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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1562975
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Kdm1a
Name: lysine demethylase 1A
Acc ID: CHEBI:4027
Term: cyclophosphamide
Definition: A phosphorodiamide that is 1,3,2-oxazaphosphinan-2-amine 2-oxide substituted by two 2-chloroethyl groups at the amino nitrogen atom.
Chemical ID: MESH:D003520
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Kdm1aincreases expressionISOKDM1A (Homo sapiens)6480464CTDCyclophosphamide results in increased expression of KDM1A proteinPMID:22007908
Kdm1amultiple interactionsISOKDM1A (Homo sapiens)6480464CTDCyclophosphamide promotes the reaction [KDM1A protein results in decreased methylation of and results in decreased degradation of DNMT1 protein]PMID:22007908
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