Apobec1 (apolipoprotein B mRNA editing enzyme catalytic subunit 1) - Rat Genome Database

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Gene: Apobec1 (apolipoprotein B mRNA editing enzyme catalytic subunit 1) Ictidomys tridecemlineatus
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Symbol: Apobec1
Name: apolipoprotein B mRNA editing enzyme catalytic subunit 1 (Ensembl:C->U-editing enzyme APOBEC-1-like)
RGD ID: 12723317
Description: ENCODES a protein that exhibits cytidine deaminase activity (ortholog); cytosine deaminase activity (ortholog); enzyme activator activity (ortholog); INVOLVED IN cellular response to insulin stimulus (ortholog); cytidine to uridine editing (ortholog); defense response to virus (ortholog); PARTICIPATES IN lipoprotein metabolic pathway; ASSOCIATED WITH colon cancer (ortholog); developmental and epileptic encephalopathy 21 (ortholog); Experimental Liver Cirrhosis (ortholog); FOUND IN apolipoprotein B mRNA editing enzyme complex (inferred); cytoplasm (inferred); nucleus (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: C->U-editing enzyme APOBEC-1; C->U-editing enzyme APOBEC-1-like; LOC101965334
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494598,775,264 - 98,783,978 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004939393628 - 6,201 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004939393628 - 6,234 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Apobec1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494598,775,264 - 98,783,978 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004939393628 - 6,201 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004939393628 - 6,234 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
APOBEC1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38127,649,400 - 7,670,599 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl127,649,400 - 7,665,908 (-)EnsemblGRCh38hg38GRCh38
GRCh37127,801,996 - 7,823,195 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36127,693,263 - 7,709,769 (-)NCBINCBI36Build 36hg18NCBI36
Build 34127,693,263 - 7,709,765NCBI
Celera129,377,416 - 9,393,928 (-)NCBICelera
Cytogenetic Map12p13.31NCBI
HuRef127,615,551 - 7,632,073 (-)NCBIHuRef
CHM1_1127,801,108 - 7,817,585 (-)NCBICHM1_1
T2T-CHM13v2.0127,663,658 - 7,684,886 (-)NCBIT2T-CHM13v2.0
Apobec1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm396122,554,755 - 122,580,068 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl6122,554,751 - 122,579,403 (-)EnsemblGRCm39 Ensembl
GRCm386122,577,792 - 122,603,024 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl6122,577,792 - 122,602,444 (-)EnsemblGRCm38mm10GRCm38
MGSCv376122,527,810 - 122,552,462 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv366122,543,411 - 122,568,063 (-)NCBIMGSCv36mm8
Celera6124,372,038 - 124,397,549 (-)NCBICelera
Cytogenetic Map6F1NCBI
cM Map657.68NCBI
Apobec1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84157,472,879 - 157,500,496 (-)NCBIGRCr8
mRatBN7.24155,800,030 - 155,828,515 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4155,800,887 - 155,827,390 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4162,064,076 - 162,078,798 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04157,847,296 - 157,862,008 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04156,493,855 - 156,508,527 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.04155,386,367 - 155,414,034 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4155,386,711 - 155,401,480 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04222,409,798 - 222,438,051 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44159,033,170 - 159,048,108 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14159,278,107 - 159,293,044 (-)NCBI
Celera4144,620,263 - 144,634,783 (-)NCBICelera
Cytogenetic Map4q42NCBI
Apobec1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554136,471,953 - 6,480,469 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554136,471,933 - 6,480,475 (-)NCBIChiLan1.0ChiLan1.0
APOBEC1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21013,212,602 - 13,225,890 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11213,209,214 - 13,223,660 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0127,777,734 - 7,793,960 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1127,939,115 - 7,950,315 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl127,939,262 - 7,944,203 (-)Ensemblpanpan1.1panPan2
APOBEC1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12737,102,728 - 37,114,084 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2737,103,016 - 37,114,556 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha279,502,214 - 9,513,600 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02737,452,077 - 37,463,466 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2737,452,249 - 37,463,777 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12737,333,157 - 37,344,537 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02737,368,031 - 37,379,426 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0278,988,480 - 8,999,873 (+)NCBIUU_Cfam_GSD_1.0
APOBEC1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl562,810,879 - 62,820,173 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1562,811,819 - 62,820,532 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2565,642,017 - 65,650,615 (-)NCBISscrofa10.2Sscrofa10.2susScr3
APOBEC1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1117,696,571 - 7,700,424 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl117,696,259 - 7,700,643 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666063490,767 - 508,119 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Apobec1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248604,938,001 - 4,957,236 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248604,938,001 - 4,957,640 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSSTOT00000022490   ⟹   ENSSTOP00000016053
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_004939393648 - 4,211 (-)Ensembl
RefSeq Acc Id: ENSSTOT00000022780   ⟹   ENSSTOP00000018747
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_004939393628 - 6,201 (-)Ensembl
RefSeq Acc Id: XM_040281863   ⟹   XP_040137797
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440494598,775,264 - 98,783,978 (-)NCBI
Protein Sequences
Protein RefSeqs XP_040137797 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSSTOP00000016053.2
  ENSSTOP00000018747.2
Reference Protein Sequences
RefSeq Acc Id: XP_040137797   ⟸   XM_040281863
RefSeq Acc Id: ENSSTOP00000018747   ⟸   ENSSTOT00000022780
RefSeq Acc Id: ENSSTOP00000016053   ⟸   ENSSTOT00000022490
Protein Domains
CMP/dCMP-type deaminase


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000021971 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSSTOT00000022490.2 UniProtKB/TrEMBL
  ENSSTOT00000022780.2 UniProtKB/TrEMBL
Gene3D-CATH Cytidine Deaminase, domain 2 UniProtKB/TrEMBL
InterPro APOBEC/CMP_deaminase_Zn-bd UniProtKB/TrEMBL
  CMP_dCMP_dom UniProtKB/TrEMBL
  Cytidine_deaminase-like UniProtKB/TrEMBL
NCBI Gene LOC101965334 ENTREZGENE
PANTHER C-U-EDITING ENZYME APOBEC-1 UniProtKB/TrEMBL
  MRNA EDITING ENZYME UniProtKB/TrEMBL
Pfam APOBEC1 UniProtKB/TrEMBL
PROSITE CYT_DCMP_DEAMINASES_1 UniProtKB/TrEMBL
  CYT_DCMP_DEAMINASES_2 UniProtKB/TrEMBL
Superfamily-SCOP SSF53927 UniProtKB/TrEMBL
UniProt I3MVA8_ICTTR UniProtKB/TrEMBL
  I3N301_ICTTR UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-26 Apobec1  apolipoprotein B mRNA editing enzyme catalytic subunit 1  LOC101965334  C->U-editing enzyme APOBEC-1-like  Symbol and/or name change 5135510 APPROVED