Ugcg (UDP-glucose ceramide glucosyltransferase) - Rat Genome Database

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Gene: Ugcg (UDP-glucose ceramide glucosyltransferase) Rattus norvegicus
Analyze
Symbol: Ugcg
Name: UDP-glucose ceramide glucosyltransferase
RGD ID: 621870
Description: Enables ceramide glucosyltransferase activity. Predicted to be involved in several processes, including cornified envelope assembly; establishment of skin barrier; and glucosylceramide biosynthetic process. Located in Golgi membrane. Biomarker of hypertension. Orthologous to human UGCG (UDP-glucose ceramide glucosyltransferase); PARTICIPATES IN Fabry disease pathway; Gaucher's disease pathway; Krabbe disease pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 2,2',4,4',5,5'-hexachlorobiphenyl; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: ceramide glucosyltransferase; GCS; GLCT-1; glucosylceramide synthase; glycosylceramide synthase; UDP-glucose:ceramide glycosyltransferase; UDP-glucose:N-acylsphingosine D-glucosyltransferase
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8578,828,006 - 78,860,725 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl578,828,006 - 78,860,417 (+)EnsemblGRCr8
mRatBN7.2574,032,978 - 74,065,701 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl574,032,978 - 74,065,393 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx575,934,197 - 75,966,827 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0577,755,827 - 77,788,455 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0577,727,974 - 77,760,604 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0576,376,722 - 76,419,564 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl576,386,836 - 76,419,560 (+)Ensemblrn6Rnor6.0
Rnor_5.0580,530,140 - 80,562,612 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4577,263,334 - 77,295,794 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera572,854,114 - 72,886,901 (+)NCBICelera
RGSC_v3.1577,268,446 - 77,300,599 (+)NCBI
Cytogenetic Map5q24NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP,ISO)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
2-palmitoylglycerol  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP,ISO)
3,3',5-triiodo-L-thyronine  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-diaminodiphenylmethane  (EXP,ISO)
4,4'-sulfonyldiphenol  (ISO)
4-vinylcyclohexene dioxide  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
all-trans-retinoic acid  (ISO)
AM-251  (ISO)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
Benzo[k]fluoranthene  (ISO)
beta-naphthoflavone  (ISO)
bisphenol A  (EXP,ISO)
bleomycin A2  (ISO)
bucladesine  (ISO)
cadmium atom  (EXP)
cadmium dichloride  (EXP,ISO)
chloroprene  (ISO)
chromium atom  (ISO)
ciguatoxin CTX1B  (ISO)
cocaine  (ISO)
copper(II) sulfate  (ISO)
crocidolite asbestos  (ISO)
cyclosporin A  (ISO)
dexamethasone  (EXP,ISO)
diallyl trisulfide  (ISO)
dibenz[a,h]anthracene  (EXP)
dibenzo[a,l]pyrene  (EXP)
dibutyl phthalate  (ISO)
diethylstilbestrol  (EXP)
dimethyl sulfoxide  (ISO)
dioxygen  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
flavonoids  (EXP)
fluoranthene  (EXP,ISO)
fumonisin B1  (ISO)
geldanamycin  (ISO)
heroin  (ISO)
hexadecanoic acid  (ISO)
hydroquinone  (ISO)
hypochlorous acid  (ISO)
indometacin  (ISO)
leflunomide  (ISO)
Licochalcone B  (ISO)
lithium atom  (ISO)
lithium chloride  (ISO)
lithium hydride  (ISO)
maneb  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
medroxyprogesterone acetate  (ISO)
menadione  (ISO)
mercury atom  (ISO)
mercury(0)  (ISO)
methimazole  (EXP)
methotrexate  (ISO)
methoxychlor  (EXP,ISO)
methylmercury chloride  (ISO)
miglustat  (ISO)
mocetinostat  (ISO)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (ISO)
N-ethyl-N-nitrosourea  (EXP)
N-nitrosodiethylamine  (EXP)
N-nitrosodimethylamine  (ISO)
oleic acid  (ISO)
paracetamol  (ISO)
paraquat  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorooctanoic acid  (EXP)
phenobarbital  (ISO)
phenol  (ISO)
phenylmercury acetate  (ISO)
pirinixic acid  (ISO)
potassium chromate  (ISO)
potassium dichromate  (ISO)
progesterone  (ISO)
quercetin  (ISO)
resveratrol  (ISO)
rotenone  (EXP)
RV 538  (ISO)
SB 431542  (ISO)
selenium atom  (ISO)
silicon dioxide  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sulfadimethoxine  (EXP)
sunitinib  (ISO)
tacedinaline  (ISO)
tamibarotene  (ISO)
tamoxifen  (ISO)
temozolomide  (ISO)
testosterone enanthate  (ISO)
tetrachloromethane  (ISO)
tetracycline  (ISO)
thimerosal  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
topotecan  (EXP)
trichloroethene  (EXP)
trichostatin A  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vincristine  (ISO)
vitamin E  (ISO)
vorinostat  (ISO)
zinc atom  (ISO)
zinc sulfate  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
Golgi membrane  (IDA,IEA,ISO)
membrane  (IBA,IDA)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Oligomerization and topology of the Golgi membrane protein glucosylceramide synthase. Marks DL, etal., J Biol Chem. 1999 Jan 1;274(1):451-6.
3. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
4. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
5. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
6. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
7. GOA pipeline RGD automated data pipeline
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
9. Diet-relevant phytochemical intake affects the cardiac AhR and nrf2 transcriptome and reduces heart failure in hypertensive rats. Seymour EM, etal., J Nutr Biochem. 2013 Sep;24(9):1580-6. doi: 10.1016/j.jnutbio.2013.01.008. Epub 2013 Mar 22.
10. Histidine-193 of rat glucosylceramide synthase resides in a UDP-glucose- and inhibitor (D-threo-1-phenyl-2-decanoylamino-3-morpholinopropan-1-ol)-binding region: a biochemical and mutational study. Wu K, etal., Biochem J 1999 Jul 15;341 ( Pt 2):395-400.
Additional References at PubMed
PMID:8643456   PMID:10430909   PMID:12873973   PMID:15181369   PMID:16109770   PMID:17145749   PMID:21270676   PMID:22851168   PMID:23554574   PMID:23748427   PMID:24270810  


Genomics

Comparative Map Data
Ugcg
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8578,828,006 - 78,860,725 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl578,828,006 - 78,860,417 (+)EnsemblGRCr8
mRatBN7.2574,032,978 - 74,065,701 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl574,032,978 - 74,065,393 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx575,934,197 - 75,966,827 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0577,755,827 - 77,788,455 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0577,727,974 - 77,760,604 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0576,376,722 - 76,419,564 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl576,386,836 - 76,419,560 (+)Ensemblrn6Rnor6.0
Rnor_5.0580,530,140 - 80,562,612 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4577,263,334 - 77,295,794 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera572,854,114 - 72,886,901 (+)NCBICelera
RGSC_v3.1577,268,446 - 77,300,599 (+)NCBI
Cytogenetic Map5q24NCBI
UGCG
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh389111,896,814 - 111,935,369 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl9111,896,814 - 111,935,374 (+)Ensemblhg38GRCh38
GRCh379114,659,094 - 114,697,649 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 369113,699,027 - 113,735,260 (+)NCBIBuild 36Build 36hg18NCBI36
Build 349111,738,760 - 111,774,986NCBI
Celera985,158,191 - 85,194,369 (+)NCBICelera
Cytogenetic Map9q31.3NCBI
HuRef984,257,257 - 84,293,341 (+)NCBIHuRef
CHM1_19114,805,585 - 114,841,763 (+)NCBICHM1_1
T2T-CHM13v2.09124,068,161 - 124,106,716 (+)NCBIT2T-CHM13v2.0
Ugcg
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39459,189,452 - 59,222,833 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl459,189,257 - 59,222,833 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38459,189,507 - 59,222,833 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl459,189,257 - 59,222,833 (+)Ensemblmm10GRCm38
MGSCv37459,202,422 - 59,235,705 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36459,283,604 - 59,316,887 (+)NCBIMGSCv36mm8
Celera459,098,657 - 59,131,595 (+)NCBICelera
Cytogenetic Map4B3NCBI
cM Map432.44NCBI
Ugcg
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541915,416,796 - 15,451,936 (-)Ensembl
ChiLan1.0NW_00495541915,417,468 - 15,451,936 (-)NCBIChiLan1.0ChiLan1.0
UGCG
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21127,497,888 - 27,536,068 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1927,500,250 - 27,538,411 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0983,024,602 - 83,065,017 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.19111,184,478 - 111,222,613 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl9111,184,478 - 111,222,613 (+)EnsemblpanPan2panpan1.1
UGCG
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11166,439,346 - 66,472,897 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1166,439,346 - 66,472,897 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1164,850,055 - 64,883,620 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01167,574,649 - 67,608,141 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1167,574,695 - 67,610,200 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11166,089,963 - 66,123,510 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01166,113,247 - 66,146,779 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01166,803,569 - 66,837,122 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Ugcg
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947181,753,275 - 181,790,956 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365591,475,592 - 1,513,273 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365591,475,684 - 1,513,273 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
UGCG
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1252,651,879 - 252,688,550 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11252,651,850 - 252,690,817 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21283,440,499 - 283,479,445 (+)NCBISscrofa10.2Sscrofa10.2susScr3
UGCG
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11227,575,519 - 27,614,114 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1227,574,970 - 27,613,811 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366603515,167,285 - 15,205,882 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ugcg
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476023,056,929 - 23,094,010 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462476023,059,141 - 23,094,013 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Ugcg
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1192,212,392 - 92,244,522 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Ugcg
156 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:291
Count of miRNA genes:170
Interacting mature miRNAs:224
Transcripts:ENSRNOT00000021110
Prediction methods:Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1298067Scl15Serum cholesterol level QTL 154.80.001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)53801167083011670Rat
1300115Hrtrt7Heart rate QTL 72.76heart pumping trait (VT:2000009)heart rate (CMO:0000002)55266537294894052Rat
1357396Bw44Body weight QTL 444.19body mass (VT:0001259)body weight (CMO:0000012)573779642118779642Rat
6907115Mcs29Mammary carcinoma susceptibility QTL 29mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)53800433183004331Rat
1549845Scl44Serum cholesterol level QTL 446blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)544924861153890773Rat
61380Edpm5Estrogen-dependent pituitary mass QTL 54.50.92pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)573779642103472210Rat
1358353Srcrtb2Stress Responsive Cort Basal QTL 23.480.003blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)52367149379046465Rat
70212Niddm25Non-insulin dependent diabetes mellitus QTL 253.54blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)538207390136631402Rat
61386Bp49Blood pressure QTL 4916.6cerebrum integrity trait (VT:0010549)brain infarction volume (CMO:0001013)565089051103648916Rat
1331801Rf33Renal function QTL 334.149kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)548523123134369373Rat
2302381Bw84Body weight QTL 844.47body mass (VT:0001259)body mass index (BMI) (CMO:0000105)573779642118779642Rat
1357402Bw46Body weight QTL 464.47body mass (VT:0001259)body mass index (BMI) (CMO:0000105)573779642118779642Rat
1598807Glom12Glomerulus QTL 122.7kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)53801167083011670Rat
1302786Kidm8Kidney mass QTL 828.15kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)53801167083011670Rat
61393Bp7Blood pressure QTL 74.50.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)565089051166764498Rat
1331782Rf36Renal function QTL 363.296kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)539019942102105896Rat
1578766Tcas11Tongue tumor susceptibility QTL 114.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)551657967166600247Rat
1576312Emca8Estrogen-induced mammary cancer QTL 84.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)555124766172190305Rat
1641912Alcrsp18Alcohol response QTL 18response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)53998594884985948Rat
1576314Eutr1Estrogen induced uterine response QTL 1uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)5692228281330203Rat
7394708Emca11Estrogen-induced mammary cancer QTL 11mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)573176602118176602Rat
1576317Eutr2Estrogen induced uterine response QTL 20.01uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)53952692484526924Rat
1331773Scl26Serum cholesterol level QTL 263.065blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)54852312391770353Rat
1578673Bmd13Bone mineral density QTL 134.9femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)569474415114474415Rat
70189Mcs5Mammary carcinoma susceptibility QTL 510.51mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)560601597137492949Rat
1331771Rf35Renal function QTL 354.36965kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)51001906491770353Rat
61359EaexExperimental allergic encephalomyelitis QTL x3nervous system integrity trait (VT:0010566)post-insult time to onset of experimental autoimmune encephalomyelitis (CMO:0001422)560511627105511627Rat
2290448Scl54Serum cholesterol level QTL 542.93blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)536460764136631402Rat
61426Scl2Serum cholesterol level QTL 27.30.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)564589016109589016Rat
1354598Srn6Serum renin concentration QTL 63.8blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)574335621156302135Rat
2290005Mcs24Mammary carcinoma susceptibility QTL 24mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)569835120114835120Rat
1331756Rf34Renal function QTL 344.16275kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)51001906487027358Rat
2306971Anxrr21Anxiety related response QTL 219.47fear/anxiety-related behavior trait (VT:1000241)number of entries into a discrete space in an experimental apparatus (CMO:0000960)570969494136328156Rat
2316954Rf57Renal function QTL 570kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)56458901693503770Rat
2316959Gluco59Glucose level QTL 594.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)556546393101546393Rat
2312671Scl64Serum cholesterol level QTL 640.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)573779642118779642Rat
2316957Pur21Proteinuria QTL 216.2urine protein amount (VT:0005160)urine protein level (CMO:0000591)56458901691762830Rat

Markers in Region
D5Rat75  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8578,853,664 - 78,853,902 (+)Marker Load Pipeline
mRatBN7.2574,058,640 - 74,058,878 (+)MAPPERmRatBN7.2
Rnor_6.0576,412,496 - 76,412,733NCBIRnor6.0
Rnor_5.0580,555,798 - 80,556,035UniSTSRnor5.0
RGSC_v3.4577,288,958 - 77,289,350RGDRGSC3.4
RGSC_v3.4577,288,992 - 77,289,229UniSTSRGSC3.4
Celera572,879,745 - 72,879,982UniSTS
RGSC_v3.1577,294,105 - 77,294,342RGD
RH 3.4 Map5514.4UniSTS
RH 3.4 Map5514.4RGD
RH 2.0 Map5395.3RGD
SHRSP x BN Map543.4999RGD
Cytogenetic Map5q24UniSTS
D5Uwm68  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2574,047,272 - 74,047,522 (+)MAPPERmRatBN7.2
Rnor_6.0576,401,130 - 76,401,379NCBIRnor6.0
Rnor_5.0580,544,432 - 80,544,681UniSTSRnor5.0
RGSC_v3.4577,277,626 - 77,277,875UniSTSRGSC3.4
Celera572,868,397 - 72,868,628UniSTS
Cytogenetic Map5q24UniSTS
D5Wox42  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2574,063,388 - 74,063,576 (+)MAPPERmRatBN7.2
Rnor_6.0576,417,248 - 76,417,435NCBIRnor6.0
Rnor_5.0580,560,300 - 80,560,487UniSTSRnor5.0
RGSC_v3.4577,293,482 - 77,293,669UniSTSRGSC3.4
Celera572,884,597 - 72,884,776UniSTS
Cytogenetic Map5q24UniSTS
RH133596  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2574,065,361 - 74,065,554 (+)MAPPERmRatBN7.2
Rnor_6.0576,419,221 - 76,419,413NCBIRnor6.0
Rnor_5.0580,562,273 - 80,562,465UniSTSRnor5.0
RGSC_v3.4577,295,455 - 77,295,647UniSTSRGSC3.4
Celera572,886,562 - 72,886,754UniSTS
RH 3.4 Map5514.4UniSTS
Cytogenetic Map5q24UniSTS
RH135237  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2574,063,033 - 74,063,233 (+)MAPPERmRatBN7.2
Rnor_6.0576,416,893 - 76,417,092NCBIRnor6.0
Rnor_5.0580,559,945 - 80,560,144UniSTSRnor5.0
RGSC_v3.4577,293,127 - 77,293,326UniSTSRGSC3.4
Celera572,884,242 - 72,884,441UniSTS
RH 3.4 Map5516.6UniSTS
Cytogenetic Map5q24UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000021110   ⟹   ENSRNOP00000021110
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl576,386,838 - 76,419,560 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000088872   ⟹   ENSRNOP00000075148
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl578,828,006 - 78,860,417 (+)Ensembl
mRatBN7.2 Ensembl574,032,978 - 74,065,393 (+)Ensembl
Rnor_6.0 Ensembl576,386,836 - 76,419,252 (+)Ensembl
RefSeq Acc Id: NM_031795   ⟹   NP_113983
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8578,828,006 - 78,860,725 (+)NCBI
mRatBN7.2574,032,978 - 74,065,701 (+)NCBI
Rnor_6.0576,386,838 - 76,419,560 (+)NCBI
Rnor_5.0580,530,140 - 80,562,612 (+)NCBI
RGSC_v3.4577,263,334 - 77,295,794 (+)RGD
Celera572,854,114 - 72,886,901 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_113983 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAD02464 (Get FASTA)   NCBI Sequence Viewer  
  CAA11853 (Get FASTA)   NCBI Sequence Viewer  
  EDL91642 (Get FASTA)   NCBI Sequence Viewer  
  EDL91643 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000075148
  ENSRNOP00000075148.1
GenBank Protein Q9R0E0 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_113983   ⟸   NM_031795
- UniProtKB: O55149 (UniProtKB/Swiss-Prot),   Q9R0E0 (UniProtKB/Swiss-Prot),   A6KDW2 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000021110   ⟸   ENSRNOT00000021110
Ensembl Acc Id: ENSRNOP00000075148   ⟸   ENSRNOT00000088872

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9R0E0-F1-model_v2 AlphaFold Q9R0E0 1-394 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621870 AgrOrtholog
BioCyc Gene G2FUF-41156 BioCyc
BioCyc Pathway PWY-7836 [ganglio-series glycosphingolipids biosynthesis] BioCyc
  PWY-7838 [globo-series glycosphingolipids biosynthesis] BioCyc
  PWY-7839 [lacto-series glycosphingolipids biosynthesis] BioCyc
  PWY-7841 [neolacto-series glycosphingolipids biosynthesis] BioCyc
BioCyc Pathway Image PWY-7836 BioCyc
  PWY-7838 BioCyc
  PWY-7839 BioCyc
  PWY-7841 BioCyc
Ensembl Genes ENSRNOG00000015644 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000088872 ENTREZGENE
  ENSRNOT00000088872.2 UniProtKB/Swiss-Prot
Gene3D-CATH Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A UniProtKB/Swiss-Prot
InterPro Ceramide_glucosylTrfase UniProtKB/Swiss-Prot
  Nucleotide-diphossugar_trans UniProtKB/Swiss-Prot
KEGG Report rno:83626 UniProtKB/Swiss-Prot
NCBI Gene 83626 ENTREZGENE
PANTHER CERAMIDE GLUCOSYLTRANSFERASE UniProtKB/Swiss-Prot
  PTHR12726 UniProtKB/Swiss-Prot
Pfam Glyco_transf_21 UniProtKB/Swiss-Prot
PhenoGen Ugcg PhenoGen
RatGTEx ENSRNOG00000015644 RatGTEx
Superfamily-SCOP SSF53448 UniProtKB/Swiss-Prot
UniProt A6KDW2 ENTREZGENE, UniProtKB/TrEMBL
  CEGT_RAT UniProtKB/Swiss-Prot
  O55149 ENTREZGENE
  Q9R0E0 ENTREZGENE
UniProt Secondary O55149 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-09-10 Ugcg  UDP-glucose ceramide glucosyltransferase    UDP-glucose:ceramide glycosyltransferase  Name updated 1299863 APPROVED
2002-08-07 Ugcg  UDP-glucose:ceramide glycosyltransferase      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_regulation inhibited by histidine-modifying reagent DEPC 634250