E2f1 (E2F transcription factor 1) - Rat Genome Database

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Gene: E2f1 (E2F transcription factor 1) Rattus norvegicus
Analyze
Symbol: E2f1
Name: E2F transcription factor 1
RGD ID: 728892
Description: Enables protein kinase binding activity and sequence-specific DNA binding activity. Involved in several processes, including cellular response to hypoxia; cellular response to nerve growth factor stimulus; and positive regulation of glial cell proliferation. Located in nuclear chromosome. Biomarker of Huntington's disease and pancreatic cancer. Human ortholog(s) of this gene implicated in lung carcinoma (multiple); osteosarcoma; and pancreatic adenocarcinoma (multiple). Orthologous to human E2F1 (E2F transcription factor 1); PARTICIPATES IN cell cycle pathway, mitotic; ceramide signaling pathway; chronic myeloid leukemia pathway; INTERACTS WITH (-)-citrinin; (-)-epigallocatechin 3-gallate; 1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: E2F-1; transcription factor E2F1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Is Marker For: Strains:   SD  
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83163,524,739 - 163,535,563 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl3163,524,739 - 163,535,563 (-)EnsemblGRCr8
mRatBN7.23143,064,535 - 143,075,362 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3143,049,478 - 143,075,361 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx3146,931,136 - 146,941,990 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03155,549,300 - 155,560,154 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03153,288,668 - 153,299,512 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.03150,062,895 - 150,073,721 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3150,047,826 - 150,073,721 (-)Ensemblrn6Rnor6.0
Rnor_5.03156,435,530 - 156,446,390 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.43145,032,489 - 145,043,729 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera3141,799,009 - 141,809,945 (-)NCBICelera
RGSC_v3.13144,943,133 - 144,943,246 (-)NCBI
Cytogenetic Map3q41NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-citrinin  (EXP)
(-)-epigallocatechin 3-gallate  (EXP)
(1->4)-beta-D-glucan  (ISO)
(25R)-cholest-5-ene-3beta,26-diol  (ISO)
(S)-colchicine  (ISO)
(S)-naringenin  (ISO)
(S)-nicotine  (ISO)
1,2-dimethylhydrazine  (ISO)
1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile  (EXP)
1-chloro-2,4-dinitrobenzene  (ISO)
1-methyltryptophan  (ISO)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2-acetamidofluorene  (EXP)
26-hydroxycholesterol  (ISO)
3-[3-(tert-butylsulfanyl)-1-(4-chlorobenzyl)-5-(propan-2-yl)-1H-indol-2-yl]-2,2-dimethylpropanoic acid  (ISO)
3-aminobenzamide  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroperoxycyclophosphamide  (ISO)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-azacytidine  (ISO)
5-fluorouracil  (ISO)
5-nitroso-8-quinolinol  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
acetylsalicylic acid  (ISO)
acrylamide  (ISO)
acteoside  (ISO)
adenine  (ISO)
adenosine  (EXP)
aflatoxin B1  (EXP,ISO)
all-trans-4-oxoretinoic acid  (ISO)
all-trans-retinoic acid  (ISO)
alpha-hexylcinnamaldehyde  (ISO)
alvocidib  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
amodiaquine  (ISO)
amphetamine  (EXP)
amphibole asbestos  (ISO)
androstane  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
aspartame  (ISO)
Aspidin  (ISO)
atrazine  (ISO)
auraptene  (ISO)
azoxystrobin  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[d]isothiazol-3-one  (ISO)
benzophenanthridine  (ISO)
biotin  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP,ISO)
bortezomib  (ISO)
Butylbenzyl phthalate  (ISO)
Butylparaben  (ISO)
cadmium acetate  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (ISO)
calcitriol  (ISO)
camptothecin  (ISO)
cannabidiol  (ISO)
capsaicin  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
Cardanol  (ISO)
carmustine  (ISO)
chlorpromazine  (ISO)
chlorpyrifos  (ISO)
choline  (EXP,ISO)
chromium(6+)  (ISO)
cilostazol  (ISO)
cisplatin  (ISO)
citalopram  (EXP)
cobalt atom  (EXP)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) chloride  (ISO)
copper(II) sulfate  (ISO)
cordycepin  (ISO)
coumestrol  (ISO)
CU-O LINKAGE  (ISO)
curcumin  (EXP)
DDT  (ISO)
deguelin  (ISO)
diarsenic trioxide  (ISO)
dibenzo[a,l]pyrene  (ISO)
Dibutyl phosphate  (ISO)
diclofenac  (ISO)
dieldrin  (EXP)
diethanolamine  (EXP,ISO)
dihydroxyacetone  (ISO)
dioxygen  (ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
endosulfan  (ISO)
escitalopram  (EXP)
etoposide  (ISO)
eugenol  (ISO)
folic acid  (ISO)
FR900359  (ISO)
fulvestrant  (ISO)
furan  (EXP)
gamma-tocopherol  (ISO)
gefitinib  (ISO)
gentamycin  (EXP)
geraniol  (ISO)
glyphosate  (ISO)
GSK-J4  (ISO)
GW 3965  (ISO)
harmine  (ISO)
heparin  (ISO)
hydroquinone  (ISO)
hydroxyurea  (ISO)
Indeno[1,2,3-cd]pyrene  (ISO)
indirubin  (ISO)
inulin  (ISO)
iron atom  (EXP)
iron(0)  (EXP)
L-methionine  (ISO)
Lasiocarpine  (ISO)
lead nitrate  (ISO)
leptomycin B  (ISO)
lidocaine  (ISO)
lipopolysaccharide  (ISO)
LY294002  (ISO)
maneb  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
melatonin  (ISO)
menadione  (ISO)
methimazole  (EXP)
methotrexate  (ISO)
methylseleninic acid  (ISO)
mifepristone  (ISO)
mitomycin C  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
monocrotaline  (ISO)
monosodium L-glutamate  (ISO)
motexafin gadolinium  (ISO)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (ISO)
N-acetyl-L-cysteine  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (ISO)
N-nitrosodiethylamine  (ISO)
nickel atom  (EXP)
nickel dichloride  (EXP,ISO)
niclosamide  (ISO)
nicotine  (ISO)
Nonylphenol  (EXP,ISO)
ochratoxin A  (ISO)
okadaic acid  (ISO)
oleic acid  (ISO)
ozone  (ISO)
p-menthan-3-ol  (ISO)
paclitaxel  (EXP,ISO)
palbociclib  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
parathion  (ISO)
pentachlorophenol  (EXP)
perfluorooctane-1-sulfonic acid  (ISO)
phenobarbital  (ISO)
phenytoin  (ISO)
phosphoramide mustard  (EXP)
phthalaldehyde  (ISO)
piperonyl butoxide  (ISO)
pirinixic acid  (ISO)
plumbagin  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
progesterone  (ISO)
propylparaben  (ISO)
PX-866  (ISO)
quercetin  (ISO)
quinoline  (ISO)
raloxifene  (ISO)
resveratrol  (ISO)
riddelliine  (ISO)
rifampicin  (ISO)
ritonavir  (ISO)
royal jelly  (EXP)
selenium atom  (ISO)
silicon dioxide  (ISO)
silver(1+) nitrate  (ISO)
simvastatin  (ISO)
sirolimus  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sulfadimethoxine  (EXP)
sulforaphane  (ISO)
sulindac  (ISO)
tamoxifen  (EXP,ISO)
tauroursodeoxycholic acid  (EXP)
tert-butyl hydroperoxide  (ISO)
testosterone  (ISO)
tetrachloromethane  (ISO)
thapsigargin  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
tocopherol  (ISO)
toluene 2,4-diisocyanate  (ISO)
trabectedin  (ISO)
trimellitic anhydride  (ISO)
triphenyl phosphate  (ISO)
Triptolide  (EXP)
troglitazone  (ISO)
trovafloxacin  (ISO)
tungsten  (EXP)
tunicamycin  (ISO)
urethane  (ISO)
ursodeoxycholic acid  (EXP)
valproic acid  (ISO)
vemurafenib  (ISO)
vincaleukoblastine  (ISO)
vinyl carbamate  (ISO)
wortmannin  (ISO)
zinc acetate  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Expression of transcription factor E2F1 and telomerase in glioblastomas: mechanistic linkage and prognostic significance. Alonso MM, etal., J Natl Cancer Inst. 2005 Nov 2;97(21):1589-600. doi: 10.1093/jnci/dji340.
2. Gamma-linolenic acid alters Ku80, E2F1, and bax expression and induces micronucleus formation in C6 glioma cells in vitro. Benadiba M, etal., IUBMB Life. 2009 Mar;61(3):244-51.
3. Lysine acetyltransferase GCN5 potentiates the growth of non-small cell lung cancer via promotion of E2F1, cyclin D1, and cyclin E1 expression. Chen L, etal., J Biol Chem. 2013 May 17;288(20):14510-21. doi: 10.1074/jbc.M113.458737. Epub 2013 Mar 29.
4. The over expression of long non-coding RNA ANRIL promotes epithelial-mesenchymal transition by activating the ATM-E2F1 signaling pathway in pancreatic cancer: An in vivo and in vitro study. Chen S, etal., Int J Biol Macromol. 2017 Sep;102:718-728. doi: 10.1016/j.ijbiomac.2017.03.123. Epub 2017 Mar 23.
5. Gene expression profile of circulating CD34(+) cells and granulocytes in chronic myeloid leukemia. Cokic VP, etal., Blood Cells Mol Dis. 2015 Dec;55(4):373-81. doi: 10.1016/j.bcmd.2015.08.002. Epub 2015 Aug 7.
6. Knockdown of E2f1 by RNA interference impairs proliferation of rat cells in vitro. Dos Reis Vasques L, etal., Genet Mol Biol. 2010 Jan;33(1):17-22. doi: 10.1590/S1415-47572009005000104. Epub 2010 Mar 1.
7. Differential expression of members of the E2F family of transcription factors in rodent testes. El-Darwish KS, etal., Reprod Biol Endocrinol. 2006 Dec 5;4:63.
8. Distinct pattern of E2F1 expression in human lung tumours: E2F1 is upregulated in small cell lung carcinoma. Eymin B, etal., Oncogene. 2001 Mar 29;20(14):1678-87. doi: 10.1038/sj.onc.1204242.
9. Impaired pancreatic growth, beta cell mass, and beta cell function in E2F1 (-/- )mice. Fajas L, etal., J Clin Invest 2004 May;113(9):1288-95.
10. E2F-1 functions in mice to promote apoptosis and suppress proliferation. Field SJ, etal., Cell 1996 May 17;85(4):549-61.
11. Differences in E2F subunit expression in quiescent and proliferating vascular smooth muscle cells. Fujita N, etal., Am J Physiol Heart Circ Physiol 2002 Jul;283(1):H204-12.
12. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
13. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
14. Transcription factor E2F-1 acts as a growth-promoting factor and is associated with adverse prognosis in non-small cell lung carcinomas. Gorgoulis VG, etal., J Pathol. 2002 Oct;198(2):142-56. doi: 10.1002/path.1121.
15. Diabetes and exocrine pancreatic insufficiency in E2F1/E2F2 double-mutant mice. Iglesias A, etal., J Clin Invest 2004 May;113(10):1398-407.
16. The transcriptional co-regulator HCF-1 is required for INS-1 β-cell glucose-stimulated insulin secretion. Iwata TN, etal., PLoS One. 2013 Nov 8;8(11):e78841. doi: 10.1371/journal.pone.0078841. eCollection 2013.
17. Altered distribution of cell cycle transcriptional regulators during Alzheimer disease. Jordan-Sciutto KL, etal., J Neuropathol Exp Neurol. 2002 Apr;61(4):358-67.
18. Cell cycle proteins exhibit altered expression patterns in lentiviral-associated encephalitis. Jordan-Sciutto KL, etal., J Neurosci. 2002 Mar 15;22(6):2185-95.
19. Adenovirus-mediated E2F-1 gene transfer in nonsmall-cell lung cancer induces cell growth arrest and apoptosis. Kuhn H, etal., Eur Respir J. 2002 Sep;20(3):703-9.
20. Expression signature of E2F1 and its associated genes predict superficial to invasive progression of bladder tumors. Lee JS, etal., J Clin Oncol. 2010 Jun 1;28(16):2660-7. doi: 10.1200/JCO.2009.25.0977. Epub 2010 Apr 26.
21. Ribosomal protein S3, a new substrate of Akt, serves as a signal mediator between neuronal apoptosis and DNA repair. Lee SB, etal., J Biol Chem. 2010 Sep 17;285(38):29457-68. doi: 10.1074/jbc.M110.131367. Epub 2010 Jul 6.
22. Tumour growth-suppressive effect of arsenic trioxide in squamous cell lung carcinoma. Leung LL, etal., Oncol Lett. 2017 Sep;14(3):3748-3754. doi: 10.3892/ol.2017.6646. Epub 2017 Jul 21.
23. Differential regulation of MMPs by E2F1, Sp1 and NF-kappa B controls the small cell lung cancer invasive phenotype. Li Z, etal., BMC Cancer. 2014 Apr 22;14:276. doi: 10.1186/1471-2407-14-276.
24. TRIM28 knockdown increases sensitivity to etoposide by upregulating E2F1 in non-small cell lung cancer. Liu L, etal., Oncol Rep. 2017 Jun;37(6):3597-3605. doi: 10.3892/or.2017.5638. Epub 2017 May 11.
25. Genome-wide array-based comparative genomic hybridization analysis of pancreatic adenocarcinoma: identification of genetic indicators that predict patient outcome. Loukopoulos P, etal., Cancer Sci. 2007 Mar;98(3):392-400. doi: 10.1111/j.1349-7006.2007.00395.x. Epub 2007 Jan 12.
26. The long noncoding RNA H19 promotes cell proliferation via E2F-1 in pancreatic ductal adenocarcinoma. Ma L, etal., Cancer Biol Ther. 2016 Oct 2;17(10):1051-1061. doi: 10.1080/15384047.2016.1219814. Epub 2016 Aug 29.
27. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
28. Up-regulation of E2F-1 in Down's syndrome brain exhibiting neuropathological features of Alzheimer-type dementia. Motonaga K, etal., Brain Res. 2001 Jun 29;905(1-2):250-3.
29. Cell cycle activation in striatal neurons from Huntington's disease patients and rats treated with 3-nitropropionic acid. Pelegri C, etal., Int J Dev Neurosci. 2008 Nov;26(7):665-71. Epub 2008 Aug 12.
30. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
31. GOA pipeline RGD automated data pipeline
32. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
33. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
34. Antagonism of E2F-1 regulated Bnip3 transcription by NF-kappaB is essential for basal cell survival. Shaw J, etal., Proc Natl Acad Sci U S A. 2008 Dec 30;105(52):20734-9. Epub 2008 Dec 16.
35. E2F1 silencing inhibits migration and invasion of osteosarcoma cells via regulating DDR1 expression. Wang Z, etal., Int J Oncol. 2017 Dec;51(6):1639-1650. doi: 10.3892/ijo.2017.4165. Epub 2017 Oct 16.
36. A retinoblastoma-binding protein that affects cell-cycle control and confers transforming ability. Woitach JT, etal., Nat Genet 1998 Aug;19(4):371-4.
37. Gene expression profiling of lung adenocarcinoma in Xuanwei, China. Wu H, etal., Eur J Cancer Prev. 2016 Nov;25(6):508-17. doi: 10.1097/CEJ.0000000000000214.
38. Gambogic acid sensitizes gemcitabine efficacy in pancreatic cancer by reducing the expression of ribonucleotide reductase subunit-M2 (RRM2). Xia G, etal., J Exp Clin Cancer Res. 2017 Aug 10;36(1):107. doi: 10.1186/s13046-017-0579-0.
39. Chromatin Remodeling Factor LSH is Upregulated by the LRP6-GSK3ß-E2F1 Axis Linking Reversely with Survival in Gliomas. Xiao D, etal., Theranostics. 2017 Jan 1;7(1):132-143. doi: 10.7150/thno.17032. eCollection 2017.
40. Antitumor and modeling studies of a penetratin-peptide that targets E2F-1 in small cell lung cancer. Xie X, etal., Cancer Biol Ther. 2013 Aug;14(8):742-51. doi: 10.4161/cbt.25184. Epub 2013 Jun 3.
41. Tumor induction and tissue atrophy in mice lacking E2F-1. Yamasaki L, etal., Cell 1996 May 17;85(4):537-48.
42. Expression of transcription factor E2F-1 in pancreatic ductal carcinoma: an immunohistochemical study. Yamazaki K, etal., Pathol Res Pract. 2003;199(1):23-8. doi: 10.1078/0344-0338-00348.
43. The cell cycle factor E2F-1 activates Bnip3 and the intrinsic death pathway in ventricular myocytes. Yurkova N, etal., Circ Res. 2008 Feb 29;102(4):472-9. Epub 2007 Dec 20.
44. The association of GSK3 beta with E2F1 facilitates nerve growth factor-induced neural cell differentiation. Zhou F, et al., J Biol Chem. 2008 May 23;283(21):14506-15. doi: 10.1074/jbc.M706136200. Epub 2008 Mar 26.
Additional References at PubMed
PMID:3951992   PMID:7797074   PMID:8673024   PMID:8918469   PMID:10082561   PMID:10597240   PMID:10779331   PMID:11004506   PMID:11071387   PMID:11095619   PMID:11331592   PMID:11418595  
PMID:11672531   PMID:12007404   PMID:12717439   PMID:12893818   PMID:14514686   PMID:14593116   PMID:14667810   PMID:15073182   PMID:15158336   PMID:15525772   PMID:15565177   PMID:15722552  
PMID:15731768   PMID:15735762   PMID:15766563   PMID:15990448   PMID:16360038   PMID:16717102   PMID:17062573   PMID:17102628   PMID:17404573   PMID:17482685   PMID:17555552   PMID:17989570  
PMID:18348166   PMID:18364697   PMID:18541936   PMID:18818403   PMID:19545562   PMID:20040599   PMID:20176812   PMID:20224733   PMID:20299467   PMID:21454377   PMID:21614651   PMID:21641965  
PMID:21937878   PMID:21964190   PMID:22476863   PMID:22592528   PMID:22848730   PMID:23332764   PMID:23629655   PMID:24014029   PMID:24453336   PMID:24726645   PMID:26306672   PMID:28125090  
PMID:29936143   PMID:34342400   PMID:35457270   PMID:36111777   PMID:37403456  


Genomics

Comparative Map Data
E2f1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83163,524,739 - 163,535,563 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl3163,524,739 - 163,535,563 (-)EnsemblGRCr8
mRatBN7.23143,064,535 - 143,075,362 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3143,049,478 - 143,075,361 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx3146,931,136 - 146,941,990 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03155,549,300 - 155,560,154 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03153,288,668 - 153,299,512 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.03150,062,895 - 150,073,721 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3150,047,826 - 150,073,721 (-)Ensemblrn6Rnor6.0
Rnor_5.03156,435,530 - 156,446,390 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.43145,032,489 - 145,043,729 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera3141,799,009 - 141,809,945 (-)NCBICelera
RGSC_v3.13144,943,133 - 144,943,246 (-)NCBI
Cytogenetic Map3q41NCBI
E2F1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382033,675,477 - 33,686,385 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2033,675,477 - 33,686,385 (-)Ensemblhg38GRCh38
GRCh372032,263,283 - 32,274,191 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362031,727,150 - 31,737,854 (-)NCBIBuild 36Build 36hg18NCBI36
Build 342031,727,149 - 31,737,854NCBI
Celera2029,016,324 - 29,027,242 (-)NCBICelera
Cytogenetic Map20q11.22NCBI
HuRef2029,049,266 - 29,060,184 (-)NCBIHuRef
CHM1_12032,164,384 - 32,175,302 (-)NCBICHM1_1
T2T-CHM13v2.02035,402,008 - 35,412,916 (-)NCBIT2T-CHM13v2.0
E2f1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392154,401,320 - 154,411,812 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2154,401,327 - 154,411,812 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm382154,559,400 - 154,569,892 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2154,559,407 - 154,569,892 (-)Ensemblmm10GRCm38
MGSCv372154,385,375 - 154,395,588 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv362154,251,080 - 154,261,293 (-)NCBIMGSCv36mm8
Celera2160,474,227 - 160,486,251 (-)NCBICelera
Cytogenetic Map2H1NCBI
cM Map276.79NCBI
E2f1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542227,633,827 - 27,642,241 (+)Ensembl
ChiLan1.0NW_00495542227,638,625 - 27,643,261 (+)NCBIChiLan1.0ChiLan1.0
E2F1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22139,366,654 - 39,382,253 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12039,359,755 - 39,370,541 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02029,963,083 - 29,973,860 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12031,103,764 - 31,115,211 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2031,103,764 - 31,110,604 (-)EnsemblpanPan2panpan1.1
E2F1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12422,895,149 - 22,904,689 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2422,878,402 - 22,904,656 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2422,540,395 - 22,549,906 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02423,581,877 - 23,591,392 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2423,581,862 - 23,616,878 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12422,874,367 - 22,883,878 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02422,967,923 - 22,977,434 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02423,399,012 - 23,408,523 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
E2f1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640171,848,495 - 171,859,005 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365616,896,063 - 6,900,026 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365616,894,827 - 6,901,058 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
E2F1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1737,178,599 - 37,189,883 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11737,178,587 - 37,190,118 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21742,116,195 - 42,125,518 (-)NCBISscrofa10.2Sscrofa10.2susScr3
E2F1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1237,968,541 - 37,980,461 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl237,968,556 - 37,980,326 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366605088,901,404 - 88,913,369 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
E2f1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248425,602,432 - 5,612,951 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248425,602,432 - 5,612,951 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
E2f1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v15133,928,146 - 133,947,590 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in E2f1
61 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:216
Count of miRNA genes:137
Interacting mature miRNAs:168
Transcripts:ENSRNOT00000022428
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2301411Bp320Blood pressure QTL 3200.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3141555229186555229Rat
12879876Bw182Body weight QTL 1820.003body mass (VT:0001259)body weight (CMO:0000012)3141555229186555229Rat
1582233Insul10Insulin level QTL 105.40.0015blood insulin amount (VT:0001560)serum insulin level times blood glucose level (CMO:0002040)3133259579178259579Rat
12879872Cm97Cardiac mass QTL 970.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)3141555229186555229Rat
1578653Vnigr3Vascular neointimal growth QTL 33.1artery morphology trait (VT:0002191)artery neointimal hyperplastic lesion area (CMO:0001414)3151075912189428310Rat
12879873Cm96Cardiac mass QTL 960.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)3141555229186555229Rat
2302373Gluco39Glucose level QTL 395.01blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)3129154923182114333Rat
12879874Cm98Cardiac mass QTL 980.005heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)3141555229186555229Rat
1298068Bp167Blood pressure QTL 1670.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3161492708189428310Rat
12879875Kidm64Kidney mass QTL 640.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)3141555229186555229Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)351581665184004958Rat
2292591Esta4Estrogen-induced thymic atrophy QTL 4thymus mass (VT:0004954)thymus wet weight (CMO:0000855)367641776167835660Rat
61335Bp20Blood pressure QTL 203arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3161799493176036425Rat
1331726Bp208Blood pressure QTL 2083.129arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3161799270187311134Rat
1578754Stresp16Stress response QTL 1640.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)3133134628178134628Rat
1582213Insul6Insulin level QTL 63.70.0009blood insulin amount (VT:0001560)calculated serum insulin level (CMO:0000359)3155759447189428310Rat
1300173Rf11Renal function QTL 113.38renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)3141508991166376254Rat
9589106Insul23Insulin level QTL 2313.860.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)3152055202189428310Rat
10755461Coatc16Coat color QTL 16coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)3142898802187898802Rat
8662816Vetf4Vascular elastic tissue fragility QTL 44renal artery integrity trait (VT:0010642)number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)379649560177741895Rat
1559282Emca5Estrogen-induced mammary cancer QTL 53.9mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)3145335553189428310Rat
2303620Vencon4Ventilatory control QTL 43.9respiration trait (VT:0001943)tidal volume (CMO:0000222)3125116475170116475Rat
1582256Insul9Insulin level QTL 94.40.0016blood insulin amount (VT:0001560)absolute change in serum insulin level (CMO:0002038)3155759447189428310Rat
1576306Schws3Schwannoma susceptibility QTL 30.001nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)3139299381184299381Rat
1300159Kidm4Kidney mass QTL 43.83kidney mass (VT:0002707)right kidney wet weight to body weight ratio (CMO:0001953)3141508991177728348Rat
5686842Rf59Renal function QTL 59urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)3122395989167395989Rat
631673Iddm13Insulin dependent diabetes mellitus QTL 131.30.663blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)3137114333182114333Rat
1582248Insul7Insulin level QTL 73.90.0041blood insulin amount (VT:0001560)calculated serum insulin level (CMO:0000359)3155759447189428310Rat
2301971Cm71Cardiac mass QTL 714.63heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)3131036586176036586Rat
2301970Bw81Body weight QTL 815.19body mass (VT:0001259)body weight (CMO:0000012)3131036586176036586Rat
1581546Pur13Proteinuria QTL 132.930.0335urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)398651826167012663Rat
1578666Vnigr1Vascular neointimal growth QTL 14.6artery morphology trait (VT:0002191)artery lumen area (CMO:0001409)3151075912189428310Rat
1578656Vnigr2Vascular neointimal growth QTL 24.2artery morphology trait (VT:0002191)lesioned artery residual lumen area (CMO:0001417)3151075912189428310Rat
12879871Am7Aortic mass QTL 70.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)3141555229186555229Rat
631541Bp81Blood pressure QTL 814arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3144575244189428310Rat
2293087Iddm27Insulin dependent diabetes mellitus QTL 272.68blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)3160357340167835660Rat

Markers in Region
D3Mgh29  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23143,087,759 - 143,087,884 (+)MAPPERmRatBN7.2
Rnor_6.03150,086,036 - 150,086,160NCBIRnor6.0
Rnor_5.03156,458,570 - 156,458,694UniSTSRnor5.0
RGSC_v3.43145,055,522 - 145,055,647RGDRGSC3.4
RGSC_v3.43145,055,523 - 145,055,647UniSTSRGSC3.4
Celera3141,820,568 - 141,820,692UniSTS
RGSC_v3.15151,483,686 - 151,484,060RGD
SHRSP x BN Map367.6099UniSTS
SHRSP x BN Map367.6099RGD
FHH x ACI Map384.7199RGD
Cytogenetic Map3q41UniSTS
UniSTS:234576  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23143,068,189 - 143,068,402 (+)MAPPERmRatBN7.2
Rnor_6.03150,066,550 - 150,066,762NCBIRnor6.0
Rnor_5.03156,439,185 - 156,439,397UniSTSRnor5.0
RGSC_v3.43145,036,144 - 145,036,356UniSTSRGSC3.4
Celera3141,802,800 - 141,803,012UniSTS
Cytogenetic Map3q41UniSTS
PMC152357P4  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23143,075,010 - 143,075,096 (+)MAPPERmRatBN7.2
Rnor_6.03150,073,371 - 150,073,456NCBIRnor6.0
Rnor_5.03156,446,040 - 156,446,125UniSTSRnor5.0
RGSC_v3.43145,043,379 - 145,043,464UniSTSRGSC3.4
Celera3141,809,595 - 141,809,680UniSTS
Cytogenetic Map3q41UniSTS
PMC152357P3  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr83163,535,408 - 163,535,488 (+)Marker Load Pipeline
mRatBN7.23143,075,205 - 143,075,286 (+)MAPPERmRatBN7.2
Rnor_6.03150,073,566 - 150,073,646NCBIRnor6.0
Rnor_5.03156,446,235 - 156,446,315UniSTSRnor5.0
RGSC_v3.43145,043,574 - 145,043,654UniSTSRGSC3.4
Celera3141,809,790 - 141,809,870UniSTS
Cytogenetic Map3q41UniSTS
E2f1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23143,065,743 - 143,066,412 (+)MAPPERmRatBN7.2
Rnor_6.03150,064,104 - 150,064,772NCBIRnor6.0
Rnor_5.03156,436,739 - 156,437,407UniSTSRnor5.0
RGSC_v3.43145,033,698 - 145,034,366UniSTSRGSC3.4
Celera3141,800,218 - 141,800,886UniSTS
Cytogenetic Map3q41UniSTS


Related Rat Strains
The following Strains have been annotated to E2f1
SD    


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 163 91 90 59 91 59 6 355 191 11 142 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000022115   ⟹   ENSRNOP00000022115
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3143,049,478 - 143,063,951 (-)Ensembl
Rnor_6.0 Ensembl3150,047,826 - 150,062,311 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000022428   ⟹   ENSRNOP00000022428
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl3163,524,739 - 163,535,563 (-)Ensembl
mRatBN7.2 Ensembl3143,049,478 - 143,075,361 (-)Ensembl
Rnor_6.0 Ensembl3150,062,895 - 150,073,721 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000086933   ⟹   ENSRNOP00000070039
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3143,049,478 - 143,063,951 (-)Ensembl
Rnor_6.0 Ensembl3150,048,341 - 150,064,438 (-)Ensembl
RefSeq Acc Id: NM_001100778   ⟹   NP_001094248
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83163,524,739 - 163,535,563 (-)NCBI
mRatBN7.23143,064,535 - 143,075,361 (-)NCBI
Rnor_6.03150,062,895 - 150,073,721 (-)NCBI
Rnor_5.03156,435,530 - 156,446,390 (-)NCBI
RGSC_v3.43145,032,489 - 145,043,729 (-)RGD
Celera3141,799,009 - 141,809,945 (-)RGD
Sequence:
RefSeq Acc Id: XM_039105617   ⟹   XP_038961545
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83163,526,006 - 163,535,560 (-)NCBI
mRatBN7.23143,065,806 - 143,075,362 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001094248 (Get FASTA)   NCBI Sequence Viewer  
  XP_038961545 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein BAA09641 (Get FASTA)   NCBI Sequence Viewer  
  EDL85956 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000022428
GenBank Protein O09139 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001094248   ⟸   NM_001100778
- UniProtKB: O09139 (UniProtKB/Swiss-Prot),   A6KHZ9 (UniProtKB/TrEMBL),   A0A8L2QBV4 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000022428   ⟸   ENSRNOT00000022428
Ensembl Acc Id: ENSRNOP00000022115   ⟸   ENSRNOT00000022115
Ensembl Acc Id: ENSRNOP00000070039   ⟸   ENSRNOT00000086933
RefSeq Acc Id: XP_038961545   ⟸   XM_039105617
- Peptide Label: isoform X1
Protein Domains
ABM   E2F/DP family winged-helix DNA-binding   EF-hand

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O09139-F1-model_v2 AlphaFold O09139 1-432 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13692575
Promoter ID:EPDNEW_R3100
Type:single initiation site
Name:E2f1_1
Description:E2F transcription factor 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.03150,073,687 - 150,073,747EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:728892 AgrOrtholog
BioCyc Gene G2FUF-47169 BioCyc
Ensembl Genes ENSRNOG00000016708 Ensembl
  ENSRNOG00000072439 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000022428 ENTREZGENE
Gene3D-CATH 1.10.10.10 UniProtKB/Swiss-Prot
  6.10.250.540 UniProtKB/Swiss-Prot
InterPro E2F UniProtKB/Swiss-Prot
  E2F-DP_heterodim UniProtKB/Swiss-Prot
  E2F_CC-MB UniProtKB/Swiss-Prot
  E2F_WHTH_DNA-bd_dom UniProtKB/Swiss-Prot
  WH-like_DNA-bd_sf UniProtKB/Swiss-Prot
  WH_DNA-bd_sf UniProtKB/Swiss-Prot
KEGG Report rno:399489 UniProtKB/Swiss-Prot
NCBI Gene 399489 ENTREZGENE
PANTHER PTHR12081 UniProtKB/Swiss-Prot
  TRANSCRIPTION FACTOR E2F1 UniProtKB/Swiss-Prot
Pfam E2F_CC-MB UniProtKB/Swiss-Prot
  E2F_TDP UniProtKB/Swiss-Prot
PharmGKB E2F1 RGD
PhenoGen E2f1 PhenoGen
RatGTEx ENSRNOG00000016708 RatGTEx
  ENSRNOG00000072439 RatGTEx
SMART E2F_TDP UniProtKB/Swiss-Prot
Superfamily-SCOP SSF144074 UniProtKB/Swiss-Prot
  SSF46785 UniProtKB/Swiss-Prot
UniProt A0A0G2JWW3_RAT UniProtKB/TrEMBL
  A0A8L2QBV4 ENTREZGENE, UniProtKB/TrEMBL
  A6KHZ9 ENTREZGENE, UniProtKB/TrEMBL
  E2F1_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-12-14 E2f1  E2F transcription factor 1      Symbol and Name status set to approved 1299863 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_disease associated with atherosclerosis, hypertension, and restenosis after injury 625751
gene_expression expressed in vascular smooth muscle cells, fibroblasts and Saos-2 cell line 625751
gene_function transcription factor 625751
gene_process controls G1/S transition of eukaryotic cells by monitoring the regulation of transcription of growth-related genes 625751
gene_process involved in induction of S phase progression in quiescent cells 625751
gene_product member of transcriptional factor family 625751
gene_regulation RNA expression levels were downregulated in quiescent cells 625751
gene_regulation fetal bovine serum [FBS] induced upregulation of E2f1 mRNA and protein levels by inducing free E2f1 binding onto its promoter 625751