Hif1a (hypoxia inducible factor 1 subunit alpha) - Rat Genome Database

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Gene: Hif1a (hypoxia inducible factor 1 subunit alpha) Rattus norvegicus
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Symbol: Hif1a
Name: hypoxia inducible factor 1 subunit alpha
RGD ID: 61928
Description: Enables sequence-specific DNA binding activity and ubiquitin protein ligase binding activity. Involved in several processes, including cellular response to decreased oxygen levels; positive regulation of angiogenesis; and positive regulation of biosynthetic process. Located in nucleus. Used to study acute kidney failure; cerebrovascular disease (multiple); diabetic retinopathy; and hepatocellular carcinoma. Biomarker of several diseases, including artery disease (multiple); bladder neck obstruction; bronchopulmonary dysplasia; ischemia (multiple); and kidney failure (multiple). Human ortholog(s) of this gene implicated in lung non-small cell carcinoma; myocardial infarction; prostate cancer; and type 2 diabetes mellitus. Orthologous to human HIF1A (hypoxia inducible factor 1 subunit alpha); PARTICIPATES IN hypoxia inducible factor pathway; phosphatidylinositol 3-kinase-Akt signaling pathway; vascular endothelial growth factor signaling pathway; INTERACTS WITH (+)-pilocarpine; 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 17beta-estradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: HIF-1 alpha; HIF-1-alpha; HIF1 alpha; HIF1-alpha; hypoxia inducible factor 1 alpha subunit; hypoxia inducible factor 1, alpha subunit; hypoxia-inducible factor 1 alpha; hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor); hypoxia-inducible factor 1-alpha; MOP1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8698,357,788 - 98,405,068 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl698,359,910 - 98,405,323 (+)EnsemblGRCr8
mRatBN7.2692,624,059 - 92,669,262 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl692,624,390 - 92,669,261 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx693,016,163 - 93,061,234 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0693,315,666 - 93,360,736 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0692,743,543 - 92,788,613 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0696,810,868 - 96,856,303 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl696,810,907 - 96,856,052 (+)Ensemblrn6Rnor6.0
Rnor_5.06106,242,409 - 106,287,957 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4696,419,024 - 96,463,891 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera691,083,300 - 91,128,125 (+)NCBICelera
RGSC_v3.1696,422,479 - 96,467,347 (+)NCBI
Cytogenetic Map6q24NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View
acute kidney failure  (IDA,IEP)
Acute-Phase Reaction  (IEP)
alcohol-associated liver disease  (IEP)
Alzheimer's disease  (ISO)
Anaplasia  (ISO)
Arterial Thrombosis  (IEP)
Asphyxia  (IEP)
asthma  (ISO)
atrial fibrillation  (ISO)
bladder neck obstruction  (IEP)
Brain Hypoxia-Ischemia  (IDA,IEP,ISO)
brain infarction  (IMP)
brain ischemia  (IDA,IEP,ISO)
Breast Neoplasms  (ISO)
bronchopulmonary dysplasia  (IEP)
Burns  (IEP)
carcinoma  (ISO)
Cardiomegaly  (ISO)
cerebral infarction  (ISO)
cholesteatoma of middle ear  (ISO)
Choroidal Neovascularization  (IEP)
Chronic Cerebral Hypoperfusion  (IEP)
Chronic Intermittent Hypoxia  (IEP)
chronic obstructive pulmonary disease  (ISO)
Colonic Neoplasms  (ISO)
colorectal cancer  (ISO)
congenital heart disease  (ISO)
congestive heart failure  (IEP,ISO)
decubitus ulcer  (IEP)
Diabetes Complications  (ISO)
Diabetic Foot  (ISO)
Diabetic Nephropathies  (IDA,IEP)
diabetic retinopathy  (IDA,IEP,ISO)
Disease Progression  (ISO)
Ductal Carcinoma  (ISO)
ductal carcinoma in situ  (ISO)
esophagus squamous cell carcinoma  (ISO)
Experimental Arthritis  (IDA)
Experimental Autoimmune Neuritis  (IEP)
Experimental Diabetes Mellitus  (IEP)
Experimental Mammary Neoplasms  (IDA)
Experimental Neoplasms  (ISO)
Experimental Radiation Injuries  (IEP,ISO)
Femur Head Necrosis  (IEP)
glioblastoma  (ISO)
glycogen storage disease V  (ISS)
glycogen storage disease VII  (ISS)
Hearing Loss, Noise-Induced  (ISO)
hemangioblastoma  (ISO)
hepatic encephalopathy  (IEP)
hepatocellular carcinoma  (IMP,ISO)
Hot Flashes  (ISO)
Hyperalgesia  (IEP)
Hyperplasia  (ISO)
hypertension  (IEP,ISO)
idiopathic pulmonary fibrosis  (ISO)
Infarction  (IEP)
interstitial cystitis  (IEP)
Intervertebral Disc Disease  (IEP)
Intervertebral Disc Displacement  (ISO)
invasive ductal carcinoma  (ISO)
kidney failure  (IEP)
Kidney Reperfusion Injury  (IDA,IMP)
limb ischemia  (IEP)
liver cirrhosis  (ISO)
lung disease  (ISO)
lung non-small cell carcinoma  (ISO)
macular retinal edema  (ISO)
malignant astrocytoma  (ISO)
Memory Disorders  (ISO)
Micronuclei, Chromosome-Defective  (ISO)
middle cerebral artery infarction  (IDA)
morbid obesity  (ISO)
mycosis fungoides  (ISO)
myocardial infarction  (IEP,ISO)
Myocardial Ischemia  (IEP)
Myocardial Reperfusion Injury  (IDA,IEP,ISO)
Neoplasm Invasiveness  (ISO)
Neoplastic Cell Transformation  (ISO)
nephroblastoma  (ISO)
obesity  (ISO)
olfactory neuroblastoma  (ISO)
osteoarthritis  (ISO)
ovarian cancer  (ISO)
Oxygen-Induced Retinopathy  (ISO)
pancreatic cancer  (ISO)
Phyllodes Tumor  (ISO)
polycystic kidney disease  (IEP)
Postmenopausal Osteoporosis  (IMP,ISO)
pre-eclampsia  (ISO)
primary biliary cholangitis  (ISO)
prostate cancer  (ISO)
Prostatic Neoplasms  (ISO)
proteinuria  (IEP)
psoriasis  (ISO)
pulmonary hypertension  (IEP,ISO)
Radiation Injuries  (ISO)
renal cell carcinoma  (ISO)
Reperfusion Injury  (IDA)
retinal ischemia  (IEP)
Retinal Neovascularization  (ISO)
rheumatoid arthritis  (ISO)
sclerosing cholangitis  (ISO)
skin melanoma  (ISO)
Skin Neoplasms  (ISO)
Spinal Cord Injuries  (IEP,ISO)
Subarachnoid Hemorrhage  (IEP)
Temporomandibular Joint Disorders  (IEP)
Testis Reperfusion Injury  (IEP)
Thyroid Neoplasms  (ISO)
transient cerebral ischemia  (IEP)
type 2 diabetes mellitus  (IEP,ISO)
Ulcer  (IEP)
urinary bladder cancer  (ISO)
Urologic Neoplasms  (ISO)
varicocele  (IEP)
Venous Thrombosis  (ISO)
Ventricular Remodeling  (IEP)
Werner syndrome  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
(+)-pilocarpine  (EXP)
(-)-epigallocatechin 3-gallate  (ISO)
(-)-noscapine  (ISO)
(25R)-cholest-5-ene-3beta,26-diol  (ISO)
(R)-adrenaline  (ISO)
(S)-nicotine  (ISO)
1,10-phenanthroline  (ISO)
1,2-dimethylhydrazine  (ISO)
1,4-benzoquinone  (ISO)
1,4-dithiothreitol  (ISO)
1,4-phenylenediamine  (ISO)
1-[(2,3,4-trimethoxyphenyl)methyl]piperazine  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (EXP,ISO)
1-methylphenanthrene  (ISO)
1-naphthyl isothiocyanate  (ISO)
1-nitropyrene  (ISO)
1-octadec-9-enoylglycero-3-phosphate  (ISO)
15-deoxy-Delta(12,14)-prostaglandin J2  (ISO)
17beta-estradiol  (EXP,ISO)
2,2'-bipyridine  (ISO)
2,3,4,7,8-Pentachlorodibenzofuran  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2-amino-2-deoxy-D-glucopyranose  (ISO)
2-hydroxypropanoic acid  (ISO)
2-methoxy-17beta-estradiol  (EXP,ISO)
26-hydroxycholesterol  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP,ISO)
3,3',5-triiodo-L-thyronine  (ISO)
3,4-dihydroxybenzoate  (EXP,ISO)
3,4-dihydroxybenzoic acid  (EXP)
3,5-diethoxycarbonyl-1,4-dihydrocollidine  (ISO)
3-bromopyruvic acid  (ISO)
3-methyladenine  (ISO)
3-methylcholanthrene  (EXP)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroperoxycyclophosphamide  (ISO)
4-hydroxy-17beta-estradiol  (ISO)
4-hydroxy-TEMPO  (EXP)
4-vinylcyclohexene dioxide  (ISO)
5,6-dichloro-1-beta-D-ribofuranosyl-1H-benzimidazole  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-chloro-7-iodoquinolin-8-ol  (ISO)
5-fluorouracil  (EXP,ISO)
6-propyl-2-thiouracil  (EXP)
7,12-dimethyltetraphene  (ISO)
7,9-dihydro-1H-purine-2,6,8(3H)-trione  (ISO)
7H-xanthine  (EXP)
8-bromo-3',5'-cyclic GMP  (ISO)
9-aminoacridine  (ISO)
9H-xanthine  (EXP)
acetaldehyde  (ISO)
acetamide  (EXP)
acrolein  (ISO)
acrylonitrile  (ISO)
actinomycin D  (ISO)
adenosine  (ISO)
aflatoxin B1  (EXP,ISO)
aldehydo-D-glucosamine  (ISO)
aldehydo-D-glucose  (EXP,ISO)
all-trans-retinoic acid  (ISO)
allethrin  (EXP)
alpha-D-galactose  (ISO)
alpha-naphthoflavone  (ISO)
alpha-pinene  (ISO)
alpinumisoflavone  (ISO)
aluminium atom  (ISO)
aluminium(0)  (ISO)
amino acid  (ISO)
aminoguanidine  (ISO)
amiodarone  (ISO)
ammonium chloride  (EXP,ISO)
amphotericin B  (ISO)
andrographolide  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
anthracen-2-amine  (ISO)
antimycin A  (EXP,ISO)
antirheumatic drug  (ISO)
apigenin  (EXP,ISO)
apocynin  (EXP,ISO)
arabinogalactan  (EXP)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenic trichloride  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
ATP  (ISO)
Azaspiracid  (ISO)
azoxystrobin  (ISO)
bafilomycin A1  (ISO)
baicalein  (ISO)
benzalkonium chloride  (ISO)
benzene  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[b]fluoranthene  (ISO)
Benzo[k]fluoranthene  (ISO)
beta-D-glucosamine  (ISO)
betulin  (ISO)
betulinic acid  (ISO)
bicalutamide  (EXP)
bilirubin IXalpha  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol A diglycidyl ether  (ISO)
bisphenol AF  (ISO)
bisphenol F  (ISO)
bleomycin A2  (ISO)
bortezomib  (ISO)
bromobenzene  (EXP)
bruceine D  (ISO)
bucladesine  (ISO)
busulfan  (ISO)
butyric acid  (ISO)
C.I. Natural Red 20  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (ISO)
calcidiol  (ISO)
calciol  (ISO)
calycosin  (ISO)
calycosin-7-O-beta-D-glucoside  (ISO)
cannabidiol  (EXP,ISO)
capecitabine  (ISO)
capsaicin  (ISO)
carbon nanotube  (ISO)
carmustine  (EXP)
carnosine  (EXP)
carvone  (ISO)
casticin  (EXP)
ceric oxide  (ISO)
cerium  (ISO)
CGP 52608  (ISO)
chenodeoxycholic acid  (ISO)
chetomin  (ISO)
chloroacetaldehyde  (ISO)
chloroquine  (ISO)
chlorpromazine  (EXP)
chlorpyrifos  (ISO)
cholesterol  (EXP)
choline  (ISO)
chromium atom  (ISO)
chromium(6+)  (EXP,ISO)
chrysin  (ISO)
ciclopirox  (EXP,ISO)
cidofovir anhydrous  (ISO)
ciglitazone  (EXP)
cisplatin  (EXP,ISO)
clodronic acid  (EXP,ISO)
clofibrate  (ISO)
cobalt atom  (EXP,ISO)
cobalt dichloride  (EXP,ISO)
cobalt(2+) sulfate  (ISO)
cobalt(II) acetate  (ISO)
cocaine  (ISO)
colforsin daropate hydrochloride  (ISO)
concanamycin A  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) chloride  (ISO)
copper(II) sulfate  (ISO)
corilagin  (EXP)
coumarin  (ISO)
coumarin 460  (ISO)
crocidolite asbestos  (ISO)
Crystal violet lactone  (ISO)
cucurbitacin B  (ISO)
curcumin  (EXP,ISO)
Curcumol  (EXP)
cycloheximide  (EXP,ISO)
cyclohexyl isocyanate  (EXP)
cyclophosphamide  (ISO)
cyclosporin A  (EXP,ISO)
cyhalothrin  (EXP)
cypermethrin  (EXP)
cytarabine  (ISO)
D-glucose  (EXP,ISO)
DAPT  (ISO)
DDE  (ISO)
deguelin  (ISO)
delphinidin  (ISO)
deoxynivalenol  (ISO)
desferrioxamine B  (EXP,ISO)
dexamethasone  (ISO)
dextran sulfate  (ISO)
diallyl trisulfide  (ISO)
diarsenic trioxide  (ISO)
dibenz[a,h]anthracene  (ISO)
dibenziodolium  (EXP,ISO)
dibenzo[a,l]pyrene  (ISO)
Dibutyl phosphate  (ISO)
dichloroacetic acid  (ISO)
diclofenac  (ISO)
Dictamnine  (ISO)
digitonin  (ISO)
digitoxin  (ISO)
digoxin  (ISO)
Dihydrotanshinone I  (ISO)
dimethyl sulfoxide  (EXP)
dimethylarsinous acid  (ISO)
dimethylselenide  (ISO)
dinophysistoxin 1  (ISO)
diosgenin  (EXP,ISO)
dioxygen  (EXP,ISO)
dopamine  (EXP,ISO)
dorsomorphin  (ISO)
doxifluridine  (ISO)
doxorubicin  (EXP,ISO)
drometrizole  (ISO)
ebselen  (ISO)
edaravone  (ISO)
ellagic acid  (ISO)
emodin  (ISO)
entinostat  (ISO)
epalrestat  (ISO)
epoxomicin  (ISO)
estrogen  (EXP)
ethambutol  (EXP)
ethanol  (EXP,ISO)
eticlopride(1+)  (EXP)
etoposide  (ISO)
eugenol  (ISO)
Evodiamine  (ISO)
fasudil  (ISO)
febuxostat  (EXP)
fenofibrate  (EXP,ISO)
fenvalerate  (EXP)
finasteride  (EXP)
fipronil  (EXP)
fisetin  (EXP,ISO)
flavanones  (ISO)
flavone  (ISO)
fluoranthene  (ISO)
fluoxetine  (ISO)
flusilazole  (ISO)
flutamide  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
formononetin  (ISO)
fulvestrant  (ISO)
furan  (EXP)
Fusaric acid  (ISO)
gadolinium atom  (ISO)
gadolinium trichloride  (ISO)
galactose  (ISO)
galangin  (ISO)
galaxolide  (ISO)
gallic acid  (ISO)
gallium nitrate  (ISO)
Garcinol  (ISO)
gefitinib  (ISO)
geldanamycin  (ISO)
gemcitabine  (ISO)
Genipin  (ISO)
genistein  (ISO)
gentamycin  (EXP,ISO)
gingerol  (ISO)
Ginsenoside Rg5  (EXP)
gliotoxin  (ISO)
glucose  (EXP,ISO)
glutathione  (ISO)
glutathione disulfide  (ISO)
glyphosate  (EXP)
GW 4064  (ISO)
hemin  (ISO)
hexachlorobenzene  (ISO)
hexadecanoic acid  (ISO)
hyaluronic acid  (EXP)
hydrazines  (EXP)
hydrogen cyanide  (ISO)
hydrogen peroxide  (EXP,ISO)
hydrogen sulfide  (ISO)
hydroxamic acid  (ISO)
ibuprofen  (ISO)
idelalisib  (ISO)
ifosfamide  (ISO)
indoxyl sulfate  (ISO)
insulin  (EXP)
inulin  (ISO)
Iodine aqueous  (ISO)
ionomycin  (ISO)
iron atom  (EXP,ISO)
iron dichloride  (ISO)
iron(0)  (EXP,ISO)
iron(2+) sulfate (anhydrous)  (ISO)
iron(3+) sulfate  (ISO)
iron(III) citrate  (ISO)
iron(III) nitrilotriacetate  (ISO)
isoniazide  (EXP)
isoprenaline  (ISO)
kaempferol  (EXP,ISO)
ketorolac  (ISO)
KN-93  (ISO)
L-1,4-dithiothreitol  (ISO)
L-ascorbic acid  (EXP,ISO)
L-methionine  (ISO)
L-mimosine  (EXP,ISO)
lactacystin  (ISO)
lapatinib  (ISO)
leflunomide  (ISO)
linderalactone  (ISO)
linuron  (ISO)
lipopolysaccharide  (EXP,ISO)
lithocholic acid  (ISO)
luteolin  (ISO)
LY294002  (EXP,ISO)
malonic acid  (EXP)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (EXP,ISO)
melatonin  (ISO)
menadione  (EXP,ISO)
mercury dichloride  (ISO)
metam  (ISO)
metformin  (EXP,ISO)
methapyrilene  (EXP)
methidathion  (ISO)
methotrexate  (ISO)
methyl methanesulfonate  (ISO)
methylglyoxal  (ISO)
methylmercury chloride  (EXP)
mevinphos  (EXP)
miconazole  (EXP)
microcystin-LR  (ISO)
minocycline  (ISO)
Mitoquinone  (ISO)
MitoTEMPO  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
motexafin gadolinium  (ISO)
mycothiazole  (ISO)
myricetin  (ISO)
N(6)-butyryl-cAMP  (EXP)
N(gamma)-nitro-L-arginine methyl ester  (ISO)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (ISO)
N-acetyl-L-cysteine  (EXP,ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (EXP,ISO)
N-methyl-4-phenylpyridinium  (EXP,ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (EXP)
N-methyl-N-nitrosourea  (EXP)
N-nitrosodiethylamine  (EXP)
N-nitrosomorpholine  (EXP)
n-propyl gallate  (EXP)
nickel atom  (EXP,ISO)
nickel dichloride  (ISO)
nickel subsulfide  (ISO)
nickel sulfate  (ISO)
niclosamide  (ISO)
nicotine  (ISO)
nicotinic acid  (EXP)
nitric oxide  (ISO)
nitrofurantoin  (EXP)
nitroprusside  (ISO)
norwogonin  (EXP)
NS-398  (ISO)
ochratoxin A  (EXP,ISO)
okadaic acid  (ISO)
oleic acid  (ISO)
oroxylin A  (ISO)
ouabain  (ISO)
oxaliplatin  (EXP)
oxybenzone  (ISO)
ozone  (EXP,ISO)
paclitaxel  (ISO)
paeoniflorin  (ISO)
Panaxynol  (EXP)
paracetamol  (ISO)
paraquat  (EXP,ISO)
pentachlorophenol  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
pevonedistat  (ISO)
phenformin  (ISO)
phenobarbital  (EXP,ISO)
PhIP  (ISO)
phloretin  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
phorone  (EXP)
picropodophyllotoxin  (ISO)
pioglitazone  (ISO)
pirfenidone  (ISO)
pirinixic acid  (ISO)
potassium chromate  (ISO)
potassium cyanide  (ISO)
potassium dichromate  (EXP,ISO)
prednisone  (ISO)
progesterone  (ISO)
promethazine  (EXP)
propofol  (ISO)
prostaglandin E2  (ISO)
protoporphyrin  (ISO)
pyrazinecarboxamide  (EXP)
pyrethrins  (EXP)
quercetin  (EXP,ISO)
quinolone  (ISO)
Quinomycin A  (ISO)
rac-lactic acid  (ISO)
radicicol  (EXP)
radon atom  (ISO)
radon(0)  (ISO)
razoxane  (ISO)
reactive oxygen species  (ISO)
resveratrol  (EXP,ISO)
Rhein  (ISO)
rifampicin  (EXP,ISO)
rimonabant  (ISO)
romidepsin  (ISO)
rosmarinic acid  (ISO)
rotenone  (EXP,ISO)
roxadustat  (EXP,ISO)
rutin  (EXP)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (EXP,ISO)
S-nitrosoglutathione  (ISO)
Salidroside  (EXP,ISO)
Salinomycin  (ISO)
SB 203580  (ISO)
scutellarin  (ISO)
selenomethionine  (ISO)
sevoflurane  (ISO)
Shikonin  (ISO)
sildenafil citrate  (EXP,ISO)
simvastatin  (EXP,ISO)
sirolimus  (EXP,ISO)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
sodium atom  (ISO)
sodium azide  (EXP)
sodium chloride  (EXP)
sodium cholate  (EXP)
sodium dichromate  (ISO)
sodium nitrite  (EXP)
sorafenib  (ISO)
spironolactone  (EXP)
squalene  (ISO)
stattic  (ISO)
streptozocin  (EXP,ISO)
succinic acid  (EXP)
sulfadimethoxine  (EXP)
sulfasalazine  (ISO)
sulfonyldimethane  (ISO)
sulforaphane  (ISO)
sulindac  (ISO)
sulprostone  (ISO)
sunitinib  (ISO)
Swertiamarin  (EXP)
T-2 toxin  (ISO)
tadalafil  (EXP)
tamoxifen  (ISO)
tanespimycin  (ISO)
Terpestacin  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (EXP,ISO)
testosterone enanthate  (EXP)
tetrachloromethane  (EXP,ISO)
tetraconazole  (ISO)
tetraethylenepentamine  (ISO)
tetramethylpyrazine  (ISO)
tetrathiomolybdate(2-)  (EXP)
Theaflavin 3,3'-digallate  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
thymidine  (ISO)
thymoquinone  (EXP)
Tiron  (ISO)
titanium dioxide  (ISO)
topotecan  (EXP,ISO)
trabectedin  (ISO)
triamterene  (ISO)
tributyrin  (ISO)
trichloroacetic acid  (EXP)
trifluoperazine  (ISO)
trimellitic anhydride  (ISO)
trimethyltin  (ISO)
triphenyl phosphate  (ISO)
troglitazone  (ISO)
Tungsten carbide  (ISO)
tunicamycin  (ISO)
ubiquinone-0  (ISO)
udenafil  (EXP)
urethane  (ISO)
ursodeoxycholic acid  (ISO)
valproic acid  (ISO)
vanadium atom  (ISO)
vanadium(0)  (ISO)
vemurafenib  (ISO)
vinclozolin  (EXP)
Vinpocetine  (EXP)
vitamin E  (ISO)
vorinostat  (ISO)
vosaroxin  (ISO)
warfarin  (ISO)
wogonin  (ISO)
wortmannin  (EXP,ISO)
Y-27632  (ISO)
zinc acetate  (ISO)
zinc atom  (ISO)
zinc dichloride  (ISO)
zinc protoporphyrin  (ISO)
zinc(0)  (ISO)
zoledronic acid  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
acute-phase response  (IEP)
angiogenesis  (ISO)
axonal transport of mitochondrion  (IEA,ISO,ISS)
B-1 B cell homeostasis  (ISO)
blood vessel development  (ISO)
blood vessel morphogenesis  (ISO)
camera-type eye morphogenesis  (ISO)
cardiac ventricle morphogenesis  (ISO)
cartilage development  (ISO)
cell differentiation  (ISO)
cellular response to anoxia  (IEP)
cellular response to carbon monoxide  (IEP)
cellular response to cobalt ion  (IEP)
cellular response to cyanide  (IEP)
cellular response to electrical stimulus  (IEP)
cellular response to estrogen stimulus  (IEP)
cellular response to glucose stimulus  (IEP)
cellular response to hydrogen peroxide  (IEP)
cellular response to hypoxia  (IBA,IEA,IEP,IMP,ISO,ISS)
cellular response to insulin stimulus  (IEP)
cellular response to interleukin-1  (IEA,IEP,ISO)
cellular response to light stimulus  (IEP)
cellular response to lipid  (IEP)
cellular response to lipopolysaccharide  (IEP)
cellular response to mechanical stimulus  (IEP)
cellular response to nitrite  (IEP)
cellular response to oxidative stress  (IEA,ISO)
cellular response to phorbol 13-acetate 12-myristate  (IEP)
cellular response to toxic substance  (IEP)
cellular response to virus  (IEA)
cellular response to wortmannin  (IEP)
cellular response to xenobiotic stimulus  (IEP)
cerebral cortex development  (ISO)
circulatory system development  (IEA)
collagen metabolic process  (IEA,ISO)
connective tissue replacement involved in inflammatory response wound healing  (IEA,ISO)
digestive tract morphogenesis  (ISO)
DNA-templated transcription  (IEA)
dopaminergic neuron differentiation  (ISO)
elastin metabolic process  (IEA,ISO)
embryonic hemopoiesis  (ISO)
embryonic placenta development  (ISO)
epithelial cell differentiation involved in mammary gland alveolus development  (ISO)
epithelial to mesenchymal transition  (IEA,ISO)
glucose homeostasis  (ISO)
heart development  (IEP)
heart looping  (ISO)
hemoglobin biosynthetic process  (ISO)
hypoxia-inducible factor-1alpha signaling pathway  (ISO)
intestinal epithelial cell maturation  (ISO)
intracellular glucose homeostasis  (IEA,ISO,ISS)
intracellular iron ion homeostasis  (ISO)
intracellular oxygen homeostasis  (IBA,IEA,ISO)
iris morphogenesis  (ISO)
iron import into the mitochondrion  (IMP)
lactate metabolic process  (ISO)
lactation  (ISO)
lung development  (IEA,IEP)
maternal process involved in female pregnancy  (IEP)
muscle cell cellular homeostasis  (ISO)
negative regulation of apoptotic process  (IMP,ISO)
negative regulation of bone mineralization  (ISO)
negative regulation of gene expression  (IEA,ISO)
negative regulation of growth  (ISO)
negative regulation of mesenchymal cell apoptotic process  (ISO)
negative regulation of miRNA transcription  (IEA,ISO)
negative regulation of neuron apoptotic process  (ISO)
negative regulation of ossification  (IEA,ISO)
negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway  (IEA,ISO)
negative regulation of reactive oxygen species biosynthetic process  (IEA,IMP,ISO)
negative regulation of thymocyte apoptotic process  (ISO)
negative regulation of TOR signaling  (ISO)
negative regulation of transcription by RNA polymerase II  (IMP)
negative regulation of vasoconstriction  (IMP)
neural crest cell migration  (ISO)
neural fold elevation formation  (ISO)
outflow tract morphogenesis  (ISO)
positive regulation of angiogenesis  (IEA,ISO)
positive regulation of apoptotic process  (IMP)
positive regulation of blood vessel endothelial cell migration  (IEA,ISO)
positive regulation of cell population proliferation  (IMP)
positive regulation of cell size  (IEP)
positive regulation of chemokine-mediated signaling pathway  (ISO)
positive regulation of cytokine production involved in inflammatory response  (IEA,ISO,ISS)
positive regulation of DNA-templated transcription  (IEA,ISO,ISS)
positive regulation of endothelial cell migration  (IMP)
positive regulation of epithelial cell migration  (IEA,ISO)
positive regulation of erythrocyte differentiation  (ISO)
positive regulation of gene expression  (IEA,IMP,ISO)
positive regulation of gluconeogenesis  (IMP)
positive regulation of glycolytic process  (ISO)
positive regulation of hormone biosynthetic process  (IEA,ISO)
positive regulation of insulin secretion involved in cellular response to glucose stimulus  (ISO)
positive regulation of macroautophagy  (ISO)
positive regulation of miRNA transcription  (IEA,ISO)
positive regulation of multicellular organismal process  (IEA)
positive regulation of neuroblast proliferation  (ISO)
positive regulation of smooth muscle cell proliferation  (IMP)
positive regulation of sprouting angiogenesis  (IMP)
positive regulation of stress granule assembly  (IMP)
positive regulation of transcription by RNA polymerase II  (IDA,IEA,IMP,ISO)
positive regulation of vascular endothelial growth factor production  (IEA,IMP,ISO,ISS)
positive regulation of vascular endothelial growth factor receptor signaling pathway  (ISO)
positive regulation of vascular wound healing  (IMP)
regulation of catalytic activity  (ISO)
regulation of cell population proliferation  (ISO)
regulation of cellular response to hypoxia  (IEP)
regulation of DNA-templated transcription  (IEA,ISO,TAS)
regulation of gene expression  (IEA,ISO)
regulation of glycolytic process  (IEA,ISO,ISS)
regulation of protein neddylation  (IEA,ISO,ISS)
regulation of thymocyte apoptotic process  (ISO)
regulation of transcription by RNA polymerase II  (IBA,ISO)
regulation of transforming growth factor beta2 production  (IEA,ISO)
response to activity  (IEP)
response to alkaloid  (IEP)
response to anesthetic  (IEP)
response to auditory stimulus  (IEP)
response to cobalt ion  (IEP)
response to estradiol  (IEP)
response to estrogen  (IEP)
response to fungicide  (IMP)
response to glucocorticoid  (IEP)
response to glucose  (IEP)
response to hypoxia  (IDA,IEA,ISO,ISS)
response to iron ion  (IEA,ISO)
response to mechanical stimulus  (IEP)
response to muscle activity  (ISO)
response to purine-containing compound  (IEP)
response to reactive oxygen species  (IEA,ISO,ISS)
response to salt stress  (IEP)
response to X-ray  (IEP)
response to xenobiotic stimulus  (IEP)
retina vasculature development in camera-type eye  (ISO)
signal transduction  (IEA,ISO)
tissue remodeling  (IEP)
tube development  (IEA)
vascular endothelial growth factor production  (IEA,ISO)
vasculature development  (ISO)
visual learning  (ISO)

Cellular Component
axon cytoplasm  (IEA)
chromatin  (IEA,ISO)
cytoplasm  (IEA,ISO)
cytosol  (IEA,ISO,ISS)
euchromatin  (IEA,ISO)
motile cilium  (IEA,ISO)
nuclear body  (IEA,ISO)
nuclear speck  (IEA,ISO,ISS)
nucleoplasm  (IEA,ISO)
nucleus  (IBA,IDA,IEA,ISO,ISS)
protein-containing complex  (IEA,ISO)
RNA polymerase II transcription regulator complex  (IEA,ISO)
transcription regulator complex  (IBA)

References

References - curated
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68. Hypoxia-inducible factor-1 and hypoxia response elements mediate the induction of plasminogen activator inhibitor-1 gene expression by insulin in primary rat hepatocytes. Kietzmann T, etal., Blood 2003 Feb 1;101(3):907-14.
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76. Chronic hypoxia- and monocrotaline-induced elevation of hypoxia-inducible factor-1 alpha levels and pulmonary hypertension. Lai YL and Law TC, J Biomed Sci. 2004 May-Jun;11(3):315-21.
77. HIF-1 inhibition decreases systemic vascular remodelling diseases by promoting apoptosis through a hexokinase 2-dependent mechanism. Lambert CM, etal., Cardiovasc Res. 2010 Oct 1;88(1):196-204. Epub 2010 May 24.
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PMID:20308610   PMID:20427666   PMID:20440072   PMID:20473743   PMID:20550877   PMID:20564420   PMID:20580263   PMID:20617879   PMID:20660157   PMID:20705587   PMID:20808783   PMID:20810912  
PMID:20823573   PMID:20881940   PMID:20889502   PMID:20972335   PMID:21046459   PMID:21056661   PMID:21180164   PMID:21186601   PMID:21208160   PMID:21212189   PMID:21270095   PMID:21275821  
PMID:21293012   PMID:21338581   PMID:21351619   PMID:21360434   PMID:21365420   PMID:21390240   PMID:21412184   PMID:21454802   PMID:21472453   PMID:21480981   PMID:21500193   PMID:21528068  
PMID:21535264   PMID:21538185   PMID:21546903   PMID:21558026   PMID:21708067   PMID:21757657   PMID:21807419   PMID:21817107   PMID:21819559   PMID:21856340   PMID:21856910   PMID:21896938  
PMID:21900602   PMID:21941213   PMID:21945600   PMID:21949366   PMID:21987385   PMID:22006794   PMID:22009797   PMID:22081627   PMID:22093793   PMID:22101263   PMID:22156356   PMID:22178140  
PMID:22223132   PMID:22227185   PMID:22235342   PMID:22252226   PMID:22342160   PMID:22349312   PMID:22349381   PMID:22384254   PMID:22407533   PMID:22426121   PMID:22465950   PMID:22472608  
PMID:22472890   PMID:22506063   PMID:22528459   PMID:22552935   PMID:22561747   PMID:22569713   PMID:22575885   PMID:22615070   PMID:22627259   PMID:22627278   PMID:22687987   PMID:22735262  
PMID:22796763   PMID:22804936   PMID:22848707   PMID:22874467   PMID:22886504   PMID:22907120   PMID:22938542   PMID:22948748   PMID:22962609   PMID:22972036   PMID:22982617   PMID:22986049  
PMID:22999929   PMID:23040263   PMID:23041290   PMID:23072112   PMID:23085511   PMID:23216940   PMID:23322610   PMID:23428131   PMID:23441597   PMID:23456363   PMID:23498787   PMID:23520526  
PMID:23530034   PMID:23555163   PMID:23592126   PMID:23628900   PMID:23658906   PMID:23671625   PMID:23693073   PMID:23847321   PMID:24011070   PMID:24030251   PMID:24040163   PMID:24048733  
PMID:24140799   PMID:24184387   PMID:24203996   PMID:24244340   PMID:24296245   PMID:24309492   PMID:24317498   PMID:24351506   PMID:24358181   PMID:24375098   PMID:24472280   PMID:24478626  
PMID:24507647   PMID:24553947   PMID:24583668   PMID:24589856   PMID:24590840   PMID:24615545   PMID:24623146   PMID:24661402   PMID:24681946   PMID:24689065   PMID:24757104   PMID:24867508  
PMID:24871629   PMID:24887017   PMID:24889205   PMID:24899725   PMID:24923288   PMID:24983504   PMID:25001932   PMID:25017576   PMID:25031727   PMID:25043030   PMID:25063991   PMID:25082844  
PMID:25108706   PMID:25179820   PMID:25187725   PMID:25192050   PMID:25201493   PMID:25201604   PMID:25251473   PMID:25270619   PMID:25283246   PMID:25388848   PMID:25401104   PMID:25407718  
PMID:25415049   PMID:25502463   PMID:25535647   PMID:25575055   PMID:25592135   PMID:25613530   PMID:25625917   PMID:25632183   PMID:25648081   PMID:25726501   PMID:25744839   PMID:25751622  
PMID:25754303   PMID:25779090   PMID:25781495   PMID:25796156   PMID:25935977   PMID:25958982   PMID:25976178   PMID:25976847   PMID:26108712   PMID:26125789   PMID:26125880   PMID:26136559  
PMID:26151308   PMID:26175156   PMID:26191216   PMID:26245371   PMID:26271978   PMID:26278717   PMID:26323652   PMID:26359097   PMID:26464661   PMID:26537366   PMID:26614261   PMID:26647409  
PMID:26648172   PMID:26702149   PMID:26707180   PMID:26720469   PMID:26765925   PMID:26781174   PMID:26813461   PMID:26852593   PMID:26879375   PMID:26891083   PMID:26920732   PMID:26927342  
PMID:26929250   PMID:26945787   PMID:26950727   PMID:26963468   PMID:26969192   PMID:26993367   PMID:27058435   PMID:27127787   PMID:27154980   PMID:27193608   PMID:27245613   PMID:27260943  
PMID:27351799   PMID:27363270   PMID:27383646   PMID:27470678   PMID:27742895   PMID:27748831   PMID:27750035   PMID:27769790   PMID:27783302   PMID:27810863   PMID:27927598   PMID:27988334  
PMID:27997905   PMID:28000380   PMID:28002632   PMID:28106131   PMID:28212880   PMID:28266762   PMID:28274939   PMID:28296633   PMID:28331062   PMID:28423052   PMID:28478272   PMID:28495754  
PMID:28629892   PMID:28686686   PMID:28738389   PMID:28820398   PMID:28838333   PMID:28924179   PMID:28940640   PMID:28980287   PMID:29158549   PMID:29189156   PMID:29287795   PMID:29308570  
PMID:29394091   PMID:29451295   PMID:29888265   PMID:29991768   PMID:30030103   PMID:30092282   PMID:30132575   PMID:30213959   PMID:30267829   PMID:30394322   PMID:30423574   PMID:30560874  
PMID:30659610   PMID:30911550   PMID:30938209   PMID:30964182   PMID:30982984   PMID:31121197   PMID:31274018   PMID:31376939   PMID:31377879   PMID:31386893   PMID:31408200   PMID:31408201  
PMID:31432135   PMID:31432144   PMID:31594995   PMID:31652450   PMID:31702030   PMID:31870966   PMID:31959353   PMID:32000757   PMID:32124933   PMID:32126269   PMID:32165091   PMID:32290638  
PMID:32321555   PMID:32328929   PMID:32437020   PMID:32451801   PMID:32510153   PMID:32579679   PMID:32626732   PMID:32750029   PMID:32816128   PMID:32939968   PMID:33077115   PMID:33237516  
PMID:33586916   PMID:33625690   PMID:33759271   PMID:33789142   PMID:33805152   PMID:33816617   PMID:33899119   PMID:33918929   PMID:34048873   PMID:34104112   PMID:34128630   PMID:34205318  
PMID:34214783   PMID:34231059   PMID:34273501   PMID:34288817   PMID:34465468   PMID:34596045   PMID:34698450   PMID:34888746   PMID:34996938   PMID:35041836   PMID:35554780   PMID:35569770  
PMID:35576220   PMID:35708531   PMID:35710352   PMID:35842683   PMID:35935584   PMID:35951252   PMID:36214718   PMID:36555780   PMID:36669549   PMID:36746787   PMID:37038623   PMID:37186198  
PMID:37356787   PMID:37566526   PMID:37644373   PMID:37776955   PMID:37817516   PMID:37848100   PMID:37874694   PMID:37933655   PMID:37954484   PMID:37986153   PMID:38235568   PMID:38253248  
PMID:38291291   PMID:38584135   PMID:38593124   PMID:38608407   PMID:38695335   PMID:38774964   PMID:38836656   PMID:38867145   PMID:38908346  


Genomics

Comparative Map Data
Hif1a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8698,357,788 - 98,405,068 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl698,359,910 - 98,405,323 (+)EnsemblGRCr8
mRatBN7.2692,624,059 - 92,669,262 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl692,624,390 - 92,669,261 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx693,016,163 - 93,061,234 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0693,315,666 - 93,360,736 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0692,743,543 - 92,788,613 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0696,810,868 - 96,856,303 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl696,810,907 - 96,856,052 (+)Ensemblrn6Rnor6.0
Rnor_5.06106,242,409 - 106,287,957 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4696,419,024 - 96,463,891 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera691,083,300 - 91,128,125 (+)NCBICelera
RGSC_v3.1696,422,479 - 96,467,347 (+)NCBI
Cytogenetic Map6q24NCBI
HIF1A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381461,695,513 - 61,748,258 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1461,695,456 - 61,748,263 (+)Ensemblhg38GRCh38
GRCh371462,162,231 - 62,214,976 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361461,231,992 - 61,284,729 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341461,231,991 - 61,284,729NCBI
Celera1442,212,391 - 42,265,247 (+)NCBICelera
Cytogenetic Map14q23.2NCBI
HuRef1442,326,005 - 42,378,869 (+)NCBIHuRef
CHM1_11462,101,569 - 62,154,420 (+)NCBICHM1_1
T2T-CHM13v2.01455,902,080 - 55,954,826 (+)NCBIT2T-CHM13v2.0
Hif1a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391273,948,186 - 73,994,304 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1273,948,149 - 73,994,304 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381273,901,324 - 73,947,554 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1273,901,375 - 73,947,530 (+)Ensemblmm10GRCm38
MGSCv371275,008,854 - 75,048,517 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361274,826,868 - 74,865,729 (+)NCBIMGSCv36mm8
Celera1275,021,612 - 75,061,060 (+)NCBICelera
Cytogenetic Map12C3NCBI
cM Map1231.99NCBI
Hif1a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554668,000,044 - 8,022,497 (-)Ensembl
ChiLan1.0NW_0049554668,000,311 - 8,022,497 (-)NCBIChiLan1.0ChiLan1.0
HIF1A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21562,825,050 - 62,878,472 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11462,041,761 - 62,094,986 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01442,295,691 - 42,348,478 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11460,552,374 - 60,604,885 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1460,552,374 - 60,604,885 (+)EnsemblpanPan2panpan1.1
HIF1A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1836,614,045 - 36,656,692 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl836,614,045 - 36,656,692 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha836,366,891 - 36,409,562 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0836,847,226 - 36,889,848 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl836,847,066 - 36,889,846 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1836,456,745 - 36,499,380 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0836,534,215 - 36,576,862 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0836,896,640 - 36,939,279 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Hif1a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864068,375,541 - 68,420,766 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364955,770,669 - 5,816,157 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049364955,770,988 - 5,816,157 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HIF1A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1190,625,244 - 190,674,845 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11190,625,436 - 190,673,926 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21212,130,958 - 212,179,888 (+)NCBISscrofa10.2Sscrofa10.2susScr3
HIF1A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12438,873,830 - 38,927,657 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2438,873,861 - 38,928,288 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366605327,124,225 - 27,177,215 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Hif1a
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473439,411,824 - 39,471,705 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462473439,414,458 - 39,471,705 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Hif1a
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1788,183,933 - 88,205,015 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Hif1a
216 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:620
Count of miRNA genes:286
Interacting mature miRNAs:351
Transcripts:ENSRNOT00000049725
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4145119Mcs25Mammary carcinoma susceptibility QTL 250.0001mammary gland integrity trait (VT:0010552)ratio of deaths to total study population during a period of time (CMO:0001023)671278722116278722Rat
70176Mcsm1Mammary carcinoma susceptibility modifier QTL 1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)664367996109367996Rat
2293088Iddm28Insulin dependent diabetes mellitus QTL 285.21blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)668767270135411972Rat
1331799Bp211Blood pressure QTL 2113.66407arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)688019181136741135Rat
1581563Uae33Urinary albumin excretion QTL 33urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)693560258136550638Rat
10054138Gmadr3Adrenal mass QTL 33.680.00045adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)690871046135871046Rat
724524Uae2Urinary albumin excretion QTL 22.70.0005urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)679198463144254945Rat
4889933Bss88Bone structure and strength QTL 883.8tibia size trait (VT:0100001)tibia total bone volume (CMO:0001724)65368492198684921Rat
737827Hcar11Hepatocarcinoma resistance QTL 114.4liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)646050607116278722Rat
2303624Vencon5Ventilatory control QTL 54.45respiration trait (VT:0001943)minute ventilation (CMO:0000132)693778632138778632Rat
1576309Emca7Estrogen-induced mammary cancer QTL 74mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)620859430113082285Rat
2293837Kiddil1Kidney dilation QTL 13.7kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)686867923110125012Rat
2293842Kiddil3Kidney dilation QTL 34.3kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)686867923110125012Rat
61329Eae9Experimental allergic encephalomyelitis QTL 93.7body mass (VT:0001259)change in body weight (CMO:0002045)684490437129490437Rat
10054123Srcrt6Stress Responsive Cort QTL 62.50.0043blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)690871046135871046Rat
724536Uae7Urinary albumin excretion QTL 73.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)693560258136550638Rat
5684963Bss99Bone structure and strength QTL 993.1tibia area (VT:1000281)tibia area measurement (CMO:0001382)65368492198684921Rat
1576302Schws4Schwannoma susceptibility QTL 40.0078nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)678204640123204640Rat
1581550Pur8Proteinuria QTL 8urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)693560258136550638Rat
5684992Bmd83Bone mineral density QTL 824.8tibia mineral mass (VT:1000283)bone mineral content (CMO:0001554)65368492198684921Rat
1300075Glom7Glomerulus QTL 75.60.0000002kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)676937178121937178Rat
1331789Rf37Renal function QTL 373.224kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)686494122112380234Rat

Markers in Region
X95580  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2692,668,147 - 92,668,346 (+)MAPPERmRatBN7.2
Rnor_6.0696,854,937 - 96,855,135NCBIRnor6.0
Rnor_5.06106,286,591 - 106,286,789UniSTSRnor5.0
RGSC_v3.4696,462,778 - 96,462,976UniSTSRGSC3.4
Celera691,127,012 - 91,127,210UniSTS
Cytogenetic Map6q24UniSTS
AA959795  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2692,669,175 - 92,669,424 (+)MAPPERmRatBN7.2
Rnor_6.0696,855,965 - 96,856,213NCBIRnor6.0
Rnor_5.06106,287,619 - 106,287,867UniSTSRnor5.0
RGSC_v3.4696,463,806 - 96,464,054UniSTSRGSC3.4
Celera691,128,040 - 91,128,288UniSTS
Cytogenetic Map6q24UniSTS
BF403954  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2692,638,224 - 92,638,384 (+)MAPPERmRatBN7.2
Rnor_6.0696,825,019 - 96,825,178NCBIRnor6.0
Rnor_5.06106,256,564 - 106,256,723UniSTSRnor5.0
RGSC_v3.4696,432,859 - 96,433,018UniSTSRGSC3.4
Celera691,097,119 - 91,097,278UniSTS
RH 3.4 Map6658.4UniSTS
Cytogenetic Map6q24UniSTS
BF399926  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2692,638,113 - 92,638,328 (+)MAPPERmRatBN7.2
Rnor_6.0696,824,908 - 96,825,122NCBIRnor6.0
Rnor_5.06106,256,453 - 106,256,667UniSTSRnor5.0
RGSC_v3.4696,432,748 - 96,432,962UniSTSRGSC3.4
Celera691,097,008 - 91,097,222UniSTS
RH 3.4 Map6656.8UniSTS
Cytogenetic Map6q24UniSTS
MARC_6691-6694:992007331:1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2692,668,000 - 92,668,566 (+)MAPPERmRatBN7.2
Rnor_6.0696,854,790 - 96,855,355NCBIRnor6.0
Rnor_5.06106,286,444 - 106,287,009UniSTSRnor5.0
RGSC_v3.4696,462,631 - 96,463,196UniSTSRGSC3.4
Celera691,126,865 - 91,127,430UniSTS
Cytogenetic Map6q24UniSTS
MARC_6693-6692:992007336:1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2692,667,981 - 92,669,063 (+)MAPPERmRatBN7.2
Rnor_6.0696,854,771 - 96,855,852NCBIRnor6.0
Rnor_5.06106,286,425 - 106,287,506UniSTSRnor5.0
RGSC_v3.4696,462,612 - 96,463,693UniSTSRGSC3.4
Celera691,126,846 - 91,127,927UniSTS
Cytogenetic Map6q24UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000049725   ⟹   ENSRNOP00000042230
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl698,359,910 - 98,405,323 (+)Ensembl
mRatBN7.2 Ensembl692,624,390 - 92,669,261 (+)Ensembl
Rnor_6.0 Ensembl696,810,907 - 96,856,052 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000077935   ⟹   ENSRNOP00000070177
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl696,834,525 - 96,854,854 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000139912   ⟹   ENSRNOP00000112230
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl698,359,922 - 98,405,323 (+)Ensembl
RefSeq Acc Id: NM_024359   ⟹   NP_077335
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8698,359,898 - 98,405,068 (+)NCBI
mRatBN7.2692,624,087 - 92,669,261 (+)NCBI
Rnor_6.0696,811,185 - 96,856,050 (+)NCBI
Rnor_5.06106,242,409 - 106,287,957 (+)NCBI
RGSC_v3.4696,419,024 - 96,463,891 (+)RGD
Celera691,083,300 - 91,128,125 (+)RGD
Sequence:
RefSeq Acc Id: XM_006240196   ⟹   XP_006240258
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8698,357,788 - 98,405,068 (+)NCBI
mRatBN7.2692,624,059 - 92,669,262 (+)NCBI
Rnor_6.0696,810,868 - 96,856,303 (+)NCBI
Rnor_5.06106,242,409 - 106,287,957 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006240197   ⟹   XP_006240259
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8698,357,788 - 98,405,068 (+)NCBI
mRatBN7.2692,624,059 - 92,669,262 (+)NCBI
Rnor_6.0696,810,868 - 96,856,303 (+)NCBI
Rnor_5.06106,242,409 - 106,287,957 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006240198   ⟹   XP_006240260
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8698,357,788 - 98,405,068 (+)NCBI
mRatBN7.2692,624,060 - 92,669,256 (+)NCBI
Rnor_6.0696,811,123 - 96,856,303 (+)NCBI
Rnor_5.06106,242,409 - 106,287,957 (+)NCBI
Sequence:
RefSeq Acc Id: NP_077335   ⟸   NM_024359
- UniProtKB: Q9WTU9 (UniProtKB/Swiss-Prot),   O35800 (UniProtKB/Swiss-Prot),   D4A8P8 (UniProtKB/TrEMBL),   A6HC66 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006240258   ⟸   XM_006240196
- Peptide Label: isoform X1
- UniProtKB: Q9WTU9 (UniProtKB/Swiss-Prot),   O35800 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006240259   ⟸   XM_006240197
- Peptide Label: isoform X2
- UniProtKB: Q9WTU9 (UniProtKB/Swiss-Prot),   O35800 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006240260   ⟸   XM_006240198
- Peptide Label: isoform X3
- UniProtKB: Q9WTU9 (UniProtKB/Swiss-Prot),   O35800 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSRNOP00000070177   ⟸   ENSRNOT00000077935
Ensembl Acc Id: ENSRNOP00000042230   ⟸   ENSRNOT00000049725
Ensembl Acc Id: ENSRNOP00000112230   ⟸   ENSRNOT00000139912
Protein Domains
bHLH   PAC   PAS

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O35800-F1-model_v2 AlphaFold O35800 1-825 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13694667
Promoter ID:EPDNEW_R5191
Type:initiation region
Name:Hif1a_1
Description:hypoxia inducible factor 1 alpha subunit
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0696,810,918 - 96,810,978EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:61928 AgrOrtholog
BioCyc Gene G2FUF-37104 BioCyc
Ensembl Genes ENSRNOG00000008292 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000049725 ENTREZGENE
  ENSRNOT00000139912 ENTREZGENE
Gene3D-CATH 4.10.280.10 UniProtKB/Swiss-Prot
  PAS domain UniProtKB/Swiss-Prot
InterPro bHLH_dom UniProtKB/Swiss-Prot
  HIF-1_alpha UniProtKB/Swiss-Prot
  HIF-1_TAD_C UniProtKB/Swiss-Prot
  HIF_alpha_subunit UniProtKB/Swiss-Prot
  HLH_DNA-bd_sf UniProtKB/Swiss-Prot
  PAC UniProtKB/Swiss-Prot
  PAS UniProtKB/Swiss-Prot
  PAS-like_dom_sf UniProtKB/Swiss-Prot
  PAS_fold_3 UniProtKB/Swiss-Prot
KEGG Report rno:29560 UniProtKB/Swiss-Prot
NCBI Gene 29560 ENTREZGENE
PANTHER HYPOXIA-INDUCIBLE FACTOR 1 ALPHA UniProtKB/Swiss-Prot
  HYPOXIA-INDUCIBLE FACTOR 1-ALPHA UniProtKB/Swiss-Prot
Pfam bHLH_HIF1A UniProtKB/Swiss-Prot
  HIF-1 UniProtKB/Swiss-Prot
  HIF-1a_CTAD UniProtKB/Swiss-Prot
  PAS_3 UniProtKB/Swiss-Prot
  PAS_9 UniProtKB/Swiss-Prot
PharmGKB HIF1A RGD
PhenoGen Hif1a PhenoGen
PRINTS HYPOXIAIF1A UniProtKB/Swiss-Prot
PROSITE BHLH UniProtKB/Swiss-Prot
  PAS UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000008292 RatGTEx
SMART HLH UniProtKB/Swiss-Prot
  PAC UniProtKB/Swiss-Prot
  PAS UniProtKB/Swiss-Prot
Superfamily-SCOP SSF47459 UniProtKB/Swiss-Prot
  SSF55785 UniProtKB/Swiss-Prot
UniProt A0ABK0M0A2_RAT UniProtKB/TrEMBL
  A6HC66 ENTREZGENE, UniProtKB/TrEMBL
  A6HC67_RAT UniProtKB/TrEMBL
  D4A8P8 ENTREZGENE, UniProtKB/TrEMBL
  HIF1A_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q9WTU9 ENTREZGENE
UniProt Secondary Q9WTU9 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-05-25 Hif1a  hypoxia inducible factor 1 subunit alpha  Hif1a  hypoxia inducible factor 1 alpha subunit  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2016-02-19 Hif1a  hypoxia inducible factor 1 alpha subunit  Hif1a  hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-24 Hif1a  hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)  Hif1a  hypoxia inducible factor 1, alpha subunit  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Hif1a  hypoxia inducible factor 1, alpha subunit      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_domains contains basic helix-loop-helix/ PAS domain 625724
gene_expression higher expression in brain cortex in response to cardiac arrest and resuscitation 625724
gene_expression expression remains constant during the fetal and postnatal developments 625724
gene_expression expressed in kidney; mRNA and protein are more abundant in the renal medulla compared with the renal cortex 625724
gene_expression expressed in the lung, neonatal cardiomyocytes and the adult cardiac tissues 625724
gene_function transcription activator 625724
gene_function binds to specific hypoxia responsive elements 625724
gene_function basic helix-loop-helix family transcription factor 628389
gene_function transcription factor 628579
gene_homology rat and mouse proteins showed 95% homology while rat and human proteins were 95% identical 625724
gene_physical_interaction binds HIF-1b to form a dimer, which activates many oxygen-sensitive genes such as those encoding erythropoietin (EPO), vascular endothelial growth factor (VEGF), glucose transporters, glycolytic enzymes, inducible nitric oxide synthase (iNOS), heme oxygen 625724
gene_process may be active in promoting cell survival after cerebral ischemia, an activity regulated by IGF-1 625724
gene_process involved in transcription activation of erythro-poietin, vascular endothelial growth factor (VEGF), GLUT1 glucose transporter, enzymes of glycolysis and the inducible form of nitric oxide synthase 625724
gene_process subunit of Hif1; involved in the regulation of adaptive responses to hypoxia in mammalian cells 625724
gene_process mediates cellular homeostatic response to alteration of tissue oxygenation 628389
gene_regulation induced by IGF-1 in response to hypoxia 625724
gene_regulation regulated by oxygen tension; degraded by ubiquitin-proteosome system under normal conditions; iron chelators block this suppression during hypoxia leading to nuclear accumulation 625724
gene_regulation RNA levels were increased by phorbol myristate acetate but not by anoxia or cobalt 625724
gene_regulation induced by angiotensin II in vascular smooth muscle cells 632995
gene_regulation activated in response to hypoxia 625724
gene_transcript transcript lacked the first 12 amino acids present in human sequence 625724