MIF (macrophage migration inhibitory factor) - Rat Genome Database

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Gene: MIF (macrophage migration inhibitory factor) Chlorocebus sabaeus
Analyze
Symbol: MIF
Name: macrophage migration inhibitory factor
RGD ID: 18601080
Description: ENCODES a protein that exhibits protease binding (ortholog); protein-containing complex binding (ortholog); INVOLVED IN brain renin-angiotensin system (ortholog); cellular response to hydrogen peroxide (ortholog); cellular response to hypoxia (ortholog); PARTICIPATES IN alkaptonuria pathway; disulfiram pharmacodynamics pathway; dopamine beta-hydroxylase deficiency pathway; ASSOCIATED WITH acute necrotizing pancreatitis (ortholog); agammaglobulinemia 2 (ortholog); Alcoholic Liver Diseases (ortholog); FOUND IN extracellular space (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: macrophage migration inhibitory factor (glycosylation-inhibiting factor)
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1197,000,837 - 7,001,700 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl197,000,793 - 7,001,757 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666100368,099 - 370,934 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
acute necrotizing pancreatitis  (ISO)
agammaglobulinemia 2  (ISO)
Alcoholic Liver Diseases  (ISO)
allergic disease  (ISO)
Animal Mammary Neoplasms  (ISO)
anti-basement membrane glomerulonephritis  (ISO)
anxiety disorder  (ISO)
arteriosclerosis  (ISO)
asthma  (ISO)
autism spectrum disorder  (ISO)
autistic disorder  (ISO)
borna disease  (ISO)
Brain Injuries  (ISO)
Breast Neoplasms  (ISO)
Bronchial Hyperreactivity  (ISO)
bronchopulmonary dysplasia  (ISO)
Burns  (ISO)
carcinoma  (ISO)
cardiomyopathy  (ISO)
chronic obstructive pulmonary disease  (ISO)
Chylothorax  (ISO)
colitis  (ISO)
Coronary Disease  (ISO)
cystic fibrosis  (ISO)
cystitis  (ISO)
depressive disorder  (ISO)
Disease Progression  (ISO)
Endotoxemia  (ISO)
epilepsy  (ISO)
Experimental Arthritis  (ISO)
Experimental Colitis  (ISO)
Experimental Diabetes Mellitus  (ISO)
Experimental Liver Cirrhosis  (ISO)
Experimental Mammary Neoplasms  (ISO)
Granuloma  (ISO)
Hamartoma  (ISO)
Hypercholesterolemia  (ISO)
hypertension  (ISO)
Inflammation  (ISO)
Insulin Resistance  (ISO)
Keloid  (ISO)
kidney disease  (ISO)
lung disease  (ISO)
lung non-small cell carcinoma  (ISO)
malignant mesothelioma  (ISO)
Memory Disorders  (ISO)
myocardial infarction  (ISO)
myocarditis  (ISO)
newborn respiratory distress syndrome  (ISO)
obesity  (ISO)
pneumonia  (ISO)
Prostatic Neoplasms  (ISO)
pulmonary edema  (ISO)
pulmonary hypertension  (ISO)
pulmonary tuberculosis  (ISO)
Radiation Pneumonitis  (ISO)
Reperfusion Injury  (ISO)
retinitis  (ISO)
rheumatoid arthritis  (ISO)
rhinitis  (ISO)
schizophrenia  (ISO)
Sepsis  (ISO)
Spinal Cord Injuries  (ISO)
Stevens-Johnson syndrome  (ISO)
Stroke  (ISO)
Systemic Juvenile Rheumatoid Arthritis  (ISO)
toxic shock syndrome  (ISO)
type 2 diabetes mellitus  (ISO)
viral pneumonia  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
brain renin-angiotensin system  (ISO)
carboxylic acid metabolic process  (IEA)
cell surface receptor signaling pathway  (IEA)
cellular response to hydrogen peroxide  (ISO)
cellular response to hypoxia  (ISO)
cellular senescence  (ISO)
DNA damage response, signal transduction by p53 class mediator  (ISO)
drinking behavior  (ISO)
hair follicle development  (ISO)
negative regulation of apoptotic process  (IEA)
negative regulation of cell migration  (IEA)
negative regulation of cellular senescence  (IEA)
negative regulation of DNA damage response, signal transduction by p53 class mediator  (IEA)
negative regulation of gene expression  (IEA)
negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator  (IEA)
negative regulation of macrophage chemotaxis  (IEA)
negative regulation of mature B cell apoptotic process  (ISO)
negative regulation of myeloid cell apoptotic process  (ISO)
negative regulation of protein metabolic process  (ISO)
positive chemotaxis  (IEA)
positive regulation of acute inflammatory response  (ISO)
positive regulation of arachidonic acid secretion  (ISO)
positive regulation of axon regeneration  (ISO)
positive regulation of B cell proliferation  (IEA)
positive regulation of cell population proliferation  (IEA)
positive regulation of chemokine (C-X-C motif) ligand 2 production  (ISO)
positive regulation of cytokine production  (IEA)
positive regulation of ERK1 and ERK2 cascade  (IEA)
positive regulation of fibroblast proliferation  (IEA)
positive regulation of glucose import  (ISO)
positive regulation of glycolytic process  (ISO)
positive regulation of immune response  (ISO)
positive regulation of lipopolysaccharide-mediated signaling pathway  (ISO)
positive regulation of myeloid leukocyte cytokine production involved in immune response  (ISO)
positive regulation of peptidyl-serine phosphorylation  (IEA)
positive regulation of peptidyl-tyrosine phosphorylation  (IEA)
positive regulation of phosphorylation  (IEA)
positive regulation of potassium ion transport  (ISO)
positive regulation of prostaglandin secretion involved in immune response  (ISO)
positive regulation of protein kinase A signaling  (IEA)
positive regulation of protein phosphorylation  (ISO)
positive regulation of smooth muscle cell migration  (ISO)
positive regulation of tumor necrosis factor production  (IEA)
prostaglandin biosynthetic process  (IEA)
protein homotrimerization  (IEA)
regulation of cell population proliferation  (ISO)
response to estradiol  (ISO)
response to glucocorticoid  (ISO)
response to hormone  (ISO)
response to inorganic substance  (ISO)
response to insulin  (ISO)
response to lipopolysaccharide  (ISO)
response to mechanical stimulus  (ISO)
response to menaquinone  (ISO)
response to progesterone  (ISO)
response to vitamin E  (ISO)
response to xenobiotic stimulus  (ISO)
skin development  (ISO)
spermatogenesis  (ISO)

Cellular Component

References
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
MIF
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1197,000,837 - 7,001,700 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl197,000,793 - 7,001,757 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666100368,099 - 370,934 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
MIF
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382223,894,383 - 23,895,223 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2223,894,383 - 23,895,227 (+)EnsemblGRCh38hg38GRCh38
GRCh372224,236,570 - 24,237,410 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362222,566,565 - 22,567,409 (+)NCBINCBI36Build 36hg18NCBI36
Build 342222,561,118 - 22,561,963NCBI
Celera228,074,325 - 8,075,169 (+)NCBICelera
Cytogenetic Map22q11.23NCBI
HuRef227,221,904 - 7,222,748 (+)NCBIHuRef
CHM1_12224,248,957 - 24,249,801 (+)NCBICHM1_1
T2T-CHM13v2.02224,338,982 - 24,339,822 (+)NCBIT2T-CHM13v2.0
Mif
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391075,695,187 - 75,696,111 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1075,695,187 - 75,696,074 (-)EnsemblGRCm39 Ensembl
GRCm381075,859,353 - 75,860,277 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1075,859,353 - 75,860,240 (-)EnsemblGRCm38mm10GRCm38
MGSCv371075,322,098 - 75,322,995 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361075,303,069 - 75,303,966 (-)NCBIMGSCv36mm8
Celera1076,904,043 - 76,904,940 (-)NCBICelera
Cytogenetic Map10C1NCBI
cM Map1038.59NCBI
Mif
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82012,767,138 - 12,791,222 (+)NCBIGRCr8
mRatBN7.22012,790,919 - 12,791,784 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2012,790,902 - 12,799,504 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2013,497,160 - 13,498,025 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02012,858,083 - 12,858,948 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02013,330,028 - 13,330,893 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02013,715,219 - 13,732,980 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2013,732,198 - 13,732,859 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02015,885,248 - 15,886,113 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42013,191,986 - 13,192,851 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12013,192,212 - 13,193,078 (+)NCBI
Celera2014,283,080 - 14,283,945 (+)NCBICelera
Cytogenetic Map20p12NCBI
Mif
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554558,367,566 - 8,368,460 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554558,367,566 - 8,368,460 (-)NCBIChiLan1.0ChiLan1.0
MIF
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22333,619,974 - 33,623,761 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12236,356,394 - 36,360,177 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0224,646,986 - 4,647,831 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12222,729,245 - 22,732,009 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2222,730,807 - 22,732,009 (+)Ensemblpanpan1.1panPan2
MIF
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Dog10K_Boxer_Tasha2627,715,404 - 27,716,260 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02630,047,047 - 30,047,902 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2630,047,057 - 30,047,856 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12628,128,386 - 28,129,245 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02627,746,427 - 27,747,273 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02628,734,407 - 28,735,264 (-)NCBIUU_Cfam_GSD_1.0
Mif
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118141,546,059 - 141,547,004 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366191,203,746 - 1,208,442 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366191,207,058 - 1,208,010 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MIF
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1449,840,305 - 49,841,068 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11449,840,303 - 49,841,063 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21453,282,553 - 53,283,313 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Mif
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474710,303,919 - 10,308,821 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474710,307,826 - 10,308,649 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

endocrine system hemolymphoid system nervous system
High
Medium 36 20 60
Low
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts XM_007975114 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JACDXN010000068 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSCSAT00000009109   ⟹   ENSCSAP00000007237
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl197,000,793 - 7,001,757 (+)Ensembl
RefSeq Acc Id: XM_007975114   ⟹   XP_007973305
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1197,000,837 - 7,001,700 (+)NCBI
Vero_WHO_p1.0NW_023666100368,099 - 370,934 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_007973305 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCSAP00000007237
  ENSCSAP00000007237.1
Reference Protein Sequences
RefSeq Acc Id: XP_007973305   ⟸   XM_007975114
- UniProtKB: A0A0D9RF48 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCSAP00000007237   ⟸   ENSCSAT00000009109


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000011019 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000009109.1 UniProtKB/TrEMBL
Gene3D-CATH 3.30.429.10 UniProtKB/TrEMBL
InterPro Macrophage_inhib_fac UniProtKB/TrEMBL
  Macrophage_inhib_fac_CS UniProtKB/TrEMBL
  Tautomerase/MIF_sf UniProtKB/TrEMBL
KEGG Report csab:103223031 UniProtKB/TrEMBL
NCBI Gene MIF ENTREZGENE
PANTHER MACROPHAGE MIGRATION INHIBITORY FACTOR UniProtKB/TrEMBL
  PTHR11954 UniProtKB/TrEMBL
Pfam MIF UniProtKB/TrEMBL
PROSITE MIF UniProtKB/TrEMBL
Superfamily-SCOP SSF55331 UniProtKB/TrEMBL
UniProt A0A0D9RF48 ENTREZGENE, UniProtKB/TrEMBL