RGD Reference Report - Effects of a thyromimetic on apolipoprotein B-100 in rats. - Rat Genome Database

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Effects of a thyromimetic on apolipoprotein B-100 in rats.

Authors: Wada, Y  Matsubara, S  Dufresne, J  Hargrove, GM  Stephan, ZF  Steele, RE  Wong, NC 
Citation: Wada Y, etal., J Mol Endocrinol. 2000 Dec;25(3):299-308.
RGD ID: 1626277
Pubmed: PMID:11116209   (View Abstract at PubMed)

We have studied the effects of a cardiac sparing thyromimetic, CGS 23425, on postprandial levels of triglycerides, abundance of apolipoprotein B (apo B) protein and hepatic apo B mRNA expression in rats. When compared with control rats, triglyceride clearance was significantly accelerated by treatment with CGS 23425. A full return to baseline values was achieved within 8 h after ingesting a large quantity of fat, as compared to >24 h in control animals. The abundance of apo B-100 protein in CGS 23425-treated hyperlipidemic rats decreased in a dose-dependent manner, but levels of apo B-48 were not significantly affected. Like L-tri-iodothyronine (L-T(3)), treatment with 30 microg/kg CGS 23425 for 6 or 9 days decreased the levels of apo B-100 protein by 80% and 40% respectively. This change was paralleled by a 27% reduction in hepatic apo B-100 mRNA. To investigate a potential mechanism of CGS 23425 action, we measured in vitro apo B mRNA editing activity in hepatocellular extract from control or CGS 23425-treated rats. Treatment with CGS 23425 increased activity of the hepatic apo B-100 editosome, apobec-1. In human hepatoma cells which lack apobec-1 activity, apo B-100 mRNA levels remained the same in cells treated with or without the agent. In summary, these observations show that CGS 23425 decreases the levels of apo B-100 in rats. This action of CGS 23425 involves apo B-100 mRNA editing activity.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
familial hyperlipidemia  ISOApobec1 (Rattus norvegicus)1626277; 1626277 RGD 
familial hyperlipidemia  IDA 1626277 RGD 

Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
response to xenobiotic stimulus  IDA 1626277 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Apobec1  (apolipoprotein B mRNA editing enzyme catalytic subunit 1)

Genes (Mus musculus)
Apobec1  (apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1)

Genes (Homo sapiens)
APOBEC1  (apolipoprotein B mRNA editing enzyme catalytic subunit 1)


Additional Information