MIF (macrophage migration inhibitory factor) - Rat Genome Database

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Gene: MIF (macrophage migration inhibitory factor) Homo sapiens
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Symbol: MIF
Name: macrophage migration inhibitory factor
RGD ID: 734203
HGNC Page HGNC:7097
Description: Enables several functions, including identical protein binding activity; intramolecular oxidoreductase activity; and receptor ligand activity. Involved in several processes, including positive regulation of cell population proliferation; positive regulation of protein phosphorylation; and regulation of intracellular signal transduction. Located in several cellular components, including cell surface; extracellular space; and nucleoplasm. Implicated in allergic disease; asthma; cystic fibrosis; lung disease (multiple); and obesity. Biomarker of artery disease (multiple); asthma; lung disease (multiple); obesity; and rhinitis.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: GIF; GLIF; L-dopachrome isomerase; L-dopachrome tautomerase; macrophage migration inhibitory factor (glycosylation-inhibiting factor); MMIF; phenylpyruvate tautomerase
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382223,894,383 - 23,895,223 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2223,894,383 - 23,895,227 (+)EnsemblGRCh38hg38GRCh38
GRCh372224,236,570 - 24,237,410 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362222,566,565 - 22,567,409 (+)NCBINCBI36Build 36hg18NCBI36
Build 342222,561,118 - 22,561,963NCBI
Celera228,074,325 - 8,075,169 (+)NCBICelera
Cytogenetic Map22q11.23NCBI
HuRef227,221,904 - 7,222,748 (+)NCBIHuRef
CHM1_12224,248,957 - 24,249,801 (+)NCBICHM1_1
T2T-CHM13v2.02224,338,982 - 24,339,822 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
acute necrotizing pancreatitis  (ISO)
agammaglobulinemia 2  (IAGP)
Alcoholic Liver Diseases  (ISO)
allergic disease  (IAGP)
Animal Mammary Neoplasms  (EXP)
anti-basement membrane glomerulonephritis  (ISO)
anxiety disorder  (EXP)
arteriosclerosis  (ISO)
asthma  (IAGP,IEP,ISO)
autism spectrum disorder  (EXP)
autistic disorder  (EXP)
borna disease  (ISO)
Brain Injuries  (ISO)
Breast Neoplasms  (EXP)
Bronchial Hyperreactivity  (ISO)
bronchopulmonary dysplasia  (IEP)
Burns  (ISO)
carcinoma  (EXP)
cardiomyopathy  (ISO)
chronic obstructive pulmonary disease  (EXP)
Chylothorax  (IEP)
colitis  (EXP,ISO)
Coronary Disease  (ISO)
cystic fibrosis  (IAGP)
cystitis  (ISO)
depressive disorder  (EXP)
Disease Progression  (EXP)
Endotoxemia  (ISO)
epilepsy  (IAGP,ISO)
Experimental Arthritis  (ISO)
Experimental Colitis  (ISO)
Experimental Diabetes Mellitus  (ISO)
Experimental Liver Cirrhosis  (ISO)
Experimental Mammary Neoplasms  (EXP)
Granuloma  (ISO)
Hamartoma  (IEP)
Hypercholesterolemia  (ISO)
hypertension  (ISO)
Inflammation  (EXP,ISO)
Insulin Resistance  (IEP)
Keloid  (EXP)
kidney disease  (ISO)
lung disease  (IAGP,IEP,ISO)
lung non-small cell carcinoma  (IEP)
malignant mesothelioma  (EXP)
Memory Disorders  (EXP)
myocardial infarction  (IEP,ISO)
myocarditis  (ISO)
newborn respiratory distress syndrome  (ISO)
obesity  (IAGP,IEP)
pneumonia  (IAGP)
Prostatic Neoplasms  (EXP)
pulmonary edema  (ISO)
pulmonary hypertension  (IEP)
pulmonary tuberculosis  (IAGP)
Radiation Pneumonitis  (IAGP)
Reperfusion Injury  (ISO)
retinitis  (ISO)
rheumatoid arthritis  (EXP)
rhinitis  (IEP,ISO)
schizophrenia  (IAGP)
Sepsis  (EXP,IEP)
Spinal Cord Injuries  (ISO)
Stevens-Johnson syndrome  (EXP)
Stroke  (IEP,ISO)
Systemic Juvenile Rheumatoid Arthritis  (EXP,IAGP)
toxic shock syndrome  (ISO)
type 2 diabetes mellitus  (ISO)
viral pneumonia  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-artemisinic acid  (EXP)
(+)-catechin  (EXP)
(1->4)-beta-D-glucan  (ISO)
(Z)-3-butylidenephthalide  (EXP)
1,10-phenanthroline  (EXP)
1,2,4-trimethylbenzene  (ISO)
1-fluoro-2,4-dinitrobenzene  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2,4,6-trinitrotoluene  (ISO)
2-amino-14,16-dimethyloctadecan-3-ol  (EXP)
3-phenylprop-2-enal  (ISO)
3H-1,2-dithiole-3-thione  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-hydroxyphenyl retinamide  (ISO)
5-chloro-7-iodoquinolin-8-ol  (EXP)
5-Isoxazoleacetic acid, 4,5-dihydro-3-(4-hydroxyphenyl)-, methyl ester  (ISO)
6-propyl-2-thiouracil  (ISO)
7,12-dimethyltetraphene  (ISO)
acetamide  (ISO)
acrylamide  (ISO)
all-trans-retinoic acid  (EXP,ISO)
ammonium chloride  (ISO)
amphibole asbestos  (EXP)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP)
antirheumatic drug  (EXP)
apocynin  (EXP)
aristolochic acid A  (EXP)
arsane  (EXP)
arsenic atom  (EXP)
arsenite(3-)  (EXP)
arsenous acid  (EXP)
asbestos  (EXP)
asperentin  (ISO)
atrazine  (ISO)
azoxystrobin  (ISO)
benzalkonium chloride  (EXP)
benzatropine  (EXP)
benzo[a]pyrene  (EXP,ISO)
bis(2-chloroethyl) sulfide  (EXP,ISO)
bisphenol A  (EXP,ISO)
bleomycin A2  (ISO)
Brevianamide A  (ISO)
bromobenzene  (ISO)
buspirone  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caffeine  (EXP)
capsaicin  (ISO)
carbamazepine  (EXP)
carbon nanotube  (EXP,ISO)
cerium trichloride  (ISO)
CGP 52608  (EXP)
chlorohydrocarbon  (ISO)
chloropicrin  (EXP)
chlorothalonil  (EXP)
chlorpyrifos  (ISO)
chromium(6+)  (ISO)
clofibric acid  (ISO)
cobalt atom  (EXP)
cobalt dichloride  (EXP)
cobalt(2+) sulfate  (EXP)
copper(II) sulfate  (EXP)
cumene  (ISO)
cyclophosphamide  (ISO)
dexamethasone  (ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (EXP)
diazinon  (EXP,ISO)
dibutyl phthalate  (ISO)
dinitrogen  (EXP)
dioxygen  (EXP,ISO)
diquat  (ISO)
disulfiram  (EXP)
doxorubicin  (EXP,ISO)
emamectin benzoate  (EXP)
enzyme inhibitor  (EXP)
epoxiconazole  (ISO)
ethanol  (ISO)
finasteride  (ISO)
flavonoids  (EXP)
fluoxetine  (ISO)
flutamide  (ISO)
folic acid  (EXP)
formaldehyde  (EXP)
gentamycin  (ISO)
glyphosate  (ISO)
heparin  (EXP)
hydrogen chloride  (ISO)
hydrogen peroxide  (EXP)
hydrogen sulfide  (ISO)
imidacloprid  (ISO)
iron atom  (ISO)
iron(0)  (ISO)
ivermectin  (EXP)
kojic acid  (ISO)
L-methionine  (ISO)
lipopolysaccharide  (EXP,ISO)
Mesaconitine  (ISO)
metam  (ISO)
methamphetamine  (ISO)
methidathion  (ISO)
methimazole  (ISO)
methylmercury chloride  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
mycophenolic acid  (ISO)
mycotoxin  (ISO)
N-nitrosodiethylamine  (ISO)
naphthalenes  (ISO)
naproxen  (ISO)
nefazodone  (ISO)
nickel atom  (ISO)
nickel sulfate  (ISO)
nitrofen  (ISO)
ochratoxin A  (ISO)
oleanolic acid  (ISO)
ozone  (ISO)
paracetamol  (ISO)
paraquat  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (ISO)
PhIP  (ISO)
phorbol 13-acetate 12-myristate  (EXP)
pirinixic acid  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
pyrogallol  (ISO)
quercetin  (EXP)
resveratrol  (ISO)
rottlerin  (EXP)
sarin  (ISO)
SB 431542  (EXP)
silicon dioxide  (EXP)
silver atom  (EXP)
silver(0)  (EXP)
sodium arsenite  (EXP,ISO)
sterigmatocystin  (ISO)
sumatriptan  (ISO)
tanespimycin  (EXP)
temozolomide  (EXP)
tetrachloroethene  (ISO)
tetrachloromethane  (ISO)
thiabendazole  (ISO)
thyroxine  (ISO)
titanium dioxide  (EXP)
TMC-120A  (ISO)
trichostatin A  (EXP)
trimellitic anhydride  (ISO)
tungsten  (ISO)
Tungsten carbide  (EXP)
valproic acid  (EXP)
vinclozolin  (ISO)
vorinostat  (ISO)
zinc dichloride  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
brain renin-angiotensin system  (ISO)
carboxylic acid metabolic process  (IDA)
cell surface receptor signaling pathway  (IDA)
cellular response to hydrogen peroxide  (ISO)
cellular response to hypoxia  (ISO)
cellular senescence  (IEA,ISO)
DNA damage response, signal transduction by p53 class mediator  (IEA,ISO)
drinking behavior  (ISO)
hair follicle development  (ISO)
inflammatory response  (IEA)
innate immune response  (IEA)
negative regulation of apoptotic process  (IDA,IEA)
negative regulation of cell migration  (IMP)
negative regulation of cellular senescence  (IDA)
negative regulation of DNA damage response, signal transduction by p53 class mediator  (IDA,IEA)
negative regulation of gene expression  (IDA)
negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator  (IDA)
negative regulation of macrophage chemotaxis  (IDA)
negative regulation of mature B cell apoptotic process  (IEA)
negative regulation of myeloid cell apoptotic process  (IEA)
negative regulation of protein metabolic process  (IEA)
positive chemotaxis  (IEA)
positive regulation of acute inflammatory response  (ISO)
positive regulation of arachidonic acid secretion  (IEA)
positive regulation of axon regeneration  (ISO)
positive regulation of B cell proliferation  (IDA)
positive regulation of cell population proliferation  (IDA)
positive regulation of chemokine (C-X-C motif) ligand 2 production  (IEA)
positive regulation of cytokine production  (IDA)
positive regulation of ERK1 and ERK2 cascade  (IDA,IEA,IGI)
positive regulation of fibroblast proliferation  (IDA,IEA)
positive regulation of glucose import  (ISO)
positive regulation of glycolytic process  (ISO)
positive regulation of immune response  (ISO)
positive regulation of lipopolysaccharide-mediated signaling pathway  (IEA)
positive regulation of myeloid leukocyte cytokine production involved in immune response  (IEA)
positive regulation of peptidyl-serine phosphorylation  (IDA,IEA)
positive regulation of peptidyl-tyrosine phosphorylation  (IDA,IEA)
positive regulation of phosphorylation  (IDA)
positive regulation of potassium ion transport  (ISO)
positive regulation of prostaglandin secretion involved in immune response  (IEA)
positive regulation of protein kinase A signaling  (IDA)
positive regulation of protein phosphorylation  (IEA)
positive regulation of smooth muscle cell migration  (ISO)
positive regulation of tumor necrosis factor production  (IDA)
prostaglandin biosynthetic process  (IDA)
protein homotrimerization  (IPI)
regulation of cell population proliferation  (IEA,ISO)
regulation of macrophage activation  (NAS)
response to estradiol  (ISO)
response to glucocorticoid  (ISO)
response to hormone  (ISO)
response to inorganic substance  (ISO)
response to insulin  (ISO)
response to lipopolysaccharide  (ISO)
response to mechanical stimulus  (ISO)
response to menaquinone  (ISO)
response to progesterone  (ISO)
response to vitamin E  (ISO)
response to xenobiotic stimulus  (ISO)
signal transduction  (IEA)
skin development  (ISO)
spermatogenesis  (ISO)

Cellular Component

Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype
Abdominal pain  (IAGP)
Abnormality of the liver  (IAGP)
Absent vas deferens  (IAGP)
Airway obstruction  (IAGP)
Anterior uveitis  (IAGP)
Anxiety  (IAGP)
Arthralgia  (IAGP)
Arthritis  (IAGP)
Asthma  (IAGP)
Autoimmunity  (IAGP)
Bronchiectasis  (IAGP)
Cirrhosis  (IAGP)
Decreased body mass index  (IAGP)
Depression  (IAGP)
Elevated circulating C-reactive protein concentration  (IAGP)
Elevated circulating hepatic transaminase concentration  (IAGP)
Elevated erythrocyte sedimentation rate  (IAGP)
Elevated sweat chloride  (IAGP)
Exocrine pancreatic insufficiency  (IAGP)
Failure to thrive  (IAGP)
Fever  (IAGP)
Gastroesophageal reflux  (IAGP)
Hearing impairment  (IAGP)
Hemoptysis  (IAGP)
Hepatomegaly  (IAGP)
Joint swelling  (IAGP)
Juvenile rheumatoid arthritis  (IAGP)
Lymphadenopathy  (IAGP)
Malabsorption  (IAGP)
Male infertility  (IAGP)
Meconium ileus  (IAGP)
Nasal polyposis  (IAGP)
Nephrolithiasis  (IAGP)
Nontuberculous mycobacterial pulmonary infection  (IAGP)
Osteopenia  (IAGP)
Osteoporosis  (IAGP)
Pericarditis  (IAGP)
Pleural effusion  (IAGP)
Pneumothorax  (IAGP)
Rectal prolapse  (IAGP)
Recurrent Aspergillus infections  (IAGP)
Recurrent Burkholderia cepacia infections  (IAGP)
Recurrent Haemophilus influenzae infections  (IAGP)
Recurrent lower respiratory tract infections  (IAGP)
Recurrent respiratory infections  (IAGP)
Recurrent Staphylococcus aureus infections  (IAGP)
Reduced forced expiratory volume in one second  (IAGP)
Schizophrenia  (IAGP)
Seizure  (IAGP)
Sinusitis  (IAGP)
Skin rash  (IAGP)
Splenomegaly  (IAGP)
Steatorrhea  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. The role of macrophage migration inhibitory factor in the cascade of events leading to reperfusion-induced inflammatory injury and lethality. Amaral FA, etal., Am J Pathol. 2007 Dec;171(6):1887-93. Epub 2007 Nov 30.
2. Borna disease virus-induced accumulation of macrophage migration inhibitory factor in rat brain astrocytes is associated with inhibition of macrophage infiltration. Bacher M, etal., Glia. 2002 Mar 15;37(4):291-306.
3. Macrophage migration inhibitory factor may contribute to vasculopathy in systemic sclerosis. Becker H, etal., Clin Rheumatol. 2008 Oct;27(10):1307-11. Epub 2008 Jul 11.
4. MIF is a noncognate ligand of CXC chemokine receptors in inflammatory and atherogenic cell recruitment. Bernhagen J, etal., Nat Med. 2007 May;13(5):587-96. Epub 2007 Apr 15.
5. Endotoxin-induced myocardial dysfunction: effects of macrophage migration inhibitory factor neutralization. Chagnon F, etal., Circ Res. 2005 May 27;96(10):1095-102. Epub 2005 May 5.
6. Proinflammatory macrophage migratory inhibition factor and interleukin-6 are concentrated in pleural effusion of human fetuses with prenatal chylothorax. Chen M, etal., Prenat Diagn. 2007 May;27(5):435-41.
7. Critical role of macrophage migration inhibitory factor activity in experimental autoimmune diabetes. Cvetkovic I, etal., Endocrinology. 2005 Jul;146(7):2942-51. Epub 2005 Mar 24.
8. Increased plasma concentration of macrophage migration inhibitory factor (MIF) and MIF mRNA in mononuclear cells in the obese and the suppressive action of metformin. Dandona P, etal., J Clin Endocrinol Metab. 2004 Oct;89(10):5043-7.
9. Cardiovascular protective role for activated protein C during endotoxemia in rats. Favory R, etal., Intensive Care Med. 2006 Jun;32(6):899-905. Epub 2006 Apr 7.
10. Polymorphisms of the macrophage inhibitory factor and C-reactive protein genes in subjects with Alzheimer's dementia. Flex A, etal., Dement Geriatr Cogn Disord. 2004;18(3-4):261-4. Epub 2004 Jul 29.
11. Macrophage migration inhibitory factor in acute lung injury: expression, biomarker, and associations. Gao L, etal., Transl Res. 2007 Jul;150(1):18-29. Epub 2007 May 25.
12. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
13. Spironolactone prevents diabetic nephropathy through an anti-inflammatory mechanism in type 2 diabetic rats. Han SY, etal., J Am Soc Nephrol. 2006 May;17(5):1362-72. Epub 2006 Mar 29.
14. Redox regulation of macrophage migration inhibitory factor expression in rat neurons. Harrison RA and Sumners C, Biochem Biophys Res Commun. 2009 Dec 4;390(1):171-5. Epub 2009 Sep 30.
15. Genetic variants in inflammation-related genes are associated with radiation-induced toxicity following treatment for non-small cell lung cancer. Hildebrandt MA, etal., PLoS One. 2010 Aug 25;5(8):e12402.
16. Functional polymorphisms in the promoter region of macrophage migration inhibitory factor and atopy. Hizawa N, etal., Am J Respir Crit Care Med. 2004 May 1;169(9):1014-8. Epub 2004 Feb 12.
17. Immunohistochemical study of macrophage migration inhibitory factor in rat liver fibrosis induced by thioacetamide. Hori Y, etal., Eur J Histochem. 2003;47(4):317-24.
18. Role of macrophage migration inhibitory factor in influenza H5N1 virus pneumonia. Hou XQ, etal., Acta Virol. 2009;53(4):225-31.
19. Sex steroid regulation of macrophage migration inhibitory factor in normal and inflamed colon in the female rat. Houdeau E, etal., Gastroenterology. 2007 Mar;132(3):982-93. Epub 2006 Dec 17.
20. Downregulation of migration inhibitory factor is critical for estrogen-mediated attenuation of lung tissue damage following trauma-hemorrhage. Hsieh YC, etal., Am J Physiol Lung Cell Mol Physiol. 2007 May;292(5):L1227-32. Epub 2007 Feb 2.
21. The -173 G/C polymorphism of the promoter region macrophage migration inhibitory factor gene is not associated with incidence of pulmonary hamartoma. Kaznowska E, etal., Pol J Pathol. 2007;58(3):189-92.
22. A role for macrophage migration inhibitory factor in the neonatal respiratory distress syndrome. Kevill KA, etal., J Immunol. 2008 Jan 1;180(1):601-8.
23. Involvement of macrophage migration inhibitory factor (MIF) in experimental uric acid nephropathy. Kim YG, etal., Mol Med. 2000 Oct;6(10):837-48.
24. Inhibition of experimental autoimmune uveoretinitis with anti-macrophage migration inhibitory factor antibodies. Kitaichi N, etal., Curr Eye Res. 2000 Feb;20(2):109-14.
25. Differences in the hepatic signal transcription pathway and cytokine expression between thermal injury and sepsis. Klein D, etal., Shock. 2003 Dec;20(6):536-43.
26. Role of macrophage migration inhibitory factor in ovalbumin-induced airway inflammation in rats. Kobayashi M, etal., Eur Respir J. 2006 Apr;27(4):726-34. Epub 2006 Feb 2.
27. Up-regulation of macrophage migration-inhibitory factor expression after compression-induced spinal cord injury in rats. Koda M, etal., Acta Neuropathol (Berl). 2004 Jul;108(1):31-6. Epub 2004 Apr 6.
28. Regulation of macrophage migration inhibitory factor by endogenous glucocorticoids in rat adjuvant-induced arthritis. Leech M, etal., Arthritis Rheum. 2000 Apr;43(4):827-33.
29. [Myocardial inflammation and injury induced by coronary microembolization in rats: role of ERK1/2 signaling pathway]. Li L, etal., Zhonghua Yi Xue Za Zhi. 2010 Mar 2;90(8):558-63.
30. Uncaria rhynchophylla upregulates the expression of MIF and cyclophilin A in kainic acid-induced epilepsy rats: A proteomic analysis. Lo WY, etal., Am J Chin Med. 2010;38(4):745-59.
31. Macrophage migration inhibitory factor is essential for allergic asthma but not for Th2 differentiation. Magalhaes ES, etal., Eur J Immunol. 2007 Apr;37(4):1097-106.
32. Effect of anti-macrophage migration inhibitory factor antibody on lipopolysaccharide-induced pulmonary neutrophil accumulation. Makita H, etal., Am J Respir Crit Care Med. 1998 Aug;158(2):573-9.
33. Role of macrophage migration inhibitory factor in acute lung injury in mice with acute pancreatitis complicated by endotoxemia. Matsuda N, etal., Am J Respir Cell Mol Biol. 2006 Aug;35(2):198-205. Epub 2006 Mar 30.
34. Blockade of macrophage migration inhibitory factor ameliorates experimental autoimmune myocarditis. Matsui Y, etal., J Mol Cell Cardiol. 2004 Aug;37(2):557-66.
35. Up-regulation of macrophage colony-stimulating factor (M-CSF) and migration inhibitory factor (MIF) expression and monocyte recruitment during lipid-induced glomerular injury in the exogenous hypercholesterolaemic (ExHC) rat. Miyazaki K, etal., Clin Exp Immunol. 1997 May;108(2):318-23.
36. Role for macrophage migration inhibitory factor in asthma. Mizue Y, etal., Proc Natl Acad Sci U S A. 2005 Oct 4;102(40):14410-5. Epub 2005 Sep 26.
37. Macrophage migration inhibitory factor in allergic rhinitis: its identification in eosinophils at the site of inflammation. Nakamaru Y, etal., Ann Otol Rhinol Laryngol. 2004 Mar;113(3 Pt 1):205-9.
38. Macrophage migration inhibitory factor (MIF) contributes to the development of allergic rhinitis. Nakamaru Y, etal., Cytokine. 2005 Jul 21;31(2):103-8.
39. Macrophage migration inhibitory factor expression in male and female ethanol-fed rats. Nanji AA, etal., J Interferon Cytokine Res. 2001 Dec;21(12):1055-62.
40. Transgenic over-expression of macrophage migration inhibitory factor renders mice markedly more susceptible to experimental colitis. Ohkawara T, etal., Clin Exp Immunol. 2005 May;140(2):241-8. doi: 10.1111/j.1365-2249.2005.02771.x.
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44. Cystic fibrosis, disease severity, and a macrophage migration inhibitory factor polymorphism. Plant BJ, etal., Am J Respir Crit Care Med. 2005 Dec 1;172(11):1412-5. Epub 2005 Sep 22.
45. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
46. Human circulating eosinophils secrete macrophage migration inhibitory factor (MIF). Potential role in asthma. Rossi AG, etal., J Clin Invest. 1998 Jun 15;101(12):2869-74.
47. Analysis of MIF, FCGR2A and FCGR3A gene polymorphisms with susceptibility to pulmonary tuberculosis in Moroccan population. Sadki K, etal., J Genet Genomics. 2010 Apr;37(4):257-64.
48. Macrophage migration inhibitory factor is a critical mediator of severe acute pancreatitis. Sakai Y, etal., Gastroenterology 2003 Mar;124(3):725-36.
49. Promoter polymorphism in the macrophage migration inhibitory factor gene is associated with obesity. Sakaue S, etal., Int J Obes (Lond). 2006 Feb;30(2):238-42.
50. Lung-derived macrophage migration inhibitory factor in sepsis induces cardio-circulatory depression. Sakuragi T, etal., Surg Infect (Larchmt). 2007 Feb;8(1):29-40.
51. The effect of therapeutic hypothermia on the expression of inflammatory response genes following moderate traumatic brain injury in the rat. Truettner JS, etal., Brain Res Mol Brain Res. 2005 Aug 18;138(2):124-34.
52. Hydrochloric acid induced changes in macrophage migration inhibitory factor in the bladder, peripheral and central nervous system of the rat. Vera PL, etal., J Urol. 2003 Aug;170(2 Pt 1):623-7.
53. Cyclophosphamide-induced cystitis increases bladder CXCR4 expression and CXCR4-macrophage migration inhibitory factor association. Vera PL, etal., PLoS One. 2008;3(12):e3898. Epub 2008 Dec 10.
54. Plasma concentrations of macrophage migration inhibitory factor are elevated in Pima Indians compared to Caucasians and are associated with insulin resistance. Vozarova B, etal., Diabetologia. 2002 Dec;45(12):1739-41. Epub 2002 Nov 16.
55. [Role of macrophage migration inhibitory factor in septic shock-induced cardiovascular dysfunction: experiment with rats] Wang FZ, etal., Zhonghua Yi Xue Za Zhi. 2007 Mar 20;87(11):768-73.
56. Upregulation of macrophage migration inhibitory factor gene expression in stroke. Wang L, etal., Stroke. 2009 Mar;40(3):973-6. Epub 2009 Jan 8.
57. Macrophage migration inhibitory factor and CXC chemokine expression in non-small cell lung cancer: role in angiogenesis and prognosis. White ES, etal., Clin Cancer Res. 2003 Feb;9(2):853-60.
58. Association of MIF promoter polymorphisms with childhood asthma in a northeastern Chinese population. Wu J, etal., Tissue Antigens. 2009 Apr;73(4):302-6.
59. Reversal of established rat crescentic glomerulonephritis by blockade of macrophage migration inhibitory factor (MIF): potential role of MIF in regulating glucocorticoid production. Yang N, etal., Mol Med. 1998 Jun;4(6):413-24.
60. The influence of macrophage migration inhibitory factor gene polymorphisms on outcome from community-acquired pneumonia. Yende S, etal., FASEB J. 2009 Aug;23(8):2403-11. Epub 2009 Apr 3.
61. Elevation of plasma level of macrophage migration inhibitory factor in patients with acute myocardial infarction. Yu CM, etal., Am J Cardiol. 2001 Oct 1;88(7):774-7.
62. Expression of macrophage migration inhibitory factor in acute ischemic myocardial injury. Yu CM, etal., J Histochem Cytochem. 2003 May;51(5):625-31.
Additional References at PubMed
PMID:1286669   PMID:2552447   PMID:3917866   PMID:7558020   PMID:7679497   PMID:7683862   PMID:7947826   PMID:8188240   PMID:8234256   PMID:8289313   PMID:8601455   PMID:8610159  
PMID:8643551   PMID:8647256   PMID:8766818   PMID:8988336   PMID:9002552   PMID:9006339   PMID:9027512   PMID:10334104   PMID:10353846   PMID:10562313   PMID:11089976   PMID:11170644  
PMID:11259268   PMID:11508429   PMID:11875000   PMID:11920501   PMID:11978887   PMID:11985788   PMID:11997397   PMID:12009356   PMID:12032852   PMID:12070782   PMID:12109441   PMID:12126556  
PMID:12180727   PMID:12186913   PMID:12218292   PMID:12218308   PMID:12235522   PMID:12355488   PMID:12402212   PMID:12445161   PMID:12477932   PMID:12480958   PMID:12507885   PMID:12607777  
PMID:12615835   PMID:12626594   PMID:12631237   PMID:12665801   PMID:12667094   PMID:12681488   PMID:12738641   PMID:12740374   PMID:12746913   PMID:12782713   PMID:12796500   PMID:12822893  
PMID:12847682   PMID:12965208   PMID:14502271   PMID:14551601   PMID:14581488   PMID:14607690   PMID:14736878   PMID:14760795   PMID:15018649   PMID:15065001   PMID:15146413   PMID:15146431  
PMID:15170913   PMID:15216464   PMID:15231747   PMID:15292349   PMID:15304087   PMID:15308783   PMID:15461802   PMID:15489334   PMID:15545061   PMID:15545824   PMID:15576462   PMID:15585204  
PMID:15585220   PMID:15592455   PMID:15612021   PMID:15630728   PMID:15659324   PMID:15757663   PMID:15800984   PMID:15815686   PMID:15820792   PMID:15838879   PMID:15857508   PMID:15910495  
PMID:15910597   PMID:16000172   PMID:16051683   PMID:16085663   PMID:16115023   PMID:16133063   PMID:16169070   PMID:16189514   PMID:16200611   PMID:16205314   PMID:16220288   PMID:16224818  
PMID:16243796   PMID:16285950   PMID:16314470   PMID:16314559   PMID:16317091   PMID:16369812   PMID:16385258   PMID:16388506   PMID:16488392   PMID:16527487   PMID:16538639   PMID:16677407  
PMID:16709839   PMID:16724072   PMID:16767681   PMID:16780713   PMID:16807115   PMID:16820919   PMID:16839849   PMID:16854377   PMID:16861224   PMID:16872482   PMID:16893895   PMID:16929348  
PMID:17005573   PMID:17029206   PMID:17045821   PMID:17075815   PMID:17108334   PMID:17142775   PMID:17166737   PMID:17172590   PMID:17181929   PMID:17206642   PMID:17215861   PMID:17224449  
PMID:17353931   PMID:17438452   PMID:17438455   PMID:17495357   PMID:17526494   PMID:17541237   PMID:17559578   PMID:17591062   PMID:17592555   PMID:17620429   PMID:17658526   PMID:17706208  
PMID:17709373   PMID:17712545   PMID:17728788   PMID:17763209   PMID:17786285   PMID:17854804   PMID:17854909   PMID:17869648   PMID:17906677   PMID:17912466   PMID:18034423   PMID:18037272  
PMID:18054247   PMID:18060744   PMID:18078632   PMID:18081874   PMID:18097599   PMID:18165264   PMID:18171527   PMID:18171602   PMID:18177450   PMID:18228042   PMID:18235500   PMID:18239193  
PMID:18242614   PMID:18261992   PMID:18270460   PMID:18356846   PMID:18362243   PMID:18426738   PMID:18466513   PMID:18469521   PMID:18474653   PMID:18490733   PMID:18493321   PMID:18502749  
PMID:18676531   PMID:18677096   PMID:18680514   PMID:18684922   PMID:18710704   PMID:18720262   PMID:18795803   PMID:18815136   PMID:18832726   PMID:18842989   PMID:18852457   PMID:18853133  
PMID:18930766   PMID:19009023   PMID:19038405   PMID:19056867   PMID:19062717   PMID:19081768   PMID:19109179   PMID:19155217   PMID:19157791   PMID:19167373   PMID:19170716   PMID:19188484  
PMID:19190083   PMID:19196797   PMID:19260777   PMID:19299454   PMID:19376177   PMID:19394321   PMID:19406662   PMID:19417556   PMID:19423540   PMID:19428548   PMID:19454686   PMID:19464392  
PMID:19475570   PMID:19591577   PMID:19601712   PMID:19602265   PMID:19644855   PMID:19665027   PMID:19720544   PMID:19723024   PMID:19724898   PMID:19726058   PMID:19737008   PMID:19738201  
PMID:19747950   PMID:19759012   PMID:19762145   PMID:19773451   PMID:19776019   PMID:19776337   PMID:19799813   PMID:19829123   PMID:19913121   PMID:19938192   PMID:19941661   PMID:19950249  
PMID:20038293   PMID:20085845   PMID:20127054   PMID:20149326   PMID:20178462   PMID:20193596   PMID:20200619   PMID:20203087   PMID:20233515   PMID:20237496   PMID:20303284   PMID:20346241  
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PMID:20471506   PMID:20499270   PMID:20534506   PMID:20546256   PMID:20573157   PMID:20598902   PMID:20621719   PMID:20628086   PMID:20646540   PMID:20673868   PMID:20805296   PMID:20807568  
PMID:20829434   PMID:20847814   PMID:20861157   PMID:20863520   PMID:20872800   PMID:20878093   PMID:20944103   PMID:20980171   PMID:21030269   PMID:21045753   PMID:21071513   PMID:21087445  
PMID:21106938   PMID:21162929   PMID:21169549   PMID:21208809   PMID:21209875   PMID:21269946   PMID:21281800   PMID:21283538   PMID:21283592   PMID:21319273   PMID:21360573   PMID:21401926  
PMID:21417823   PMID:21512965   PMID:21515791   PMID:21553324   PMID:21575460   PMID:21607559   PMID:21607712   PMID:21623990   PMID:21641401   PMID:21684012   PMID:21725855   PMID:21750916  
PMID:21773885   PMID:21792010   PMID:21817065   PMID:21823060   PMID:21848392   PMID:21852299   PMID:21873635   PMID:21875883   PMID:21890178   PMID:21942715   PMID:21988832   PMID:21990375  
PMID:22001757   PMID:22007254   PMID:22079264   PMID:22099602   PMID:22127710   PMID:22166284   PMID:22174124   PMID:22206839   PMID:22271573   PMID:22302395   PMID:22327470   PMID:22415145  
PMID:22430150   PMID:22449335   PMID:22451332   PMID:22461895   PMID:22543583   PMID:22609310   PMID:22611320   PMID:22623428   PMID:22649515   PMID:22676646   PMID:22693633   PMID:22742858  
PMID:22759564   PMID:22782901   PMID:22810585   PMID:22813781   PMID:22820623   PMID:22821831   PMID:22883521   PMID:22892326   PMID:22893706   PMID:22898364   PMID:22898393   PMID:22909194  
PMID:22927777   PMID:22939113   PMID:22939629   PMID:22949182   PMID:22952837   PMID:22988252   PMID:23023114   PMID:23028743   PMID:23043599   PMID:23050964   PMID:23060578   PMID:23064787  
PMID:23068083   PMID:23125447   PMID:23179933   PMID:23207293   PMID:23246423   PMID:23272137   PMID:23315862   PMID:23354841   PMID:23376485   PMID:23383040   PMID:23402792   PMID:23403077  
PMID:23403292   PMID:23410506   PMID:23411097   PMID:23451183   PMID:23497377   PMID:23523092   PMID:23526214   PMID:23533145   PMID:23537651   PMID:23552723   PMID:23556458   PMID:23566229  
PMID:23707797   PMID:23721694   PMID:23728617   PMID:23759989   PMID:23770720   PMID:23776208   PMID:23794947   PMID:23846621   PMID:23882081   PMID:23895962   PMID:23913513   PMID:23978362  
PMID:23985752   PMID:24003215   PMID:24039418   PMID:24066864   PMID:24091309   PMID:24098445   PMID:24138931   PMID:24151396   PMID:24158957   PMID:24167613   PMID:24194192   PMID:24273891  
PMID:24274936   PMID:24337577   PMID:24356968   PMID:24366206   PMID:24379579   PMID:24384723   PMID:24396292   PMID:24424397   PMID:24429801   PMID:24441872   PMID:24490973   PMID:24527464  
PMID:24530749   PMID:24551192   PMID:24569872   PMID:24644543   PMID:24667663   PMID:24683185   PMID:24687413   PMID:24711643   PMID:24826917   PMID:24840392   PMID:24850900   PMID:24862346  
PMID:24879618   PMID:24932684   PMID:24939415   PMID:24951298   PMID:24981860   PMID:25022961   PMID:25056219   PMID:25105152   PMID:25108206   PMID:25168062   PMID:25172501   PMID:25329590  
PMID:25416956   PMID:25458401   PMID:25460285   PMID:25463068   PMID:25487600   PMID:25503271   PMID:25530499   PMID:25561410   PMID:25593081   PMID:25600533   PMID:25712213   PMID:25712805  
PMID:25716200   PMID:25730019   PMID:25762421   PMID:25821795   PMID:25861163   PMID:25930990   PMID:25961459   PMID:25963833   PMID:25966103   PMID:25972622   PMID:25998484   PMID:26005773  
PMID:26020638   PMID:26039541   PMID:26087187   PMID:26107210   PMID:26138061   PMID:26139098   PMID:26209628   PMID:26234719   PMID:26272322   PMID:26280537   PMID:26281331   PMID:26344197  
PMID:26345783   PMID:26348853   PMID:26352431   PMID:26403072   PMID:26412712   PMID:26426302   PMID:26453918   PMID:26474589   PMID:26485680   PMID:26496610   PMID:26530123   PMID:26535701  
PMID:26541175   PMID:26542751   PMID:26549761   PMID:26603621   PMID:26638028   PMID:26638075   PMID:26656832   PMID:26719579   PMID:26741693   PMID:26750167   PMID:26752645   PMID:26783235  
PMID:26825917   PMID:26829742   PMID:26851955   PMID:26852939   PMID:26858459   PMID:26866879   PMID:26872252   PMID:26883190   PMID:26884830   PMID:26911630   PMID:26933127   PMID:26935642  
PMID:26952810   PMID:26976591   PMID:26979993   PMID:26980763   PMID:26985869   PMID:27049098   PMID:27068509   PMID:27079941   PMID:27101443   PMID:27105877   PMID:27107014   PMID:27145382  
PMID:27157615   PMID:27163877   PMID:27190066   PMID:27197190   PMID:27207917   PMID:27211553   PMID:27226569   PMID:27248496   PMID:27270225   PMID:27298517   PMID:27337548   PMID:27342658  
PMID:27364992   PMID:27381622   PMID:27402018   PMID:27426952   PMID:27434219   PMID:27453287   PMID:27460703   PMID:27462432   PMID:27509135   PMID:27544048   PMID:27573366   PMID:27598332  
PMID:27609421   PMID:27612504   PMID:27619729   PMID:27696094   PMID:27721403   PMID:27793992   PMID:27811451   PMID:27844180   PMID:27846469   PMID:27872288   PMID:28086136   PMID:28160516  
PMID:28230058   PMID:28331211   PMID:28338494   PMID:28366792   PMID:28370484   PMID:28407372   PMID:28429502   PMID:28513076   PMID:28515276   PMID:28574571   PMID:28578664   PMID:28624489  
PMID:28642171   PMID:28656911   PMID:28657145   PMID:28668810   PMID:28703031   PMID:28704499   PMID:28726057   PMID:28729134   PMID:28768722   PMID:28801314   PMID:28823650   PMID:28905103  
PMID:28912189   PMID:28923927   PMID:28965181   PMID:28977666   PMID:28993199   PMID:29079416   PMID:29096759   PMID:29120365   PMID:29128334   PMID:29186613   PMID:29207023   PMID:29208960  
PMID:29229926   PMID:29239244   PMID:29247897   PMID:29257298   PMID:29289260   PMID:29298432   PMID:29371591   PMID:29397904   PMID:29403061   PMID:29412660   PMID:29449217   PMID:29467282  
PMID:29487418   PMID:29487601   PMID:29507755   PMID:29509190   PMID:29581527   PMID:29601965   PMID:29661540   PMID:29669180   PMID:29669352   PMID:29690804   PMID:29702687   PMID:29723777  
PMID:29759141   PMID:29769287   PMID:29773680   PMID:29807404   PMID:29809055   PMID:29845934   PMID:29856236   PMID:29863307   PMID:29870971   PMID:29896883   PMID:29953750   PMID:29996006  
PMID:30009530   PMID:30041958   PMID:30074218   PMID:30077612   PMID:30097533   PMID:30108299   PMID:30120767   PMID:30160778   PMID:30226561   PMID:30226567   PMID:30258100   PMID:30274020  
PMID:30295645   PMID:30348174   PMID:30366984   PMID:30371153   PMID:30383785   PMID:30455355   PMID:30467094   PMID:30503813   PMID:30506423   PMID:30511959   PMID:30567353   PMID:30569239  
PMID:30616035   PMID:30626475   PMID:30628898   PMID:30667094   PMID:30747392   PMID:30802541   PMID:30841876   PMID:30868074   PMID:30903991   PMID:30948266   PMID:30962001   PMID:30968541  
PMID:30983881   PMID:30997501   PMID:31036057   PMID:31036774   PMID:31046837   PMID:31069878   PMID:31108057   PMID:31154458   PMID:31173234   PMID:31174614   PMID:31180524   PMID:31219646  
PMID:31267487   PMID:31300519   PMID:31370326   PMID:31422388   PMID:31499270   PMID:31501420   PMID:31515488   PMID:31586073   PMID:31701681   PMID:31752120   PMID:31790982   PMID:31811089  
PMID:31866994   PMID:31889466   PMID:31924846   PMID:31936865   PMID:31960418   PMID:31973534   PMID:31978276   PMID:32044623   PMID:32129710   PMID:32196575   PMID:32279906   PMID:32296183  
PMID:32317702   PMID:32375447   PMID:32410863   PMID:32433911   PMID:32457219   PMID:32515296   PMID:32525926   PMID:32560699   PMID:32582913   PMID:32683105   PMID:32694731   PMID:32705792  
PMID:32707033   PMID:32769903   PMID:32800392   PMID:32807901   PMID:32811420   PMID:32885302   PMID:32929329   PMID:33046033   PMID:33046523   PMID:33046825   PMID:33148606   PMID:33179462  
PMID:33181151   PMID:33279833   PMID:33330982   PMID:33370549   PMID:33385298   PMID:33401503   PMID:33417871   PMID:33525493   PMID:33542244   PMID:33545068   PMID:33610191   PMID:33673075  
PMID:33729478   PMID:33787014   PMID:33823474   PMID:33839715   PMID:33850223   PMID:33916271   PMID:33945507   PMID:33961781   PMID:33985351   PMID:34012010   PMID:34013373   PMID:34129019  
PMID:34133714   PMID:34189442   PMID:34264160   PMID:34278453   PMID:34306312   PMID:34314630   PMID:34349018   PMID:34384784   PMID:34428256   PMID:34443554   PMID:34482268   PMID:34533238  
PMID:34662363   PMID:34673115   PMID:34901782   PMID:35013218   PMID:35091838   PMID:35121729   PMID:35151822   PMID:35205271   PMID:35234206   PMID:35253629   PMID:35256949   PMID:35271311  
PMID:35446349   PMID:35545034   PMID:35545047   PMID:35563296   PMID:35585040   PMID:35717879   PMID:35732118   PMID:35831314   PMID:35904178   PMID:35944360   PMID:36094626   PMID:36114006  
PMID:36166743   PMID:36180891   PMID:36215168   PMID:36222594   PMID:36257465   PMID:36298774   PMID:36326455   PMID:36424410   PMID:36516121   PMID:36518052   PMID:36610398   PMID:36631486  
PMID:36634849   PMID:36925198   PMID:36958712   PMID:37252795   PMID:37272017   PMID:37317750   PMID:37326070   PMID:37331297   PMID:37363971   PMID:37373198   PMID:37498233   PMID:37506885  
PMID:37645013   PMID:37665108   PMID:37735872   PMID:37774962   PMID:37784249   PMID:37803493   PMID:37827155   PMID:37956411   PMID:37982154   PMID:38113892   PMID:38145300   PMID:38159470  
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Genomics

Comparative Map Data
MIF
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382223,894,383 - 23,895,223 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2223,894,383 - 23,895,227 (+)EnsemblGRCh38hg38GRCh38
GRCh372224,236,570 - 24,237,410 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362222,566,565 - 22,567,409 (+)NCBINCBI36Build 36hg18NCBI36
Build 342222,561,118 - 22,561,963NCBI
Celera228,074,325 - 8,075,169 (+)NCBICelera
Cytogenetic Map22q11.23NCBI
HuRef227,221,904 - 7,222,748 (+)NCBIHuRef
CHM1_12224,248,957 - 24,249,801 (+)NCBICHM1_1
T2T-CHM13v2.02224,338,982 - 24,339,822 (+)NCBIT2T-CHM13v2.0
Mif
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391075,695,187 - 75,696,111 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1075,695,187 - 75,696,074 (-)EnsemblGRCm39 Ensembl
GRCm381075,859,353 - 75,860,277 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1075,859,353 - 75,860,240 (-)EnsemblGRCm38mm10GRCm38
MGSCv371075,322,098 - 75,322,995 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361075,303,069 - 75,303,966 (-)NCBIMGSCv36mm8
Celera1076,904,043 - 76,904,940 (-)NCBICelera
Cytogenetic Map10C1NCBI
cM Map1038.59NCBI
Mif
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82012,767,138 - 12,791,222 (+)NCBIGRCr8
mRatBN7.22012,790,919 - 12,791,784 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2012,790,902 - 12,799,504 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2013,497,160 - 13,498,025 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02012,858,083 - 12,858,948 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02013,330,028 - 13,330,893 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02013,715,219 - 13,732,980 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2013,732,198 - 13,732,859 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02015,885,248 - 15,886,113 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42013,191,986 - 13,192,851 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12013,192,212 - 13,193,078 (+)NCBI
Celera2014,283,080 - 14,283,945 (+)NCBICelera
Cytogenetic Map20p12NCBI
Mif
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554558,367,566 - 8,368,460 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554558,367,566 - 8,368,460 (-)NCBIChiLan1.0ChiLan1.0
MIF
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22333,619,974 - 33,623,761 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12236,356,394 - 36,360,177 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0224,646,986 - 4,647,831 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12222,729,245 - 22,732,009 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2222,730,807 - 22,732,009 (+)Ensemblpanpan1.1panPan2
MIF
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Dog10K_Boxer_Tasha2627,715,404 - 27,716,260 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02630,047,047 - 30,047,902 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2630,047,057 - 30,047,856 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12628,128,386 - 28,129,245 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02627,746,427 - 27,747,273 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02628,734,407 - 28,735,264 (-)NCBIUU_Cfam_GSD_1.0
Mif
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118141,546,059 - 141,547,004 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366191,203,746 - 1,208,442 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366191,207,058 - 1,208,010 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MIF
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1449,840,305 - 49,841,068 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11449,840,303 - 49,841,063 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21453,282,553 - 53,283,313 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MIF
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1197,000,837 - 7,001,700 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl197,000,793 - 7,001,757 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666100368,099 - 370,934 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mif
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474710,303,919 - 10,308,821 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474710,307,826 - 10,308,649 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in MIF
9 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
NR_038911.1(MIF-AS1):n.1697C>G single nucleotide variant Rheumatoid arthritis, systemic juvenile, susceptibility to [RCV000015433] Chr22:23894205 [GRCh38]
Chr22:24236392 [GRCh37]
Chr22:22q11.23		 risk factor
GRCh37/hg19 22q11.23(chr22:23720171-25065576) copy number gain Cerebellar ataxia [RCV000626496] Chr22:23720171..25065576 [GRCh37]
Chr22:22q11.23		 uncertain significance
GRCh38/hg38 22q11.21-12.3(chr22:18178957-31821193)x3 copy number gain See cases [RCV000050768] Chr22:18178957..31821193 [GRCh38]
Chr22:18661724..32217179 [GRCh37]
Chr22:17041724..30547179 [NCBI36]
Chr22:22q11.21-12.3		 pathogenic
GRCh38/hg38 22q11.22-11.23(chr22:22669543-24563859)x3 copy number gain See cases [RCV000050739] Chr22:22669543..24563859 [GRCh38]
Chr22:23012013..24959827 [GRCh37]
Chr22:21342013..23289827 [NCBI36]
Chr22:22q11.22-11.23		 conflicting interpretations of pathogenicity|uncertain significance|conflicting data from submitters
GRCh38/hg38 22q11.23(chr22:23338443-24610403)x3 copy number gain See cases [RCV000053174] Chr22:23338443..24610403 [GRCh38]
Chr22:23680630..25006370 [GRCh37]
Chr22:22010630..23336370 [NCBI36]
Chr22:22q11.23		 uncertain significance
GRCh38/hg38 22q11.21-11.23(chr22:21454661-24197852)x1 copy number loss Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053084]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053084]|See cases [RCV000053084] Chr22:21454661..24197852 [GRCh38]
Chr22:21808950..24593820 [GRCh37]
Chr22:20138950..22923820 [NCBI36]
Chr22:22q11.21-11.23		 pathogenic
GRCh38/hg38 22q11.21-11.23(chr22:21457690-24220231)x1 copy number loss See cases [RCV000053087] Chr22:21457690..24220231 [GRCh38]
Chr22:21811979..24616199 [GRCh37]
Chr22:20141979..22946199 [NCBI36]
Chr22:22q11.21-11.23		 pathogenic
GRCh38/hg38 22q11.23(chr22:23338443-24577664)x3 copy number gain See cases [RCV000053175] Chr22:23338443..24577664 [GRCh38]
Chr22:23680630..24973632 [GRCh37]
Chr22:22010630..23303632 [NCBI36]
Chr22:22q11.23		 uncertain significance
GRCh38/hg38 22q11.23(chr22:23354221-24541945)x3 copy number gain See cases [RCV000053176] Chr22:23354221..24541945 [GRCh38]
Chr22:23696408..24937913 [GRCh37]
Chr22:22026408..23267913 [NCBI36]
Chr22:22q11.23		 uncertain significance
GRCh38/hg38 22q11.23(chr22:23369950-24669609)x3 copy number gain See cases [RCV000053177] Chr22:23369950..24669609 [GRCh38]
Chr22:23712137..25065576 [GRCh37]
Chr22:22042137..23395576 [NCBI36]
Chr22:22q11.23		 uncertain significance
GRCh38/hg38 22q11.23(chr22:23377784-24564000)x3 copy number gain See cases [RCV000053178] Chr22:23377784..24564000 [GRCh38]
Chr22:23719971..24959968 [GRCh37]
Chr22:22049971..23289968 [NCBI36]
Chr22:22q11.23		 uncertain significance
GRCh38/hg38 22q11.23(chr22:23377984-24563859)x3 copy number gain See cases [RCV000053179] Chr22:23377984..24563859 [GRCh38]
Chr22:23720171..24959827 [GRCh37]
Chr22:22050171..23289827 [NCBI36]
Chr22:22q11.23		 conflicting interpretations of pathogenicity|uncertain significance|conflicting data from submitters
GRCh38/hg38 22q11.21-11.23(chr22:21562911-24307688)x1 copy number loss See cases [RCV000053090] Chr22:21562911..24307688 [GRCh38]
Chr22:21917200..24703656 [GRCh37]
Chr22:20247200..23033656 [NCBI36]
Chr22:22q11.21-11.23		 pathogenic
GRCh38/hg38 22q11.23(chr22:23377984-24669609)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053181]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053181]|See cases [RCV000053181] Chr22:23377984..24669609 [GRCh38]
Chr22:23720171..25065576 [GRCh37]
Chr22:22050171..23395576 [NCBI36]
Chr22:22q11.23		 uncertain significance
GRCh38/hg38 22q11.23(chr22:23414627-24563859)x3 copy number gain See cases [RCV000053182] Chr22:23414627..24563859 [GRCh38]
Chr22:23756814..24959827 [GRCh37]
Chr22:22086814..23289827 [NCBI36]
Chr22:22q11.23		 uncertain significance
GRCh38/hg38 22q11.1-11.23(chr22:16916608-24358936)x3 copy number gain See cases [RCV000053104] Chr22:16916608..24358936 [GRCh38]
Chr22:17397498..24754904 [GRCh37]
Chr22:15777498..23084904 [NCBI36]
Chr22:22q11.1-11.23		 pathogenic
GRCh38/hg38 22q11.22-11.23(chr22:22686122-24577664)x3 copy number gain See cases [RCV000053161] Chr22:22686122..24577664 [GRCh38]
Chr22:23028586..24973632 [GRCh37]
Chr22:21358586..23303632 [NCBI36]
Chr22:22q11.22-11.23		 uncertain significance
GRCh38/hg38 22q11.22-11.23(chr22:22703701-24669609)x3 copy number gain See cases [RCV000053163] Chr22:22703701..24669609 [GRCh38]
Chr22:23046186..25065576 [GRCh37]
Chr22:21376186..23395576 [NCBI36]
Chr22:22q11.22-11.23		 uncertain significance
GRCh38/hg38 22q11.23(chr22:23285152-24723136)x3 copy number gain See cases [RCV000053164] Chr22:23285152..24723136 [GRCh38]
Chr22:23627339..25119103 [GRCh37]
Chr22:21957339..23449103 [NCBI36]
Chr22:22q11.23		 uncertain significance
GRCh38/hg38 22q11.21-11.23(chr22:21443815-24235645)x1 copy number loss See cases [RCV000053074] Chr22:21443815..24235645 [GRCh38]
Chr22:21798104..24631613 [GRCh37]
Chr22:20128104..22961613 [NCBI36]
Chr22:22q11.21-11.23		 pathogenic
GRCh38/hg38 22q11.21-11.23(chr22:21454461-24247296)x1 copy number loss See cases [RCV000053077] Chr22:21454461..24247296 [GRCh38]
Chr22:21808750..24643264 [GRCh37]
Chr22:20138750..22973264 [NCBI36]
Chr22:22q11.21-11.23		 pathogenic
GRCh38/hg38 22q11.21-11.23(chr22:21454661-24289119)x1 copy number loss Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053079]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053079]|See cases [RCV000053079] Chr22:21454661..24289119 [GRCh38]
Chr22:21808950..24685087 [GRCh37]
Chr22:20138950..23015087 [NCBI36]
Chr22:22q11.21-11.23		 pathogenic
GRCh38/hg38 22q11.1-13.33(chr22:16916608-50739836)x3 copy number gain See cases [RCV000133646] Chr22:16916608..50739836 [GRCh38]
Chr22:17397498..51178264 [GRCh37]
Chr22:15777498..49525130 [NCBI36]
Chr22:22q11.1-13.33		 pathogenic
GRCh38/hg38 22q11.1-13.33(chr22:16916743-50739785)x3 copy number gain See cases [RCV000134730] Chr22:16916743..50739785 [GRCh38]
Chr22:17397633..51178213 [GRCh37]
Chr22:15777633..49525079 [NCBI36]
Chr22:22q11.1-13.33		 pathogenic
GRCh38/hg38 22q11.23(chr22:23859833-23930947)x3 copy number gain See cases [RCV000135173] Chr22:23859833..23930947 [GRCh38]
Chr22:24202020..24273134 [GRCh37]
Chr22:22532020..22603134 [NCBI36]
Chr22:22q11.23		 likely benign
GRCh38/hg38 22q11.22-11.23(chr22:22669599-24670517)x3 copy number gain See cases [RCV000136060] Chr22:22669599..24670517 [GRCh38]
Chr22:23012069..25066484 [GRCh37]
Chr22:21342069..23396484 [NCBI36]
Chr22:22q11.22-11.23		 uncertain significance
GRCh38/hg38 22q11.21-11.23(chr22:20726972-24197852)x1 copy number loss See cases [RCV000136889] Chr22:20726972..24197852 [GRCh38]
Chr22:21081260..24593820 [GRCh37]
Chr22:19411260..22923820 [NCBI36]
Chr22:22q11.21-11.23		 pathogenic
GRCh38/hg38 22q11.23(chr22:23787850-23954973)x3 copy number gain See cases [RCV000137648] Chr22:23787850..23954973 [GRCh38]
Chr22:24130037..24297160 [GRCh37]
Chr22:22460037..22627160 [NCBI36]
Chr22:22q11.23		 uncertain significance
GRCh38/hg38 22q11.21-11.23(chr22:21454661-24247140)x1 copy number loss See cases [RCV000137685] Chr22:21454661..24247140 [GRCh38]
Chr22:21808950..24643108 [GRCh37]
Chr22:20138950..22973108 [NCBI36]
Chr22:22q11.21-11.23		 pathogenic
GRCh38/hg38 22q11.23(chr22:23311976-24644628)x3 copy number gain See cases [RCV000137701] Chr22:23311976..24644628 [GRCh38]
Chr22:23654163..25040595 [GRCh37]
Chr22:21984163..23370595 [NCBI36]
Chr22:22q11.23		 uncertain significance
GRCh38/hg38 22q11.22-11.23(chr22:22660239-24644628)x3 copy number gain See cases [RCV000137410] Chr22:22660239..24644628 [GRCh38]
Chr22:23002709..25040595 [GRCh37]
Chr22:21332709..23370595 [NCBI36]
Chr22:22q11.22-11.23		 uncertain significance
GRCh38/hg38 22q11.23(chr22:23804407-24669609)x3 copy number gain See cases [RCV000137178] Chr22:23804407..24669609 [GRCh38]
Chr22:24146594..25065576 [GRCh37]
Chr22:22476594..23395576 [NCBI36]
Chr22:22q11.23		 uncertain significance
GRCh38/hg38 22q11.23-12.3(chr22:23279231-36247369)x3 copy number gain See cases [RCV000138172] Chr22:23279231..36247369 [GRCh38]
Chr22:23621418..36643415 [GRCh37]
Chr22:21951418..34973361 [NCBI36]
Chr22:22q11.23-12.3		 pathogenic
GRCh38/hg38 22q11.23(chr22:23311976-24600238)x3 copy number gain See cases [RCV000137995] Chr22:23311976..24600238 [GRCh38]
Chr22:23654163..24996205 [GRCh37]
Chr22:21984163..23326205 [NCBI36]
Chr22:22q11.23		 uncertain significance
GRCh38/hg38 22q11.22-11.23(chr22:22660239-24600238)x3 copy number gain See cases [RCV000137795] Chr22:22660239..24600238 [GRCh38]
Chr22:23002709..24996205 [GRCh37]
Chr22:21332709..23326205 [NCBI36]
Chr22:22q11.22-11.23		 uncertain significance
GRCh38/hg38 22q11.21-12.3(chr22:20907226-37187347)x3 copy number gain See cases [RCV000137926] Chr22:20907226..37187347 [GRCh38]
Chr22:21261514..37583387 [GRCh37]
Chr22:19591514..35913333 [NCBI36]
Chr22:22q11.21-12.3		 pathogenic
GRCh38/hg38 22q11.21-11.23(chr22:21207181-24247140)x3 copy number gain See cases [RCV000138673] Chr22:21207181..24247140 [GRCh38]
Chr22:21561470..24643108 [GRCh37]
Chr22:19891470..22973108 [NCBI36]
Chr22:22q11.21-11.23		 uncertain significance
GRCh38/hg38 22q11.22-11.23(chr22:22660239-24596054)x3 copy number gain See cases [RCV000138249] Chr22:22660239..24596054 [GRCh38]
Chr22:23002709..24992021 [GRCh37]
Chr22:21332709..23322021 [NCBI36]
Chr22:22q11.22-11.23		 uncertain significance
GRCh38/hg38 22q11.23(chr22:23311976-24669609)x3 copy number gain See cases [RCV000139440] Chr22:23311976..24669609 [GRCh38]
Chr22:23654163..25065576 [GRCh37]
Chr22:21984163..23395576 [NCBI36]
Chr22:22q11.23		 likely benign|uncertain significance
GRCh38/hg38 22q11.22-11.23(chr22:22655333-24663664)x3 copy number gain See cases [RCV000141936] Chr22:22655333..24663664 [GRCh38]
Chr22:22997803..25059631 [GRCh37]
Chr22:21327803..23389631 [NCBI36]
Chr22:22q11.22-11.23		 uncertain significance
GRCh38/hg38 22q11.23(chr22:23308686-24647020)x3 copy number gain See cases [RCV000141802] Chr22:23308686..24647020 [GRCh38]
Chr22:23650873..25042987 [GRCh37]
Chr22:21980873..23372987 [NCBI36]
Chr22:22q11.23		 uncertain significance
GRCh38/hg38 22q11.22-11.23(chr22:22655333-24630890)x3 copy number gain See cases [RCV000142221] Chr22:22655333..24630890 [GRCh38]
Chr22:22997803..25026857 [GRCh37]
Chr22:21327803..23356857 [NCBI36]
Chr22:22q11.22-11.23		 uncertain significance
GRCh38/hg38 22q11.22-11.23(chr22:22655333-24647020)x3 copy number gain See cases [RCV000143750] Chr22:22655333..24647020 [GRCh38]
Chr22:22997803..25042987 [GRCh37]
Chr22:21327803..23372987 [NCBI36]
Chr22:22q11.22-11.23		 uncertain significance
GRCh38/hg38 22q11.22-11.23(chr22:22669543-24563859)x3 copy number gain See cases [RCV000148079] Chr22:22669543..24563859 [GRCh38]
Chr22:23012013..24959827 [GRCh37]
Chr22:21342013..23289827 [NCBI36]
Chr22:22q11.22-11.23		 uncertain significance
GRCh38/hg38 22q11.23(chr22:23348201-24647020)x3 copy number gain See cases [RCV000143627] Chr22:23348201..24647020 [GRCh38]
Chr22:23690388..25042987 [GRCh37]
Chr22:22020388..23372987 [NCBI36]
Chr22:22q11.23		 uncertain significance
GRCh38/hg38 22q11.22-11.23(chr22:22920775-24606692)x3 copy number gain See cases [RCV000143543] Chr22:22920775..24606692 [GRCh38]
Chr22:23262947..25002659 [GRCh37]
Chr22:21592947..23332659 [NCBI36]
Chr22:22q11.22-11.23		 uncertain significance
GRCh38/hg38 22q11.23(chr22:23310399-24643051)x3 copy number gain See cases [RCV000143562] Chr22:23310399..24643051 [GRCh38]
Chr22:23652586..25039018 [GRCh37]
Chr22:21982586..23369018 [NCBI36]
Chr22:22q11.23		 likely benign|uncertain significance
GRCh38/hg38 22q11.23(chr22:23377984-24563859)x3 copy number gain See cases [RCV000148169] Chr22:23377984..24563859 [GRCh38]
Chr22:23720171..24959827 [GRCh37]
Chr22:22050171..23289827 [NCBI36]
Chr22:22q11.23		 uncertain significance
GRCh37/hg19 22q11.23(chr22:23891773-24991691)x3 copy number gain See cases [RCV000203419] Chr22:23891773..24991691 [GRCh37]
Chr22:22q11.23		 likely pathogenic
GRCh37/hg19 22q11.22-11.23(chr22:23258229-25046803)x3 copy number gain See cases [RCV000239808] Chr22:23258229..25046803 [GRCh37]
Chr22:22q11.22-11.23		 pathogenic
GRCh37/hg19 22q11.21-12.1(chr22:18738296-25914592)x1 copy number loss Premature ovarian failure [RCV000225330] Chr22:18738296..25914592 [GRCh37]
Chr22:22q11.21-12.1		 benign
GRCh37/hg19 22q11.22-11.23(chr22:22976696-25053311)x3 copy number gain See cases [RCV000239999] Chr22:22976696..25053311 [GRCh37]
Chr22:22q11.22-11.23		 pathogenic
GRCh37/hg19 22q11.1-13.33(chr22:16054691-51237518)x3 copy number gain See cases [RCV000240091] Chr22:16054691..51237518 [GRCh37]
Chr22:22q11.1-13.33		 pathogenic
GRCh37/hg19 22q11.23(chr22:23950632-24276233)x4 copy number gain See cases [RCV000240514] Chr22:23950632..24276233 [GRCh37]
Chr22:22q11.23		 uncertain significance
GRCh37/hg19 22q11.22-11.23(chr22:22988879-24276233)x3 copy number gain See cases [RCV000240234] Chr22:22988879..24276233 [GRCh37]
Chr22:22q11.22-11.23		 pathogenic
GRCh37/hg19 22q11.23(chr22:24132414-24256480)x3 copy number gain See cases [RCV000240452] Chr22:24132414..24256480 [GRCh37]
Chr22:22q11.23		 uncertain significance
GRCh37/hg19 22q11.1-12.1(chr22:16054691-27296513)x3 copy number gain See cases [RCV000240348] Chr22:16054691..27296513 [GRCh37]
Chr22:22q11.1-12.1		 pathogenic
GRCh37/hg19 22q11.1-13.33(chr22:16054691-51220902)x3 copy number gain See cases [RCV000446956] Chr22:16054691..51220902 [GRCh37]
Chr22:22q11.1-13.33		 pathogenic
GRCh37/hg19 22q11.22-11.23(chr22:23258938-25002659)x3 copy number gain See cases [RCV000446585] Chr22:23258938..25002659 [GRCh37]
Chr22:22q11.22-11.23		 pathogenic
GRCh37/hg19 22q11.22-11.23(chr22:22997802-25002659)x3 copy number gain See cases [RCV000445706] Chr22:22997802..25002659 [GRCh37]
Chr22:22q11.22-11.23		 likely pathogenic
GRCh37/hg19 22q11.22-11.23(chr22:23258229-25046758)x3 copy number gain See cases [RCV000445819] Chr22:23258229..25046758 [GRCh37]
Chr22:22q11.22-11.23		 pathogenic
GRCh37/hg19 22q11.21-11.23(chr22:21804562-24659578)x3 copy number gain See cases [RCV000445928] Chr22:21804562..24659578 [GRCh37]
Chr22:22q11.21-11.23		 pathogenic
GRCh37/hg19 22q11.23(chr22:23652517-25042987)x3 copy number gain See cases [RCV000448006] Chr22:23652517..25042987 [GRCh37]
Chr22:22q11.23		 uncertain significance
NC_000022.10:g.(?_23667751)_(25041986_?)dup duplication Schizophrenia [RCV000416698] Chr22:23667751..25041986 [GRCh37]
Chr22:21997751..23371986 [NCBI36]
Chr22:22q11.23		 likely pathogenic
GRCh37/hg19 22q11.1-13.33(chr22:16054691-51237463)x3 copy number gain See cases [RCV000448847] Chr22:16054691..51237463 [GRCh37]
Chr22:22q11.1-13.33		 pathogenic
NC_000022.10:g.(?_22971580)_(25041986_?)dup duplication Schizophrenia [RCV000416783] Chr22:22971580..25041986 [GRCh37]
Chr22:21301580..23371986 [NCBI36]
Chr22:22q11.22-11.23		 likely pathogenic
GRCh37/hg19 22q11.23(chr22:23739611-24544632)x4 copy number gain See cases [RCV000448428] Chr22:23739611..24544632 [GRCh37]
Chr22:22q11.23		 pathogenic
NC_000022.10:g.(?_23667751)_(24991609_?)dup duplication Schizophrenia [RCV000416915] Chr22:23667751..24991609 [GRCh37]
Chr22:21997751..23321609 [NCBI36]
Chr22:22q11.23		 likely pathogenic
GRCh37/hg19 22q11.23(chr22:24134807-24271732)x3 copy number gain See cases [RCV000510555] Chr22:24134807..24271732 [GRCh37]
Chr22:22q11.23		 uncertain significance
GRCh37/hg19 22q11.23(chr22:24174144-24261143)x3 copy number gain See cases [RCV000510701] Chr22:24174144..24261143 [GRCh37]
Chr22:22q11.23		 uncertain significance
GRCh37/hg19 22q11.21-11.23(chr22:21798907-24963935)x3 copy number gain See cases [RCV000510487] Chr22:21798907..24963935 [GRCh37]
Chr22:22q11.21-11.23		 uncertain significance
GRCh37/hg19 22q11.23(chr22:23690387-25039018)x3 copy number gain See cases [RCV000511883] Chr22:23690387..25039018 [GRCh37]
Chr22:22q11.23		 uncertain significance
GRCh37/hg19 22q11.22-11.23(chr22:22997802-25033630)x3 copy number gain See cases [RCV000511378] Chr22:22997802..25033630 [GRCh37]
Chr22:22q11.22-11.23		 uncertain significance
GRCh37/hg19 22q11.23(chr22:24174144-24258392)x3 copy number gain See cases [RCV000511524] Chr22:24174144..24258392 [GRCh37]
Chr22:22q11.23		 uncertain significance
GRCh37/hg19 22q11.23(chr22:23690387-25066472)x3 copy number gain See cases [RCV000511837] Chr22:23690387..25066472 [GRCh37]
Chr22:22q11.23		 uncertain significance
GRCh37/hg19 22q11.23(chr22:23690387-24666092)x1 copy number loss See cases [RCV000511065] Chr22:23690387..24666092 [GRCh37]
Chr22:22q11.23		 pathogenic
GRCh37/hg19 22q11.1-13.33(chr22:16888900-51197838) copy number gain See cases [RCV000510873] Chr22:16888900..51197838 [GRCh37]
Chr22:22q11.1-13.33		 pathogenic
GRCh37/hg19 22q11.23-12.3(chr22:23637907-36614412)x3 copy number gain See cases [RCV000511098] Chr22:23637907..36614412 [GRCh37]
Chr22:22q11.23-12.3		 pathogenic
GRCh37/hg19 22q11.23(chr22:23653979-25066472)x3 copy number gain See cases [RCV000512168] Chr22:23653979..25066472 [GRCh37]
Chr22:22q11.23		 uncertain significance
GRCh37/hg19 22q11.1-13.33(chr22:16888900-51197838)x3 copy number gain See cases [RCV000512333] Chr22:16888900..51197838 [GRCh37]
Chr22:22q11.1-13.33		 pathogenic
GRCh37/hg19 22q11.23(chr22:23652549-25042987)x3 copy number gain See cases [RCV000512454] Chr22:23652549..25042987 [GRCh37]
Chr22:22q11.23		 uncertain significance
NM_002415.2(MIF):c.172G>A (p.Ala58Thr) single nucleotide variant not provided [RCV000658931] Chr22:23894835 [GRCh38]
Chr22:24237022 [GRCh37]
Chr22:22q11.23		 uncertain significance
GRCh37/hg19 22q11.22-11.23(chr22:22951048-25156289)x3 copy number gain not provided [RCV000684506] Chr22:22951048..25156289 [GRCh37]
Chr22:22q11.22-11.23		 likely pathogenic
GRCh37/hg19 22q11.21-11.23(chr22:21465661-24653491)x1 copy number loss not provided [RCV000684518] Chr22:21465661..24653491 [GRCh37]
Chr22:22q11.21-11.23		 pathogenic
GRCh37/hg19 22q11.21-11.23(chr22:21465661-24885806)x1 copy number loss not provided [RCV000684520] Chr22:21465661..24885806 [GRCh37]
Chr22:22q11.21-11.23		 pathogenic
GRCh37/hg19 22q11.22-12.3(chr22:22460754-35198232)x3 copy number gain not provided [RCV000684530] Chr22:22460754..35198232 [GRCh37]
Chr22:22q11.22-12.3		 pathogenic
GRCh37/hg19 22q11.23(chr22:23650871-25002659)x3 copy number gain not provided [RCV000684494] Chr22:23650871..25002659 [GRCh37]
Chr22:22q11.23		 likely pathogenic
GRCh37/hg19 22q11.22-11.23(chr22:22945889-25059631)x3 copy number gain not provided [RCV000684504] Chr22:22945889..25059631 [GRCh37]
Chr22:22q11.22-11.23		 pathogenic|likely pathogenic
Single allele duplication Schizophrenia [RCV000754256] Chr22:22624794..24654160 [GRCh38]
Chr22:22q11.22-11.23		 likely pathogenic
Single allele duplication Schizophrenia [RCV000754258] Chr22:23317839..24597843 [GRCh38]
Chr22:22q11.23		 likely pathogenic
Single allele duplication Schizophrenia [RCV000754259] Chr22:23317839..24654160 [GRCh38]
Chr22:22q11.23		 likely pathogenic
GRCh37/hg19 22q11.1-13.33(chr22:16054667-51243435)x3 copy number gain not provided [RCV000741689] Chr22:16054667..51243435 [GRCh37]
Chr22:22q11.1-13.33		 pathogenic
GRCh37/hg19 22q11.1-13.33(chr22:16114244-51195728)x3 copy number gain not provided [RCV000741691] Chr22:16114244..51195728 [GRCh37]
Chr22:22q11.1-13.33		 pathogenic
GRCh37/hg19 22q11.1-13.33(chr22:16114244-51211392)x3 copy number gain not provided [RCV000741692] Chr22:16114244..51211392 [GRCh37]
Chr22:22q11.1-13.33		 pathogenic
NM_002415.2(MIF):c.221G>T (p.Arg74Leu) single nucleotide variant not specified [RCV004318629] Chr22:23894884 [GRCh38]
Chr22:24237071 [GRCh37]
Chr22:22q11.23		 uncertain significance
NM_002415.2(MIF):c.282-7C>A single nucleotide variant not provided [RCV000884652] Chr22:23895033 [GRCh38]
Chr22:24237220 [GRCh37]
Chr22:22q11.23		 benign
NC_000022.10:g.(?_24129357)_(24836024_?)del deletion not provided [RCV001031302] Chr22:24129357..24836024 [GRCh37]
Chr22:22q11.23		 pathogenic
NM_002415.2(MIF):c.282-9C>T single nucleotide variant not provided [RCV000963214] Chr22:23895031 [GRCh38]
Chr22:24237218 [GRCh37]
Chr22:22q11.23		 benign
GRCh37/hg19 22q11.23(chr22:23653987-25158391) copy number gain not provided [RCV000767635] Chr22:23653987..25158391 [GRCh37]
Chr22:22q11.23		 likely pathogenic
GRCh37/hg19 22q11.23(chr22:23650871-25066472)x3 copy number gain not provided [RCV000845636] Chr22:23650871..25066472 [GRCh37]
Chr22:22q11.23		 pathogenic
GRCh37/hg19 22q11.23(chr22:23652517-25002659)x3 copy number gain 22q11.2 distal duplication syndrome [RCV000788073] Chr22:23652517..25002659 [GRCh37]
Chr22:22q11.23		 uncertain significance
GRCh37/hg19 22q11.23(chr22:24134356-24354513)x3 copy number gain not provided [RCV000848818] Chr22:24134356..24354513 [GRCh37]
Chr22:22q11.23		 uncertain significance
GRCh37/hg19 22q11.23(chr22:23650871-25066472)x3 copy number gain not provided [RCV001007176] Chr22:23650871..25066472 [GRCh37]
Chr22:22q11.23		 pathogenic
GRCh37/hg19 22q11.22-11.23(chr22:22962195-25002659)x3 copy number gain not provided [RCV000846628] Chr22:22962195..25002659 [GRCh37]
Chr22:22q11.22-11.23		 pathogenic
GRCh37/hg19 22q11.22-11.23(chr22:22998284-25119103)x3 copy number gain Global developmental delay [RCV000787284] Chr22:22998284..25119103 [GRCh37]
Chr22:22q11.22-11.23		 likely pathogenic
Single allele duplication not provided [RCV000845076] Chr22:24133746..24257275 [GRCh37]
Chr22:22q11.23		 not provided
GRCh37/hg19 22q11.22-11.23(chr22:22962196-25145601)x3 copy number gain not provided [RCV000845609] Chr22:22962196..25145601 [GRCh37]
Chr22:22q11.22-11.23		 pathogenic
GRCh37/hg19 22q11.23(chr22:23698818-25042987)x3 copy number gain not provided [RCV000849671] Chr22:23698818..25042987 [GRCh37]
Chr22:22q11.23		 pathogenic
GRCh37/hg19 22q11.23(chr22:24171304-24258403)x3 copy number gain not provided [RCV000849745] Chr22:24171304..24258403 [GRCh37]
Chr22:22q11.23		 uncertain significance
GRCh37/hg19 22q11.22-11.23(chr22:22962196-25059631)x3 copy number gain not provided [RCV000847639] Chr22:22962196..25059631 [GRCh37]
Chr22:22q11.22-11.23		 pathogenic
GRCh37/hg19 22q11.23(chr22:24173393-24261143)x3 copy number gain not provided [RCV000845931] Chr22:24173393..24261143 [GRCh37]
Chr22:22q11.23		 uncertain significance
GRCh37/hg19 22q11.23(chr22:23650200-25066472)x3 copy number gain not provided [RCV000849234] Chr22:23650200..25066472 [GRCh37]
Chr22:22q11.23		 pathogenic
GRCh37/hg19 22q11.1-13.33(chr22:16888899-51197838)x3 copy number gain not provided [RCV000846344] Chr22:16888899..51197838 [GRCh37]
Chr22:22q11.1-13.33		 pathogenic
GRCh37/hg19 22q11.23(chr22:24134808-24271732)x3 copy number gain not provided [RCV002472764] Chr22:24134808..24271732 [GRCh37]
Chr22:22q11.23		 uncertain significance
GRCh37/hg19 22q11.23(chr22:23650872-25002483)x3 copy number gain not provided [RCV002473884] Chr22:23650872..25002483 [GRCh37]
Chr22:22q11.23		 likely pathogenic
GRCh37/hg19 22q11.1-12.1(chr22:16888899-26483608)x3 copy number gain Cat eye syndrome [RCV001263219] Chr22:16888899..26483608 [GRCh37]
Chr22:22q11.1-12.1		 pathogenic
GRCh37/hg19 22q11.1-12.1(chr22:16888899-27657507)x3 copy number gain not provided [RCV001007163] Chr22:16888899..27657507 [GRCh37]
Chr22:22q11.1-12.1		 pathogenic
GRCh37/hg19 22q11.21-11.23(chr22:20732808-25193541)x3 copy number gain not provided [RCV001007169] Chr22:20732808..25193541 [GRCh37]
Chr22:22q11.21-11.23		 pathogenic
GRCh37/hg19 22q11.22-11.23(chr22:22953514-25002483)x3 copy number gain not provided [RCV001007174] Chr22:22953514..25002483 [GRCh37]
Chr22:22q11.22-11.23		 pathogenic|likely pathogenic
NC_000022.10:g.(?_24129357)_(24836024_?)dup duplication not provided [RCV001031059] Chr22:24129357..24836024 [GRCh37]
Chr22:22q11.23		 uncertain significance
GRCh37/hg19 22q11.22-11.23(chr22:23258368-25059827)x3 copy number gain not provided [RCV001258774] Chr22:23258368..25059827 [GRCh37]
Chr22:22q11.22-11.23		 pathogenic
GRCh37/hg19 22q11.23(chr22:23650873-25043046)x3 copy number gain not provided [RCV001258776] Chr22:23650873..25043046 [GRCh37]
Chr22:22q11.23		 pathogenic
NC_000022.10:g.(?_24129357)_(24836024_?)dup duplication not provided [RCV001324555] Chr22:24129357..24836024 [GRCh37]
Chr22:22q11.23		 uncertain significance
GRCh37/hg19 22q11.23(chr22:23720181-25066484)x3 copy number gain See cases [RCV001263027] Chr22:23720181..25066484 [GRCh37]
Chr22:22q11.23		 uncertain significance
GRCh37/hg19 22q11.1-13.33(chr22:16197005-51224252)x3 copy number gain See cases [RCV001263056] Chr22:16197005..51224252 [GRCh37]
Chr22:22q11.1-13.33		 pathogenic
Single allele duplication Epilepsy [RCV001293375] Chr22:23699269..24992266 [GRCh37]
Chr22:22q11.23		 pathogenic
NC_000022.10:g.(?_23915453)_(24921762_?)dup duplication not provided [RCV003120543] Chr22:23915453..24921762 [GRCh37]
Chr22:22q11.23		 uncertain significance
GRCh37/hg19 22q11.22-11.23(chr22:23166334-24237343)x3 copy number gain Generalized-onset seizure [RCV001801186] Chr22:23166334..24237343 [GRCh37]
Chr22:22q11.22-11.23		 uncertain significance
GRCh37/hg19 22q11.23(chr22:23689960-25000632)x3 copy number gain not provided [RCV001795844] Chr22:23689960..25000632 [GRCh37]
Chr22:22q11.23		 uncertain significance
GRCh37/hg19 22q11.21-11.23(chr22:21465661-24631791)x3 copy number gain not provided [RCV001836553] Chr22:21465661..24631791 [GRCh37]
Chr22:22q11.21-11.23		 pathogenic
GRCh37/hg19 22q11.23(chr22:24134356-24271818)x3 copy number gain not provided [RCV001827619] Chr22:24134356..24271818 [GRCh37]
Chr22:22q11.23		 uncertain significance
NC_000022.10:g.(?_23915453)_(24237293_?)del deletion Agammaglobulinemia 2, autosomal recessive [RCV001941512] Chr22:23915453..24237293 [GRCh37]
Chr22:22q11.23		 uncertain significance
NC_000022.10:g.(?_24130008)_(24237293_?)dup duplication not provided [RCV003113205] Chr22:24130008..24237293 [GRCh37]
Chr22:22q11.23		 uncertain significance
GRCh37/hg19 22q11.23(chr22:23652519-25059631)x3 copy number gain Unilateral renal agenesis [RCV002282735] Chr22:23652519..25059631 [GRCh37]
Chr22:22q11.23		 uncertain significance
GRCh37/hg19 22q11.21-11.23(chr22:21798906-25039018) copy number gain Chromosome 22q11.2 microduplication syndrome [RCV002280733] Chr22:21798906..25039018 [GRCh37]
Chr22:22q11.21-11.23		 pathogenic
GRCh37/hg19 22q11.22-11.23(chr22:22953515-24995256)x3 copy number gain not provided [RCV002474578] Chr22:22953515..24995256 [GRCh37]
Chr22:22q11.22-11.23		 likely pathogenic
GRCh37/hg19 22q11.23(chr22:23650201-24992266)x3 copy number gain not provided [RCV002472515] Chr22:23650201..24992266 [GRCh37]
Chr22:22q11.23		 likely pathogenic
GRCh37/hg19 22q11.22-11.23(chr22:22997929-24995256)x3 copy number gain not provided [RCV002473547] Chr22:22997929..24995256 [GRCh37]
Chr22:22q11.22-11.23		 pathogenic
NM_002415.2(MIF):c.100C>A (p.Pro34Thr) single nucleotide variant not specified [RCV004227062] Chr22:23894574 [GRCh38]
Chr22:24236761 [GRCh37]
Chr22:22q11.23		 uncertain significance
NM_002415.2(MIF):c.83C>T (p.Ala28Val) single nucleotide variant not specified [RCV004074265] Chr22:23894557 [GRCh38]
Chr22:24236744 [GRCh37]
Chr22:22q11.23		 uncertain significance
NM_002415.2(MIF):c.142A>G (p.Met48Val) single nucleotide variant not specified [RCV004309194] Chr22:23894805 [GRCh38]
Chr22:24236992 [GRCh37]
Chr22:22q11.23		 uncertain significance
GRCh37/hg19 22q11.23(chr22:23658260-25114888)x3 copy number gain Chromosome 22q11.2 microduplication syndrome [RCV003329499] Chr22:23658260..25114888 [GRCh37]
Chr22:22q11.23		 pathogenic
NM_002415.2(MIF):c.195C>G (p.Ile65Met) single nucleotide variant not specified [RCV004343143] Chr22:23894858 [GRCh38]
Chr22:24237045 [GRCh37]
Chr22:22q11.23		 uncertain significance
GRCh37/hg19 22q11.23(chr22:23690388-25066472)x3 copy number gain not provided [RCV003485241] Chr22:23690388..25066472 [GRCh37]
Chr22:22q11.23		 pathogenic
GRCh37/hg19 22q11.22-11.23(chr22:22989453-25019883)x3 copy number gain not provided [RCV003457365] Chr22:22989453..25019883 [GRCh37]
Chr22:22q11.22-11.23		 likely pathogenic
NM_002415.2(MIF):c.5C>G (p.Pro2Arg) single nucleotide variant not provided [RCV003433179] Chr22:23894479 [GRCh38]
Chr22:24236666 [GRCh37]
Chr22:22q11.23		 uncertain significance
NM_002415.2(MIF):c.204C>A (p.Ile68=) single nucleotide variant MIF-related condition [RCV003912215] Chr22:23894867 [GRCh38]
Chr22:24237054 [GRCh37]
Chr22:22q11.23		 likely benign
GRCh37/hg19 22q11.23(chr22:23702548-25008068)x3 copy number gain not provided [RCV004442850] Chr22:23702548..25008068 [GRCh37]
Chr22:22q11.23		 uncertain significance
NM_002415.2(MIF):c.220C>G (p.Arg74Gly) single nucleotide variant not specified [RCV004419850] Chr22:23894883 [GRCh38]
Chr22:24237070 [GRCh37]
Chr22:22q11.23		 uncertain significance
GRCh37/hg19 22q11.21-11.23(chr22:21804597-24629406)x3 copy number gain not provided [RCV004442791] Chr22:21804597..24629406 [GRCh37]
Chr22:22q11.21-11.23		 uncertain significance
NM_002415.2(MIF):c.224C>T (p.Ser75Phe) single nucleotide variant MIF-related condition [RCV003961552] Chr22:23894887 [GRCh38]
Chr22:24237074 [GRCh37]
Chr22:22q11.23		 likely benign
GRCh37/hg19 22q11.23(chr22:23652549-25002659)x3 copy number gain See cases [RCV004442788] Chr22:23652549..25002659 [GRCh37]
Chr22:22q11.23		 pathogenic
NM_002415.2(MIF):c.282-6C>G single nucleotide variant MIF-related condition [RCV003982062] Chr22:23895034 [GRCh38]
Chr22:24237221 [GRCh37]
Chr22:22q11.23		 benign
miRNA Target Status

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
MIR451Ahsa-miR-451aMirtarbaseexternal_infoELISA//Luciferase reporter assay//Microarray//qRT-Functional MTI19318487
MIR451Ahsa-miR-451aOncomiRDBexternal_infoNANA21948564
MIR451Ahsa-miR-451aOncomiRDBexternal_infoNANA19318487

Predicted Target Of
Summary Value
Count of predictions:974
Count of miRNA genes:510
Interacting mature miRNAs:576
Transcripts:ENST00000215754, ENST00000465752, ENST00000498385
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Markers in Region
D22S1553  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh372224,237,238 - 24,237,384UniSTSGRCh37
Build 362222,567,238 - 22,567,384RGDNCBI36
Celera228,074,998 - 8,075,144RGD
Cytogenetic Map22q11.23UniSTS
HuRef227,222,577 - 7,222,723UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High 1 1 1 2 2 1 2 8 4
Medium 239 32 281 205 338 208 394 71 617 262 677 373 10 5 73 4
Low 2155 2497 1415 389 1282 233 3592 1785 3068 154 769 1206 159 1 1087 2415 2 2
Below cutoff 42 418 29 30 276 24 343 314 47 1 6 27 6 100 278

Sequence

Nucleotide Sequences
RefSeq Transcripts NG_012099 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_002415 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AF469046 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK311929 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AP000350 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC000447 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC007376 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC007676 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC008914 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC013976 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC022414 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC051440 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC053376 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BT007148 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471095 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068256 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CR407644 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CR456520 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CR541651 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ307455 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GQ891502 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JQ846015 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L10612 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L19686 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M25639 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M95775 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MN205537 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  Z23063 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000215754   ⟹   ENSP00000215754
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl2223,894,383 - 23,895,223 (+)Ensembl
RefSeq Acc Id: ENST00000465752
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl2223,894,450 - 23,895,227 (+)Ensembl
RefSeq Acc Id: ENST00000498385
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl2223,894,698 - 23,895,227 (+)Ensembl
RefSeq Acc Id: NM_002415   ⟹   NP_002406
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh382223,894,383 - 23,895,223 (+)NCBI
GRCh372224,236,565 - 24,237,409 (+)ENTREZGENE
Build 362222,566,565 - 22,567,409 (+)NCBI Archive
HuRef227,221,904 - 7,222,748 (+)ENTREZGENE
CHM1_12224,248,957 - 24,249,801 (+)NCBI
T2T-CHM13v2.02224,338,982 - 24,339,822 (+)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_002406   ⟸   NM_002415
- UniProtKB: Q2V4Y5 (UniProtKB/Swiss-Prot),   B2R4S3 (UniProtKB/Swiss-Prot),   A5Z1R8 (UniProtKB/Swiss-Prot),   Q6FHV0 (UniProtKB/Swiss-Prot),   P14174 (UniProtKB/Swiss-Prot),   I4AY87 (UniProtKB/TrEMBL),   A6MUU8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSP00000215754   ⟸   ENST00000215754

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P14174-F1-model_v2 AlphaFold P14174 1-115 view protein structure

Promoters
RGD ID:6800140
Promoter ID:HG_KWN:41979
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   CD4+TCell_2Hour,   HeLa_S3,   Jurkat,   K562,   Lymphoblastoid,   NB4
Transcripts:OTTHUMT00000320009,   OTTHUMT00000320010,   OTTHUMT00000320011
Position:
Human AssemblyChrPosition (strand)Source
Build 362222,565,316 - 22,567,087 (+)MPROMDB
RGD ID:6851882
Promoter ID:EP73747
Type:initiation region
Name:HS_MIF
Description:Macrophage migration inhibitory factor (glycosylation-inhibitingfactor).
SO ACC ID:SO:0000170
Source:EPD (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:NEDO full length human cDNA sequencing project.; Oligo-capping
Position:
Human AssemblyChrPosition (strand)Source
Build 362222,566,570 - 22,566,630EPD
RGD ID:13603454
Promoter ID:EPDNEW_H27911
Type:initiation region
Name:MIF_1
Description:macrophage migration inhibitory factor (glycosylation-inhibitingfactor)
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H27912  
Experiment Methods:Single-end sequencing.; Paired-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh382223,894,383 - 23,894,443EPDNEW
RGD ID:13603458
Promoter ID:EPDNEW_H27912
Type:initiation region
Name:MIF_2
Description:macrophage migration inhibitory factor (glycosylation-inhibitingfactor)
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H27911  
Experiment Methods:Single-end sequencing.; Paired-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh382223,894,767 - 23,894,827EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:7097 AgrOrtholog
COSMIC MIF COSMIC
Ensembl Genes ENSG00000240972 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
  ENSG00000276701 UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000215754 ENTREZGENE
  ENST00000215754.8 UniProtKB/Swiss-Prot
  ENST00000613839.2 UniProtKB/Swiss-Prot
Gene3D-CATH 3.30.429.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000240972 GTEx
  ENSG00000276701 GTEx
HGNC ID HGNC:7097 ENTREZGENE
Human Proteome Map MIF Human Proteome Map
InterPro Macrophage_inhib_fac UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Macrophage_inhib_fac_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tautomerase/MIF_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:4282 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 4282 ENTREZGENE
OMIM 153620 OMIM
PANTHER MACROPHAGE MIGRATION INHIBITORY FACTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11954 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam MIF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA30819 PharmGKB
PROSITE MIF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF55331 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A5Z1R8 ENTREZGENE
  A6MUU8 ENTREZGENE, UniProtKB/TrEMBL
  B2R4S3 ENTREZGENE
  I4AY87 ENTREZGENE, UniProtKB/TrEMBL
  MIF_HUMAN UniProtKB/Swiss-Prot, ENTREZGENE
  Q2V4Y5 ENTREZGENE
  Q6FHV0 ENTREZGENE
UniProt Secondary A5Z1R8 UniProtKB/Swiss-Prot
  B2R4S3 UniProtKB/Swiss-Prot
  Q2V4Y5 UniProtKB/Swiss-Prot
  Q6FHV0 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-08-08 MIF  macrophage migration inhibitory factor  MIF  macrophage migration inhibitory factor (glycosylation-inhibiting factor)  Symbol and/or name change 5135510 APPROVED