Gab1 (GRB2-associated binding protein 1) - Rat Genome Database

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Gene: Gab1 (GRB2-associated binding protein 1) Rattus norvegicus
Analyze
Symbol: Gab1
Name: GRB2-associated binding protein 1
RGD ID: 1311085
Description: Predicted to enable signaling adaptor activity. Involved in response to hepatocyte growth factor. Predicted to be located in cell-cell junction. Predicted to be active in cell cortex. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 26. Orthologous to human GAB1 (GRB2 associated binding protein 1); PARTICIPATES IN epidermal growth factor/neuregulin signaling pathway; erythropoietin signaling pathway; fibroblast growth factor signaling pathway; INTERACTS WITH 6-propyl-2-thiouracil; amphetamine; atrazine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: GRB2-associated binding protein 1 long isoform; GRB2-associated-binding protein 1; growth factor receptor bound protein 2-associated protein 1; LOC361388
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81944,035,693 - 44,143,617 (+)NCBIGRCr8
mRatBN7.21927,131,262 - 27,239,236 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1927,131,262 - 27,239,236 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1933,982,820 - 34,090,922 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01934,636,884 - 34,744,979 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01936,863,071 - 36,971,252 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01930,794,290 - 30,903,819 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1930,794,571 - 30,902,008 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01941,699,636 - 41,808,268 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41928,980,284 - 29,088,877 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11928,977,650 - 29,091,892 (+)NCBI
Celera1926,648,689 - 26,756,049 (+)NCBICelera
Cytogenetic Map19q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
(S)-nicotine  (ISO)
1,2-dimethylhydrazine  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2-hydroxypropanoic acid  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
amphetamine  (EXP)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
atrazine  (EXP)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP,ISO)
Brodifacoum  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
calcitriol  (ISO)
carbamazepine  (ISO)
CGP 52608  (ISO)
chromium(6+)  (ISO)
cisplatin  (ISO)
copper(II) sulfate  (ISO)
coumarin  (ISO)
cyclosporin A  (ISO)
cylindrospermopsin  (ISO)
diclofenac  (ISO)
diethyl maleate  (ISO)
dioxygen  (ISO)
disodium selenite  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
entinostat  (ISO)
epoxiconazole  (ISO)
ethanol  (ISO)
ethyl methanesulfonate  (ISO)
fenthion  (ISO)
flutamide  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
FR900359  (ISO)
gentamycin  (EXP)
glafenine  (EXP)
hyaluronic acid  (ISO)
hydrogen cyanide  (ISO)
lipopolysaccharide  (ISO)
lutein  (ISO)
melphalan  (ISO)
metam  (ISO)
methidathion  (ISO)
methotrexate  (ISO)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
nicotine  (ISO)
ozone  (EXP,ISO)
p-menthan-3-ol  (ISO)
paracetamol  (ISO)
paraquat  (ISO)
perfluorohexanesulfonic acid  (ISO)
permethrin  (ISO)
PhIP  (ISO)
potassium chromate  (ISO)
propiconazole  (ISO)
quercetin  (ISO)
rac-lactic acid  (ISO)
resveratrol  (EXP)
SB 431542  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
tamoxifen  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
titanium dioxide  (ISO)
troglitazone  (ISO)
valproic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Adapter protein CRKII signaling is involved in the rat pancreatic acini response to reactive oxygen species. Andreolotti AG, etal., J Cell Biochem. 2006 Feb 1;97(2):359-67.
2. Met, metastasis, motility and more. Birchmeier C, etal., Nat Rev Mol Cell Biol. 2003 Dec;4(12):915-25.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. The Met tyrosine kinase receptor in development and cancer. Gentile A, etal., Cancer Metastasis Rev. 2008 Mar;27(1):85-94.
5. Grb2-associated binder 1 polymorphism was associated with the risk of Helicobactor pylori infection and gastric atrophy. Goto Y, etal., Int J Med Sci. 2006 Nov 1;4(1):1-6. doi: 10.7150/ijms.4.1.
6. Loss of Gab1 adaptor protein in hepatocytes aggravates experimental liver fibrosis in mice. Kizu T, etal., Am J Physiol Gastrointest Liver Physiol. 2015 Apr 1;308(7):G613-24. doi: 10.1152/ajpgi.00289.2014. Epub 2015 Jan 23.
7. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
8. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
9. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
10. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
11. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10779359   PMID:11146548   PMID:11940581   PMID:12218049   PMID:12808090   PMID:14551245   PMID:15736129   PMID:16166380   PMID:16185843   PMID:17178724   PMID:19359598   PMID:24126105  
PMID:25217442   PMID:26090437   PMID:26706435   PMID:28738535   PMID:35591810  


Genomics

Comparative Map Data
Gab1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81944,035,693 - 44,143,617 (+)NCBIGRCr8
mRatBN7.21927,131,262 - 27,239,236 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1927,131,262 - 27,239,236 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1933,982,820 - 34,090,922 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01934,636,884 - 34,744,979 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01936,863,071 - 36,971,252 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01930,794,290 - 30,903,819 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1930,794,571 - 30,902,008 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01941,699,636 - 41,808,268 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41928,980,284 - 29,088,877 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11928,977,650 - 29,091,892 (+)NCBI
Celera1926,648,689 - 26,756,049 (+)NCBICelera
Cytogenetic Map19q11NCBI
GAB1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh384143,336,876 - 143,474,565 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl4143,336,876 - 143,474,565 (+)EnsemblGRCh38hg38GRCh38
GRCh374144,258,029 - 144,395,718 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 364144,477,500 - 144,610,729 (+)NCBINCBI36Build 36hg18NCBI36
Celera4141,587,895 - 141,725,726 (+)NCBICelera
Cytogenetic Map4q31.21NCBI
HuRef4139,987,709 - 140,125,505 (+)NCBIHuRef
CHM1_14144,235,244 - 144,372,935 (+)NCBICHM1_1
T2T-CHM13v2.04146,654,097 - 146,791,778 (+)NCBIT2T-CHM13v2.0
Gab1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39881,491,060 - 81,607,151 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl881,491,063 - 81,607,148 (-)EnsemblGRCm39 Ensembl
GRCm38880,764,431 - 80,880,519 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl880,764,438 - 80,880,519 (-)EnsemblGRCm38mm10GRCm38
MGSCv37883,288,333 - 83,404,378 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36883,660,180 - 83,776,225 (-)NCBIMGSCv36mm8
Celera885,038,223 - 85,155,227 (-)NCBICelera
Cytogenetic Map8C2NCBI
cM Map838.47NCBI
Gab1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495547161,120 - 191,175 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495547161,580 - 191,175 (-)NCBIChiLan1.0ChiLan1.0
GAB1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v23141,213,273 - 141,349,862 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan14141,601,058 - 141,736,803 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v04135,697,939 - 135,834,755 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.14146,996,936 - 147,134,576 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl4146,996,936 - 147,133,672 (+)Ensemblpanpan1.1panPan2
GAB1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11910,269 - 117,808 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1912,616 - 156,694 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha19260,188 - 375,446 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01933,411 - 148,702 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1933,413 - 149,200 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11913,780 - 129,344 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.019370,970 - 486,927 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.019720,877 - 842,755 (-)NCBIUU_Cfam_GSD_1.0
Gab1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530147,497,408 - 47,611,336 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365354,932,261 - 5,048,693 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365354,934,743 - 5,048,698 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GAB1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl884,257,965 - 84,391,621 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1884,257,958 - 84,391,511 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2889,408,945 - 89,540,504 (-)NCBISscrofa10.2Sscrofa10.2susScr3
GAB1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1790,197,374 - 90,323,024 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl790,197,620 - 90,322,077 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603769,798,419 - 69,923,554 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Gab1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248532,639,891 - 2,765,144 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248532,639,882 - 2,763,195 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Gab1
813 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:196
Count of miRNA genes:144
Interacting mature miRNAs:175
Transcripts:ENSRNOT00000024390
Prediction methods:Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10054132Srcrt9Stress Responsive Cort QTL 92.870.0017blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)19127355345Rat
631678Cm9Cardiac mass QTL 94.270.0001aorta mass (VT:0002845)aorta weight (CMO:0000076)19128982497Rat
631681Cm12Cardiac mass QTL 123.330.00053heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)19128982497Rat
1549847Bss8Bone structure and strength QTL 84lumbar vertebra strength trait (VT:0010574)vertebra ultimate force (CMO:0001678)19131963836Rat
9590298Uminl5Urine mineral level QTL 53.590.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)19136824771Rat
8552935Pigfal10Plasma insulin-like growth factor 1 level QTL 105.7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)19136824771Rat
9590250Scort11Serum corticosterone level QTL 1123.450.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)19136824771Rat
9590090Insglur8Insulin/glucose ratio QTL 810.810.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)19136824771Rat
9589102Slep13Serum leptin concentration QTL 134.630.001blood leptin amount (VT:0005667)plasma leptin level (CMO:0000781)1956937445569374Rat
8694186Bw152Body weight QTL 1523.340.001body mass (VT:0001259)body weight gain (CMO:0000420)1956937445569374Rat
7247442Uae39Urinary albumin excretion QTL 39urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)19218792746708701Rat
724566Uae12Urinary albumin excretion QTL 125urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19218792756457239Rat
61447Tcas1Tongue tumor susceptibility QTL 16.08tongue integrity trait (VT:0010553)squamous cell carcinoma of the tongue maximum tumor diameter (CMO:0001875)19231612147316121Rat
2317848Alcrsp21Alcohol response QTL 211.8999999761581420.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)19320477748204777Rat
1331737Uae29Urinary albumin excretion QTL 295.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19409615555283277Rat
724518Uae19Urinary albumin excretion QTL 195.5urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)19745724942983518Rat
724565Tcas5Tongue tumor susceptibility QTL 510.04tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)19997775339654489Rat
61423Cia14Collagen induced arthritis QTL 143joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)191082797043544039Rat
61407Scl12Serum cholesterol level QTL 120.001blood HDL cholesterol amount (VT:0000184)serum high density lipoprotein cholesterol level (CMO:0000361)191392640130303727Rat
1558656Prcs1Prostate cancer susceptibility QTL 15prostate integrity trait (VT:0010571)percentage of study population developing ventral prostate tumorous lesions during a period of time (CMO:0000943)191511459834521833Rat
7411549Bw130Body weight QTL 13050.001body mass (VT:0001259)body weight gain (CMO:0000420)191545586057337602Rat
1331788Rf45Renal function QTL 452.818kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)191560502346559041Rat
1578764Stresp19Stress response QTL 193.60.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)191563020157337602Rat
2298478Eau8Experimental allergic uveoretinitis QTL 80.0163uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)191715443357337602Rat
61350Bp32Blood pressure QTL 320.012arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)192048357557337602Rat
61328Eae8Experimental allergic encephalomyelitis QTL 84nervous system integrity trait (VT:0010566)percentage of study population developing experimental autoimmune encephalomyelitis during a period of time (CMO:0001047)192481604133061905Rat
1549835Tcas7Tongue tumor susceptibility QTL 70.001tongue integrity trait (VT:0010553)squamous cell carcinoma of the head and neck tumor number (CMO:0001876)192481797839654489Rat

Markers in Region
RH127625  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21927,238,743 - 27,238,947 (+)MAPPERmRatBN7.2
Rnor_6.01930,903,327 - 30,903,530NCBIRnor6.0
Rnor_5.01941,807,776 - 41,807,979UniSTSRnor5.0
RGSC_v3.41929,088,385 - 29,088,588UniSTSRGSC3.4
Celera1926,755,557 - 26,755,760UniSTS
Cytogenetic Map19q11UniSTS
RH135107  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21927,161,680 - 27,161,880 (+)MAPPERmRatBN7.2
Rnor_6.01930,824,649 - 30,824,848NCBIRnor6.0
Rnor_5.01941,729,988 - 41,730,187UniSTSRnor5.0
RGSC_v3.41929,010,998 - 29,011,197UniSTSRGSC3.4
Celera1926,678,736 - 26,678,935UniSTS
Cytogenetic Map19q11UniSTS
BF390263  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21927,165,309 - 27,165,462 (+)MAPPERmRatBN7.2
Rnor_6.01930,828,284 - 30,828,434NCBIRnor6.0
Rnor_6.01930,828,284 - 30,828,395NCBIRnor6.0
Rnor_5.01941,733,623 - 41,733,773UniSTSRnor5.0
Rnor_5.01941,733,623 - 41,733,734UniSTSRnor5.0
RGSC_v3.41929,014,633 - 29,014,744UniSTSRGSC3.4
RGSC_v3.41929,014,633 - 29,014,783UniSTSRGSC3.4
Celera1926,682,371 - 26,682,521UniSTS
Celera1926,682,371 - 26,682,482UniSTS
Cytogenetic Map19q11UniSTS
UniSTS:235942  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21927,163,960 - 27,164,201 (+)MAPPERmRatBN7.2
Rnor_6.01930,826,928 - 30,827,168NCBIRnor6.0
Rnor_5.01941,732,267 - 41,732,507UniSTSRnor5.0
RGSC_v3.41929,013,277 - 29,013,517UniSTSRGSC3.4
Celera1926,681,015 - 26,681,255UniSTS
Cytogenetic Map19q11UniSTS
AA555564  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21927,157,106 - 27,157,155 (+)MAPPERmRatBN7.2
mRatBN7.21618,919,438 - 18,919,486 (+)MAPPERmRatBN7.2
Rnor_6.01620,669,759 - 20,669,806NCBIRnor6.0
Rnor_6.01930,820,088 - 30,820,136NCBIRnor6.0
Rnor_5.01941,725,371 - 41,725,419UniSTSRnor5.0
Rnor_5.01620,525,238 - 20,525,285UniSTSRnor5.0
RGSC_v3.41619,426,189 - 19,426,236UniSTSRGSC3.4
RGSC_v3.41929,006,376 - 29,006,424UniSTSRGSC3.4
Celera1926,674,176 - 26,674,224UniSTS
Celera1619,110,815 - 19,110,862UniSTS
Cytogenetic Map16p14UniSTS
Cytogenetic Map19q11UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 38 20 10 7 10 2 2 74 35 41 11 2
Low 1 5 37 31 12 31 6 9 6
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000024390   ⟹   ENSRNOP00000024390
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1927,131,262 - 27,239,236 (+)Ensembl
Rnor_6.0 Ensembl1930,794,571 - 30,902,005 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000083219   ⟹   ENSRNOP00000071006
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1927,131,262 - 27,239,236 (+)Ensembl
Rnor_6.0 Ensembl1930,794,571 - 30,902,008 (+)Ensembl
RefSeq Acc Id: NM_001108444   ⟹   NP_001101914
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81944,035,693 - 44,143,617 (+)NCBI
mRatBN7.21927,131,262 - 27,239,236 (+)NCBI
Rnor_6.01930,794,290 - 30,903,819 (+)NCBI
Rnor_5.01941,699,636 - 41,808,268 (+)NCBI
RGSC_v3.41928,980,284 - 29,088,877 (+)RGD
Celera1926,648,689 - 26,756,049 (+)RGD
Sequence:
RefSeq Acc Id: XM_039097821   ⟹   XP_038953749
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81944,035,839 - 44,143,568 (+)NCBI
mRatBN7.21927,131,490 - 27,239,187 (+)NCBI
RefSeq Acc Id: XM_039097823   ⟹   XP_038953751
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81944,054,656 - 44,143,568 (+)NCBI
mRatBN7.21927,150,129 - 27,239,187 (+)NCBI
RefSeq Acc Id: XM_039097824   ⟹   XP_038953752
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81944,035,839 - 44,143,568 (+)NCBI
mRatBN7.21927,138,701 - 27,239,187 (+)NCBI
RefSeq Acc Id: XM_063278117   ⟹   XP_063134187
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81944,035,839 - 44,132,971 (+)NCBI
RefSeq Acc Id: XM_063278118   ⟹   XP_063134188
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81944,054,745 - 44,143,568 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_001101914   ⟸   NM_001108444
- UniProtKB: A6IYG9 (UniProtKB/TrEMBL),   A0A0G2JZD5 (UniProtKB/TrEMBL),   C6JUQ2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000024390   ⟸   ENSRNOT00000024390
RefSeq Acc Id: ENSRNOP00000071006   ⟸   ENSRNOT00000083219
RefSeq Acc Id: XP_038953749   ⟸   XM_039097821
- Peptide Label: isoform X1
- UniProtKB: D3ZAL7 (UniProtKB/TrEMBL),   A0A0G2JZD5 (UniProtKB/TrEMBL),   C6JUQ2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038953752   ⟸   XM_039097824
- Peptide Label: isoform X2
- UniProtKB: A0A0G2JZD5 (UniProtKB/TrEMBL),   C6JUQ2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038953751   ⟸   XM_039097823
- Peptide Label: isoform X2
- UniProtKB: A0A0G2JZD5 (UniProtKB/TrEMBL),   C6JUQ2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063134187   ⟸   XM_063278117
- Peptide Label: isoform X3
RefSeq Acc Id: XP_063134188   ⟸   XM_063278118
- Peptide Label: isoform X4
Protein Domains
PH

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2JZD5-F1-model_v2 AlphaFold A0A0G2JZD5 1-720 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1311085 AgrOrtholog
BioCyc Gene G2FUF-5978 BioCyc
Ensembl Genes ENSRNOG00000017879 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000024390.6 UniProtKB/TrEMBL
  ENSRNOT00000083219 ENTREZGENE
  ENSRNOT00000083219.2 UniProtKB/TrEMBL
Gene3D-CATH 2.30.29.30 UniProtKB/TrEMBL
InterPro Gab1-4-like UniProtKB/TrEMBL
  PH_type UniProtKB/TrEMBL
  Pleckstrin_homology UniProtKB/TrEMBL
KEGG Report rno:361388 UniProtKB/TrEMBL
NCBI Gene 361388 ENTREZGENE
PANTHER GRB2-ASSOCIATED-BINDING PROTEIN 1 UniProtKB/TrEMBL
  PTHR45960 UniProtKB/TrEMBL
Pfam PF00169 UniProtKB/TrEMBL
PharmGKB GAB1 RGD
PhenoGen Gab1 PhenoGen
PROSITE PH_DOMAIN UniProtKB/TrEMBL
RatGTEx ENSRNOG00000017879 RatGTEx
SMART SM00233 UniProtKB/TrEMBL
Superfamily-SCOP PH domain-like UniProtKB/TrEMBL
UniProt A0A0G2JZD5 ENTREZGENE
  A6IYG9 ENTREZGENE, UniProtKB/TrEMBL
  C6JUQ2 ENTREZGENE, UniProtKB/TrEMBL
  D3ZAL7 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary A0A0G2JZD5 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-09-19 Gab1  GRB2-associated binding protein 1  Gab1  growth factor receptor bound protein 2-associated protein 1   Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Gab1  growth factor receptor bound protein 2-associated protein 1   Gab1_predicted  growth factor receptor bound protein 2-associated protein 1 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Gab1_predicted  growth factor receptor bound protein 2-associated protein 1 (predicted)      Symbol and Name status set to approved 70820 APPROVED