Gene:	Fzd2 ( Rattus norvegicus ) frizzled homolog 2 (Drosophila)
Description:	G-protein coupled receptor that binds Wnt proteins and induces intracellular calcium release; also mediates signaling via inhibition of cGMP
Synonyms:	Drosophila polarity gene (frizzled) homologue; Fz-10; Drosophila polarity gene homolog 2; Fzd10;
ArrayIDs:	6187471; A_43_P13417; GE19589; 1377954_at; 5973947; 6083313; 1391067_at; 6558888; 1398304_at; rc_AI136728_at; 1379404_at; 6184753; 6233368; 5838281; 5748261; L02530_at; 6676319; 6309818; 6256561; rc_AI229650_at;  (details...)
Gene Type:	protein-coding
Additional Data
Homologs
Homo sapiens: FZD2     See the Human gene in context in:     UCSC     NCBI MapViewer
Mus musculus: Fzd2     See the Mouse gene in context in:     UCSC     NCBI MapViewer
Comparative Map Data Species Symbol Map Name Chr. Position Rattus norvegicus Fzd2 Rat Celera Assembly 10 86269032 - 86270942     RGSC genome assembly v3.4 10 91709222 - 91711132     Cytogenetic 10 q32.1     genome assembly 3.1 10 91723591 - 91725502 Mus musculus Fzd2 Mouse genome assembly build 36.1 11 102465745 - 102469372     Cytogenetic 11 11 E1 Homo sapiens FZD2 human genome assembly 17 39990450 - 39992433     Human genome assembly build 36.2 17 39990451 - 39992433     Cytogenetic 17 q21.1   View comparative maps:      NCBI MapViewer
Genome
View:
Browsers:	Select a browser to viewGene (GBrowse)Gene and SNPs (GBrowse)UCSCVCMAPEnsemblNCBIECRVISTAVISTA+UCSC
Annotation
Molecular Function	Gene Ontology protein binding,  non-G-protein coupled 7TM receptor activity,  G-protein coupled receptor activity ...  (details...)
Biological Process	Gene Ontology elevation of cytosolic calcium ion concentration,  multicellular organismal development,  G-protein coupled receptor protein signaling pathway ...  (details...)
Cellular Component	Gene Ontology membrane,  integral to membrane (details...)
Disease	Ontology Breast Neoplasms,  Leiomyoma (details...)
Pathway	Ontology Wnt signaling pathway (details...)
External Links
Databases	DATABASE ID SOURCE SMART: FRI IPI PROSITE: FZ IPI PROSITE: G_PROTEIN_RECEP_F2_4 IPI UNIPARC: UPI000012AE09 IPI KEGG Report: rno:64512 ENTREZGENE HomoloGene Group ID: 20377 ENTREZGENE Germonline: 620345 Germonline: 71012 Pfam: Frizzled IPI Pfam: Fz IPI KEGG Pathway: 04310 ENTREZGENE KEGG Pathway: 04916 ENTREZGENE KEGG Pathway: 05210 ENTREZGENE KEGG Pathway: 05217 ENTREZGENE KEGG Pathway: 05200 ENTREZGENE InterPro: Frizzled_Cys-rich. IPI InterPro: Frizzled-like_dom. IPI InterPro: Frizzled. IPI InterPro: GPCR_2-like. IPI InterPro: Frizzled_related. IPI InterPro: Frizzled_dom_subgr. IPI IPI: IPI00200613 IPI Ensembl Protein: ENSRNOP00000036154 IPI Gene3D-CATH: Frizzled_Cys-rich IPI Entrez Gene: Fzd2 ENTREZGENE UniProt: FZD2_RAT IPI Ensembl Genes: ENSRNOG00000021962 IPI Superfamily-SCOP: Frizzled_Cys-rich IPI PANTHER: Fz_related IPI PRINTS: FRIZZLED. IPI
Sequences	Nucleotide: NM_172035 Get FASTA Search GEO Profiles Nucleotide: L02530 Get FASTA Search GEO Profiles (View all 2 Nucleotide Accessions) Protein: Q08464 Get FASTA Protein: NP_742032 Get FASTA Protein: AAA41172 Get FASTA (View all 3 Protein Accessions)
Clusters	UniGene: 92324
References
Curated References	12 references in RGD related to Fzd2
Other References	5 other references at PubMed related to Fzd2
Database Information
RGD ID	71012
History	Date Current Symbol Current Name Previous Symbol Previous name Status Description Reference 15-AUG-05: Fzd2 frizzled homolog 2 (Drosophila) Fzd10 Drosophila polarity gene (frizzled) homologue APPROVED Data Merged 737654 28-APR-03: Fzd10 Drosophila polarity gene (frizzled) homologue WITHDRAWN Symbol withdrawn 625702 07-AUG-02: Fzd10 Drosophila polarity gene (frizzled) homologue PROVISIONAL Symbol and Name status set to provisional 70820 09-JUL-02: Fzd2 frizzled homolog 2 (Drosophila) APPROVED Symbol and Name updated to reflect Human and Mouse nomenclature 70877