Enables chromatin binding activity. Involved in several processes, including cellular response to cAMP; nervous system development; and positive regulation of cell size. Part of chromatin. Biomarker of breast cancer; diabetic retinopathy; schizophrenia; and transient cerebral ischemia. Orthologous to human KDM1A (lysine demethylase 1A); PARTICIPATES IN histone modification pathway; Notch signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; aldehydo-D-glucose; bisphenol A.
[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of KDM1A mRNA and Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to KDM1A promoter]
[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of KDM1A mRNA
[Valproic Acid co-treated with Arsenic Trioxide] results in increased expression of KDM1A mRNA and [Valproic Acid co-treated with Arsenic Trioxide] results in increased expression of KDM1A protein
[2-amino-1-methyl-6-phenylimidazo(4 and 5-b)pyridine co-treated with 4-biphenylamine co-treated with Benzo(a)pyrene] affects the localization of KDM1A protein
[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of KDM1A mRNA
[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of KDM1A mRNA
[Valproic Acid co-treated with Arsenic Trioxide] results in increased expression of KDM1A mRNA and [Valproic Acid co-treated with Arsenic Trioxide] results in increased expression of KDM1A protein
[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of KDM1A mRNA
[Valproic Acid co-treated with arsenic trioxide] results in increased expression of KDM1A mRNA and [Valproic Acid co-treated with arsenic trioxide] results in increased expression of KDM1A protein
Lysine-specific demethylase 1 in breast cancer cells contributes to the production of endogenous formaldehyde in the metastatic bone cancer pain model of rats.