FZD2 (frizzled class receptor 2) - Rat Genome Database

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Gene: FZD2 (frizzled class receptor 2) Canis lupus familiaris
Analyze
Symbol: FZD2
Name: frizzled class receptor 2
RGD ID: 12101174
Description: ENCODES a protein that exhibits identical protein binding (ortholog); protein heterodimerization activity (ortholog); Wnt receptor activity (ortholog); INVOLVED IN cell-cell signaling (ortholog); cellular response to growth factor stimulus (ortholog); cellular response to peptide hormone stimulus (ortholog); PARTICIPATES IN Wnt signaling pathway; Wnt signaling, non-canonical pathway; ASSOCIATED WITH autosomal dominant Robinow syndrome 1 (ortholog); autosomal dominant Robinow syndrome 2 (ortholog); autosomal dominant Robinow syndrome 3 (ortholog); FOUND IN cytoplasm (inferred); membrane (inferred); plasma membrane (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: frizzled 2, seven transmembrane spanning receptor; frizzled family receptor 2; frizzled homolog 2; frizzled-2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1918,888,711 - 18,890,549 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl918,888,696 - 18,890,525 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha918,275,000 - 18,278,038 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0919,578,886 - 19,581,949 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl919,580,230 - 19,581,927 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1918,433,221 - 18,436,253 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0918,616,401 - 18,619,457 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0918,760,592 - 18,763,652 (-)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:29502342   PMID:30032202  


Genomics

Comparative Map Data
FZD2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1918,888,711 - 18,890,549 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl918,888,696 - 18,890,525 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha918,275,000 - 18,278,038 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0919,578,886 - 19,581,949 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl919,580,230 - 19,581,927 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1918,433,221 - 18,436,253 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0918,616,401 - 18,619,457 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0918,760,592 - 18,763,652 (-)NCBIUU_Cfam_GSD_1.0
FZD2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381744,557,484 - 44,561,262 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1744,557,484 - 44,561,262 (+)EnsemblGRCh38hg38GRCh38
GRCh371742,634,852 - 42,638,630 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361739,990,451 - 39,992,433 (+)NCBINCBI36Build 36hg18NCBI36
Build 341739,990,450 - 39,992,433NCBI
Celera1739,345,439 - 39,347,421 (+)NCBICelera
Cytogenetic Map17q21.31NCBI
HuRef1738,399,310 - 38,404,081 (+)NCBIHuRef
CHM1_11742,870,888 - 42,874,706 (+)NCBICHM1_1
T2T-CHM13v2.01745,411,390 - 45,415,168 (+)NCBIT2T-CHM13v2.0
Fzd2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3911102,495,257 - 102,498,884 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl11102,495,222 - 102,498,884 (+)EnsemblGRCm39 Ensembl
GRCm3811102,604,431 - 102,608,058 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11102,604,396 - 102,608,058 (+)EnsemblGRCm38mm10GRCm38
MGSCv3711102,465,745 - 102,469,372 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3611102,420,625 - 102,422,672 (+)NCBIMGSCv36mm8
Celera11114,314,619 - 114,318,312 (+)NCBICelera
Cytogenetic Map11E1NCBI
cM Map1166.45NCBI
Fzd2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81088,061,988 - 88,063,898 (+)NCBIGRCr8
mRatBN7.21087,561,866 - 87,563,776 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1087,561,326 - 87,565,334 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1092,598,641 - 92,600,551 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01092,064,095 - 92,066,005 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01087,457,426 - 87,459,336 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01090,550,147 - 90,552,057 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1090,550,147 - 90,552,057 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01090,343,133 - 90,345,043 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41091,709,222 - 91,711,132 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11091,723,591 - 91,725,502 (+)NCBI
Celera1086,269,032 - 86,270,942 (+)NCBICelera
Cytogenetic Map10q32.1NCBI
Fzd2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495545117,501,410 - 17,503,726 (+)NCBIChiLan1.0ChiLan1.0
FZD2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21920,351,899 - 20,354,575 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11722,313,946 - 22,318,336 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01712,839,362 - 12,843,803 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11713,007,752 - 13,013,346 (-)NCBIpanpan1.1PanPan1.1panPan2
Fzd2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560218,226,127 - 18,229,463 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936541965,131 - 966,798 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936541965,135 - 967,018 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FZD2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1218,740,653 - 18,742,420 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11218,740,417 - 18,742,301 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21219,086,025 - 19,087,228 (-)NCBISscrofa10.2Sscrofa10.2susScr3
FZD2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11661,837,202 - 61,839,126 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1661,837,304 - 61,839,013 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607732,597,814 - 32,601,732 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Fzd2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624795578,571 - 580,235 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624795577,350 - 584,110 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in FZD2
11 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 5 1 10
Low 5 11 6 5 1 12 6
Below cutoff 5 4 4 4 5 8

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000022432   ⟹   ENSCAFP00000020828
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl918,888,696 - 18,890,525 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845013702   ⟹   ENSCAFP00845010636
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl919,580,230 - 19,581,927 (-)Ensembl
RefSeq Acc Id: XM_038487589   ⟹   XP_038343517
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1918,433,221 - 18,436,253 (-)NCBI
RefSeq Acc Id: XM_038546095   ⟹   XP_038402023
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0918,760,592 - 18,763,652 (-)NCBI
RefSeq Acc Id: XM_038610119   ⟹   XP_038466047
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0918,616,401 - 18,619,457 (-)NCBI
RefSeq Acc Id: XM_038675184   ⟹   XP_038531112
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0919,578,886 - 19,581,949 (-)NCBI
RefSeq Acc Id: XM_548060   ⟹   XP_548060
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1918,888,711 - 18,890,549 (-)NCBI
Dog10K_Boxer_Tasha918,275,000 - 18,278,038 (-)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: XP_548060   ⟸   XM_548060
- UniProtKB: A0A8I3N4R2 (UniProtKB/TrEMBL),   A0A8P0SIN7 (UniProtKB/TrEMBL),   A0A8C0K7J1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000020828   ⟸   ENSCAFT00000022432
RefSeq Acc Id: XP_038343517   ⟸   XM_038487589
RefSeq Acc Id: XP_038466047   ⟸   XM_038610119
RefSeq Acc Id: XP_038531112   ⟸   XM_038675184
- UniProtKB: A0A8I3N4R2 (UniProtKB/TrEMBL),   A0A8P0SIN7 (UniProtKB/TrEMBL),   A0A8C0K7J1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038402023   ⟸   XM_038546095
- UniProtKB: A0A8C0K7J1 (UniProtKB/TrEMBL),   A0A8I3N4R2 (UniProtKB/TrEMBL),   A0A8P0SIN7 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCAFP00845010636   ⟸   ENSCAFT00845013702
Protein Domains
FZ   G-protein coupled receptors family 2 profile

Promoters
RGD ID:13684486
Promoter ID:EPDNEW_C2554
Type:initiation region
Name:FZD2_1
Description:frizzled class receptor 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1918,890,724 - 18,890,784EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000014134 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00845007799 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000022432.6 UniProtKB/TrEMBL
  ENSCAFT00845013702 ENTREZGENE
  ENSCAFT00845013702.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.2000.10 UniProtKB/TrEMBL
  Rhodopsin 7-helix transmembrane proteins UniProtKB/TrEMBL
InterPro Frizzled/SFRP UniProtKB/TrEMBL
  Frizzled/Smoothened_TM UniProtKB/TrEMBL
  Frizzled_dom UniProtKB/TrEMBL
  Frizzled_dom_sf UniProtKB/TrEMBL
  FZ2_CRD UniProtKB/TrEMBL
  GPCR_2-like UniProtKB/TrEMBL
KEGG Report cfa:490937 UniProtKB/TrEMBL
NCBI Gene FZD2 ENTREZGENE
PANTHER PTHR11309 UniProtKB/TrEMBL
  PTHR11309:SF34 UniProtKB/TrEMBL
Pfam Frizzled UniProtKB/TrEMBL
  PF01392 UniProtKB/TrEMBL
PRINTS FRIZZLED UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F2_4 UniProtKB/TrEMBL
  PS50038 UniProtKB/TrEMBL
SMART FRI UniProtKB/TrEMBL
  Frizzled UniProtKB/TrEMBL
Superfamily-SCOP SSF63501 UniProtKB/TrEMBL
UniProt A0A8C0K7J1 ENTREZGENE
  A0A8I3N4R2 ENTREZGENE, UniProtKB/TrEMBL
  A0A8P0SIN7 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:41030 ENTREZGENE