Bcl2l11 (Bcl2-like 11) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Bcl2l11 (Bcl2-like 11) Rattus norvegicus
Analyze
Symbol: Bcl2l11
Name: Bcl2-like 11
RGD ID: 628774
Description: Predicted to enable protein kinase binding activity. Predicted to contribute to microtubule binding activity. Involved in several processes, including cellular response to amyloid-beta; cellular response to estradiol stimulus; and positive regulation of autophagy in response to ER overload. Predicted to be located in several cellular components, including cytosol; intracellular membrane-bounded organelle; and microtubule. Predicted to be part of BIM-BCL-2 complex and BIM-BCL-xl complex. Predicted to be active in mitochondrion. Orthologous to human BCL2L11 (BCL2 like 11); PARTICIPATES IN intrinsic apoptotic pathway; INTERACTS WITH 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane; 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Bcl-2 related apoptotic gene product BimL; bcl-2-like protein 11; bcl-2-related ovarian death protein; BCL2 like 11; bcl2-interacting mediator of cell death; bcl2-L-11; BCL2-like 11 (apoptosis facilitator); Bim; BimL; Bod
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83135,820,042 - 135,857,330 (+)NCBIGRCr8
mRatBN7.23115,366,783 - 115,404,068 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3115,366,646 - 115,404,068 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3119,256,253 - 119,293,586 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03127,851,801 - 127,889,132 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03125,512,142 - 125,549,477 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03120,726,906 - 120,764,192 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3120,726,906 - 120,764,192 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03126,567,484 - 126,604,461 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43115,692,323 - 115,722,701 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13115,597,895 - 115,628,274 (+)NCBI
Celera3114,200,283 - 114,237,903 (+)NCBICelera
Cytogenetic Map3q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model



  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Bcl2l11Ratglomerulonephritis  ISOBcl2l11 (Mus musculus)734641 RGD 
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Bcl2l11RatFamilial Prostate Cancer  ISOBCL2L11 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:29892016
Bcl2l11Ratsclerosing cholangitis  ISOBCL2L11 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:21151127
Bcl2l11Rattype 2 diabetes mellitus  ISOBCL2L11 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:28869590

1 to 20 of 429 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Bcl2l11Rat(-)-demecolcine increases expressionISOBCL2L11 (Homo sapiens)6480464Demecolcine results in increased expression of BCL2L11 mRNACTDPMID:23649840
Bcl2l11Rat(S)-amphetamine multiple interactionsISOBCL2L11 (Homo sapiens)6480464[N-Methyl-3 more ...CTDPMID:23820845
Bcl2l11Rat(S)-amphetamine increases expressionISOBCL2L11 (Homo sapiens)6480464Dextroamphetamine results in increased expression of BCL2L11 mRNA and Dextroamphetamine results in increased expression of BCL2L11 proteinCTDPMID:23820845
Bcl2l11Rat1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane increases expressionEXP 6480464o more ...CTDPMID:22937105
Bcl2l11Rat1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane decreases expressionEXP 6480464o and p'-DDT analog results in decreased expression of BCL2L11 mRNACTDPMID:22937105
Bcl2l11Rat1,1-dichloroethene increases expressionISOBcl2l11 (Mus musculus)6480464vinylidene chloride results in increased expression of BCL2L11 mRNACTDPMID:26682919
Bcl2l11Rat1,2-dimethylhydrazine decreases expressionISOBcl2l11 (Mus musculus)64804641 and 2-Dimethylhydrazine results in decreased expression of BCL2L11 mRNACTDPMID:22206623
Bcl2l11Rat1-[4,4-bis(4-fluorophenyl)butyl]-4-[4-chloro-3-(trifluoromethyl)phenyl]-4-piperidinol multiple interactionsISOBCL2L11 (Homo sapiens)6480464dorsomorphin inhibits the reaction [Penfluridol results in increased expression of BCL2L11 mRNA] more ...CTDPMID:35530161
Bcl2l11Rat1-[4,4-bis(4-fluorophenyl)butyl]-4-[4-chloro-3-(trifluoromethyl)phenyl]-4-piperidinol increases expressionISOBCL2L11 (Homo sapiens)6480464Penfluridol results in increased expression of BCL2L11 mRNA and Penfluridol results in increased expression of BCL2L11 proteinCTDPMID:35530161
Bcl2l11Rat1-naphthyl isothiocyanate increases expressionEXP 64804641-Naphthylisothiocyanate results in increased expression of BCL2L11 mRNACTDPMID:30723492
Bcl2l11Rat17beta-estradiol affects expressionISOBCL2L11 (Homo sapiens)6480464Estradiol affects the expression of BCL2L11 mRNACTDPMID:21826169
Bcl2l11Rat17beta-estradiol increases expressionISOBCL2L11 (Homo sapiens)6480464Estradiol results in increased expression of BCL2L11 mRNACTDPMID:23373633 more ...
Bcl2l11Rat1H-pyrazole increases expressionISOBcl2l11 (Mus musculus)6480464pyrazole results in increased expression of BCL2L11 mRNACTDPMID:17945193
Bcl2l11Rat2,2',4,4',5,5'-hexachlorobiphenyl multiple interactionsISOBcl2l11 (Mus musculus)64804642 more ...CTDPMID:21851831
Bcl2l11Rat2,2',4,4'-Tetrabromodiphenyl ether affects expressionISOBCL2L11 (Homo sapiens)64804642 more ...CTDPMID:27589474
Bcl2l11Rat2,3,7,8-tetrachlorodibenzodioxine increases expressionEXP 6480464Tetrachlorodibenzodioxin results in increased expression of BCL2L11 mRNACTDPMID:19520675 and PMID:33387578
Bcl2l11Rat2,3,7,8-tetrachlorodibenzodioxine affects expressionEXP 6480464Tetrachlorodibenzodioxin affects the expression of BCL2L11 mRNACTDPMID:34747641
Bcl2l11Rat2,3,7,8-tetrachlorodibenzodioxine increases expressionISOBcl2l11 (Mus musculus)6480464Tetrachlorodibenzodioxin results in increased expression of BCL2L11 mRNACTDPMID:15800033 more ...
Bcl2l11Rat2,3,7,8-tetrachlorodibenzodioxine affects expressionISOBcl2l11 (Mus musculus)6480464Tetrachlorodibenzodioxin affects the expression of BCL2L11 mRNACTDPMID:21570461
Bcl2l11Rat2,3,7,8-tetrachlorodibenzodioxine multiple interactionsISOBcl2l11 (Mus musculus)64804642 more ...CTDPMID:21851831 and PMID:25975270

1 to 20 of 429 rows

Biological Process
1 to 20 of 52 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Bcl2l11Ratapoptotic process involved_inIEAUniProtKB-KW:KW-00531600115GO_REF:0000043UniProtGO_REF:0000043
Bcl2l11Ratapoptotic process involved in embryonic digit morphogenesis acts_upstream_of_or_withinISOBcl2l11 (Mus musculus)1624291MGI:99702 PMID:15967824RGDPMID:15967824
Bcl2l11RatB cell homeostasis acts_upstream_of_or_withinISOBcl2l11 (Mus musculus)1624291MGI:1097161 more ...RGDPMID:15967824 more ...
Bcl2l11Ratcell-matrix adhesion acts_upstream_of_or_withinISOBcl2l11 (Mus musculus)1624291MGI:2156483 PMID:17276340RGDPMID:17276340
Bcl2l11Ratcellular response to amyloid-beta  IEP 14394420 RGD 
Bcl2l11Ratcellular response to estradiol stimulus  IEP 14394420 RGD 
Bcl2l11Ratcellular response to nerve growth factor stimulus  IEP 704413 RGD 
Bcl2l11Ratdevelopmental pigmentation acts_upstream_of_or_withinISOBcl2l11 (Mus musculus)1624291MGI:88138 PMID:11709185RGDPMID:11709185
Bcl2l11Ratear development acts_upstream_of_or_withinISOBcl2l11 (Mus musculus)1624291MGI:88138 PMID:11709185RGDPMID:11709185
Bcl2l11Ratextrinsic apoptotic signaling pathway in absence of ligand acts_upstream_of_or_withinISOBcl2l11 (Mus musculus)1624291MGI:1097161 more ...RGDPMID:15967824
Bcl2l11Ratin utero embryonic development acts_upstream_of_or_withinISOBcl2l11 (Mus musculus)1624291MGI:97603 PMID:16282979RGDPMID:16282979
Bcl2l11Ratintrinsic apoptotic signaling pathway in response to DNA damage acts_upstream_of_or_withinISOBCL2L11 (Homo sapiens)1624291 PMID:11546872RGDPMID:11546872
Bcl2l11Ratintrinsic apoptotic signaling pathway in response to DNA damage acts_upstream_of_or_withinISOBcl2l11 (Mus musculus)1624291MGI:1097161 more ...RGDPMID:15967824
Bcl2l11Ratkidney development acts_upstream_of_or_withinISOBcl2l11 (Mus musculus)1624291MGI:88138 PMID:11709185RGDPMID:11709185
Bcl2l11Ratleukocyte homeostasis acts_upstream_of_or_withinISOBcl2l11 (Mus musculus)1624291MGI:1097161 more ...RGDPMID:15967824
Bcl2l11Ratlymphocyte apoptotic process acts_upstream_ofISOBcl2l11 (Mus musculus)1624291MGI:2156498 PMID:16270031RGDPMID:16270031
Bcl2l11Ratlymphocyte homeostasis acts_upstream_of_or_withinISOBcl2l11 (Mus musculus)1624291MGI:2156498 more ...RGDPMID:11709185 and PMID:15818405
Bcl2l11Ratmale gonad development acts_upstream_of_or_withinISOBcl2l11 (Mus musculus)1624291MGI:1206591 PMID:16270031RGDPMID:16270031
Bcl2l11Ratmammary gland development acts_upstream_of_or_withinISOBcl2l11 (Mus musculus)1624291MGI:2156483 PMID:17276340RGDPMID:17276340
Bcl2l11Ratmeiosis I involved_inIBAMGI:3028590 and PANTHER:PTN0017388991600115GO_REF:0000033GO_CentralGO_REF:0000033
1 to 20 of 52 rows

Cellular Component
1 to 16 of 16 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Bcl2l11RatBcl-2 family protein complex part_ofISOBcl2l11 (Mus musculus)1624291 PMID:16645638RGDPMID:16645638
Bcl2l11RatBcl-2 family protein complex part_ofISOBCL2L11 (Homo sapiens)1624291 PMID:20066663RGDPMID:20066663
Bcl2l11RatBIM-BCL-2 complex part_ofISOBCL2L11 (Homo sapiens) and UniProtKB:O43521-11624291 PMID:21671007RGDPMID:21671007
Bcl2l11RatBIM-BCL-xl complex part_ofISOBCL2L11 (Homo sapiens) and UniProtKB:O43521-11624291 PMID:21671007RGDPMID:21671007
Bcl2l11Ratcytoplasm located_inISOBcl2l11 (Mus musculus)1624291 PMID:15136728RGDPMID:15136728
Bcl2l11Ratcytosol located_inTAS 1600115Reactome:R-RNO-9622598ReactomeReactome:R-RNO-9622598
Bcl2l11Ratcytosol located_inISOBCL2L11 (Homo sapiens) and UniProtKB:O43521-11624291 PMID:21671007RGDPMID:21671007
Bcl2l11Ratintracellular membrane-bounded organelle located_inISOBcl2l11 (Mus musculus)1624291 PMID:15136728RGDPMID:15136728
Bcl2l11Ratmembrane located_inISOBcl2l11 (Mus musculus)1624291 PMID:15136728RGDPMID:15136728
Bcl2l11Ratmembrane located_inIEAUniProtKB-SubCell:SL-01621600115GO_REF:0000044UniProtGO_REF:0000044
Bcl2l11Ratmembrane located_inIEAUniProtKB-KW:KW-04721600115GO_REF:0000043UniProtGO_REF:0000043
Bcl2l11Ratmicrotubule located_inISOBCL2L11 (Homo sapiens) and UniProtKB:O43521-11624291 PMID:21671007RGDPMID:21671007
Bcl2l11Ratmitochondrion is_active_inIBAMGI:1197519 and PANTHER:PTN0017389021600115GO_REF:0000033GO_CentralGO_REF:0000033
Bcl2l11Ratmitochondrion located_inIEAUniProtKB-SubCell:SL-01731600115GO_REF:0000044UniProtGO_REF:0000044
Bcl2l11Ratmitochondrion located_inISOBcl2l11 (Mus musculus)1624291 PMID:15136728RGDPMID:15136728
Bcl2l11Ratmitochondrion located_inIEAUniProtKB-KW:KW-04961600115GO_REF:0000043UniProtGO_REF:0000043
1 to 16 of 16 rows

Molecular Function
1 to 15 of 15 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Bcl2l11Ratmicrotubule binding contributes_toISOBCL2L11 (Homo sapiens) and UniProtKB:O43521-11624291 PMID:21671007RGDPMID:21671007
Bcl2l11Ratmicrotubule binding enablesISOBcl2l11 (Mus musculus)1624291 PMID:16832056RGDPMID:16832056
Bcl2l11Ratprotein binding  IPIMcl1 (Rattus norvegicus)633263 RGD 
Bcl2l11Ratprotein binding enablesISOBcl2l11 (Mus musculus)1624291PR:P63168 more ...RGDPMID:14561217 more ...
Bcl2l11Ratprotein binding enablesISOBcl2l11 (Mus musculus) and PR:O54918-11624291UniProtKB:P10417 more ...RGDPMID:18420585 and PMID:21151042
Bcl2l11Ratprotein binding enablesISOBcl2l11 (Mus musculus) and PR:O54918-31624291UniProtKB:Q07817-1 and PMID:17177603RGDPMID:17177603
Bcl2l11Ratprotein binding enablesISOBCL2L11 (Homo sapiens) and UniProtKB:O43521-11624291UniProtKB:Q07817-1 more ...RGDPMID:15694340 and PMID:23235460
Bcl2l11Ratprotein binding enablesISOBCL2L11 (Homo sapiens) and UniProtKB:O43521-21624291UniProtKB:P10415 and PMID:15694340RGDPMID:15694340
Bcl2l11Ratprotein binding enablesISOBCL2L11 (Homo sapiens) more ...1624291UniProtKB:P10415 more ...RGDPMID:17289999 and PMID:17692808
Bcl2l11Ratprotein binding enablesISOBCL2L11 (Homo sapiens) and UniProtKB:O43521-21624291UniProtKB:P14174 and PMID:18677096RGDPMID:18677096
Bcl2l11Ratprotein binding enablesISOBCL2L11 (Homo sapiens) and UniProtKB:O43521-11624291UniProtKB:P10415 more ...RGDPMID:15661735 and PMID:21671007
Bcl2l11Ratprotein binding enablesISOBCL2L11 (Homo sapiens)1624291UniProtKB:P03495 more ...RGDPMID:14596824 more ...
Bcl2l11Ratprotein binding enablesIPIUniProtKB:Q9C0408554586PMID:21478148UniProt 
Bcl2l11Ratprotein binding  IPIBcl2l1 (Rattus norvegicus)704412 RGD 
Bcl2l11Ratprotein kinase binding enablesISOBcl2l11 (Mus musculus)1624291UniProtKB:Q2NL51 more ...RGDPMID:20371704
1 to 15 of 15 rows

RGD Manual Annotations


  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Bcl2l11Ratintrinsic apoptotic pathway   ISOBCL2L11 (Homo sapiens)2314029 RGD 

1 to 15 of 15 rows
#
Reference Title
Reference Citation
1. Nerve growth factor (NGF) down-regulates the Bcl-2 homology 3 (BH3) domain-only protein Bim and suppresses its proapoptotic activity by phosphorylation. Biswas SC and Greene LA, J Biol Chem 2002 Dec 20;277(51):49511-6.
2. Proapoptotic Bcl-2 relative Bim required for certain apoptotic responses, leukocyte homeostasis, and to preclude autoimmunity. Bouillet P, etal., Science 1999 Nov 26;286(5445):1735-8.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. BH3-only Bcl-2 family members are coordinately regulated by the JNK pathway and require Bax to induce apoptosis in neurons. Harris CA and Johnson EM Jr, J Biol Chem 2001 Oct 12;276(41):37754-60.
6. BOD (Bcl-2-related ovarian death gene) is an ovarian BH3 domain-containing proapoptotic Bcl-2 protein capable of dimerization with diverse antiapoptotic Bcl-2 members. Hsu SY, etal., Mol Endocrinol 1998 Sep;12(9):1432-40.
7. Characterization of the antiapoptotic Bcl-2 family member myeloid cell leukemia-1 (Mcl-1) and the stimulation of its message by gonadotropins in the rat ovary. Leo CP, etal., Endocrinology 1999 Dec;140(12):5469-77.
8. BH3-only proteins in apoptosis and beyond: an overview. Lomonosova E and Chinnadurai G, Oncogene. 2008 Dec;27 Suppl 1:S2-19.
9. [Impact of stress response genes induced by L-glutamine on warm ischemia and reperfusion injury in the rat small intestine] Masuko Y Hokkaido Igaku Zasshi 2002 Mar;77(2):169-83.
10. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
11. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
12. Postnatal developmental regulation of Bcl-2 family proteins in brain mitochondria. Soane L, etal., J Neurosci Res. 2008 May 1;86(6):1267-76.
13. Identification of a novel Bcl-2-interacting mediator of cell death (Bim) E3 ligase, tripartite motif-containing protein 2 (TRIM2), and its role in rapid ischemic tolerance-induced neuroprotection. Thompson S, etal., J Biol Chem. 2011 Jun 3;286(22):19331-9. doi: 10.1074/jbc.M110.197707. Epub 2011 Apr 8.
14. Estrogen regulates Bcl-w and Bim expression: role in protection against beta-amyloid peptide-induced neuronal death. Yao M, etal., J Neurosci. 2007 Feb 7;27(6):1422-33. doi: 10.1523/JNEUROSCI.2382-06.2007.
15. Hepatocyte autophagy is linked to C/EBP-homologous protein, Bcl2-interacting mediator of cell death, and BH3-interacting domain death agonist gene expression. Zhang J, etal., J Surg Res. 2015 May 15;195(2):588-95. doi: 10.1016/j.jss.2015.01.039. Epub 2015 Jan 28.
1 to 15 of 15 rows
PMID:11546872   PMID:11709185   PMID:11997495   PMID:12142566   PMID:12818176   PMID:12913110   PMID:14667574   PMID:15136728   PMID:15231831   PMID:15356200   PMID:15384421   PMID:15818405  
PMID:15967824   PMID:16055554   PMID:16092929   PMID:16092944   PMID:16153157   PMID:16162916   PMID:16270031   PMID:16282323   PMID:16282979   PMID:16431916   PMID:16645638   PMID:16818494  
PMID:16832056   PMID:17251057   PMID:17276340   PMID:17289999   PMID:17591857   PMID:17658509   PMID:17702754   PMID:17705137   PMID:18195012   PMID:18351462   PMID:18465250   PMID:19438724  
PMID:19767770   PMID:20371704   PMID:20857401   PMID:21041309   PMID:21159964   PMID:21164521   PMID:21378313   PMID:21439021   PMID:21451041   PMID:21671007   PMID:21762482   PMID:22761832  
PMID:23661003   PMID:23815625   PMID:23828564   PMID:23896225   PMID:24014123   PMID:24567336   PMID:27220268   PMID:27483389   PMID:28125090   PMID:28202414   PMID:28770951   PMID:29048431  
PMID:31058341   PMID:32605511   PMID:35036441  



Bcl2l11
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83135,820,042 - 135,857,330 (+)NCBIGRCr8
mRatBN7.23115,366,783 - 115,404,068 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3115,366,646 - 115,404,068 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3119,256,253 - 119,293,586 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03127,851,801 - 127,889,132 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03125,512,142 - 125,549,477 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03120,726,906 - 120,764,192 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3120,726,906 - 120,764,192 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03126,567,484 - 126,604,461 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43115,692,323 - 115,722,701 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13115,597,895 - 115,628,274 (+)NCBI
Celera3114,200,283 - 114,237,903 (+)NCBICelera
Cytogenetic Map3q36NCBI
BCL2L11
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382111,120,914 - 111,168,445 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2111,119,378 - 111,168,444 (+)EnsemblGRCh38hg38GRCh38
GRCh372111,878,491 - 111,926,022 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362111,594,962 - 111,642,493 (+)NCBINCBI36Build 36hg18NCBI36
Build 342111,597,540 - 111,640,814NCBI
Celera2105,529,086 - 105,576,607 (+)NCBICelera
Cytogenetic Map2q13NCBI
HuRef2104,757,646 - 104,805,166 (+)NCBIHuRef
CHM1_12111,882,732 - 111,930,286 (+)NCBICHM1_1
T2T-CHM13v2.02111,543,978 - 111,591,507 (+)NCBIT2T-CHM13v2.0
Bcl2l11
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392127,967,958 - 128,004,467 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2127,967,958 - 128,004,467 (+)EnsemblGRCm39 Ensembl
GRCm382128,126,038 - 128,162,547 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2128,126,038 - 128,162,547 (+)EnsemblGRCm38mm10GRCm38
MGSCv372127,951,774 - 127,988,283 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362127,817,479 - 127,853,613 (+)NCBIMGSCv36mm8
Celera2129,356,352 - 129,393,704 (+)NCBICelera
Cytogenetic Map2F1NCBI
cM Map262.23NCBI
Bcl2l11
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049554702,740,682 - 2,780,225 (-)NCBIChiLan1.0ChiLan1.0
BCL2L11
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21216,914,260 - 16,961,753 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A16,917,024 - 16,964,367 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A90,862,070 - 90,909,833 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A112,337,927 - 112,385,079 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A112,337,927 - 112,385,079 (+)Ensemblpanpan1.1panPan2
BCL2L11
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11735,619,804 - 35,665,782 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1735,619,582 - 35,664,587 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1735,391,228 - 35,441,388 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01736,397,661 - 36,447,779 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1736,397,342 - 36,445,321 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11735,515,071 - 35,565,168 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01735,589,049 - 35,639,236 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01735,800,089 - 35,850,247 (+)NCBIUU_Cfam_GSD_1.0
Bcl2l11
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629281,122,091 - 81,156,497 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493678318,194 - 50,983 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493678315,493 - 50,959 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
BCL2L11
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl345,160,155 - 45,201,186 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1345,156,791 - 45,202,996 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2347,180,506 - 47,223,992 (-)NCBISscrofa10.2Sscrofa10.2susScr3
BCL2L11
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11414,178,159 - 14,205,337 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660805,463,438 - 5,508,960 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Bcl2l11
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247491,091,096 - 1,125,341 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247491,033,824 - 1,130,099 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

.

.
Variants in Bcl2l11
196 total Variants

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
Mir222rno-miR-222-3pMirtarbaseexternal_infoImmunoblot//Luciferase reporter assay//qRT-PCR//ReFunctional MTI19438724
Mir221rno-miR-221-3pMirtarbaseexternal_infoImmunoblot//Luciferase reporter assay//qRT-PCR//ReFunctional MTI19438724

Predicted Target Of
Summary Value
Count of predictions:171
Count of miRNA genes:97
Interacting mature miRNAs:104
Transcripts:ENSRNOT00000022596, ENSRNOT00000051069
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 40 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
2312673Scl63Serum cholesterol level QTL 630.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)398535255168026850Rat
2301414Kidm37Kidney mass QTL 370.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)370653097121056321Rat
1582238Bw68Body weight QTL 683.20.0064body mass (VT:0001259)body weight (CMO:0000012)353184593115665732Rat
2302373Gluco39Glucose level QTL 395.01blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)398535386161695835Rat
1582239Epfw1Epididymal fat weight QTL 14.50.0006epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)353184593115665732Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)331172320163586636Rat
2292591Esta4Estrogen-induced thymic atrophy QTL 4thymus mass (VT:0004954)thymus wet weight (CMO:0000855)347233211147415807Rat
1358362Srcrt2Stress Responsive Cort QTL 22.78blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)338192233133483320Rat
1582216Bw65Body weight QTL 656.3body mass (VT:0001259)body weight (CMO:0000012)3102200529115665732Rat
737818Hcar12Hepatocarcinoma resistance QTL 122.6liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)329463235118376539Rat

1 to 10 of 40 rows
BF402027  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23115,390,987 - 115,391,128 (+)MAPPERmRatBN7.2
Rnor_6.03120,751,113 - 120,751,253NCBIRnor6.0
Rnor_5.03126,580,423 - 126,580,563UniSTSRnor5.0
RGSC_v3.43115,713,859 - 115,713,999UniSTSRGSC3.4
Celera3114,224,824 - 114,224,964UniSTS
RH 3.4 Map3986.9UniSTS
Cytogenetic Map3q36UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31



Ensembl Acc Id: ENSRNOT00000022596   ⟹   ENSRNOP00000022596
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3115,366,805 - 115,370,549 (+)Ensembl
Rnor_6.0 Ensembl3120,728,688 - 120,760,292 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000051069   ⟹   ENSRNOP00000039006
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3115,368,335 - 115,404,068 (+)Ensembl
Rnor_6.0 Ensembl3120,726,906 - 120,764,192 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000108485   ⟹   ENSRNOP00000076665
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3115,368,335 - 115,401,099 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000113569   ⟹   ENSRNOP00000080342
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3115,366,646 - 115,404,068 (+)Ensembl
RefSeq Acc Id: NM_171988   ⟹   NP_741985
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83135,820,042 - 135,857,330 (+)NCBI
mRatBN7.23115,366,783 - 115,404,068 (+)NCBI
Rnor_6.03120,726,906 - 120,764,192 (+)NCBI
Rnor_5.03126,567,484 - 126,604,461 (-)NCBI
RGSC_v3.43115,692,323 - 115,722,701 (+)RGD
Celera3114,200,283 - 114,237,903 (+)NCBI
Sequence:
1 to 11 of 11 rows
Protein RefSeqs NP_741985 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAC23593 (Get FASTA)   NCBI Sequence Viewer  
  AAC23594 (Get FASTA)   NCBI Sequence Viewer  
  AAC23595 (Get FASTA)   NCBI Sequence Viewer  
  AAD26594 (Get FASTA)   NCBI Sequence Viewer  
  AAQ67409 (Get FASTA)   NCBI Sequence Viewer  
  EDL80131 (Get FASTA)   NCBI Sequence Viewer  
  EDL80132 (Get FASTA)   NCBI Sequence Viewer  
  EDL80133 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000080342
GenBank Protein O88498 (Get FASTA)   NCBI Sequence Viewer  
1 to 11 of 11 rows
RefSeq Acc Id: NP_741985   ⟸   NM_171988
- UniProtKB: O88497 (UniProtKB/Swiss-Prot),   Q9WUI8 (UniProtKB/Swiss-Prot),   O88498 (UniProtKB/Swiss-Prot),   A6HQ32 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000039006   ⟸   ENSRNOT00000051069
Ensembl Acc Id: ENSRNOP00000022596   ⟸   ENSRNOT00000022596
Ensembl Acc Id: ENSRNOP00000076665   ⟸   ENSRNOT00000108485
Ensembl Acc Id: ENSRNOP00000080342   ⟸   ENSRNOT00000113569
Apoptosis Bim N-terminal   Bcl-x interacting BH3

Name Modeler Protein Id AA Range Protein Structure
AF-O88498-F1-model_v2 AlphaFold O88498 1-196 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13692412
Promoter ID:EPDNEW_R2937
Type:single initiation site
Name:Bcl2l11_1
Description:BCL2 like 11
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.03120,726,929 - 120,726,989EPDNEW


1 to 29 of 29 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-47955 BioCyc
Ensembl Genes ENSRNOG00000016551 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000113569 ENTREZGENE
InterPro Apoptosis_Bim_N UniProtKB/Swiss-Prot
  Bcl-2-like_11 UniProtKB/Swiss-Prot
  Bcl-x_interacting_BH3_dom UniProtKB/Swiss-Prot
  Immune_Signaling-Apoptosis_Reg UniProtKB/Swiss-Prot
KEGG Report rno:64547 UniProtKB/Swiss-Prot
NCBI Gene 64547 ENTREZGENE
PANTHER BCL-2-LIKE PROTEIN 11 UniProtKB/Swiss-Prot
  BCL2 INTERACTING MEDIATOR OF CELL DEATH UniProtKB/Swiss-Prot
Pfam Bclx_interact UniProtKB/Swiss-Prot
  Bim_N UniProtKB/Swiss-Prot
PhenoGen Bcl2l11 PhenoGen
PIRSF Bcl-2-like_p11 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000016551 RatGTEx
UniProt A0A8I5ZK47_RAT UniProtKB/TrEMBL
  A0A8I5ZPX5_RAT UniProtKB/TrEMBL
  A0A8L2QCL5_RAT UniProtKB/TrEMBL
  A0A8L2QJ59_RAT UniProtKB/TrEMBL
  A6HQ30_RAT UniProtKB/TrEMBL
  A6HQ31_RAT UniProtKB/TrEMBL
  A6HQ32 ENTREZGENE, UniProtKB/TrEMBL
  B2L11_RAT UniProtKB/Swiss-Prot
  O88497 ENTREZGENE
  O88498 ENTREZGENE
  Q9WUI8 ENTREZGENE
UniProt Secondary O88497 UniProtKB/Swiss-Prot
  Q9WUI8 UniProtKB/Swiss-Prot
1 to 29 of 29 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-04-05 Bcl2l11  Bcl2-like 11  BCL2l11  BCL2-like 11  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2022-04-05 BCL2l11  BCL2-like 11  Bcl2l11  BCL2 like 11  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2016-01-20 Bcl2l11  BCL2 like 11  Bcl2l11  BCL2-like 11 (apoptosis facilitator)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-02-26 Bcl2l11  BCL2-like 11 (apoptosis facilitator)      Symbol and Name status set to approved 625702 APPROVED
2003-02-27 Bcl2l11  BCL2-like 11 (apoptosis facilitator)      Symbol and Name status set to provisional 70820 PROVISIONAL

Note Type Note Reference
gene_mutations_overexpression deletion delays neuronal apoptosis 70303
gene_pathway proapoptotic activity is inhibited by NGF phosphorylation and down-regulation of expression, both of which occur via the MEK/MAPK signaling pathway 704413
gene_process apoptosis facilitator 70303
gene_regulation mRNA increases after NGF withdrawal of sympathetic neurons 70303