RGD Reference Report - Cell cycle activation in striatal neurons from Huntington's disease patients and rats treated with 3-nitropropionic acid. - Rat Genome Database

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Cell cycle activation in striatal neurons from Huntington's disease patients and rats treated with 3-nitropropionic acid.

Authors: Pelegri, C  Duran-Vilaregut, J  Del Valle, J  Crespo-Biel, N  Ferrer, I  Pallas, M  Camins, A  Vilaplana, J 
Citation: Pelegri C, etal., Int J Dev Neurosci. 2008 Nov;26(7):665-71. Epub 2008 Aug 12.
RGD ID: 2316262
Pubmed: PMID:18768156   (View Abstract at PubMed)
DOI: DOI:10.1016/j.ijdevneu.2008.07.016   (Journal Full-text)

This study was undertaken to investigate the potential role of cell cycle re-entry in an experimental model of Huntington's disease and in human brain samples. We found that after treatment of rats with the mitochondrial neurotoxin 3-nitropropionic acid, the expression of cell cycle markers of G1 phase measured by immunohistochemistry was induced in the striatal brain region. Furthermore, we detected an increase in the nuclear and also cytoplasmatic E2F-1 expression, suggesting that this protein could activate the apoptotic cascade in rat brain. Western blot analysis of post-mortem brain samples from patients also showed an increase in the expression of E2F-1 and cyclin D1 in comparison with control samples. These results indicate that cell cycle re-entry is activated in Huntington's disease and may contribute to the neurodegenerative process.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Huntington's disease  IEP 2316262; 2316262protein:increased expression:brainRGD 
Huntington's disease  ISO and 2316262protein:increased expression:brainRGD 

Objects Annotated

Genes (Rattus norvegicus)
E2f1  (E2F transcription factor 1)

Genes (Mus musculus)
E2f1  (E2F transcription factor 1)

Genes (Homo sapiens)
E2F1  (E2F transcription factor 1)


Additional Information