Actn1 (actinin, alpha 1) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Behavioral & Substance Use Disorder Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Actn1 (actinin, alpha 1) Rattus norvegicus
Analyze
Symbol: Actn1
Name: actinin, alpha 1
RGD ID: 70907
Description: Enables cytoskeletal regulatory protein binding activity and protein domain specific binding activity. Predicted to be involved in several processes, including actin filament organization; focal adhesion assembly; and platelet formation. Located in actin cytoskeleton; dendritic spine; and plasma membrane. Is active in postsynaptic actin cytoskeleton. Human ortholog(s) of this gene implicated in platelet-type bleeding disorder 15. Orthologous to human ACTN1 (actinin alpha 1); PARTICIPATES IN E-cadherin signaling pathway; syndecan signaling pathway; arrhythmogenic right ventricular cardiomyopathy pathway; INTERACTS WITH (R)-adrenaline; 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: alpha-actinin cytoskeletal isoform; alpha-actinin-1; F-actin cross-linking protein; non-muscle alpha-actinin 1; non-muscle alpha-actinin-1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: Actn1_v3 ; Actn1_v2 ; Actn1_v1
Candidate Gene For: Uae22
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86104,731,485 - 104,826,312 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl6104,731,485 - 104,826,172 (-)EnsemblGRCr8
mRatBN7.2698,998,553 - 99,093,334 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl698,998,556 - 99,093,251 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx699,420,854 - 99,515,776 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0699,719,945 - 99,814,871 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0699,099,910 - 99,194,634 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.06103,376,557 - 103,470,497 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6103,375,799 - 103,470,555 (-)Ensemblrn6Rnor6.0
Rnor_5.06116,056,248 - 116,149,471 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.46103,188,593 - 103,282,873 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera697,355,796 - 97,450,012 (-)NCBICelera
RGSC_v3.16103,192,048 - 103,286,329NCBI
Cytogenetic Map6q24NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
(R)-adrenaline  (EXP)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,3,3',4,4',5,5'-Heptachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,6-dimethoxyphenol  (ISO)
2,6-dinitrotoluene  (EXP)
2-nitrotoluene  (EXP)
3-chloropropane-1,2-diol  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
7,12-dimethyltetraphene  (EXP)
acetamide  (EXP)
acrolein  (ISO)
aflatoxin B1  (EXP)
all-trans-retinoic acid  (ISO)
allethrin  (EXP)
alpha-pinene  (ISO)
ammonium chloride  (EXP)
androgen antagonist  (EXP)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
atrazine  (EXP)
Azoxymethane  (ISO)
azoxystrobin  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
beta-lapachone  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
bleomycin A2  (EXP)
bromochloroacetic acid  (EXP)
buspirone  (EXP)
Butylbenzyl phthalate  (ISO)
Butylparaben  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (ISO)
cannabidiol  (EXP)
carbamazepine  (ISO)
carbon nanotube  (ISO)
carmustine  (ISO)
carnosic acid  (ISO)
chloropicrin  (ISO)
chromium(6+)  (ISO)
cisplatin  (ISO)
clofibrate  (ISO)
cobalt dichloride  (ISO)
copper(II) chloride  (ISO)
copper(II) sulfate  (ISO)
corosolic acid  (ISO)
crocidolite asbestos  (ISO)
cyclosporin A  (ISO)
cyhalothrin  (EXP)
cypermethrin  (EXP)
cyproconazole  (ISO)
DDE  (EXP)
dexamethasone  (ISO)
dextran sulfate  (ISO)
diazinon  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP,ISO)
diclofenac  (EXP)
dicrotophos  (ISO)
dieldrin  (EXP)
dimethyl sulfoxide  (ISO)
dimethylarsinic acid  (EXP)
dioxygen  (EXP,ISO)
diuron  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
entinostat  (ISO)
enzacamene  (EXP)
enzyme inhibitor  (ISO)
epoxiconazole  (EXP,ISO)
ethanol  (ISO)
fenamidone  (ISO)
fenvalerate  (EXP)
folic acid  (ISO)
furfural  (ISO)
gentamycin  (EXP)
hydrogen peroxide  (ISO)
indometacin  (ISO)
ionomycin  (EXP)
isoflavones  (EXP)
ivermectin  (ISO)
lead(0)  (ISO)
leflunomide  (ISO)
linuron  (EXP)
lipopolysaccharide  (ISO)
Mesaconitine  (EXP)
metformin  (EXP)
methimazole  (EXP)
methoxychlor  (EXP)
methylmercury chloride  (ISO)
methylmercury(1+)  (ISO)
microcystin-LR  (EXP)
Muraglitazar  (EXP)
N-nitrosodimethylamine  (EXP)
ochratoxin A  (ISO)
okadaic acid  (ISO)
oxycodone  (EXP)
ozone  (EXP,ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP)
perfluorooctane-1-sulfonic acid  (ISO)
phenylmercury acetate  (ISO)
picoxystrobin  (ISO)
potassium dichromate  (ISO)
prochloraz  (EXP)
procymidone  (EXP)
progesterone  (ISO)
prostaglandin A1  (ISO)
pyrethrins  (EXP)
quercitrin  (ISO)
resveratrol  (ISO)
rotenone  (EXP,ISO)
SB 431542  (ISO)
selenium atom  (ISO)
silicon dioxide  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
sodium fluoride  (ISO)
Soman  (EXP)
starch  (EXP)
sulindac sulfide  (ISO)
tauroursodeoxycholic acid  (EXP)
tert-butyl hydroperoxide  (ISO)
tetrachloromethane  (ISO)
thapsigargin  (EXP,ISO)
titanium dioxide  (ISO)
triadimefon  (ISO)
tributylstannane  (ISO)
Tributyltin oxide  (ISO)
triphenyl phosphate  (ISO)
troglitazone  (EXP)
ursodeoxycholic acid  (EXP)
valproic acid  (EXP,ISO)
vancomycin  (ISO)
vinclozolin  (EXP)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Protein interactions with the glucose transporter binding protein GLUT1CBP that provide a link between GLUT1 and the cytoskeleton. Bunn RC, etal., Mol Biol Cell 1999 Apr;10(4):819-32.
2. The cyclin-dependent kinase 5 activators p35 and p39 interact with the alpha-subunit of Ca2+/calmodulin-dependent protein kinase II and alpha-actinin-1 in a calcium-dependent manner. Dhavan R, etal., J Neurosci. 2002 Sep 15;22(18):7879-91.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. Brain-specific splicing of alpha-actinin 1 (ACTN1) mRNA. Kremerskothen J, etal., Biochem Biophys Res Commun 2002 Jul 19;295(3):678-81.
6. Postsynaptic recruitment of Dendrin depends on both dendritic mRNA transport and synaptic anchoring. Kremerskothen J, etal., J Neurochem. 2006 Mar;96(6):1659-66. doi: 10.1111/j.1471-4159.2006.03679.x. Epub 2006 Feb 8.
7. Growth cone morphology and spreading are regulated by a dynamin-cortactin complex at point contacts in hippocampal neurons. Kurklinsky S, etal., J Neurochem. 2011 Apr;117(1):48-60. doi: 10.1111/j.1471-4159.2011.07169.x. Epub 2011 Feb 9.
8. Alpha-actinin associates with polycystin-2 and regulates its channel activity. Li Q, etal., Hum Mol Genet. 2005 Jun 15;14(12):1587-603. Epub 2005 Apr 20.
9. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
10. CLP36 and RIL recruit a-actinin-1 to stress fibers and differentially regulate stress fiber dynamics in F2408 fibroblasts. Miyazaki K, etal., Exp Cell Res. 2012 Aug 15;318(14):1716-25. doi: 10.1016/j.yexcr.2012.05.006. Epub 2012 May 30.
11. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
12. Phosphorylation-dependent interactions of alpha-Actinin-1/IQGAP1 with the AMPA receptor subunit GluR4. Nuriya M, etal., J Neurochem. 2005 Oct;95(2):544-52. doi: 10.1111/j.1471-4159.2005.03410.x.
13. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
14. Involvement of LMO7 in the association of two cell-cell adhesion molecules, nectin and E-cadherin, through afadin and alpha-actinin in epithelial cells. Ooshio T, etal., J Biol Chem 2004 Jul 23;279(30):31365-73. Epub 2004 May 12.
15. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
16. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
17. GOA pipeline RGD automated data pipeline
18. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
19. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
20. Expression and tissue localization of beta-catenin, alpha-actinin and chondroitin sulfate proteoglycan 6 is modulated during rat and human left ventricular hypertrophy. Ridinger H, etal., Exp Mol Pathol. 2009 Feb;86(1):23-31. Epub 2008 Nov 27.
21. [Organization of the activities of the medical-sanitary battalion] Sherniakov MA Voen Med Zh 1978 Nov;(11):20-2.
22. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
23. Pdlim2, a novel PDZ-LIM domain protein, interacts with alpha-actinins and filamin A. Torrado M, etal., Invest Ophthalmol Vis Sci 2004 Nov;45(11):3955-63.
24. The PDZ-LIM protein RIL modulates actin stress fiber turnover and enhances the association of alpha-actinin with F-actin. Vallenius T, etal., Exp Cell Res 2004 Feb 1;293(1):117-28.
25. Integrated Analysis of Multiple Microarray Studies to Identify Core Gene-Expression Signatures Involved in Tubulointerstitial Injury in Diabetic Nephropathy. Zhou H, etal., Biomed Res Int. 2022 May 10;2022:9554658. doi: 10.1155/2022/9554658. eCollection 2022.
Additional References at PubMed
PMID:7750553   PMID:7983147   PMID:11223950   PMID:11274145   PMID:11732910   PMID:12493766   PMID:12837758   PMID:15465019   PMID:15665106   PMID:15988023   PMID:16025302   PMID:16043482  
PMID:16170337   PMID:16502470   PMID:16807302   PMID:16820411   PMID:17298598   PMID:17311919   PMID:17854826   PMID:17944866   PMID:18332105   PMID:18519573   PMID:19056867   PMID:19160484  
PMID:19199708   PMID:19943616   PMID:20124353   PMID:20215401   PMID:20368620   PMID:21266579   PMID:21362503   PMID:21423176   PMID:21784188   PMID:22114352   PMID:22351778   PMID:22772996  
PMID:22871113   PMID:23434115   PMID:23533145   PMID:23890175   PMID:24069336   PMID:24364879   PMID:24625528   PMID:24780915   PMID:25931508   PMID:26316108   PMID:28131823   PMID:29429936  
PMID:29476059   PMID:30039887   PMID:35352799  


Genomics

Comparative Map Data
Actn1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86104,731,485 - 104,826,312 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl6104,731,485 - 104,826,172 (-)EnsemblGRCr8
mRatBN7.2698,998,553 - 99,093,334 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl698,998,556 - 99,093,251 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx699,420,854 - 99,515,776 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0699,719,945 - 99,814,871 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0699,099,910 - 99,194,634 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.06103,376,557 - 103,470,497 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6103,375,799 - 103,470,555 (-)Ensemblrn6Rnor6.0
Rnor_5.06116,056,248 - 116,149,471 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.46103,188,593 - 103,282,873 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera697,355,796 - 97,450,012 (-)NCBICelera
RGSC_v3.16103,192,048 - 103,286,329NCBI
Cytogenetic Map6q24NCBI
ACTN1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381468,874,128 - 68,979,302 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1468,874,121 - 68,980,277 (-)Ensemblhg38GRCh38
GRCh371469,340,845 - 69,446,019 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361468,410,793 - 68,515,709 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341468,410,792 - 68,515,709NCBI
Celera1449,401,716 - 49,506,993 (-)NCBICelera
Cytogenetic Map14q24.1NCBI
HuRef1449,510,917 - 49,616,121 (-)NCBIHuRef
CHM1_11469,279,215 - 69,384,488 (-)NCBICHM1_1
T2T-CHM13v2.01463,083,135 - 63,188,360 (-)NCBIT2T-CHM13v2.0
Actn1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391280,214,316 - 80,307,165 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1280,214,321 - 80,307,145 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381280,167,542 - 80,260,420 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1280,167,547 - 80,260,371 (-)Ensemblmm10GRCm38
MGSCv371281,268,529 - 81,361,358 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361281,086,387 - 81,179,156 (-)NCBIMGSCv36mm8
Celera1281,632,311 - 81,725,181 (-)NCBICelera
Cytogenetic Map12C3NCBI
cM Map1236.49NCBI
Actn1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554661,388,507 - 1,480,282 (+)Ensembl
ChiLan1.0NW_0049554661,388,507 - 1,480,990 (+)NCBIChiLan1.0ChiLan1.0
ACTN1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21569,990,975 - 70,096,691 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11469,207,296 - 69,313,200 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01449,460,390 - 49,565,986 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11468,335,694 - 68,440,836 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1468,335,694 - 68,440,836 (-)EnsemblpanPan2panpan1.1
ACTN1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1842,714,806 - 42,808,318 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl842,712,142 - 42,808,323 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha842,404,474 - 42,497,710 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0842,945,028 - 43,038,491 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl842,945,037 - 43,038,504 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1842,559,338 - 42,652,710 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0842,634,268 - 42,727,356 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0842,993,500 - 43,086,762 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Actn1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864061,974,520 - 62,067,210 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493649512,124,443 - 12,217,242 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493649512,124,489 - 12,217,223 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ACTN1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl792,550,007 - 92,644,842 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1792,550,132 - 92,644,842 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2798,863,871 - 98,874,025 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ACTN1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12446,089,989 - 46,196,897 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2446,085,751 - 46,196,886 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366605334,323,625 - 34,430,616 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Actn1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473432,097,671 - 32,192,729 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462473432,097,364 - 32,190,162 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Actn1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1794,253,955 - 94,348,380 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Actn1
337 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:64
Count of miRNA genes:58
Interacting mature miRNAs:63
Transcripts:ENSRNOT00000068522
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2293088Iddm28Insulin dependent diabetes mellitus QTL 285.21blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)668767270135411972Rat
1331799Bp211Blood pressure QTL 2113.66407arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)688019181136741135Rat
61329Eae9Experimental allergic encephalomyelitis QTL 93.7body mass (VT:0001259)change in body weight (CMO:0002045)684490437129490437Rat
2313399Anxrr28Anxiety related response QTL 28aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)6101593607138161926Rat
1331789Rf37Renal function QTL 373.224kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)686494122112380234Rat
1331725Bp212Blood pressure QTL 2123.52475arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)699437079125323237Rat
1331722Thshl1Thyroid stimulating hormone level QTL 111.70.0001blood thyroid-stimulating hormone amount (VT:0005119)serum thyroid stimulating hormone level (CMO:0001248)699708426112483760Rat
4145119Mcs25Mammary carcinoma susceptibility QTL 250.0001mammary gland integrity trait (VT:0010552)ratio of deaths to total study population during a period of time (CMO:0001023)671278722116278722Rat
70176Mcsm1Mammary carcinoma susceptibility modifier QTL 1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)664367996109367996Rat
10054138Gmadr3Adrenal mass QTL 33.680.00045adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)690871046135871046Rat
1581563Uae33Urinary albumin excretion QTL 33urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)693560258136550638Rat
1641917Colcr5Colorectal carcinoma resistance QTL 53.180.0009intestine integrity trait (VT:0010554)benign colorectal tumor number (CMO:0001795)698944780143944780Rat
61414Pia3Pristane induced arthritis QTL 34.5joint integrity trait (VT:0010548)post-insult time to onset of experimental arthritis (CMO:0001450)6100704576136029228Rat
724524Uae2Urinary albumin excretion QTL 22.70.0005urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)679198463144254945Rat
737827Hcar11Hepatocarcinoma resistance QTL 114.4liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)646050607116278722Rat
2303624Vencon5Ventilatory control QTL 54.45respiration trait (VT:0001943)minute ventilation (CMO:0000132)693778632138778632Rat
1576309Emca7Estrogen-induced mammary cancer QTL 74mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)620859430113082285Rat
2293837Kiddil1Kidney dilation QTL 13.7kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)686867923110125012Rat
2293842Kiddil3Kidney dilation QTL 34.3kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)686867923110125012Rat
10054123Srcrt6Stress Responsive Cort QTL 62.50.0043blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)690871046135871046Rat
724536Uae7Urinary albumin excretion QTL 73.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)693560258136550638Rat
1576302Schws4Schwannoma susceptibility QTL 40.0078nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)678204640123204640Rat
1581550Pur8Proteinuria QTL 8urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)693560258136550638Rat
1300075Glom7Glomerulus QTL 75.60.0000002kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)676937178121937178Rat
12801471Schws9Schwannoma susceptibility QTL 9nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)6101593607146593607Rat

Markers in Region
C77473  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2698,998,858 - 98,998,992 (+)MAPPERmRatBN7.2
Rnor_6.06103,376,175 - 103,376,308NCBIRnor6.0
Rnor_5.06116,055,867 - 116,055,999UniSTSRnor5.0
RGSC_v3.46103,188,211 - 103,188,344UniSTSRGSC3.4
Celera697,355,417 - 97,355,550UniSTS
Cytogenetic Map6q24UniSTS
RH142024  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2699,000,729 - 99,000,918 (+)MAPPERmRatBN7.2
Rnor_6.06103,378,046 - 103,378,234NCBIRnor6.0
Rnor_5.06116,057,737 - 116,057,925UniSTSRnor5.0
RGSC_v3.46103,190,082 - 103,190,270UniSTSRGSC3.4
Celera697,357,285 - 97,357,473UniSTS
RH 3.4 Map6692.1UniSTS
Cytogenetic Map6q24UniSTS
BE119221  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2699,091,243 - 99,091,419 (+)MAPPERmRatBN7.2
Rnor_6.06103,468,554 - 103,468,729NCBIRnor6.0
Rnor_5.06116,147,528 - 116,147,703UniSTSRnor5.0
RGSC_v3.46103,280,930 - 103,281,105UniSTSRGSC3.4
Celera697,448,069 - 97,448,244UniSTS
RH 3.4 Map6690.0UniSTS
Cytogenetic Map6q24UniSTS
BE098731  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2699,094,236 - 99,094,390 (+)MAPPERmRatBN7.2
Rnor_6.06103,471,547 - 103,471,700NCBIRnor6.0
Rnor_5.06116,150,521 - 116,150,674UniSTSRnor5.0
RGSC_v3.46103,283,923 - 103,284,076UniSTSRGSC3.4
Celera697,451,062 - 97,451,215UniSTS
RH 3.4 Map6711.3UniSTS
Cytogenetic Map6q24UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 163 91 90 59 92 59 6 356 192 11 142 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000079824   ⟹   ENSRNOP00000074946
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl6104,731,485 - 104,826,172 (-)Ensembl
mRatBN7.2 Ensembl698,998,559 - 99,093,245 (-)Ensembl
Rnor_6.0 Ensembl6103,375,873 - 103,470,555 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000088795   ⟹   ENSRNOP00000069598
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl6104,734,255 - 104,826,172 (-)Ensembl
mRatBN7.2 Ensembl698,998,751 - 99,093,251 (-)Ensembl
Rnor_6.0 Ensembl6103,376,557 - 103,470,501 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000091560   ⟹   ENSRNOP00000068851
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl6104,731,485 - 104,826,172 (-)Ensembl
mRatBN7.2 Ensembl698,998,556 - 99,093,031 (-)Ensembl
Rnor_6.0 Ensembl6103,375,799 - 103,470,427 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000110416   ⟹   ENSRNOP00000097894
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl6104,731,485 - 104,825,919 (-)Ensembl
mRatBN7.2 Ensembl698,998,556 - 99,092,992 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000111498   ⟹   ENSRNOP00000087449
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl6104,733,219 - 104,825,919 (-)Ensembl
mRatBN7.2 Ensembl699,000,287 - 99,092,992 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000112260   ⟹   ENSRNOP00000085943
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl6104,731,485 - 104,769,828 (-)Ensembl
mRatBN7.2 Ensembl698,998,556 - 99,036,899 (-)Ensembl
RefSeq Acc Id: NM_031005   ⟹   NP_112267
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86104,731,485 - 104,826,172 (-)NCBI
mRatBN7.2698,998,553 - 99,093,245 (-)NCBI
Rnor_6.06103,376,557 - 103,470,497 (-)NCBI
Rnor_5.06116,056,248 - 116,149,471 (-)NCBI
RGSC_v3.46103,188,593 - 103,282,873 (-)RGD
Celera697,355,796 - 97,450,012 (-)RGD
Sequence:
RefSeq Acc Id: XM_039112992   ⟹   XP_038968920
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86104,731,488 - 104,826,222 (-)NCBI
mRatBN7.2698,998,556 - 99,093,334 (-)NCBI
RefSeq Acc Id: XM_039112993   ⟹   XP_038968921
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86104,731,488 - 104,826,312 (-)NCBI
mRatBN7.2698,998,556 - 99,093,332 (-)NCBI
RefSeq Acc Id: XM_063262548   ⟹   XP_063118618
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86104,731,488 - 104,825,744 (-)NCBI
RefSeq Acc Id: XM_063262549   ⟹   XP_063118619
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86104,731,488 - 104,825,754 (-)NCBI
RefSeq Acc Id: NP_112267   ⟸   NM_031005
- UniProtKB: Q9Z1P2 (UniProtKB/Swiss-Prot),   A0A8I6AV34 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000074946   ⟸   ENSRNOT00000079824
Ensembl Acc Id: ENSRNOP00000068851   ⟸   ENSRNOT00000091560
Ensembl Acc Id: ENSRNOP00000069598   ⟸   ENSRNOT00000088795
RefSeq Acc Id: XP_038968920   ⟸   XM_039112992
- Peptide Label: isoform X1
- UniProtKB: Q6T487 (UniProtKB/TrEMBL),   A0A8I6AV34 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038968921   ⟸   XM_039112993
- Peptide Label: isoform X2
- UniProtKB: Q6GMN8 (UniProtKB/TrEMBL),   A0A8I6AV34 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000085943   ⟸   ENSRNOT00000112260
Ensembl Acc Id: ENSRNOP00000087449   ⟸   ENSRNOT00000111498
Ensembl Acc Id: ENSRNOP00000097894   ⟸   ENSRNOT00000110416
RefSeq Acc Id: XP_063118619   ⟸   XM_063262549
- Peptide Label: isoform X4
- UniProtKB: A0A8I6GDI3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063118618   ⟸   XM_063262548
- Peptide Label: isoform X3
- UniProtKB: A0A8I6GDI3 (UniProtKB/TrEMBL)
Protein Domains
Calponin-homology (CH)   EF-hand

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9Z1P2-F1-model_v2 AlphaFold Q9Z1P2 1-892 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13694699
Promoter ID:EPDNEW_R5221
Type:initiation region
Name:Actn1_1
Description:actinin, alpha 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.06103,470,564 - 103,470,624EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:70907 AgrOrtholog
BioCyc Gene G2FUF-36940 BioCyc
Ensembl Genes ENSRNOG00000056756 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000079824 ENTREZGENE
  ENSRNOT00000091560 ENTREZGENE
  ENSRNOT00000091560.2 UniProtKB/Swiss-Prot
  ENSRNOT00000112260 ENTREZGENE
Gene3D-CATH 1.10.418.10 UniProtKB/Swiss-Prot
  1.20.58.60 UniProtKB/Swiss-Prot
  EF-hand UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7099133 IMAGE-MGC_LOAD
InterPro Actinin_actin-bd_CS UniProtKB/Swiss-Prot
  CH-domain UniProtKB/Swiss-Prot
  CH_dom_sf UniProtKB/Swiss-Prot
  EF-hand-dom_pair UniProtKB/Swiss-Prot
  EF-hand_Ca_insen UniProtKB/Swiss-Prot
  EF_Hand_1_Ca_BS UniProtKB/Swiss-Prot
  EF_hand_dom UniProtKB/Swiss-Prot
  Spectrin/alpha-actinin UniProtKB/Swiss-Prot
  Spectrin_repeat UniProtKB/Swiss-Prot
KEGG Report rno:81634 UniProtKB/Swiss-Prot
MGC_CLONE MGC:91658 IMAGE-MGC_LOAD
NCBI Gene 81634 ENTREZGENE
PANTHER SPECTRIN/FILAMIN RELATED CYTOSKELETAL PROTEIN UniProtKB/Swiss-Prot
Pfam EF-hand_6 UniProtKB/Swiss-Prot
  EFhand_Ca_insen UniProtKB/Swiss-Prot
  PF00307 UniProtKB/Swiss-Prot
  Spectrin UniProtKB/Swiss-Prot
PhenoGen Actn1 PhenoGen
PROSITE ACTININ_1 UniProtKB/Swiss-Prot
  ACTININ_2 UniProtKB/Swiss-Prot
  EF_HAND_1 UniProtKB/Swiss-Prot
  EF_HAND_2 UniProtKB/Swiss-Prot
  PS50021 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000056756 RatGTEx
SMART EFh UniProtKB/Swiss-Prot
  efhand_Ca_insen UniProtKB/Swiss-Prot
  SM00033 UniProtKB/Swiss-Prot
  SPEC UniProtKB/Swiss-Prot
Superfamily-SCOP Spectrin repeat UniProtKB/Swiss-Prot
  SSF47473 UniProtKB/Swiss-Prot
  SSF47576 UniProtKB/Swiss-Prot
UniProt A0A8I6A472_RAT UniProtKB/TrEMBL
  A0A8I6AV34 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6GDI3 ENTREZGENE, UniProtKB/TrEMBL
  A0A8L2R171_RAT UniProtKB/TrEMBL
  ACTN1_RAT UniProtKB/Swiss-Prot
  Q6GMN8 ENTREZGENE, UniProtKB/TrEMBL
  Q6T487 ENTREZGENE, UniProtKB/TrEMBL
  Q9Z1P2 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-07-09 Actn1  actinin, alpha 1      Symbol and Name updated to reflect Human and Mouse nomenclature 70877 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_domains has an N-terminal region containing two actin-binding motifs, a central four spectrin-like domain with the dimer forming sequence and a C-terminal domain with two EF hand motifs 625419
gene_expression expressed in the adult brain, with highest in neurons of the hippocampus, cortex, and caudate putamen while the cerebellum and other subcortical structures showed low expression 625419
gene_expression expressed in the adult rat brain 625419