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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 71012 Species: Rattus norvegicus RGD Object: Gene Symbol: Fzd2 Name: frizzled family receptor 2

Acc ID: CHEBI:28119 Term: 2,3,7,8-tetrachlorodibenzodioxine Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2. CasRN: 1746-01-6 Chemical ID: MESH:D013749

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
multiple interactions	ISO	RGD:732092	6480464	CTD	Tetrachlorodibenzodioxin inhibits the reaction [[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of FZD2 mRNA]	PMID:16054899
affects expression	ISO	RGD:732092	6480464	CTD	Tetrachlorodibenzodioxin affects the expression of FZD2 mRNA	PMID:21570461