RGD Reference Report - Increased expression of a homologue of drosophila tissue polarity gene "frizzled" in left ventricular hypertrophy in the rat, as identified by subtractive hybridization. - Rat Genome Database

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Increased expression of a homologue of drosophila tissue polarity gene "frizzled" in left ventricular hypertrophy in the rat, as identified by subtractive hybridization.

Authors: Blankesteijn, WM  Essers-Janssen, YP  Ulrich, MM  Smits, JF 
Citation: Blankesteijn WM, etal., J Mol Cell Cardiol. 1996 May;28(5):1187-91.
RGD ID: 4107053
Pubmed: PMID:8762054   (View Abstract at PubMed)

The molecular mechanisms that govern the development of left ventricular hypertrophy are not fully elucidated. We performed a subtractive hybridization procedure to identify genes controlling this adaptive process. Using this approach, we isolated a rat homologue of Drosophila tissue polarity gene "frizzled" 2 (fz-2). The expression of this gene was quantified by competitive reverse transcriptase polymerase chain reactions. The expression was higher in hypertrophic left ventricles at all time points tested, reaching statistical significance at days 1 and 10. We conclude that the fz-2 gene, a highly conserved gene for which a role in intra- and intercellular communication has been described, may be involved in the spatial control of ventricular remodeling.



RGD Manual Disease Annotations    Click to see Annotation Detail View
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
FZD2HumanLeft Ventricular Hypertrophy  ISOFzd2 (Rattus norvegicus)mRNA:increased expression:heart left ventricleRGD 
Fzd2RatLeft Ventricular Hypertrophy  IEP mRNA:increased expression:heart left ventricleRGD 
Fzd2MouseLeft Ventricular Hypertrophy  ISOFzd2 (Rattus norvegicus)mRNA:increased expression:heart left ventricleRGD 

Objects Annotated

Genes (Rattus norvegicus)
Fzd2  (frizzled class receptor 2)

Genes (Mus musculus)
Fzd2  (frizzled class receptor 2)

Genes (Homo sapiens)
FZD2  (frizzled class receptor 2)


Additional Information