RGD Reference Report - Impaired pancreatic growth, beta cell mass, and beta cell function in E2F1 (-/- )mice. - Rat Genome Database

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Impaired pancreatic growth, beta cell mass, and beta cell function in E2F1 (-/- )mice.

Authors: Fajas, L  Annicotte, JS  Miard, S  Sarruf, D  Watanabe, M  Auwerx, J 
Citation: Fajas L, etal., J Clin Invest 2004 May;113(9):1288-95.
RGD ID: 1300307
Pubmed: PMID:15124020   (View Abstract at PubMed)
PMCID: PMC398423   (View Article at PubMed Central)
DOI: DOI:10.1172/JCI18555   (Journal Full-text)

We evaluated the effects of E2F1 on glucose homeostasis using E2F1(-/-) mice. E2F1(-/-) mice show an overall reduction in pancreatic size as the result of impaired postnatal pancreatic growth. Furthermore, these animals have dysfunctional beta cells, linked to impaired PDX-1 activity. Because of the disproportionate small pancreas and dysfunctional islets, E2F1(-/-) mice secrete insufficient amounts of insulin in response to a glucose load, resulting in glucose intolerance. Despite this glucose intolerance, E2F1(-/-) mice do not develop overt diabetes mellitus because they have insulin hypersensitivity, which is secondary to a diminished adipose tissue mass and altered adipocytokine levels, which compensates for the defect in insulin secretion. These data demonstrate that factors controlling cell proliferation, such as E2F1, determine pancreatic growth and function, subsequently affecting metabolic homeostasis.

Objects referenced in this article
Gene E2F1 E2F transcription factor 1 Homo sapiens
Gene Ccne2 cyclin E2 Mus musculus
Gene Tk1 thymidine kinase 1 Mus musculus
Gene E2f1 E2F transcription factor 1 Rattus norvegicus

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