Amd1 (adenosylmethionine decarboxylase 1) - Rat Genome Database

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Gene: Amd1 (adenosylmethionine decarboxylase 1) Rattus norvegicus
Analyze
Symbol: Amd1
Name: adenosylmethionine decarboxylase 1
RGD ID: 2104
Description: Enables adenosylmethionine decarboxylase activity and putrescine binding activity. Involved in S-adenosylmethionine metabolic process; spermidine biosynthetic process; and spermine biosynthetic process. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in lung non-small cell carcinoma. Orthologous to human AMD1 (adenosylmethionine decarboxylase 1); PARTICIPATES IN methionine cycle/metabolic pathway; polyamine metabolic pathway; putrescine metabolic pathway; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 3,4-methylenedioxymethamphetamine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: adoMetDC; Amd1a; Amd1b; S-adenosylmethionine decarboxylase 1; S-Adenosylmethionine decarboxylase 1A; S-Adenosylmethionine decarboxylase 1B; S-adenosylmethionine decarboxylase proenzyme; SAMDC
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Related Pseudogenes: Amd1-ps2   Amd1-ps3  
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82045,250,289 - 45,324,939 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl2045,250,289 - 45,265,982 (-)EnsemblGRCr8
mRatBN7.22043,695,783 - 43,711,476 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2043,697,237 - 43,711,476 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx2045,444,766 - 45,460,459 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02045,103,953 - 45,119,647 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02045,848,695 - 45,864,247 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd2045,303,703 - 45,319,220 (-)NCBIDahl_SR_JrHsd
Lyon_Normotensive2046,370,213 - 46,385,730 (-)NCBILyon_Normotensive
Lyon_Hypertensive2046,433,184 - 46,448,701 (-)NCBILyon_Hypertensive
F344_StmMcwi2045,254,537 - 45,270,054 (-)NCBIF344_StmMcwi
Rnor_6.02045,384,000 - 45,399,694 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2045,384,000 - 45,399,694 (-)Ensemblrn6Rnor6.0
Rnor_5.02047,103,749 - 47,119,386 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.42044,452,475 - 44,468,111 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera2044,399,688 - 44,415,381 (-)NCBICelera
RGSC_v3.12044,475,485 - 44,491,122 (-)NCBI
Cytogenetic Map20q12NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(S)-nicotine  (ISO)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-methylcholine  (ISO)
3,4-methylenedioxymethamphetamine  (EXP)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
acrolein  (ISO)
afimoxifene  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
atrazine  (EXP,ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
beta-lapachone  (ISO)
bicalutamide  (ISO)
bisphenol A  (EXP,ISO)
butan-1-ol  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
CGP 52608  (ISO)
chlorpyrifos  (ISO)
cisplatin  (ISO)
cobalt dichloride  (ISO)
copper(II) sulfate  (ISO)
coumestrol  (ISO)
cyclosporin A  (ISO)
decabromodiphenyl ether  (EXP)
diarsenic trioxide  (ISO)
dibutyl phthalate  (ISO)
dicrotophos  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
Enterolactone  (ISO)
ethanol  (ISO)
ethyl methanesulfonate  (ISO)
finasteride  (EXP)
fipronil  (EXP)
flavonoids  (EXP,ISO)
flutamide  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
FR900359  (ISO)
gentamycin  (EXP)
hydrogen peroxide  (ISO)
indometacin  (ISO)
leflunomide  (EXP,ISO)
methyl methanesulfonate  (ISO)
nefazodone  (EXP)
nickel atom  (ISO)
nicotine  (ISO)
okadaic acid  (ISO)
ozone  (EXP,ISO)
paracetamol  (EXP,ISO)
perfluorooctanoic acid  (EXP,ISO)
phenobarbital  (ISO)
pirinixic acid  (ISO)
putrescine  (ISO)
reserpine  (ISO)
resveratrol  (ISO)
rotenone  (EXP)
sevoflurane  (EXP)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sulindac  (ISO)
tamibarotene  (ISO)
tert-butyl hydroperoxide  (ISO)
titanium dioxide  (ISO)
triphenyl phosphate  (ISO)
trovafloxacin  (EXP)
valproic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytosol  (IBA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Dysregulated gene expression predicts tumor aggressiveness in African-American prostate cancer patients. Ali HEA, etal., Sci Rep. 2018 Nov 5;8(1):16335. doi: 10.1038/s41598-018-34637-8.
2. Genetic variants in RUNX3, AMD1 and MSRA in the methionine metabolic pathway and survival in nonsmall cell lung cancer patients. Chen K, etal., Int J Cancer. 2019 Jan 16. doi: 10.1002/ijc.32128.
3. Aminooxy analogues of spermidine as inhibitors of spermine synthase and substrates of hepatic polyamine acetylating activity. Eloranta TO, etal., J Biochem. 1990 Oct;108(4):593-8.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. The role of polyamines in growth factor induced DNA synthesis in cultured rat hepatocytes. Higaki I, etal., Hepatogastroenterology. 1999 May-Jun;46(27):1874-9.
6. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
7. S-adenosylmethionine in liver health, injury, and cancer. Lu SC and Mato JM, Physiol Rev. 2012 Oct;92(4):1515-42. doi: 10.1152/physrev.00047.2011.
8. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
9. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
10. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
11. Structures and chromosomal localizations of two rat genes encoding S-adenosylmethionine decarboxylase. Pulkka A, etal., Genomics 1993 May;16(2):342-9.
12. Polyamine depletion delays apoptosis of rat intestinal epithelial cells. Ray RM, etal., Am J Physiol Cell Physiol. 2000 Mar;278(3):C480-9.
13. GOA pipeline RGD automated data pipeline
14. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
15. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
16. Genetic variant of AMD1 is associated with obesity in urban Indian children. Tabassum R, etal., PLoS One. 2012;7(4):e33162. doi: 10.1371/journal.pone.0033162. Epub 2012 Apr 9.
17. Conformational stabilization of rat s-adenosylmethionine decarboxylase by putrescine. Wada M and Shirahata A, Biol Pharm Bull. 2010;33(11):1800-5.
18. A perspective of polyamine metabolism. Wallace HM, etal., Biochem J. 2003 Nov 15;376(Pt 1):1-14.
19. Effect of putrescine on S-adenosylmethionine decarboxylase in a small intestinal crypt cell line. Wang JY, etal., Am J Physiol. 1992 Oct;263(4 Pt 1):G494-501.
20. The decarboxylation of S-adenosylmethionine by detergent-treated extracts of rat liver. Wilson J, etal., Biochem J. 1979 Jun 15;180(3):515-22.
Additional References at PubMed
PMID:1936275   PMID:2323572   PMID:2460457   PMID:10570962   PMID:10829027   PMID:11741992   PMID:11856372   PMID:15489334   PMID:15917810   PMID:35352799  


Genomics

Comparative Map Data
Amd1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82045,250,289 - 45,324,939 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl2045,250,289 - 45,265,982 (-)EnsemblGRCr8
mRatBN7.22043,695,783 - 43,711,476 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2043,697,237 - 43,711,476 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx2045,444,766 - 45,460,459 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02045,103,953 - 45,119,647 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02045,848,695 - 45,864,247 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd2045,303,703 - 45,319,220 (-)NCBIDahl_SR_JrHsd
Lyon_Normotensive2046,370,213 - 46,385,730 (-)NCBILyon_Normotensive
Lyon_Hypertensive2046,433,184 - 46,448,701 (-)NCBILyon_Hypertensive
F344_StmMcwi2045,254,537 - 45,270,054 (-)NCBIF344_StmMcwi
Rnor_6.02045,384,000 - 45,399,694 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2045,384,000 - 45,399,694 (-)Ensemblrn6Rnor6.0
Rnor_5.02047,103,749 - 47,119,386 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.42044,452,475 - 44,468,111 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera2044,399,688 - 44,415,381 (-)NCBICelera
RGSC_v3.12044,475,485 - 44,491,122 (-)NCBI
Cytogenetic Map20q12NCBI
AMD1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh386110,814,617 - 110,895,713 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl6110,874,770 - 110,898,879 (+)Ensemblhg38GRCh38
GRCh376111,135,820 - 111,216,916 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 366111,302,680 - 111,323,606 (+)NCBIBuild 36Build 36hg18NCBI36
Build 346111,302,680 - 111,323,599NCBI
Celera6111,942,595 - 111,963,525 (+)NCBICelera
Cytogenetic Map6q21NCBI
HuRef6108,767,311 - 108,788,282 (+)NCBIHuRef
CHM1_16111,459,114 - 111,480,041 (+)NCBICHM1_1
T2T-CHM13v2.06111,993,221 - 112,074,322 (+)NCBIT2T-CHM13v2.0
Amd1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391040,163,454 - 40,178,184 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1040,163,454 - 40,178,184 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381040,287,458 - 40,302,188 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1040,287,458 - 40,302,188 (-)Ensemblmm10GRCm38
MGSCv371040,007,265 - 40,021,992 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361039,976,874 - 39,991,588 (-)NCBIMGSCv36mm8
Celera1036,613,234 - 36,615,716 (-)NCBICelera
Cytogenetic Map10B1NCBI
cM Map1021.85NCBI
Amd1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541135,541,517 - 35,563,209 (+)Ensembl
ChiLan1.0NW_00495541135,541,517 - 35,563,209 (+)NCBIChiLan1.0ChiLan1.0
AMD1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v25130,884,293 - 130,905,305 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan16128,770,354 - 128,794,437 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v06108,678,741 - 108,699,695 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.16112,761,072 - 112,782,074 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl6112,761,072 - 112,782,074 (+)EnsemblpanPan2panpan1.1
AMD1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11267,432,871 - 67,453,791 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1267,448,141 - 67,451,696 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1267,251,123 - 67,272,026 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01268,311,059 - 68,331,965 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1268,311,069 - 68,334,115 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11267,662,003 - 67,682,902 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01267,507,932 - 67,528,835 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01267,786,118 - 67,807,019 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Amd1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404946102,381,927 - 102,400,701 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365646,656,746 - 6,673,462 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365646,656,789 - 6,675,564 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
AMD1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl176,839,731 - 76,863,738 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1176,839,448 - 76,863,745 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2186,399,564 - 86,423,858 (-)NCBISscrofa10.2Sscrofa10.2susScr3
AMD1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11362,977,659 - 62,999,150 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604035,281,244 - 35,302,558 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Amd1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046249161,837,242 - 1,854,883 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046249161,837,258 - 1,855,450 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Amd1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11840,064,688 - 40,080,375 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Amd1
455 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:840
Count of miRNA genes:321
Interacting mature miRNAs:431
Transcripts:ENSRNOT00000000715
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4889610Pancm3Pancreatic morphology QTL 33.750.001pancreas mass (VT:0010144)pancreas wet weight (CMO:0000626)20418947649189476Rat
2303587Bw93Body weight QTL 9313body mass (VT:0001259)body weight (CMO:0000012)202668936256021148Rat
1598858Cm61Cardiac mass QTL 613.6heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)20821635953216359Rat
2305926Iddm37Insulin dependent diabetes mellitus QTL 376blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)20153308346533083Rat
1331747Hrtrt16Heart rate QTL 163.163heart pumping trait (VT:2000009)heart rate (CMO:0000002)202679235356021148Rat
1598816Memor12Memory QTL 122.4exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)201224324249189476Rat
2303626Vencon10Ventilatory control QTL 100.001respiration trait (VT:0001943)respiration rate (CMO:0000289)202074558556021148Rat
2303578Gluco50Glucose level QTL 502blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)202668936256021148Rat
1598869Memor6Memory QTL 63.1exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)202668936256021148Rat
1598870Bp289Blood pressure QTL 2892.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)20821635953216359Rat
2300188Bmd68Bone mineral density QTL 686.40.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)202668936256021148Rat
70158Bp60Blood pressure QTL 603arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)203215696745978663Rat

Markers in Region
GDB:192496  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22043,711,249 - 43,711,393 (+)MAPPERmRatBN7.2
mRatBN7.2829,943,612 - 29,943,758 (+)MAPPERmRatBN7.2
Rnor_6.0832,642,313 - 32,642,458NCBIRnor6.0
Rnor_6.02045,399,468 - 45,399,611NCBIRnor6.0
Rnor_5.02047,119,214 - 47,119,357UniSTSRnor5.0
Rnor_5.0832,666,962 - 32,667,107UniSTSRnor5.0
RGSC_v3.42044,467,939 - 44,468,082UniSTSRGSC3.4
RGSC_v3.4831,256,877 - 31,257,022UniSTSRGSC3.4
Celera831,404,040 - 31,404,185UniSTS
Celera2044,415,155 - 44,415,298UniSTS
Cytogenetic Map20q12UniSTS
Cytogenetic Map8q13UniSTS
Amd1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X149,273,775 - 149,274,413 (-)MAPPERmRatBN7.2
Rnor_6.01451,485,458 - 51,486,095NCBIRnor6.0
Rnor_5.01451,644,789 - 51,645,426UniSTSRnor5.0
Cytogenetic Map20q12UniSTS
Cytogenetic MapXq37UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_031011 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063279557 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063279558 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AY724509 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC061532 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH474051 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FM031711 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FM123317 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ213619 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ232080 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ234346 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ234398 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000020 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M34464 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M64274 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  Z15109 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  Z15122 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000000715   ⟹   ENSRNOP00000000715
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2045,251,743 - 45,265,982 (-)Ensembl
mRatBN7.2 Ensembl2043,697,237 - 43,711,476 (-)Ensembl
Rnor_6.0 Ensembl2045,384,000 - 45,399,694 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000137078   ⟹   ENSRNOP00000105391
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2045,250,289 - 45,265,855 (-)Ensembl
RefSeq Acc Id: NM_031011   ⟹   NP_112273
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82045,250,289 - 45,265,982 (-)NCBI
mRatBN7.22043,695,783 - 43,711,476 (-)NCBI
Dahl_SR_JrHsd2045,303,703 - 45,319,220 (-)NCBI
Lyon_Normotensive2046,370,213 - 46,385,730 (-)NCBI
Lyon_Hypertensive2046,433,184 - 46,448,701 (-)NCBI
F344_StmMcwi2045,254,537 - 45,270,054 (-)NCBI
Rnor_6.02045,384,000 - 45,399,694 (-)NCBI
Rnor_5.02047,103,749 - 47,119,386 (-)NCBI
RGSC_v3.42044,452,475 - 44,468,111 (-)RGD
Celera2044,399,688 - 44,415,381 (-)NCBI
Sequence:
RefSeq Acc Id: XM_063279557   ⟹   XP_063135627
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82045,250,289 - 45,324,939 (-)NCBI
RefSeq Acc Id: XM_063279558   ⟹   XP_063135628
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82045,250,289 - 45,265,423 (-)NCBI
RefSeq Acc Id: NP_112273   ⟸   NM_031011
- UniProtKB: P17708 (UniProtKB/Swiss-Prot),   A6KII8 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000000715   ⟸   ENSRNOT00000000715
RefSeq Acc Id: XP_063135627   ⟸   XM_063279557
- Peptide Label: isoform X1
- UniProtKB: P17708 (UniProtKB/Swiss-Prot),   A6KII8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063135628   ⟸   XM_063279558
- Peptide Label: isoform X2
Ensembl Acc Id: ENSRNOP00000105391   ⟸   ENSRNOT00000137078

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P17708-F1-model_v2 AlphaFold P17708 1-333 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701659
Promoter ID:EPDNEW_R12182
Type:single initiation site
Name:Amd1_1
Description:adenosylmethionine decarboxylase 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.02045,399,694 - 45,399,754EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2104 AgrOrtholog
BioCyc Gene G2FUF-3430 BioCyc
BioCyc Pathway ARGSPECAT-PWY [spermine biosynthesis] BioCyc
  BSUBPOLYAMSYN-PWY [spermidine biosynthesis I] BioCyc
BioCyc Pathway Image ARGSPECAT-PWY BioCyc
  BSUBPOLYAMSYN-PWY BioCyc
Ensembl Genes ENSRNOG00000000585 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000137078 ENTREZGENE
Gene3D-CATH S-adenosylmethionine decarboxylase UniProtKB/Swiss-Prot
InterPro AdoMetDC-like UniProtKB/Swiss-Prot
  S-AdoMet_decarboxylase UniProtKB/Swiss-Prot
  S-AdoMet_deCO2ase_core UniProtKB/Swiss-Prot
  S-AdoMet_deCO2ase_CS UniProtKB/Swiss-Prot
KEGG Report rno:81640 UniProtKB/Swiss-Prot
NCBI Gene Amd1 ENTREZGENE
PANTHER PTHR11570 UniProtKB/Swiss-Prot
  S-ADENOSYLMETHIONINE DECARBOXYLASE PROENZYME UniProtKB/Swiss-Prot
Pfam SAM_decarbox UniProtKB/Swiss-Prot
PhenoGen Amd1 PhenoGen
PIRSF S-AdenosylMet_decarboxylase UniProtKB/Swiss-Prot
PROSITE ADOMETDC UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000000585 RatGTEx
Superfamily-SCOP SSF56276 UniProtKB/Swiss-Prot
UniProt A0A8L2PYG7_RAT UniProtKB/TrEMBL
  A0ABK0LI95_RAT UniProtKB/TrEMBL
  A6KII8 ENTREZGENE, UniProtKB/TrEMBL
  A6KII9_RAT UniProtKB/TrEMBL
  DCAM_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-09-26 Amd1  adenosylmethionine decarboxylase 1  Amd1  S-adenosylmethionine decarboxylase 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2003-04-09 Amd1  S-adenosylmethionine decarboxylase 1      Symbol and Name updated 629477 APPROVED
2003-03-07 Amd1  S-adenosylmethionine decarboxylase 1  Amd1a  S-Adenosylmethionine decarboxylase 1A  Data merged from RGD:2103 628472 PROVISIONAL
2003-03-07 Amd1    Amd1b  S-adenosylmethionine decarboxylase 1  Symbol updated 61478 PROVISIONAL
2002-06-10 Amd1a  S-Adenosylmethionine decarboxylase 1A      Symbol and Name status set to approved 70586 APPROVED
2002-06-10 Amd1b  S-Adenosylmethionine decarboxylase 1B      Symbol and Name status set to approved 70586 APPROVED