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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621870
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ugcg
Name: UDP-glucose ceramide glucosyltransferase
Acc ID: CHEBI:28748
Term: doxorubicin
Definition: An anthracycline antibiotic that has formula C27H29NO11.
Chemical ID: MESH:D004317
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ugcgdecreases expressionISOUGCG (Homo sapiens)6480464CTDDoxorubicin results in decreased expression of UGCG mRNAPMID:16404146 PMID:29803840
Ugcgdecreases expressionISOUgcg (Mus musculus)6480464CTDDoxorubicin results in decreased expression of UGCG mRNAPMID:19277126
Ugcgdecreases response to substanceISOUGCG (Homo sapiens)6480464CTDUGCG protein results in decreased susceptibility to DoxorubicinPMID:18245173
Ugcgincreases expressionISOUGCG (Homo sapiens)6480464CTDDoxorubicin results in increased expression of UGCG mRNAPMID:18245173
Ugcgmultiple interactionsISOUGCG (Homo sapiens)6480464CTD[N-caproylsphingosine results in increased expression of UGCG mRNA] which results in decreased susceptibility to Doxorubicin; [UGCG protein results in decreased abundance of Ceramides] which results in decreased susceptibility to Doxorubicin; fumonisin B1 inhibits the reaction [Doxorubicin results in increased expression of UGCG mRNA]PMID:18245173 PMID:25195822
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