing complex catalytic subunit 1 (APOBEC1). Petersen-Mahrt SK and Neuberger MS, J Biol Chem 2003 May 30;278(22):19583-6. Epub 2003 Apr 14.
14. Regulation of hepatic apolipoprotein B RNA editing in the genetically obese Zucker rat. Phung TL, etal., Metabolism. 1996 Sep;45(9):1056-8.
15. Low expression of the apolipoprotein B mRNA-editing transgene in mice reduces LDL levels but does not cause liver dysplasia or tumors. Qian X, etal., Arterioscler Thromb Vasc Biol. 1998 Jun;18(6):1013-20.
16. Plasma apolipoprotein B-48, hepatic apolipoprotein B mRNA editing and apolipoprotein B mRNA editing catalytic subunit-1 mRNA levels are altered in zinc-deficient rats. Reaves SK, etal., J Nutr. 1999 Oct;129(10):1855-61.
17. GOA pipeline RGD automated data pipeline
18. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
19. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
20. Molecular cloning of an apolipoprotein B messenger RNA editing protein. Teng B, etal., Science 1993 Jun 18;260(5115):1816-9.
21. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
22. Ethanol increases apolipoprotein B mRNA editing in rat primary hepatocytes and McArdle cells. Van Mater D, etal., Biochem Biophys Res Commun. 1998 Nov 18;252(2):334-9.
23. Insulin increases expression of apobec-1, the catalytic subunit of the apolipoprotein B mRNA editing complex in rat hepatocytes. von Wronski MA, etal., Metabolism. 1998 Jul;47(7):869-73.
24. Effects of a thyromimetic on apolipoprotein B-100 in rats. Wada Y, etal., J Mol Endocrinol. 2000 Dec;25(3):299-308.
25. Multiple protein domains determine the cell type-specific nuclear distribution of the catalytic subunit required for apolipoprotein B mRNA editing. Yang Y, etal., Proc Natl Acad Sci U S A. 1997 Nov 25;94(24):13075-80.
Additional References at PubMed
PMID:8626621   PMID:8692961   PMID:9240444   PMID:10403781   PMID:12477932   PMID:13130124   PMID:15286366   PMID:15480992   PMID:15489334   PMID:15963568   PMID:17875695   PMID:21496894  
PMID:21775448   PMID:22326345   PMID:22580899   PMID:23609497   PMID:24916387   PMID:25085003   PMID:29553573  


Genomics

Comparative Map Data
Apobec1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84157,472,879 - 157,500,496 (-)NCBIGRCr8
mRatBN7.24155,800,030 - 155,828,515 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4155,800,887 - 155,827,390 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4162,064,076 - 162,078,798 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04157,847,296 - 157,862,008 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04156,493,855 - 156,508,527 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.04155,386,367 - 155,414,034 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4155,386,711 - 155,401,480 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04222,409,798 - 222,438,051 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44159,033,170 - 159,048,108 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14159,278,107 - 159,293,044 (-)NCBI
Celera4144,620,263 - 144,634,783 (-)NCBICelera
Cytogenetic Map4q42NCBI
APOBEC1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38127,649,400 - 7,670,599 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl127,649,400 - 7,665,908 (-)EnsemblGRCh38hg38GRCh38
GRCh37127,801,996 - 7,823,195 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36127,693,263 - 7,709,769 (-)NCBINCBI36Build 36hg18NCBI36
Build 34127,693,263 - 7,709,765NCBI
Celera129,377,416 - 9,393,928 (-)NCBICelera
Cytogenetic Map12p13.31NCBI
HuRef127,615,551 - 7,632,073 (-)NCBIHuRef
CHM1_1127,801,108 - 7,817,585 (-)NCBICHM1_1
T2T-CHM13v2.0127,663,658 - 7,684,886 (-)NCBIT2T-CHM13v2.0
Apobec1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm396122,554,755 - 122,580,068 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl6122,554,751 - 122,579,403 (-)EnsemblGRCm39 Ensembl
GRCm386122,577,792 - 122,603,024 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl6122,577,792 - 122,602,444 (-)EnsemblGRCm38mm10GRCm38
MGSCv376122,527,810 - 122,552,462 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv366122,543,411 - 122,568,063 (-)NCBIMGSCv36mm8
Celera6124,372,038 - 124,397,549 (-)NCBICelera
Cytogenetic Map6F1NCBI
cM Map657.68NCBI
Apobec1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554136,471,953 - 6,480,469 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554136,471,933 - 6,480,475 (-)NCBIChiLan1.0ChiLan1.0
APOBEC1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21013,212,602 - 13,225,890 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11213,209,214 - 13,223,660 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0127,777,734 - 7,793,960 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1127,939,115 - 7,950,315 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl127,939,262 - 7,944,203 (-)Ensemblpanpan1.1panPan2
APOBEC1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12737,102,728 - 37,114,084 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2737,103,016 - 37,114,556 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha279,502,214 - 9,513,600 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02737,452,077 - 37,463,466 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2737,452,249 - 37,463,777 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12737,333,157 - 37,344,537 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02737,368,031 - 37,379,426 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0278,988,480 - 8,999,873 (+)NCBIUU_Cfam_GSD_1.0
Apobec1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494598,775,264 - 98,783,978 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004939393628 - 6,201 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004939393628 - 6,234 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
APOBEC1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl562,810,879 - 62,820,173 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1562,811,819 - 62,820,532 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2565,642,017 - 65,650,615 (-)NCBISscrofa10.2Sscrofa10.2susScr3
APOBEC1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1117,696,571 - 7,700,424 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl117,696,259 - 7,700,643 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666063490,767 - 508,119 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Apobec1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248604,938,001 - 4,957,236 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248604,938,001 - 4,957,640 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Apobec1
253 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:32
Count of miRNA genes:31
Interacting mature miRNAs:32
Transcripts:ENSRNOT00000020735
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)411320076180699135Rat
1576305Emca6Estrogen-induced mammary cancer QTL 65.8mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)444463720155883716Rat
631674Iddm14Insulin dependent diabetes mellitus QTL 14blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)464528739157573521Rat
1576316Ept5Estrogen-induced pituitary tumorigenesis QTL 53.8pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)483428419177635233Rat
1358202Gluco11Glucose level QTL 112.40.02adipocyte glucose uptake trait (VT:0004185)absolute change in adipocyte glucose uptake (CMO:0000873)485379421167139601Rat
634335Anxrr16Anxiety related response QTL 167.22locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)493308457167139447Rat
737821Hcar9Hepatocarcinoma resistance QTL 93.7liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)4109866907167139601Rat
1331759Hrtrt13Heart rate QTL 133.54628heart pumping trait (VT:2000009)heart rate (CMO:0000002)4110275411168266883Rat
6478760Anxrr45Anxiety related response QTL 450.06717locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4110870972155870972Rat
6478763Anxrr46Anxiety related response QTL 460.07428locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4110870972155870972Rat
12798519Anxrr54Anxiety related response QTL 542.540.05locomotor behavior trait (VT:0001392)distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)4114627026159627026Rat
724535Cm18Cardiac mass QTL 182.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)4118856416163856416Rat
1331802Srn5Serum renin concentration QTL 53.045renin activity (VT:0005581)plasma renin activity level (CMO:0000116)4119428175157578333Rat
634347Hcar8Hepatocarcinoma resistance QTL 85.8liver integrity trait (VT:0010547)liver tumorous lesion area to total liver area ratio (CMO:0001075)4123143783168143783Rat
631683Bp116Blood pressure QTL 1160.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)4124303370169303370Rat
6478778Anxrr51Anxiety related response QTL 510.25384locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)4124778595169778595Rat
7411558Bw133Body weight QTL 13313.840.001body mass (VT:0001259)body weight gain (CMO:0000420)4125590636170590636Rat
61451Ciaa4CIA Autoantibody QTL 43.1blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)4126395976167139601Rat
737978Pia23Pristane induced arthritis QTL 235.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4131730738167139601Rat
631511Pia7Pristane induced arthritis QTL 74.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4131730738167139601Rat
1549827Scl46Serum cholesterol level QTL 463.5blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)4132396220177396220Rat
724558Plsm2Polydactyly-luxate syndrome (PLS) morphotypes QTL 20.0003hindlimb integrity trait (VT:0010563)hind foot phalanges count (CMO:0001949)4132422778177422778Rat
61422Cia13Collagen induced arthritis QTL 134.5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4132642577167139601Rat
2303623Vencon2Ventilatory control QTL 23.8respiration trait (VT:0001943)minute ventilation (CMO:0000132)4135204660180204660Rat
1578674Bmd12Bone mineral density QTL 123.8femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)4135699135180699135Rat
2293659Bmd35Bone mineral density QTL 354.50.0001femur strength trait (VT:0010010)femoral neck ultimate force (CMO:0001703)4137755016181392681Rat
61362Oia2Oil induced arthritis QTL 20.001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4138503169173369699Rat
1298524Oia8Oil induced arthritis QTL 8joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4138503169173369699Rat
1331738Bp209Blood pressure QTL 2092.979arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)4138503169179293946Rat
6478718Anxrr34Anxiety related response QTL 340.00896locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4144639524182687754Rat
6478748Anxrr42Anxiety related response QTL 420.28008locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4144639524182687754Rat
6478754Anxrr43Anxiety related response QTL 430.14035locomotor behavior trait (VT:0001392)distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)4144639524182687754Rat
6478693Anxrr32Anxiety related response QTL 320.00092locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)4144639524182687754Rat
6478700Anxrr33Anxiety related response QTL 330.00896locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4144639524182687754Rat
10401796Kidm48Kidney mass QTL 48kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)4145568712182687754Rat
634342Cia24Collagen induced arthritis QTL 244.5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4146565735175236377Rat
12798525Anxrr57Anxiety related response QTL 573.210.05locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4147278504167139601Rat
1582237Kidm34Kidney mass QTL 3440.0001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)4148090542168069246Rat
61446Coreg2Compensatory renal growth QTL 23.5kidney mass (VT:0002707)compensatory renal growth score (CMO:0001894)4148423102157580971Rat
1581574Eae20Experimental allergic encephalomyelitis QTL 207.8nervous system integrity trait (VT:0010566)percentage of study population developing experimental autoimmune encephalomyelitis during a period of time (CMO:0001047)4153031106158841762Rat
10053718Scort25Serum corticosterone level QTL 252.150.0097blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)4155561574182687754Rat

Markers in Region
UniSTS:224890  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24155,800,828 - 155,800,939 (+)MAPPERmRatBN7.2
Rnor_6.04155,386,640 - 155,386,750NCBIRnor6.0
Rnor_5.04222,411,105 - 222,411,215UniSTSRnor5.0
RGSC_v3.44159,033,101 - 159,033,211UniSTSRGSC3.4
Celera4144,620,194 - 144,620,304UniSTS
Cytogenetic Map4q42UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 7 7 11 7 2 4 1
Low 35 50 34 8 34 8 11 70 33 34 10 8
Below cutoff 4 4 3

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_012907 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006237290 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006237291 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006237292 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006237293 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008763219 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017592483 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017592484 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039107109 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039107110 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039107113 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AJ006695 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC085335 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473964 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000004 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L07114 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000020735   ⟹   ENSRNOP00000020735
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4155,800,887 - 155,821,328 (-)Ensembl
Rnor_6.0 Ensembl4155,386,711 - 155,401,480 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000106242   ⟹   ENSRNOP00000078194
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4155,800,887 - 155,816,217 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000109144   ⟹   ENSRNOP00000077863
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4155,800,887 - 155,827,390 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000118333   ⟹   ENSRNOP00000094681
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4155,800,887 - 155,827,390 (-)Ensembl
RefSeq Acc Id: NM_012907   ⟹   NP_037039
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84157,472,879 - 157,487,601 (-)NCBI
mRatBN7.24155,800,898 - 155,815,625 (-)NCBI
Rnor_6.04155,386,709 - 155,401,480 (-)NCBI
Rnor_5.04222,409,798 - 222,438,051 (-)NCBI
RGSC_v3.44159,033,170 - 159,048,108 (-)RGD
Celera4144,620,263 - 144,634,783 (-)RGD
Sequence:
RefSeq Acc Id: XM_006237290   ⟹   XP_006237352
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84157,472,879 - 157,499,350 (-)NCBI
mRatBN7.24155,800,030 - 155,827,378 (-)NCBI
Rnor_6.04155,386,367 - 155,413,479 (-)NCBI
Rnor_5.04222,409,798 - 222,438,051 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006237293   ⟹   XP_006237355
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84157,472,879 - 157,500,496 (-)NCBI
mRatBN7.24155,800,030 - 155,828,266 (-)NCBI
Rnor_6.04155,386,367 - 155,413,797 (-)NCBI
Rnor_5.04222,409,798 - 222,438,051 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017592483   ⟹   XP_017447972
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84157,472,879 - 157,499,352 (-)NCBI
mRatBN7.24155,800,030 - 155,827,380 (-)NCBI
Rnor_6.04155,386,367 - 155,413,479 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017592484   ⟹   XP_017447973
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84157,472,879 - 157,499,350 (-)NCBI
mRatBN7.24155,800,030 - 155,827,378 (-)NCBI
Rnor_6.04155,386,367 - 155,413,479 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039107109   ⟹   XP_038963037
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84157,472,879 - 157,494,764 (-)NCBI
mRatBN7.24155,800,030 - 155,822,674 (-)NCBI
RefSeq Acc Id: XM_039107110   ⟹   XP_038963038
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84157,472,879 - 157,500,382 (-)NCBI
mRatBN7.24155,800,030 - 155,828,405 (-)NCBI
RefSeq Acc Id: XM_039107113   ⟹   XP_038963041
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84157,472,879 - 157,500,496 (-)NCBI
mRatBN7.24155,800,030 - 155,828,515 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_037039   ⟸   NM_012907
- UniProtKB: P38483 (UniProtKB/Swiss-Prot),   A6ILF2 (UniProtKB/TrEMBL),   A0A8L2QAE9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006237355   ⟸   XM_006237293
- Peptide Label: isoform X2
- UniProtKB: P38483 (UniProtKB/Swiss-Prot),   A6ILF2 (UniProtKB/TrEMBL),   A0A8L2QAE9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006237352   ⟸   XM_006237290
- Peptide Label: isoform X2
- UniProtKB: P38483 (UniProtKB/Swiss-Prot),   A6ILF2 (UniProtKB/TrEMBL),   A0A8L2QAE9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017447973   ⟸   XM_017592484
- Peptide Label: isoform X2
- UniProtKB: P38483 (UniProtKB/Swiss-Prot),   A6ILF2 (UniProtKB/TrEMBL),   A0A8L2QAE9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017447972   ⟸   XM_017592483
- Peptide Label: isoform X1
- UniProtKB: A0A8I6B1D0 (UniProtKB/TrEMBL),   A0A8I5Y2I8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000020735   ⟸   ENSRNOT00000020735
RefSeq Acc Id: XP_038963041   ⟸   XM_039107113
- Peptide Label: isoform X2
- UniProtKB: P38483 (UniProtKB/Swiss-Prot),   A6ILF2 (UniProtKB/TrEMBL),   A0A8L2QAE9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038963038   ⟸   XM_039107110
- Peptide Label: isoform X1
- UniProtKB: A0A8I6B1D0 (UniProtKB/TrEMBL),   A0A8I5Y2I8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038963037   ⟸   XM_039107109
- Peptide Label: isoform X1
- UniProtKB: A0A8I6B1D0 (UniProtKB/TrEMBL),   A0A8I5Y2I8 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000078194   ⟸   ENSRNOT00000106242
RefSeq Acc Id: ENSRNOP00000094681   ⟸   ENSRNOT00000118333
RefSeq Acc Id: ENSRNOP00000077863   ⟸   ENSRNOT00000109144
Protein Domains
CMP/dCMP-type deaminase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P38483-F1-model_v2 AlphaFold P38483 1-229 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2133 AgrOrtholog
BioCyc Gene G2FUF-43150 BioCyc
Ensembl Genes ENSRNOG00000015411 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000020735.6 UniProtKB/TrEMBL
  ENSRNOT00000106242 ENTREZGENE
  ENSRNOT00000106242.1 UniProtKB/TrEMBL
  ENSRNOT00000109144.1 UniProtKB/TrEMBL
  ENSRNOT00000118333.1 UniProtKB/TrEMBL
Gene3D-CATH Cytidine Deaminase, domain 2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7301703 IMAGE-MGC_LOAD
InterPro APOBEC/CMP_deaminase_Zn-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  APOBEC1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CMP_dCMP_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cytidine_deaminase-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25383 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:105503 IMAGE-MGC_LOAD
NCBI Gene 25383 ENTREZGENE
PANTHER C-U-EDITING ENZYME APOBEC-1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MRNA EDITING ENZYME UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam APOBEC4_like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Apobec1 PhenoGen
PROSITE CYT_DCMP_DEAMINASES_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CYT_DCMP_DEAMINASES_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000015411 RatGTEx
Superfamily-SCOP SSF53927 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC222613
UniProt A0A8I5Y1P0_RAT UniProtKB/TrEMBL
  A0A8I5Y2I8 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6B1D0 ENTREZGENE, UniProtKB/TrEMBL
  A0A8L2QAE9 ENTREZGENE, UniProtKB/TrEMBL
  A6ILF2 ENTREZGENE, UniProtKB/TrEMBL
  A6ILF3_RAT UniProtKB/TrEMBL
  ABEC1_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-15 Apobec1  apolipoprotein B mRNA editing enzyme catalytic subunit 1  Apobec1  apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-25 Apobec1  apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1  Apobec1  apolipoprotein B editing complex 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Apobec1  Apolipoprotein B editing protein      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_domains contains several phosphorylation sites 634661
gene_domains contains leucine zipper domains 634661
gene_expression expressed in small intestine 634661
gene_process required for post transcriptional mRNA editing of apolipoprotein B 634661
gene_process contributes to post transcriptional cytidine deamination of apolipoprotein B mRNA 634661