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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1311085 Species: Rattus norvegicus RGD Object: Gene Symbol: Gab1 Name: GRB2-associated binding protein 1

Acc ID: CHEBI:4903 Term: 17alpha-ethynylestradiol Definition: A 17-hydroxy steroid that has formula C20H24O2. CasRN: 57-63-6 Chemical ID: MESH:D004997

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
affects expression	ISO	RGD:1322355	6480464	CTD	Ethinyl Estradiol affects the expression of GAB1 mRNA	PMID:17555576
decreases expression	ISO	RGD:1322355	6480464	CTD	Ethinyl Estradiol results in decreased expression of GAB1 mRNA	PMID:17942748
multiple interactions	ISO	RGD:1322355	6480464	CTD	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in decreased expression of GAB1 mRNA	PMID:17942748