RGD Reference Report - Up-regulation of hypoxia-inducible factor-1 alpha by cobalt chloride prevents hearing loss in noise-exposed mice. - Rat Genome Database

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Up-regulation of hypoxia-inducible factor-1 alpha by cobalt chloride prevents hearing loss in noise-exposed mice.

Authors: Chung, JW  Shin, JE  Han, KW  Ahn, JH  Kim, YJ  Park, JW  So, HS 
Citation: Chung JW, etal., Environ Toxicol Pharmacol. 2011 Jan;31(1):153-9. doi: 10.1016/j.etap.2010.10.002. Epub 2010 Oct 16.
RGD ID: 8695948
Pubmed: PMID:21787680   (View Abstract at PubMed)
DOI: DOI:10.1016/j.etap.2010.10.002   (Journal Full-text)

Since hypoxia-inducible factor-1alpha (HIF-1alpha) is the key transcription factor that enables cells to survive in hypoxia, we have investigated whether an upregulation of HIF-1alpha prevents the noise-induced hearing loss in BALB/c hybrid mice, which were intraperitoneally injected with CoCl(2) (a HIF-1alpha inducer) and exposed to white band noise with 120 dB peak equivalent sound pressure level for 3h once daily for 3 days. In the CoCl(2) treatment group, HIF-1alpha was found to be up-regulated in the cochlear tissues and the hearing loss was largely prevented. Histologically, the loss of sensory hair cells was also significantly lower in the CoCl(2) treatment group than the Control group. However, YC-1 (a HIF-1alpha inhibitor) attenuated the preventive effect of CoCl(2) on the noise-induced hearing loss. These results suggest that HIF-1alpha plays a crucial role in the prevention against noise trauma in the inner ear.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Hearing Loss, Noise-Induced treatmentISOHif1a (Mus musculus)8695948; 8695948 RGD 
Hearing Loss, Noise-Induced treatmentIDA 8695948 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Hif1a  (hypoxia inducible factor 1 subunit alpha)

Genes (Mus musculus)
Hif1a  (hypoxia inducible factor 1, alpha subunit)

Genes (Homo sapiens)
HIF1A  (hypoxia inducible factor 1 subunit alpha)


Additional Information