Pkm (pyruvate kinase M1/2) - Rat Genome Database

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Gene: Pkm (pyruvate kinase M1/2) Rattus norvegicus
Analyze
Symbol: Pkm
Name: pyruvate kinase M1/2
RGD ID: 3337
Description: Enables several functions, including ADP binding activity; pyruvate kinase activity; and thyroid hormone binding activity. Involved in several processes, including monocarboxylic acid metabolic process; protein homotetramerization; and response to insulin. Part of pyruvate kinase complex. Biomarker of hypertension. Orthologous to human PKM (pyruvate kinase M1/2); PARTICIPATES IN glycolysis pathway; pyruvate metabolic pathway; hypoxia inducible factor pathway; INTERACTS WITH (R)-adrenaline; 1,2,4-trimethylbenzene; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: M2 pyruvate kinase; PK; Pk3; PKM12; Pkm2; pyruvate kinase isozymes M1/M2; Pyruvate kinase muscle; pyruvate kinase muscle isozyme; pyruvate kinase PKM; pyruvate kinase, muscle; threonine-protein kinase PKM2; tyrosine-protein kinase PKM2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Related Pseudogenes: Pkm-ps20  
Allele / Splice: Pkm_v2 ; Pkm_v1
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8868,949,731 - 68,975,394 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl868,948,815 - 68,975,396 (+)EnsemblGRCr8
mRatBN7.2860,057,629 - 60,079,600 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl860,057,402 - 60,079,599 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx865,580,124 - 65,601,628 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0863,853,049 - 63,874,553 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0861,722,501 - 61,744,005 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0864,480,963 - 64,502,957 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl864,481,172 - 64,502,722 (+)Ensemblrn6Rnor6.0
Rnor_5.0864,243,957 - 64,265,970 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4863,486,492 - 63,508,016 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera859,500,837 - 59,522,361 (+)NCBICelera
RGSC_v3.1863,505,545 - 63,527,070 (+)NCBI
RH 3.4 Map8703.1RGD
Cytogenetic Map8q24NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
(R)-adrenaline  (EXP,ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (ISO)
1,2,4-trimethylbenzene  (EXP)
1,4-benzoquinone  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
14-Deoxy-11,12-didehydroandrographolide  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (EXP)
2,4-dinitrotoluene  (EXP)
2,5-hexanedione  (EXP)
2,6-dimethoxyphenol  (ISO)
2-acetamidofluorene  (EXP)
2-deoxy-D-glucose  (ISO)
2-hydroxypropanoic acid  (ISO)
2-methoxyethanol  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,5-diethoxycarbonyl-1,4-dihydrocollidine  (ISO)
3-chloropropane-1,2-diol  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-methyladenine  (ISO)
3-phenylprop-2-enal  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-chlorobiphenyl  (ISO)
4-hydroxynon-2-enal  (ISO)
4-phenylbutyric acid  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-azacytidine  (ISO)
5-Hydroxyflavone  (ISO)
6-Hydroxyflavone  (ISO)
7-hydroxyflavone  (ISO)
7H-xanthine  (EXP)
9-cis-retinoic acid  (ISO)
9H-xanthine  (EXP)
acetamide  (EXP)
acrolein  (ISO)
acrylamide  (EXP)
actinomycin D  (ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
alpha-D-galactose  (ISO)
alpha-naphthoflavone  (ISO)
alpha-pinene  (ISO)
alpha-Zearalanol  (EXP)
ammonium chloride  (EXP)
ampicillin  (ISO)
apigenin  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atorvastatin calcium  (EXP)
atrazine  (ISO)
AZD3965  (ISO)
baicalein  (ISO)
baicalin  (ISO)
Bardoxolone methyl  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
beta-lapachone  (ISO)
bifenthrin  (ISO)
bis(2-chloroethyl) sulfide  (EXP)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
bruceine D  (ISO)
Butylbenzyl phthalate  (ISO)
C.I. Natural Red 20  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
cadmium sulfate  (ISO)
caffeine  (ISO)
carbon nanotube  (ISO)
CCCP  (ISO)
celastrol  (ISO)
CGP 52608  (ISO)
chloromethylisothiazolinone  (ISO)
choline  (ISO)
chromium(6+)  (ISO)
cisplatin  (ISO)
clobetasol  (ISO)
clozapine  (EXP)
cobalt dichloride  (ISO)
cocaine  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
coumarin  (ISO)
coumestrol  (ISO)
crocidolite asbestos  (ISO)
curcumin  (ISO)
cyclosporin A  (ISO)
D-glucose  (ISO)
DDT  (ISO)
deoxynivalenol  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (ISO)
dichloroacetic acid  (ISO)
dicrotophos  (ISO)
dihydroartemisinin  (ISO)
diosmetin  (ISO)
dioxygen  (ISO)
diuron  (EXP)
dopamine  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
emodin  (EXP)
endosulfan  (EXP)
Enterolactone  (ISO)
enzyme inhibitor  (ISO)
ethanol  (ISO)
flavone  (ISO)
flavonol  (ISO)
folic acid  (ISO)
formaldehyde  (EXP,ISO)
FR900359  (ISO)
fructose  (EXP)
fulvestrant  (ISO)
furfural  (ISO)
Fusaric acid  (ISO)
galactose  (ISO)
geldanamycin  (ISO)
gemcitabine  (ISO)
genistein  (EXP)
glucose  (ISO)
glycine  (ISO)
glyphosate  (ISO)
gold atom  (ISO)
gold(0)  (ISO)
GW 3965  (ISO)
haloperidol  (EXP)
hexadecanoic acid  (ISO)
hydrogen peroxide  (EXP,ISO)
Icaritin  (ISO)
indometacin  (ISO)
isoniazide  (ISO)
ivermectin  (ISO)
L-ascorbic acid  (ISO)
L-methionine  (ISO)
lactucin  (ISO)
lipopolysaccharide  (ISO)
lovastatin  (ISO)
luteolin  (ISO)
LY294002  (ISO)
mercury dichloride  (ISO)
methamphetamine  (EXP)
methapyrilene  (EXP)
methidathion  (ISO)
methoxychlor  (EXP)
methylazoxymethanol  (ISO)
methylmercury chloride  (ISO)
miconazole  (ISO)
N-acetyl-L-cysteine  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-methyl-N-nitrosourea  (EXP)
naphthalene  (ISO)
nickel dichloride  (ISO)
nickel subsulfide  (ISO)
niclosamide  (ISO)
nitrates  (ISO)
NMN zwitterion  (ISO)
Nutlin-3  (ISO)
ochratoxin A  (ISO)
okadaic acid  (ISO)
ozone  (ISO)
paclitaxel  (ISO)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP)
PCB138  (EXP)
perfluorooctane-1-sulfonic acid  (ISO)
Pf-06840003  (ISO)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
PhIP  (EXP)
phosphoenolpyruvate  (ISO)
pifithrin-alpha hydrobromide  (ISO)
potassium dichromate  (ISO)
progesterone  (ISO)
promethazine  (EXP)
Propiverine  (EXP)
protosappanin A  (ISO)
quartz  (ISO)
quercetin  (ISO)
rac-lactic acid  (ISO)
reactive oxygen species  (ISO)
resveratrol  (EXP,ISO)
rotenone  (EXP)
SAICAR  (ISO)
SB 431542  (ISO)
scutellarin  (ISO)
selenium atom  (ISO)
Shikonin  (ISO)
silicon dioxide  (ISO)
sirolimus  (ISO)
sodium arsenite  (EXP,ISO)
sodium chloride  (ISO)
sodium fluoride  (ISO)
sodium nitrate  (ISO)
sorafenib  (ISO)
streptozocin  (ISO)
sulindac sulfide  (ISO)
sunitinib  (ISO)
T-2 toxin  (EXP)
tanespimycin  (ISO)
tangeretin  (ISO)
temozolomide  (ISO)
tetrachloromethane  (EXP,ISO)
thapsigargin  (EXP,ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
tributylstannane  (ISO)
trichloroethene  (ISO)
trichostatin A  (ISO)
triclosan  (ISO)
trimellitic anhydride  (ISO)
triphenylstannane  (ISO)
Triptolide  (ISO)
tunicamycin  (ISO)
ubiquinone-0  (ISO)
undecane  (EXP)
uranium atom  (ISO)
valproic acid  (ISO)
vitamin E  (ISO)
vorinostat  (ISO)
warfarin  (ISO)
wogonin  (ISO)
Yessotoxin  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Alteration in the capacities as well as in the zonal and cellular distributions of pyruvate kinase L and M2 in regenerating rat liver. Chatzipanagiotou S, etal., Biol Chem Hoppe Seyler. 1985 Mar;366(3):271-80.
2. Effects of Tianshu Capsule on Spontaneously Hypertensive Rats as Revealed by 1H-NMR-Based Metabolic Profiling. Gao J, etal., Front Pharmacol. 2019 Sep 11;10:989. doi: 10.3389/fphar.2019.00989. eCollection 2019.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. Relationships between concentration of hepatic intermediary metabolites and induction of the key glycolytic enzymes in vivo. Gunn JM and Taylor CB, Biochem J. 1973 Nov;136(3):455-65.
6. Use of adenine nucleotide derivatives to assess the potential of exo-active-site-directed reagents as species- or isozyme-specific enzyme inactivators. 5. Interactions of adenosine 5'-triphosphate derivatives with rat pyruvate kinases, Escherichia coli thymidine kinase, and yeast and rat hexokinases. Hampton A, etal., J Med Chem. 1982 Apr;25(4):386-92.
7. Dominant negative role of the glutamic acid residue conserved in the pyruvate kinase M(1) isozyme in the heterotropic allosteric effect involving fructose-1,6-bisphosphate. Ikeda Y, etal., J Biol Chem. 2000 Mar 31;275(13):9150-6. doi: 10.1074/jbc.275.13.9150.
8. Control of glucose utilization in working perfused rat heart. Kashiwaya Y, etal., J Biol Chem. 1994 Oct 14;269(41):25502-14.
9. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
10. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
11. Metabolic cooperation between different oncogenes during cell transformation: interaction between activated ras and HPV-16 E7. Mazurek S, etal., Oncogene. 2001 Oct 18;20(47):6891-8. doi: 10.1038/sj.onc.1204792.
12. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
13. Dietary whey protein increases liver and skeletal muscle glycogen levels in exercise-trained rats. Morifuji M, etal., Br J Nutr. 2005 Apr;93(4):439-45.
14. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
15. Increased striatal mRNA and protein levels of the immunophilin FKBP-12 in experimental Parkinson's disease and identification of FKBP-12-binding proteins. Nilsson A, etal., J Proteome Res. 2007 Oct;6(10):3952-61. Epub 2007 Sep 18.
16. The M1- and M2-type isozymes of rat pyruvate kinase are produced from the same gene by alternative RNA splicing. Noguchi T, etal., J Biol Chem 1986 Oct 15;261(29):13807-12.
17. The monomer of pyruvate kinase, subtype M1, is both a kinase and a cytosolic thyroid hormone binding protein. Parkison C, etal., Biochem Biophys Res Commun. 1991 Aug 30;179(1):668-74.
18. The nucleotide sequence of a full length cDNA encoding rat pituitary pyruvate kinase. Parkison C, etal., Nucleic Acids Res 1989 Sep 12;17(17):7106.
19. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
20. Response of rat cerebral glycolytic enzymes to hyperammonemic states. Ratnakumari L and Murthy CR, Neurosci Lett. 1993 Oct 14;161(1):37-40.
21. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
22. Metabolic adaptation of muscles to exercise, vibration and raised temperature under the influence of cernitins. Sawicka TJ, etal., Acta Physiol Pol. 1984 Mar-Apr;35(2):141-50.
23. Energy metabolism pathways in rat muscle under conditions of simulated microgravity. Stein T, etal., J Nutr Biochem. 2002 Aug;13(8):471.
24. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
25. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
26. Effect of immobilization on some glycolytic enzymes of skeletal muscle. Vereb G, etal., Acta Physiol Hung. 1984;63(1):55-61.
27. Developmental patterns of glycolytic enzymes in regenerating skeletal muscle after autogenous free grafting. Wagner KR, etal., J Neurol Sci. 1977 Dec;34(3):373-90.
28. Regulation of glycolytic enzyme RNA transcriptional rates by oxygen availability in skeletal muscle cells. Webster KA Mol Cell Biochem. 1987 Sep;77(1):19-28.
29. Biosynthesis of pyruvate kinase isozymes in rat liver. Wu SW, etal., Eur J Biochem. 1981 Dec;121(1):59-63.
Additional References at PubMed
PMID:2914912   PMID:7262549   PMID:7295297   PMID:9990017   PMID:11487543   PMID:11960989   PMID:12519789   PMID:14651853   PMID:15682487   PMID:15996096   PMID:16132722   PMID:16687649  
PMID:17308100   PMID:17634366   PMID:18050275   PMID:18191611   PMID:18298799   PMID:18418703   PMID:18587448   PMID:19056867   PMID:19182904   PMID:19190083   PMID:19199708   PMID:20005212  
PMID:20458337   PMID:20833797   PMID:21362503   PMID:21630459   PMID:22658674   PMID:22871113   PMID:23106098   PMID:23376485   PMID:23533145   PMID:23620342   PMID:23658023   PMID:23979707  
PMID:24481450   PMID:24497038   PMID:24625528   PMID:24769233   PMID:25457184   PMID:25468996   PMID:25990228   PMID:26151495   PMID:26774701   PMID:26780311   PMID:27199445   PMID:29476059  
PMID:30738168   PMID:30911983   PMID:31086462   PMID:31202897   PMID:31505169   PMID:31686426   PMID:31916291   PMID:32017072   PMID:32357304   PMID:32503893   PMID:33130045   PMID:33744886  
PMID:34240478   PMID:35087114   PMID:35232222   PMID:35563621   PMID:36734266   PMID:36769016   PMID:37382601   PMID:37702892   PMID:38062516   PMID:38471282   PMID:39444090  


Genomics

Comparative Map Data
Pkm
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8868,949,731 - 68,975,394 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl868,948,815 - 68,975,396 (+)EnsemblGRCr8
mRatBN7.2860,057,629 - 60,079,600 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl860,057,402 - 60,079,599 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx865,580,124 - 65,601,628 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0863,853,049 - 63,874,553 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0861,722,501 - 61,744,005 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0864,480,963 - 64,502,957 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl864,481,172 - 64,502,722 (+)Ensemblrn6Rnor6.0
Rnor_5.0864,243,957 - 64,265,970 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4863,486,492 - 63,508,016 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera859,500,837 - 59,522,361 (+)NCBICelera
RGSC_v3.1863,505,545 - 63,527,070 (+)NCBI
RH 3.4 Map8703.1RGD
Cytogenetic Map8q24NCBI
PKM
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381572,199,029 - 72,231,591 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1572,199,026 - 72,231,819 (-)Ensemblhg38GRCh38
GRCh371572,491,370 - 72,523,531 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361570,278,424 - 70,310,738 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341570,278,423 - 70,310,738NCBI
Celera1549,377,704 - 49,410,018 (-)NCBICelera
Cytogenetic Map15q23NCBI
HuRef1549,321,965 - 49,354,312 (-)NCBIHuRef
CHM1_11572,609,505 - 72,641,870 (-)NCBICHM1_1
T2T-CHM13v2.01570,015,755 - 70,047,883 (-)NCBIT2T-CHM13v2.0
Pkm
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39959,563,859 - 59,586,655 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl959,563,651 - 59,586,658 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38959,656,576 - 59,679,372 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl959,656,368 - 59,679,375 (+)Ensemblmm10GRCm38
MGSCv37959,504,415 - 59,527,182 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36959,454,614 - 59,477,381 (+)NCBIMGSCv36mm8
Celera956,883,742 - 56,906,668 (+)NCBICelera
Cytogenetic Map9BNCBI
cM Map932.03NCBI
Pkm
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554504,907,788 - 4,936,199 (+)Ensembl
ChiLan1.0NW_0049554504,907,962 - 4,935,179 (+)NCBIChiLan1.0ChiLan1.0
PKM
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21661,463,312 - 61,495,601 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11565,627,528 - 65,659,784 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01551,149,584 - 51,182,193 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11569,913,455 - 69,946,070 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1569,913,455 - 69,945,832 (-)EnsemblpanPan2panpan1.1
PKM
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13035,712,853 - 35,737,643 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3035,649,842 - 35,676,381 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.03035,917,488 - 35,942,263 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3035,912,436 - 35,944,108 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13035,870,513 - 35,897,163 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03035,898,407 - 35,923,216 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03036,153,315 - 36,179,852 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Pkm
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640113,741,261 - 113,769,688 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647131,589,324 - 31,617,873 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493647131,589,322 - 31,617,891 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PKM
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl761,013,723 - 61,032,777 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1 Ensembl760,975,667 - 61,004,316 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1760,971,807 - 61,032,780 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2765,514,303 - 65,575,391 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PKM
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12611,224,332 - 11,255,538 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666048130,316,867 - 130,349,792 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pkm
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247811,796,801 - 1,824,144 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247811,796,909 - 1,823,787 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Pkm
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1853,497,467 - 53,518,958 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Pkm
123 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:326
Count of miRNA genes:185
Interacting mature miRNAs:200
Transcripts:ENSRNOT00000015332
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1298065Scl16Serum cholesterol level QTL 163.8blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)83975280384752803Rat
1554321Bmd3Bone mineral density QTL 37.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)849849908118871671Rat
1578769Uae31Urinary albumin excretion QTL 313.30.001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)839106363103375781Rat
1298079Activ2Activity QTL 29.50.000001voluntary movement trait (VT:0003491)rearing measurement (CMO:0001515)85076395195763951Rat
11556286Cm81Cardiac mass QTL 810.01heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)83910625884106258Rat
70161Bp62Blood pressure QTL 622.90.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)85158969999045312Rat
1578765Klgr1Kidney lesion grade QTL 13.30.0001kidney morphology trait (VT:0002135)organ lesion measurement (CMO:0000677)839106363103375781Rat
61464Niddm11Non-insulin dependent diabetes mellitus QTL 113.10.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)84447792689477926Rat
4889938Bss89Bone structure and strength QTL 893.8tibia size trait (VT:0100001)tibia cortical bone volume (CMO:0001725)85899169791341052Rat
1578755Pur5Proteinuria QTL 53.30.0001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)839106258103375958Rat
2313088Bss75Bone structure and strength QTL 753.10.0001body length (VT:0001256)body length, nose to rump (CMO:0000079)83910625891341052Rat
631210Bw3Body weight QTL35.9mesenteric fat pad mass (VT:0010427)mesenteric fat pad weight to body weight ratio (CMO:0000654)861019838121662124Rat
8662823Vetf5Vascular elastic tissue fragility QTL 51.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)863404444108404444Rat
1358896Bp262Blood pressure QTL 2622.89arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)835464071107982864Rat
731182Uae24Urinary albumin excretion QTL 246.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)84754141992541419Rat
61353Bp35Blood pressure QTL 350.001arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)83910625884106258Rat
631842Inf1Infertility severity QTL 14.10.001seminal gland mass (VT:0010524)seminal vesicle wet weight (CMO:0001603)83154366176543661Rat
1359033Bp273Blood pressure QTL 273arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83910625884106258Rat
1331769Rf39Renal function QTL 393.871urine output (VT:0003620)timed urine volume (CMO:0000260)850763951107970527Rat
61358Bp39Blood pressure QTL 392arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)84444783789447837Rat
1358906Bp253Blood pressure QTL 25340.0004arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)84961020494610204Rat
1358907Cm40Cardiac mass QTL 401.89heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)835464071107982864Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)855428333127966348Rat
2316950Scl66Serum cholesterol level QTL 664.1blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)839106363114525825Rat
1582254Kidm31Kidney mass QTL 313kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)84924517894245178Rat
724540Uae8Urinary albumin excretion QTL 85urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)839106258103375958Rat
10402857Bp380Blood pressure QTL 3800.95arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)862848139107848139Rat
1358892Kidm26Kidney mass QTL 263.69kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)835464071107982864Rat
1582243Bw66Body weight QTL 663.40.0048body mass (VT:0001259)body weight (CMO:0000012)84924517894245178Rat
5684973Bss100Bone structure and strength QTL 1004.7tibia area (VT:1000281)tibia area measurement (CMO:0001382)85899169791341052Rat
61373Mcs4Mammary carcinoma susceptibility QTL 41.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)84447504389475043Rat
2313057Bss76Bone structure and strength QTL 7630.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)83910625891341052Rat
12879878Bw183Body weight QTL 1830.001body mass (VT:0001259)body weight (CMO:0000012)862848139107848139Rat
1300177Cm2Cardiac mass QTL 23.65heart mass (VT:0007028)heart weight (CMO:0000017)863141536109261840Rat
1549908Neudeg1Neurodegradation QTL 15.50nervous system integrity trait (VT:0010566)logarithm of the ratio of the lesioned side motor neuron count to contralateral side motor neuron count (CMO:0001986)858337123103337123Rat
12879879Cm99Cardiac mass QTL 990.001heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)862848139107848139Rat
2313067Bss77Bone structure and strength QTL 773.10.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)83910625891341052Rat
1331804Cm30Cardiac mass QTL 303.77443heart mass (VT:0007028)heart wet weight (CMO:0000069)862970527107970527Rat
12879880Cm100Cardiac mass QTL 1000.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)862848139107848139Rat
12879881Cm101Cardiac mass QTL 1010.001heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)862848139107848139Rat
12879882Am8Aortic mass QTL 80.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)862848139107848139Rat
12879883Kidm65Kidney mass QTL 650.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)862848139107848139Rat
71120Niddm21Non-insulin dependent diabetes mellitus QTL 213.73blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)866992095111992095Rat
1358912Bw51Body weight QTL 512.95body mass (VT:0001259)body weight (CMO:0000012)860248093105248093Rat
2313086Bss60Bone structure and strength QTL 604.10.0001tibia length (VT:0004357)tibia length (CMO:0000450)85899169791341052Rat
2293697Bmd39Bone mineral density QTL 39femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)862848139107848139Rat
631648Stl5Serum triglyceride level QTL 540.0003blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)83546407171842899Rat
1331837Bw23Body weight QTL 234.190.00007body mass (VT:0001259)body weight (CMO:0000012)855428416107963099Rat
1331838Niddm61Non-insulin dependent diabetes mellitus QTL 613.530.0004blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)862963099107963099Rat
1581557Eae16Experimental allergic encephalomyelitis QTL 163.8nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)868690349119799881Rat
2313046Bss78Bone structure and strength QTL 783.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)83910625891341052Rat
2301402Bp316Blood pressure QTL 3160.005arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)862848139107848139Rat
631664Hcar3Hepatocarcinoma resistance QTL 32.90.0005liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)862982864107982864Rat

Markers in Region
RH94821  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8868,968,206 - 68,968,480 (+)Marker Load Pipeline
mRatBN7.2860,072,412 - 60,072,686 (+)MAPPERmRatBN7.2
Rnor_6.0864,495,746 - 64,496,019NCBIRnor6.0
Rnor_5.0864,258,759 - 64,259,032UniSTSRnor5.0
RGSC_v3.4863,501,064 - 63,501,337UniSTSRGSC3.4
Celera859,515,409 - 59,515,682UniSTS
RH 3.4 Map8703.1UniSTS
Cytogenetic Map8q24UniSTS
Pkm2  
Rat AssemblyChrPosition (strand)SourceJBrowse
Celera859,519,198 - 59,519,266UniSTS
Cytogenetic Map8q24UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_053297 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006243188 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006243190 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017595480 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063264953 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063264954 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063264955 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063264956 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063264957 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063264958 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063264960 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063264961 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063264962 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063264963 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063264964 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AY724474 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC061541 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473975 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ221493 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ223721 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ224316 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ229350 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HB883753 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HB883769 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HC941162 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HC941178 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000008 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M14377 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M24359 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X15800 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000015332   ⟹   ENSRNOP00000015331
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl868,962,390 - 68,975,393 (+)Ensembl
mRatBN7.2 Ensembl860,057,798 - 60,079,590 (+)Ensembl
Rnor_6.0 Ensembl864,481,172 - 64,502,722 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000083666   ⟹   ENSRNOP00000069474
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl868,953,131 - 68,975,396 (+)Ensembl
mRatBN7.2 Ensembl860,057,402 - 60,079,594 (+)Ensembl
Rnor_6.0 Ensembl864,489,942 - 64,502,429 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000098634   ⟹   ENSRNOP00000079846
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl868,948,815 - 68,975,396 (+)Ensembl
mRatBN7.2 Ensembl860,059,124 - 60,079,594 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000118042   ⟹   ENSRNOP00000089941
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl868,955,526 - 68,974,205 (+)Ensembl
mRatBN7.2 Ensembl860,059,124 - 60,079,599 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000122070   ⟹   ENSRNOP00000110552
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl868,953,131 - 68,974,205 (+)Ensembl
RefSeq Acc Id: NM_053297   ⟹   NP_445749
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8868,953,635 - 68,975,159 (+)NCBI
mRatBN7.2860,057,840 - 60,079,365 (+)NCBI
Rnor_6.0864,481,174 - 64,502,722 (+)NCBI
Rnor_5.0864,243,957 - 64,265,970 (+)NCBI
RGSC_v3.4863,486,492 - 63,508,016 (+)RGD
Celera859,500,837 - 59,522,361 (+)RGD
Sequence:
RefSeq Acc Id: XM_006243188   ⟹   XP_006243250
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8868,949,731 - 68,975,394 (+)NCBI
mRatBN7.2860,057,629 - 60,079,600 (+)NCBI
Rnor_6.0864,480,963 - 64,502,957 (+)NCBI
Rnor_5.0864,243,957 - 64,265,970 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006243190   ⟹   XP_006243252
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8868,955,466 - 68,975,394 (+)NCBI
mRatBN7.2860,059,758 - 60,079,600 (+)NCBI
Rnor_6.0864,483,092 - 64,502,957 (+)NCBI
Rnor_5.0864,243,957 - 64,265,970 (+)NCBI
Sequence:
RefSeq Acc Id: XM_063264953   ⟹   XP_063121023
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8868,953,469 - 68,975,394 (+)NCBI
RefSeq Acc Id: XM_063264954   ⟹   XP_063121024
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8868,953,462 - 68,975,394 (+)NCBI
RefSeq Acc Id: XM_063264955   ⟹   XP_063121025
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8868,960,402 - 68,973,056 (+)NCBI
RefSeq Acc Id: XM_063264956   ⟹   XP_063121026
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8868,960,402 - 68,974,205 (+)NCBI
RefSeq Acc Id: XM_063264957   ⟹   XP_063121027
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8868,953,469 - 68,975,394 (+)NCBI
RefSeq Acc Id: XM_063264958   ⟹   XP_063121028
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8868,953,462 - 68,975,394 (+)NCBI
RefSeq Acc Id: XM_063264960   ⟹   XP_063121030
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8868,955,531 - 68,975,394 (+)NCBI
RefSeq Acc Id: XM_063264961   ⟹   XP_063121031
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8868,953,783 - 68,975,394 (+)NCBI
RefSeq Acc Id: XM_063264962   ⟹   XP_063121032
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8868,958,736 - 68,975,394 (+)NCBI
RefSeq Acc Id: XM_063264963   ⟹   XP_063121033
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8868,958,740 - 68,975,394 (+)NCBI
RefSeq Acc Id: XM_063264964   ⟹   XP_063121034
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8868,960,465 - 68,975,394 (+)NCBI
Protein Sequences
Protein RefSeqs NP_445749 (Get FASTA)   NCBI Sequence Viewer  
  XP_006243250 (Get FASTA)   NCBI Sequence Viewer  
  XP_006243252 (Get FASTA)   NCBI Sequence Viewer  
  XP_063121023 (Get FASTA)   NCBI Sequence Viewer  
  XP_063121024 (Get FASTA)   NCBI Sequence Viewer  
  XP_063121025 (Get FASTA)   NCBI Sequence Viewer  
  XP_063121026 (Get FASTA)   NCBI Sequence Viewer  
  XP_063121027 (Get FASTA)   NCBI Sequence Viewer  
  XP_063121028 (Get FASTA)   NCBI Sequence Viewer  
  XP_063121030 (Get FASTA)   NCBI Sequence Viewer  
  XP_063121031 (Get FASTA)   NCBI Sequence Viewer  
  XP_063121032 (Get FASTA)   NCBI Sequence Viewer  
  XP_063121033 (Get FASTA)   NCBI Sequence Viewer  
  XP_063121034 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAB93666 (Get FASTA)   NCBI Sequence Viewer  
  AAB93667 (Get FASTA)   NCBI Sequence Viewer  
  AAH61541 (Get FASTA)   NCBI Sequence Viewer  
  CAA33799 (Get FASTA)   NCBI Sequence Viewer  
  CBF66093 (Get FASTA)   NCBI Sequence Viewer  
  CBF66101 (Get FASTA)   NCBI Sequence Viewer  
  CBU90966 (Get FASTA)   NCBI Sequence Viewer  
  CBU90974 (Get FASTA)   NCBI Sequence Viewer  
  EDL95704 (Get FASTA)   NCBI Sequence Viewer  
  EDL95705 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000015331
  ENSRNOP00000069474
  ENSRNOP00000089941
GenBank Protein P11980 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_445749   ⟸   NM_053297
- UniProtKB: P11981 (UniProtKB/Swiss-Prot),   P11980 (UniProtKB/Swiss-Prot),   A6J531 (UniProtKB/TrEMBL),   A0A8L2Q7B9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006243250   ⟸   XM_006243188
- Peptide Label: isoform X7
- UniProtKB: A0A8L2Q7B9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006243252   ⟸   XM_006243190
- Peptide Label: isoform X8
- UniProtKB: A0A8I6ABE3 (UniProtKB/TrEMBL),   A0A8L2Q7B9 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000069474   ⟸   ENSRNOT00000083666
Ensembl Acc Id: ENSRNOP00000015331   ⟸   ENSRNOT00000015332
Ensembl Acc Id: ENSRNOP00000089941   ⟸   ENSRNOT00000118042
Ensembl Acc Id: ENSRNOP00000079846   ⟸   ENSRNOT00000098634
RefSeq Acc Id: XP_063121024   ⟸   XM_063264954
- Peptide Label: isoform X2
- UniProtKB: A0A8L2Q7B9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063121028   ⟸   XM_063264958
- Peptide Label: isoform X6
- UniProtKB: A0A8L2Q7B9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063121023   ⟸   XM_063264953
- Peptide Label: isoform X1
- UniProtKB: A0A8L2Q7B9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063121027   ⟸   XM_063264957
- Peptide Label: isoform X5
- UniProtKB: A0A8L2Q7B9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063121031   ⟸   XM_063264961
- Peptide Label: isoform X10
- UniProtKB: P11981 (UniProtKB/Swiss-Prot),   P11980 (UniProtKB/Swiss-Prot),   A6J531 (UniProtKB/TrEMBL),   A0A8L2Q7B9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063121030   ⟸   XM_063264960
- Peptide Label: isoform X9
- UniProtKB: A0A8I6G5T6 (UniProtKB/TrEMBL),   A0A8L2Q7B9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063121032   ⟸   XM_063264962
- Peptide Label: isoform X10
- UniProtKB: P11981 (UniProtKB/Swiss-Prot),   P11980 (UniProtKB/Swiss-Prot),   A6J531 (UniProtKB/TrEMBL),   A0A8L2Q7B9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063121033   ⟸   XM_063264963
- Peptide Label: isoform X11
- UniProtKB: A6J532 (UniProtKB/TrEMBL),   A0A8L2Q7B9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063121026   ⟸   XM_063264956
- Peptide Label: isoform X4
- UniProtKB: A0A0G2JVG3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063121025   ⟸   XM_063264955
- Peptide Label: isoform X3
- UniProtKB: A0A0G2JVG3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063121034   ⟸   XM_063264964
- Peptide Label: isoform X12
- UniProtKB: A0A8L2Q7B9 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000110552   ⟸   ENSRNOT00000122070
Protein Domains
Pyruvate kinase barrel   Pyruvate kinase C-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P11980-F1-model_v2 AlphaFold P11980 1-531 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696042
Promoter ID:EPDNEW_R6566
Type:multiple initiation site
Name:Pkm_1
Description:pyruvate kinase M1/2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0864,481,166 - 64,481,226EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3337 AgrOrtholog
BioCyc Gene G2FUF-30234 BioCyc
Ensembl Genes ENSRNOG00000011329 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000015332 ENTREZGENE
  ENSRNOT00000083666 ENTREZGENE
  ENSRNOT00000118042 ENTREZGENE
Gene3D-CATH 2.40.33.10 UniProtKB/Swiss-Prot
  3.20.20.60 UniProtKB/Swiss-Prot
  3.40.1380.20 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:6888187 IMAGE-MGC_LOAD
InterPro Pyr_Knase UniProtKB/Swiss-Prot
  Pyrv/PenolPyrv_Kinase-like_dom UniProtKB/Swiss-Prot
  Pyrv_Kinase-like_dom_sf UniProtKB/Swiss-Prot
  Pyrv_Knase-like_insert_dom_sf UniProtKB/Swiss-Prot
  Pyrv_Knase_AS UniProtKB/Swiss-Prot
  Pyrv_Knase_brl UniProtKB/Swiss-Prot
  Pyrv_Knase_C UniProtKB/Swiss-Prot
  Pyrv_Knase_C_sf UniProtKB/Swiss-Prot
  Pyrv_Knase_insert_dom_sf UniProtKB/Swiss-Prot
KEGG Report rno:25630 UniProtKB/Swiss-Prot
MGC_CLONE MGC:72751 IMAGE-MGC_LOAD
NCBI Gene 25630 ENTREZGENE
PANTHER PTHR11817 UniProtKB/Swiss-Prot
Pfam PF00224 UniProtKB/Swiss-Prot
  PK_C UniProtKB/Swiss-Prot
PhenoGen Pkm PhenoGen
PRINTS PYRUVTKNASE UniProtKB/Swiss-Prot
PROSITE PYRUVATE_KINASE UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000011329 RatGTEx
Superfamily-SCOP SSF50800 UniProtKB/Swiss-Prot
  SSF51621 UniProtKB/Swiss-Prot
  SSF52935 UniProtKB/Swiss-Prot
TIGR TC204001
  TC204002
UniProt A0A0G2JVG3 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6ABE3 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6G5T6 ENTREZGENE, UniProtKB/TrEMBL
  A0A8L2Q7B9 ENTREZGENE, UniProtKB/TrEMBL
  A0ABK0M2P9_RAT UniProtKB/TrEMBL
  A6J531 ENTREZGENE, UniProtKB/TrEMBL
  A6J532 ENTREZGENE, UniProtKB/TrEMBL
  KPYM_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  P11981 ENTREZGENE
UniProt Secondary P11981 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-09-28 Pkm  pyruvate kinase M1/2  Pkm  pyruvate kinase, muscle  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-05-23 Pkm  pyruvate kinase, muscle  Pkm2  pyruvate kinase, muscle  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-11-06 Pkm2  pyruvate kinase, muscle    Pyruvate kinase, muscle  Name updated 625702 APPROVED
2002-06-10 Pkm2  Pyruvate kinase, muscle      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression M1 isoform replaces M2 during development in skeletal muscle, heart, and brain 633549