Fadd (Fas associated via death domain) - Rat Genome Database

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Gene: Fadd (Fas associated via death domain) Rattus norvegicus
Analyze
Symbol: Fadd
Name: Fas associated via death domain
RGD ID: 628700
Description: Enables protease binding activity; receptor serine/threonine kinase binding activity; and tumor necrosis factor receptor superfamily binding activity. Involved in behavioral response to cocaine; kidney development; and regulation of necroptotic process. Located in cell body. Part of CD95 death-inducing signaling complex. Used to study morphine dependence and prostatic hypertrophy. Biomarker of several diseases, including abdominal obesity-metabolic syndrome 1; brain glioma; cerebrovascular disease (multiple); depressive disorder; and obesity. Human ortholog(s) of this gene implicated in immunodeficiency 90 and leukemia. Orthologous to human FADD (Fas associated via death domain); PARTICIPATES IN ceramide signaling pathway; FasL mediated signaling pathway; Trail mediated signaling pathway; INTERACTS WITH 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-D.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Fas (TNFRSF6)-associated via death domain; Mort1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81209,169,245 - 209,175,423 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1209,169,318 - 209,174,976 (-)EnsemblGRCr8
mRatBN7.21199,743,200 - 199,745,746 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1199,739,994 - 199,745,653 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1208,126,497 - 208,128,902 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01215,210,505 - 215,212,909 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01207,884,688 - 207,887,092 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01217,746,176 - 217,748,581 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1217,742,929 - 217,748,628 (-)Ensemblrn6Rnor6.0
Rnor_5.01224,603,556 - 224,605,961 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41205,010,363 - 205,012,768 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1197,302,715 - 197,305,120 (-)NCBICelera
RGSC_v3.11205,163,017 - 205,166,234 (-)NCBI
Cytogenetic Map1q42NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
(S)-naringenin  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (EXP)
1,2-dimethylhydrazine  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-D  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
2-methylcholine  (ISO)
3,4-methylenedioxymethamphetamine  (EXP)
3,5-dichloro-N-[[(2S)-1-ethyl-2-pyrrolidinyl]methyl]-2-hydroxy-6-methoxybenzamide  (EXP)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-nitrophenol  (ISO)
5,7-dihydroxy-4'-methoxyflavone  (ISO)
5-aminolevulinic acid  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (ISO)
aconitine  (EXP,ISO)
acrylamide  (ISO)
actinomycin D  (ISO)
adenosine  (ISO)
aflatoxin B1  (ISO)
all-trans-acitretin  (ISO)
all-trans-retinoic acid  (ISO)
Aloe emodin  (ISO)
ammonium chloride  (EXP)
anthocyanin  (EXP)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
arachidonic acid  (ISO)
arecoline  (EXP)
arsenous acid  (ISO)
atorvastatin calcium  (EXP)
atrazine  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
Beta-Solamarine  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
cadmium atom  (EXP)
cadmium dichloride  (ISO)
cadmium sulfide  (ISO)
caffeine  (ISO)
cannabidiol  (ISO)
capsaicin  (EXP)
casticin  (ISO)
celecoxib  (ISO)
cholesterol  (EXP)
cisplatin  (ISO)
cocaine  (EXP)
coenzyme Q10  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
coumarin  (ISO)
curcumin  (ISO)
cyclosporin A  (ISO)
Destruxin B  (ISO)
diarsenic trioxide  (ISO)
diazinon  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (ISO)
dieldrin  (EXP)
diethylstilbestrol  (ISO)
Dimethyl phthalate  (EXP)
dioscin  (ISO)
dioxygen  (ISO)
dipyridamole  (ISO)
doxorubicin  (EXP,ISO)
edaravone  (EXP)
elemental selenium  (ISO)
emamectin benzoate  (ISO)
emodin  (ISO)
endosulfan  (EXP,ISO)
enzyme inhibitor  (ISO)
escitalopram  (EXP)
ethanol  (ISO)
fenthion  (ISO)
ferrosoferric oxide  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
fructose  (EXP)
furosemide  (EXP)
genistein  (ISO)
gentamycin  (EXP)
GSK-J4  (ISO)
hydrogen peroxide  (EXP)
hydroquinone  (ISO)
iron dichloride  (ISO)
isoflurane  (EXP)
ivermectin  (ISO)
leflunomide  (ISO)
lipopolysaccharide  (EXP,ISO)
magnesium oxide  (ISO)
mercury dichloride  (ISO)
methidathion  (ISO)
methimazole  (EXP)
ML-7  (ISO)
morin  (ISO)
motexafin gadolinium  (ISO)
Myrtucommulone A  (ISO)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (ISO)
N-acetyl-L-cysteine  (EXP,ISO)
N-nitrosodimethylamine  (ISO)
naproxen  (EXP)
naringin  (ISO)
nystatin  (ISO)
o-anisidine  (ISO)
obeticholic acid  (ISO)
ochratoxin A  (ISO)
osthole  (ISO)
ouabain  (ISO)
ozone  (ISO)
p-menthan-3-ol  (ISO)
paclitaxel  (ISO)
Panduratin A  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
PCB138  (ISO)
potassium chromate  (ISO)
probenecid  (ISO)
progesterone  (ISO)
propylparaben  (ISO)
pyrethrins  (ISO)
quercetin  (ISO)
raloxifene  (ISO)
reactive oxygen species  (ISO)
resveratrol  (ISO)
rutin  (EXP)
S-allylcysteine  (ISO)
Salidroside  (EXP)
SB 203580  (ISO)
SCH 23390  (EXP)
selenium atom  (ISO)
semilicoisoflavone B  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (EXP,ISO)
sorafenib  (ISO)
streptozocin  (EXP)
Suillin  (ISO)
sumatriptan  (EXP)
sunitinib  (ISO)
syringic acid  (ISO)
tamoxifen  (ISO)
temozolomide  (ISO)
tetrachloromethane  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
Tomentosin  (ISO)
Torularhodin  (ISO)
triamcinolone acetonide  (EXP)
trichloroethene  (ISO)
urethane  (ISO)
ursodeoxycholic acid  (ISO)
usnic acid  (ISO)
vinclozolin  (EXP)
vorinostat  (ISO)
zinc acetate  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
apoptotic process  (IEA,ISO,ISS)
apoptotic signaling pathway  (IEA,ISO)
behavioral response to cocaine  (IEP)
cellular response to mechanical stimulus  (IEA,ISO)
death-inducing signaling complex assembly  (IEA,ISO)
defense response  (IEA)
defense response to virus  (IEA,ISO)
extrinsic apoptotic signaling pathway  (IBA,IEA,ISO)
extrinsic apoptotic signaling pathway in absence of ligand  (ISO)
extrinsic apoptotic signaling pathway via death domain receptors  (IEA,ISO)
immune system process  (IEA)
innate immune response  (IEA)
kidney development  (IEP)
lymph node development  (IEA,ISO,ISS)
motor neuron apoptotic process  (ISO)
necroptotic signaling pathway  (IEA,ISO)
negative regulation of activation-induced cell death of T cells  (IEA,ISO,ISS)
negative regulation of necroptotic process  (ISO)
positive regulation of activated T cell proliferation  (IEA,ISO,ISS)
positive regulation of adaptive immune response  (IEA,ISO,ISS)
positive regulation of apoptotic process  (IEA,ISO)
positive regulation of canonical NF-kappaB signal transduction  (IEA,ISO)
positive regulation of CD8-positive, alpha-beta cytotoxic T cell extravasation  (IEA,ISO,ISS)
positive regulation of cytokine production  (IEA)
positive regulation of execution phase of apoptosis  (IEA,ISO)
positive regulation of extrinsic apoptotic signaling pathway  (IEA,ISO)
positive regulation of immune response  (IEA)
positive regulation of innate immune response  (IBA)
positive regulation of interleukin-8 production  (IEA,ISO)
positive regulation of macrophage differentiation  (IEA,ISO)
positive regulation of proteolysis  (IEA,ISO)
positive regulation of T cell mediated cytotoxicity  (IEA,ISO,ISS)
positive regulation of transcription by RNA polymerase II  (IEA,ISO)
positive regulation of tumor necrosis factor production  (IEA,ISO)
positive regulation of type I interferon-mediated signaling pathway  (IEA,ISO)
positive regulation of type II interferon production  (IEA,ISO,ISS)
regulation of apoptotic process  (IEA)
regulation of necroptotic process  (IMP)
response to cocaine  (IEP)
response to other organism  (IEA)
signal transduction  (IEA)
spleen development  (IEA,ISO,ISS)
T cell differentiation in thymus  (IEA,ISO,ISS)
T cell homeostasis  (IEA,ISO,ISS)
thymus development  (IEA,ISO,ISS)
TRAIL-activated apoptotic signaling pathway  (IEA,ISO)

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Molecular adaptations of apoptotic pathways and signaling partners in the cerebral cortex of human cocaine addicts and cocaine-treated rats. Alvaro-Bartolome M, etal., Neuroscience. 2011 Nov 24;196:1-15. doi: 10.1016/j.neuroscience.2011.08.074. Epub 2011 Sep 8.
2. T11TS Treatment Augments Apoptosis of Glioma Associated Brain Endothelial Cells, Hint Toward Anti-Angiogenic Action in Glioma. Bhattacharya D, etal., J Cell Physiol. 2017 Mar;232(3):526-539. doi: 10.1002/jcp.25447. Epub 2016 Jun 21.
3. Expression and localization of Fas-associated proteins following focal cerebral ischemia in rats. Bi FF, etal., Brain Res. 2008 Jan 29;1191:30-8. Epub 2007 Nov 12.
4. Pretreatment with low-dose gadolinium chloride attenuates myocardial ischemia/reperfusion injury in rats. Chen M, etal., Acta Pharmacol Sin. 2016 Apr;37(4):453-62. doi: 10.1038/aps.2015.156. Epub 2016 Mar 7.
5. Activated apoptotic and anti-survival effects on rat hearts with fructose induced metabolic syndrome. Cheng SM, etal., Cell Biochem Funct. 2014 Mar;32(2):133-41. doi: 10.1002/cbf.2982. Epub 2013 May 9.
6. Effect of infliximab combined with methylprednisolone on expressions of NF-kappaB, TRADD, and FADD in rat acute spinal cord injury. Chengke L, etal., Spine (Phila Pa 1976). 2013 Jun 15;38(14):E861-9. doi: 10.1097/BRS.0b013e318294892c.
7. C5b-9 terminal complex protects oligodendrocytes from apoptotic cell death by inhibiting caspase-8 processing and up-regulating FLIP. Cudrici C, etal., J Immunol. 2006 Mar 1;176(5):3173-80.
8. FasL, Fas, and death-inducing signaling complex (DISC) proteins are recruited to membrane rafts after spinal cord injury. Davis AR, etal., J Neurotrauma. 2007 May;24(5):823-34.
9. Anti-apoptotic and pro-survival effect of protocatechuic acid on hypertensive hearts. Deng JS, etal., Chem Biol Interact. 2014 Feb 25;209:77-84. doi: 10.1016/j.cbi.2013.11.017. Epub 2013 Dec 17.
10. A critical role for Fas/CD-95 dependent signaling pathways in the pathogenesis of hyperoxia-induced brain injury. Dzietko M, etal., Ann Neurol. 2008 Dec;64(6):664-73. doi: 10.1002/ana.21516.
11. TRAIL signalling: decisions between life and death. Falschlehner C, etal., Int J Biochem Cell Biol. 2007;39(7-8):1462-75. Epub 2007 Feb 14.
12. Effect of cocaine on Fas-associated protein with death domain in the rat brain: individual differences in a model of differential vulnerability to drug abuse. Garcia-Fuster MJ, etal., Neuropsychopharmacology. 2009 Apr;34(5):1123-34. doi: 10.1038/npp.2008.88. Epub 2008 Jun 25.
13. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
14. Hepato-protective effect of rutin via IL-6/STAT3 pathway in CCl4-induced hepatotoxicity in rats. Hafez MM, etal., Biol Res. 2015 Jun 11;48:30. doi: 10.1186/s40659-015-0022-y.
15. Common variation in genes related to immune response and risk of childhood leukemia. Han S, etal., Hum Immunol. 2012 Mar;73(3):316-9. doi: 10.1016/j.humimm.2011.12.018. Epub 2011 Dec 28.
16. Improved age-related deficits in cognitive performance and affective-like behavior following acute, but not repeated, 8-OH-DPAT treatments in rats: regulation of hippocampal FADD. Hernández-Hernández E, etal., Neurobiol Aging. 2018 Jul 29;71:115-126. doi: 10.1016/j.neurobiolaging.2018.07.014.
17. Estrogen inhibits Fas-mediated apoptosis in experimental stroke. Jia J, etal., Exp Neurol. 2009 Jan;215(1):48-52. doi: 10.1016/j.expneurol.2008.09.015. Epub 2008 Oct 7.
18. Rice Hull Extract Suppresses Benign Prostate Hyperplasia by Decreasing Inflammation and Regulating Cell Proliferation in Rats. Kim CY, etal., J Med Food. 2016 Aug;19(8):746-54. doi: 10.1089/jmf.2016.3686. Epub 2016 Jul 21.
19. Hepatocyte Fas-associating death domain protein/mediator of receptor-induced toxicity (FADD/MORT1) levels increase in response to pro-apoptotic stimuli. Kim PK, etal., J Biol Chem 2002 Oct 11;277(41):38855-62.
20. Role of heme oxygenase 1 in TNF/TNF receptor-mediated apoptosis after hepatic ischemia/reperfusion in rats. Kim SJ, etal., Shock. 2013 Apr;39(4):380-8. doi: 10.1097/SHK.0b013e31828aab7f.
21. The coexistence of nocturnal sustained hypoxia and obesity additively increases cardiac apoptosis. Lee SD, etal., J Appl Physiol. 2008 Apr;104(4):1144-53. Epub 2008 Jan 17.
22. Edaravone attenuates neuronal apoptosis in hypoxic-ischemic brain damage rat model via suppression of TRAIL signaling pathway. Li C, etal., Int J Biochem Cell Biol. 2018 Jun;99:169-177. doi: 10.1016/j.biocel.2018.03.020. Epub 2018 Apr 7.
23. Effect of Danshen aqueous extract on serum hs-CRP, IL-8, IL-10, TNF-alpha levels, and IL-10 mRNA, TNF-alpha mRNA expression levels, cerebral TGF-beta1 positive expression level and its neuroprotective mechanisms in CIR rats. Liang XY, etal., Mol Biol Rep. 2013 Apr;40(4):3419-27. doi: 10.1007/s11033-012-2419-9. Epub 2013 Feb 2.
24. Anti-apoptotic and Pro-survival Effects of Food Restriction on High-Fat Diet-Induced Obese Hearts. Lin YY, etal., Cardiovasc Toxicol. 2017 Apr;17(2):163-174. doi: 10.1007/s12012-016-9370-2.
25. Tumor necrosis factor receptor 1 and its signaling intermediates are recruited to lipid rafts in the traumatized brain. Lotocki G, etal., J Neurosci. 2004 Dec 8;24(49):11010-6.
26. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
27. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
28. Effect of superoxide anion scavenger on rat hearts with chronic intermittent hypoxia. Pai P, etal., J Appl Physiol (1985). 2016 Apr 15;120(8):982-90. doi: 10.1152/japplphysiol.01109.2014. Epub 2016 Jan 14.
29. Playing the DISC: turning on TRAIL death receptor-mediated apoptosis in cancer. Pennarun B, etal., Biochim Biophys Acta. 2010 Apr;1805(2):123-40. Epub 2009 Dec 2.
30. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
31. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
32. Correlation of rat cortical Fas-associated death domain (FADD) protein phosphorylation with the severity of spontaneous morphine abstinence syndrome: role of alpha(2)-adrenoceptors and extracellular signal-regulated kinases. Ramos-Miguel A, etal., J Psychopharmacol. 2011 Dec;25(12):1691-702. doi: 10.1177/0269881110387842. Epub 2010 Nov 18.
33. GOA pipeline RGD automated data pipeline
34. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
35. 14-Deoxyandrographolide desensitizes hepatocytes to tumour necrosis factor-alpha-induced apoptosis through calcium-dependent tumour necrosis factor receptor superfamily member 1A release via the NO/cGMP pathway. Roy DN, etal., Br J Pharmacol. 2010 Aug;160(7):1823-43.
36. Differential activation of CD95-mediated apoptosis related proteins in proximal and distal tubules during rat renal development. Song XF, etal., Tissue Cell. 2016 Oct;48(5):417-24. doi: 10.1016/j.tice.2016.08.006. Epub 2016 Aug 21.
37. The many roles of FAS receptor signaling in the immune system. Strasser A, etal., Immunity. 2009 Feb 20;30(2):180-92.
38. Novel cardiac apoptotic pathway: the dephosphorylation of apoptosis repressor with caspase recruitment domain by calcineurin. Tan WQ, etal., Circulation. 2008 Nov 25;118(22):2268-76. doi: 10.1161/CIRCULATIONAHA.107.750869. Epub 2008 Nov 10.
39. Absence or low expression of fas-associated protein with death domain in acute myeloid leukemia cells predicts resistance to chemotherapy and poor outcome. Tourneur L, etal., Cancer Res. 2004 Nov 1;64(21):8101-8.
40. Tumor necrosis factor signaling. Wajant H, etal., Cell Death Differ. 2003 Jan;10(1):45-65.
41. Dominant negative FADD dissipates the proapoptotic signalosome of the unfolded protein response in diabetic embryopathy. Wang F, etal., Am J Physiol Endocrinol Metab. 2015 Nov 15;309(10):E861-73. doi: 10.1152/ajpendo.00215.2015. Epub 2015 Sep 29.
42. MicroRNA-103/107 Regulate Programmed Necrosis and Myocardial Ischemia/Reperfusion Injury Through Targeting FADD. Wang JX, etal., Circ Res. 2015 Jul 31;117(4):352-63. doi: 10.1161/CIRCRESAHA.117.305781. Epub 2015 Jun 2.
43. Apoptotic signals within the basal forebrain cholinergic neurons in Alzheimer's disease. Wu CK, etal., Exp Neurol. 2005 Oct;195(2):484-96. doi: 10.1016/j.expneurol.2005.06.020.
44. Sodium hydrosulfide alleviates lung inflammation and cell apoptosis following resuscitated hemorrhagic shock in rats. Xu DQ, etal., Acta Pharmacol Sin. 2013 Dec;34(12):1515-25. doi: 10.1038/aps.2013.96. Epub 2013 Oct 14.
45. Anti-apoptosis effects on hearts of SHSST cyclodextrin complex in a carbon tetrachloride-induced cirrhotic cardiomyopathy rat model. Yang CH, etal., Chin J Physiol. 2015 Feb 28;58(1):38-45. doi: 10.4077/CJP.2015.BAD286.
46. Anti-apoptotic effect of San Huang Shel Shin Tang cyclodextrin complex (SHSSTc) on CCl -induced hepatotoxicity in rats. Yang CH, etal., Environ Toxicol. 2014 Nov 28. doi: 10.1002/tox.22078.
Additional References at PubMed
PMID:7536190   PMID:8681376   PMID:9208847   PMID:9343261   PMID:10588860   PMID:11101870   PMID:11717445   PMID:11821383   PMID:12761501   PMID:13679421   PMID:13679576   PMID:16127453  
PMID:16183742   PMID:16226958   PMID:16482086   PMID:16538385   PMID:16611992   PMID:17047155   PMID:18387192   PMID:19593445   PMID:20935634   PMID:21109225   PMID:21525013   PMID:21737330  
PMID:21785459   PMID:21796105   PMID:21803845   PMID:21876153   PMID:22089168   PMID:22510408   PMID:22675671   PMID:22891283   PMID:25502805   PMID:30561431   PMID:31515488  


Genomics

Comparative Map Data
Fadd
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81209,169,245 - 209,175,423 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1209,169,318 - 209,174,976 (-)EnsemblGRCr8
mRatBN7.21199,743,200 - 199,745,746 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1199,739,994 - 199,745,653 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1208,126,497 - 208,128,902 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01215,210,505 - 215,212,909 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01207,884,688 - 207,887,092 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01217,746,176 - 217,748,581 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1217,742,929 - 217,748,628 (-)Ensemblrn6Rnor6.0
Rnor_5.01224,603,556 - 224,605,961 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41205,010,363 - 205,012,768 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1197,302,715 - 197,305,120 (-)NCBICelera
RGSC_v3.11205,163,017 - 205,166,234 (-)NCBI
Cytogenetic Map1q42NCBI
FADD
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381170,203,296 - 70,207,390 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1170,203,295 - 70,207,395 (+)Ensemblhg38GRCh38
GRCh371170,049,402 - 70,053,496 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361169,726,917 - 69,731,144 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341169,726,916 - 69,731,134NCBI
Celera1167,315,851 - 67,320,090 (+)NCBICelera
Cytogenetic Map11q13.3NCBI
HuRef1166,308,990 - 66,313,229 (+)NCBIHuRef
CHM1_11169,932,172 - 69,936,414 (+)NCBICHM1_1
T2T-CHM13v2.01170,218,250 - 70,222,344 (+)NCBIT2T-CHM13v2.0
Fadd
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397144,132,060 - 144,136,178 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7144,131,055 - 144,136,200 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm387144,578,323 - 144,582,441 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7144,577,318 - 144,582,463 (-)Ensemblmm10GRCm38
MGSCv377151,764,228 - 151,768,341 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv367144,387,713 - 144,391,826 (-)NCBIMGSCv36mm8
Celera7144,342,191 - 144,346,305 (-)NCBICelera
Cytogenetic Map7F5NCBI
cM Map788.85NCBI
Fadd
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542216,031,280 - 16,036,281 (-)Ensembl
ChiLan1.0NW_00495542216,026,323 - 16,035,808 (-)NCBIChiLan1.0ChiLan1.0
FADD
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2971,170,462 - 71,177,552 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11172,214,724 - 72,218,869 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01165,300,889 - 65,305,020 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11168,590,184 - 68,593,905 (+)NCBIPanPan1.1PanPan1.1panPan2
FADD
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11848,087,447 - 48,094,497 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1846,692,062 - 46,704,606 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01848,765,020 - 48,771,948 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1848,765,607 - 48,771,913 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11848,212,163 - 48,219,087 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01847,792,264 - 47,804,830 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01848,543,968 - 48,550,895 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Fadd
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049474,192,521 - 4,197,087 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936599633,330 - 639,456 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936599633,501 - 639,412 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FADD
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl23,185,675 - 3,194,818 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.123,191,718 - 3,194,820 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.221,388,619 - 1,389,394 (+)NCBISscrofa10.2Sscrofa10.2susScr3
FADD
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.114,358,314 - 4,361,863 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666038101,642,664 - 101,647,269 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Fadd
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476717,055,509 - 17,059,705 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462476717,050,929 - 17,059,648 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Fadd
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v125,142,335 - 5,145,109 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Fadd
55 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:480
Count of miRNA genes:257
Interacting mature miRNAs:326
Transcripts:ENSRNOT00000075089
Prediction methods:Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1578778Pur4Proteinuria QTL 43.30.003urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)1160111531262090437Rat
1354646Kidm18Kidney mass QTL 185.7kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1160573753266453731Rat
1357335Bw39Body weight QTL 393.3body mass (VT:0001259)body weight (CMO:0000012)1207243873252243873Rat
1354652Kidm20Kidney mass QTL 204.3kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1186658830266453731Rat
1354653Despr9Despair related QTL 90.00019locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1177339686222339686Rat
2293673Bss27Bone structure and strength QTL 2718.630.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)1181059071226059071Rat
2293677Bss41Bone structure and strength QTL 419.380.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra cross-sectional area (CMO:0001689)1181059071226059071Rat
1549830Bss1Bone structure and strength QTL 14.8femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)1182039247227039247Rat
70163Bw20Body weight QTL 205.1body mass (VT:0001259)body weight (CMO:0000012)1183564652228564652Rat
1600395Niddm69Non-insulin dependent diabetes mellitus QTL 694.140.0002blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1205233991267096252Rat
1600396Niddm68Non-insulin dependent diabetes mellitus QTL 684.970.0003blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1205233991267096252Rat
1354624Cm35Cardiac mass QTL355.7heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1186658830266453731Rat
1600397Edcs4Endometrial carcinoma susceptibility QTL 42.2uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)1176288899270518180Rat
631838Niddm36Non-insulin dependent diabetes mellitus QTL 360.01insulin secretion trait (VT:0003564)calculated pancreatic islet insulin release measurement (CMO:0001217)1193964073238964073Rat
1354636Lmblg1Limb length QTL 16.4tibia length (VT:0004357)tibia length (CMO:0000450)1160573753210707719Rat
1549837Hcar15Hepatocarcinoma resistance QTL 150.05liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1162548015270518180Rat
2293689Bss47Bone structure and strength QTL 477.250.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)1181059071226059071Rat
1600388Niddm67Non-insulin dependent diabetes mellitus QTL 675.840.000004blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1205233991267096252Rat
152025235Bw194Body weight QTL 1944.86body mass (VT:0001259)1132966869252856240Rat
1598853Memor3Memory QTL 34.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)1152919152268496042Rat
61341Bp26Blood pressure QTL 26arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1139442053223964440Rat
1354634Kidm12Kidney mass QTL 123.9kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)1160573753210707719Rat
4889428Stresp24Stress response QTL 240.05heart pumping trait (VT:2000009)absolute change in electrocardiographic low frequency R-R spectral component to high frequency R-R spectral component ratio (CMO:0002162)1165278545210278545Rat
2293693Bss22Bone structure and strength QTL 2233.520.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1181059071226059071Rat
1578759Uae30Urinary albumin excretion QTL 303.30.003urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1160111531262090437Rat
2300161Bmd43Bone mineral density QTL 438.40.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1181059071226059071Rat
1300145Rf7Renal function QTL 72.96urine creatinine amount (VT:0010540)urine creatinine level (CMO:0000125)1194575422239575422Rat
1358902Bw47Body weight QTL 471.67body mass (VT:0001259)body weight (CMO:0000012)199645382221502378Rat
61347Bp197Blood pressure QTL 1974.2arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)1168063662213063662Rat
8655655Arrd2Age-related retinal degeneration QTL 27.79retinal layer morphology trait (VT:0003727)percentage of study population developing retinopathy during a period of time (CMO:0002453)1193400541238400541Rat
1358898Bp255Blood pressure QTL 2553.6arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1200449456256003563Rat
631214Bw61Body weight QTL613.40.0001intramuscular adipose amount (VT:0010044)intramuscular fat area (CMO:0001162)1182535316227535316Rat
7771612Cm80Cardiac mass QTL 808.4heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)1146080545243492863Rat
731168Bp154Blood pressure QTL 1543.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1103779152223964440Rat
731175Uae20Urinary albumin excretion QTL 203.50.0018urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1207163993269633915Rat
2300174Bmd42Bone mineral density QTL 428.40.0001lumbar vertebra mineral mass (VT:0010511)bone mineral density (CMO:0001226)1181059071226059071Rat
737828Hcas3Hepatocarcinoma susceptibility QTL 34.9liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)1153679879232414077Rat
1354661Bw33Body weight QTL 335.2body mass (VT:0001259)body weight (CMO:0000012)1160573753266453731Rat
1358886Bp260Blood pressure QTL 2603.67arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1160574007235238518Rat
2293654Bss30Bone structure and strength QTL 3032.650.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1181059071226059071Rat
1298084Thym4Thymus enlargement QTL 410.68thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)1207243873252243873Rat
724531Uae5Urinary albumin excretion QTL 54urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)1160111426262090599Rat
2300187Bmd41Bone mineral density QTL 418.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1181059071226059071Rat
8552891Epfw5Epididymal fat weight QTL 54.4epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)1202543537247543537Rat
1354580Scort1Serum corticosterone level QTL 13.4blood corticosterone amount (VT:0005345)blood corticosterone level (CMO:0001172)1154961463266453731Rat
634313Niddm43Non-insulin dependent diabetes mellitus QTL 43blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1208479811269633915Rat
1358292Cm37Cardiac mass QTL 376.28e-07heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)1205674651250674651Rat
61376Bp42Blood pressure QTL 4223.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1207243873252243873Rat
634312Bp143Blood pressure QTL 14330.0002arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1203300512229359342Rat
1358294Bw37Body weight QTL 3750.000011body mass (VT:0001259)body weight (CMO:0000012)1180739993225739993Rat
724559Pancm1Pancreatic morphology QTL 17.1islet of Langerhans morphology trait (VT:0005215)pancreatic islet damage composite score (CMO:0001156)1191190115223964326Rat
2312420Pur17Proteinuria QTL 177.10.0001urine protein amount (VT:0005160)urine total protein excretion rate (CMO:0000756)1172718770228180370Rat
10059600Bp378Blood pressure QTL 3783.080.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1186298393231298393Rat
1354591Cm36Cardiac mass QTL 364.1heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1111949780210707719Rat
2312564Glom18Glomerulus QTL 182.40.003kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)1194786607262083703Rat
2292218Kidm35Kidney mass QTL 35kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1208798288253798288Rat
634321Hc1Hypercalciuria QTL 12.91urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1188241285250779312Rat
724562Rends1Renal damage susceptibility QTL 10.05kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)1139442053223964440Rat
1300168Bp170Blood pressure QTL 1702.76arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1192995199237995199Rat
61403Niddm4Non-insulin dependent diabetes mellitus QTL 4blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1201464383246464383Rat
2292222Bp307Blood pressure QTL 3073.060.0014arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1186298393231298393Rat
2292220Bp306Blood pressure QTL 3063.470.00087arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1186298393231298393Rat
1641926Teswt2Testicular weight QTL 22.82testis mass (VT:1000644)both testes wet weight (CMO:0000175)1203675682248675682Rat
631658Cm7Cardiac mass QTL 75.320.0001aorta mass (VT:0002845)aorta weight (CMO:0000076)1205674651250674651Rat
1354615Cm32Cardiac mass QTL 325.2heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1111949780210707719Rat
1600380Niddm70Non-insulin dependent diabetes mellitus QTL 703.10.0008blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1185979875230979875Rat
1582206Kidm33Kidney mass QTL 336.9kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1197807365233480676Rat
1354610Bw34Body weight QTL 344.1body mass (VT:0001259)body weight (CMO:0000012)1160573753266453731Rat
1354620Kidm19Kidney mass QTL 194kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1160573753210707719Rat
634338Hcar4Hepatocarcinoma resistance QTL 44.6liver integrity trait (VT:0010547)liver tumorous lesion number to liver area ratio (CMO:0001210)1202851915223964440Rat
8655855Arrd3Age-related retinal degeneration QTL 33.07lens clarity trait (VT:0001304)cataract incidence/prevalence measurement (CMO:0001585)1193400541238400541Rat
6480783Insul19Insulin level QTL 194.33blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1203300512213659238Rat
1600374Mcs17Mammary carcinoma susceptibility QTL 173mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1207099883252099883Rat
1354618Kidm15Kidney mass QTL 155kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)1165707719210707719Rat
6903303Scl34Serum cholesterol QTL 342.50.0033blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)1173363824227535316Rat
2293083Iddm25Insulin dependent diabetes mellitus QTL 254.18blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1191260175236260175Rat
1354606Bp246Blood pressure QTL 2463.6arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)1111949780228180370Rat
738032Hcas5Hepatocarcinoma susceptibility QTL 53.12liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1185857683270518180Rat
2325727Pia41Pristane induced arthritis QTL 41joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1188241285233241285Rat
1354602Bw35Body weight QTL 3512.2body mass (VT:0001259)body weight (CMO:0000012)1160573753210707719Rat

Markers in Region
RH127743  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21199,742,479 - 199,742,680 (+)MAPPERmRatBN7.2
Rnor_6.01217,745,456 - 217,745,656NCBIRnor6.0
Rnor_5.01224,602,836 - 224,603,036UniSTSRnor5.0
RGSC_v3.41205,009,643 - 205,009,843UniSTSRGSC3.4
Celera1197,301,995 - 197,302,195UniSTS
RH 3.4 Map11549.11UniSTS
Cytogenetic Map1q42UniSTS
PMC305633P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21199,743,261 - 199,743,529 (+)MAPPERmRatBN7.2
Rnor_6.01217,746,238 - 217,746,505NCBIRnor6.0
Rnor_5.01224,603,618 - 224,603,885UniSTSRnor5.0
RGSC_v3.41205,010,425 - 205,010,692UniSTSRGSC3.4
Celera1197,302,777 - 197,303,044UniSTS
Cytogenetic Map1q42UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 11 67 161 91 90 59 92 59 6 355 191 9 140 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000075089   ⟹   ENSRNOP00000066289
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1209,169,318 - 209,174,976 (-)Ensembl
mRatBN7.2 Ensembl1199,739,994 - 199,745,653 (-)Ensembl
Rnor_6.0 Ensembl1217,742,929 - 217,748,628 (-)Ensembl
RefSeq Acc Id: NM_152937   ⟹   NP_690920
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81209,172,524 - 209,174,929 (-)NCBI
mRatBN7.21199,743,200 - 199,745,606 (-)NCBI
Rnor_6.01217,746,176 - 217,748,581 (-)NCBI
Rnor_5.01224,603,556 - 224,605,961 (-)NCBI
RGSC_v3.41205,010,363 - 205,012,768 (-)RGD
Celera1197,302,715 - 197,305,120 (-)RGD
Sequence:
RefSeq Acc Id: XM_039102426   ⟹   XP_038958354
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81209,169,245 - 209,175,423 (-)NCBI
mRatBN7.21199,743,458 - 199,745,746 (-)NCBI
Protein Sequences
Protein RefSeqs NP_690920 (Get FASTA)   NCBI Sequence Viewer  
  XP_038958354 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAN01113 (Get FASTA)   NCBI Sequence Viewer  
  CAD29628 (Get FASTA)   NCBI Sequence Viewer  
  EDM12244 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000066289
  ENSRNOP00000066289.1
RefSeq Acc Id: NP_690920   ⟸   NM_152937
- UniProtKB: Q8R2E7 (UniProtKB/TrEMBL),   M0R9V8 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000066289   ⟸   ENSRNOT00000075089
RefSeq Acc Id: XP_038958354   ⟸   XM_039102426
- Peptide Label: isoform X1
Protein Domains
Death   DED

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8R2E7-F1-model_v2 AlphaFold Q8R2E7 1-208 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13690585
Promoter ID:EPDNEW_R1110
Type:initiation region
Name:Fadd_1
Description:Fas associated via death domain
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01217,748,569 - 217,748,629EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:628700 AgrOrtholog
BioCyc Gene G2FUF-56847 BioCyc
Ensembl Genes ENSRNOG00000047035 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000075089 ENTREZGENE
  ENSRNOT00000075089.5 UniProtKB/TrEMBL
Gene3D-CATH 1.10.533.10 UniProtKB/TrEMBL
InterPro Death UniProtKB/TrEMBL
  DEATH-like UniProtKB/TrEMBL
  DED UniProtKB/TrEMBL
  FADD UniProtKB/TrEMBL
  FADD_vert UniProtKB/TrEMBL
KEGG Report rno:266610 UniProtKB/TrEMBL
NCBI Gene 266610 ENTREZGENE
PANTHER FAS-ASSOCIATED DEATH DOMAIN PROTEIN UniProtKB/TrEMBL
  PTHR15077 UniProtKB/TrEMBL
Pfam Death UniProtKB/TrEMBL
  DED UniProtKB/TrEMBL
PhenoGen Fadd PhenoGen
PIRSF FADD UniProtKB/TrEMBL
PROSITE DEATH_DOMAIN UniProtKB/TrEMBL
  DED UniProtKB/TrEMBL
RatGTEx ENSRNOG00000047035 RatGTEx
SMART DEATH UniProtKB/TrEMBL
  DED UniProtKB/TrEMBL
Superfamily-SCOP DEATH_like UniProtKB/TrEMBL
UniProt M0R9V8 ENTREZGENE, UniProtKB/TrEMBL
  Q8R2E7 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-11-25 Fadd  Fas associated via death domain  Fadd  Fas (TNFRSF6)-associated via death domain  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Fadd  Fas (TNFRSF6)-associated via death domain      Symbol and Name status set to approved 1299863 APPROVED
2003-02-27 Fadd  Fas (TNFRSF6)-associated via death domain      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_regulation protein expression induced by cellular stresses including actinomycin D, ultraviolet irradiation and heat shock 632757