Csf2 (colony stimulating factor 2) - Rat Genome Database

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Gene: Csf2 (colony stimulating factor 2) Rattus norvegicus
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Symbol: Csf2
Name: colony stimulating factor 2
RGD ID: 621065
Description: Enables cytokine activity. Involved in several processes, including cellular response to lipopolysaccharide; epithelial fluid transport; and response to silicon dioxide. Located in extracellular space. Used to study Parkinsonism and myocardial infarction. Biomarker of abdominal aortic aneurysm; interstitial cystitis; and lung disease (multiple). Human ortholog(s) of this gene implicated in acute myeloid leukemia; juvenile myelomonocytic leukemia; neutropenia; pulmonary alveolar proteinosis; and visceral leishmaniasis. Orthologous to human CSF2 (colony stimulating factor 2); PARTICIPATES IN Fc epsilon receptor mediated signaling pathway; granulocyte-macrophage colony-stimulating factor signaling pathway; syndecan signaling pathway; INTERACTS WITH (+)-pilocarpine; 2-amino-2-deoxy-D-glucopyranose; 7,12-dimethyltetraphene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: colony stimulating factor 2 (granulocyte-macrophage); colony-stimulating factor; CSF; Gm-csf; Gmcsf; granulocyte-macrophage colony-stimulating factor
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81038,887,692 - 38,889,673 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1038,887,692 - 38,890,031 (-)EnsemblGRCr8
mRatBN7.21038,386,945 - 38,388,926 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1038,386,945 - 38,389,199 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1043,071,621 - 43,073,600 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01042,561,720 - 42,563,699 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01038,065,426 - 38,067,405 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01039,602,089 - 39,604,070 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1039,602,089 - 39,604,070 (-)Ensemblrn6Rnor6.0
Rnor_5.01039,379,120 - 39,381,430 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41039,665,850 - 39,667,831 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1037,727,629 - 37,729,611 (-)NCBICelera
RGSC_v3.11039,679,472 - 39,681,403 (-)NCBI
Cytogenetic Map10q22NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View
abdominal aortic aneurysm  (IEP)
acute myeloid leukemia  (ISO)
agranulocytosis  (ISO)
amnestic disorder  (ISO)
anemia  (ISO)
aplastic anemia  (ISO)
asthma  (ISO)
B-cell lymphoma  (ISO)
Bacteremia  (ISO)
Bone Marrow Failure Disorders  (ISO)
Brain Injuries  (IDA)
Breast Neoplasms  (ISO)
bronchiolitis obliterans  (IEP)
carcinoma  (ISO)
chronic obstructive pulmonary disease  (ISO)
colon adenocarcinoma  (ISO)
Colorectal Neoplasms  (ISO)
congestive heart failure  (ISO)
Cough  (ISO)
COVID-19  (ISO)
disease of cellular proliferation  (ISO)
Drug-Related Side Effects and Adverse Reactions  (ISO)
eyelid disease  (ISO)
Femoral Fractures  (IEP)
Gastrointestinal Hemorrhage  (ISO)
hepatocellular carcinoma  (ISO)
Human Influenza  (ISO)
Inflammation  (ISO)
interstitial cystitis  (IEP)
juvenile myelomonocytic leukemia  (ISO)
limb ischemia  (ISO)
Liver Neoplasms  (ISO)
Lymphoma, AIDS-Related  (ISO)
melanoma  (ISO)
metabolic dysfunction-associated steatotic liver disease  (ISO)
mucositis  (ISO)
multiple myeloma  (ISO)
Muscle Weakness  (ISO)
myocardial infarction  (IMP)
Neoplasm, Residual  (ISO)
neural tube defect  (ISO)
neutropenia  (ISO)
non-Hodgkin lymphoma  (ISO)
Pain  (ISO)
Parkinsonism  (IDA)
pneumocystosis  (IEP)
pneumonia  (ISO)
Premature Birth  (ISO)
Pseudomonas Infections  (ISO)
psoriasis  (ISO)
pulmonary alveolar proteinosis  (ISO,ISS)
pulmonary fibrosis  (IEP,ISO)
Radiation Injuries  (ISO)
rheumatoid arthritis  (ISO)
sarcoma  (ISO)
Sepsis  (ISO)
silicosis  (IEP)
Spinal Cord Injuries  (ISO)
temporal arteritis  (ISO)
thrombocytopenia  (ISO)
Thyroid Neoplasms  (ISO)
Venous Thrombosis  (ISO)
Viral Bronchiolitis  (ISO)
visceral leishmaniasis  (ISO)
Weight Loss  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (EXP)
(S)-colchicine  (ISO)
(S)-nicotine  (ISO)
1,4-benzoquinone  (ISO)
1,4-phenylenediamine  (ISO)
1-[2-(3,4-dichlorophenyl)ethyl]-4-methylpiperazine  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
1-nitropyrene  (ISO)
15-deoxy-Delta(12,14)-prostaglandin J2  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,5-dihydroxycinnamic acid methyl ester  (ISO)
2,6-di-tert-butyl-4-methylphenol  (ISO)
2-amino-2-deoxy-D-glucopyranose  (EXP)
3,5-diethoxycarbonyl-1,4-dihydrocollidine  (ISO)
3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione  (ISO)
3-acetyldeoxynivalenol  (ISO)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (ISO)
4-hydroxynon-2-enal  (ISO)
4-nitroquinoline N-oxide  (ISO)
4-nonylphenol  (ISO)
4-phenylbutyric acid  (ISO)
5-fluorouracil  (ISO)
5-Isoxazoleacetic acid, 4,5-dihydro-3-(4-hydroxyphenyl)-, methyl ester  (ISO)
5-oxo-ETE  (ISO)
7,12-dimethyltetraphene  (EXP,ISO)
7-ketocholesterol  (ISO)
acetaldehyde  (ISO)
acetylcholine  (ISO)
acrolein  (ISO)
acrylamide  (EXP)
actinomycin D  (ISO)
afimoxifene  (ISO)
aflatoxin B1  (ISO)
albuterol  (ISO)
alclometasone dipropionate  (ISO)
aldehydo-D-glucosamine  (EXP)
all-trans-retinoic acid  (ISO)
alpha-amanitin  (ISO)
alpha-naphthoflavone  (ISO)
aluminium hydroxide  (ISO)
aluminium oxide  (ISO)
ammonium chloride  (EXP)
amphibole asbestos  (ISO)
amphotericin B  (ISO)
ampicillin  (ISO)
andrastin A  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
anthracene-1,8,9-triol  (ISO)
apigenin  (ISO)
apocynin  (ISO)
aripiprazole  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (EXP,ISO)
asbestos  (ISO)
asperuloside  (ISO)
atorvastatin calcium  (ISO)
ATP  (ISO)
Azoxymethane  (ISO)
baicalein  (ISO)
beclomethasone  (ISO)
benzalkonium chloride  (ISO)
benzene  (ISO)
benzene-1,2,4-triol  (ISO)
benzo[a]pyrene  (ISO)
beta-D-glucosamine  (EXP)
beta-lapachone  (ISO)
betamethasone valerate  (ISO)
bilirubin IXalpha  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bleomycin A2  (ISO)
boric acid  (ISO)
Botulinum toxin type A  (ISO)
brefeldin A  (ISO)
bromoacetate  (ISO)
budesonide  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (ISO)
Calcimycin  (EXP,ISO)
calcitriol  (ISO)
cannabidiol  (ISO)
capsaicin  (EXP)
carbon nanotube  (ISO)
carmustine  (ISO)
carvedilol  (ISO)
chenodeoxycholic acid  (ISO)
CHIR 99021  (ISO)
choline  (ISO)
chromium(6+)  (ISO)
ciprofloxacin  (ISO)
cisplatin  (ISO)
clobetasol  (ISO)
cobalt atom  (EXP,ISO)
columbamine  (ISO)
cortisol  (ISO)
crocidolite asbestos  (ISO)
crotonaldehyde  (ISO)
cyanidin cation  (EXP,ISO)
cycloheximide  (ISO)
cyclophosphamide  (EXP,ISO)
cyclosporin A  (ISO)
cypermethrin  (ISO)
cytochalasin B  (ISO)
cytochalasin D  (ISO)
D-penicillamine  (EXP)
deoxycholic acid  (ISO)
desferrioxamine B  (ISO)
dexamethasone  (ISO)
dextran sulfate  (ISO)
diallyl trisulfide  (ISO)
diarsenic trioxide  (EXP,ISO)
dichlorine  (ISO)
Didecyldimethylammonium  (ISO)
dihydroxyacetone  (ISO)
dinitrogen  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
enzyme inhibitor  (ISO)
ethanol  (ISO)
ethyl acetate  (ISO)
ethylene glycol bis(2-aminoethyl)tetraacetic acid  (ISO)
fenofibrate  (EXP)
ferroheme b  (ISO)
flavonoids  (EXP)
fluticasone  (ISO)
formaldehyde  (ISO)
formoterol fumarate  (ISO)
fulvestrant  (ISO)
gemcitabine  (ISO)
genistein  (ISO)
gentamycin  (EXP)
glycyrrhetinate  (ISO)
glycyrrhetinic acid  (ISO)
gold atom  (ISO)
gold(0)  (ISO)
graphite  (ISO)
GSK-J4  (ISO)
GW 4064  (ISO)
heme b  (ISO)
histamine  (EXP,ISO)
HU-308  (ISO)
hydrogen peroxide  (ISO)
hydroquinone  (ISO)
IC-87114  (ISO)
indometacin  (ISO)
ionomycin  (ISO)
iron atom  (EXP)
iron(0)  (EXP)
iron(2+) sulfate (anhydrous)  (ISO)
isotretinoin  (EXP)
kaempferol  (ISO)
lead diacetate  (ISO)
lead(0)  (ISO)
leukotriene B4  (ISO)
leukotriene D4  (ISO)
linuron  (ISO)
lipoarabinomannan  (ISO)
lipopolysaccharide  (EXP,ISO)
lipoteichoic acid  (ISO)
luteolin  (EXP,ISO)
LY294002  (ISO)
lycopene  (ISO)
malathion  (EXP,ISO)
manganese(II) chloride  (EXP,ISO)
mangiferin  (ISO)
mercury dichloride  (ISO)
metam  (ISO)
methamphetamine  (ISO)
methanol  (ISO)
methyl caffeate  (ISO)
methylmercury chloride  (ISO)
metronidazole  (ISO)
microcystin-LR  (ISO)
ML-7  (ISO)
mometasone furoate  (ISO)
monensin A  (ISO)
N,N-diethyl-m-toluamide  (EXP)
N,N-dimethylacetamide  (ISO)
N-acetyl-L-cysteine  (ISO)
N-methyl-N-nitrosourea  (ISO)
N-nitrosodiethylamine  (EXP)
NAD zwitterion  (ISO)
NAD(+)  (ISO)
naproxen  (EXP)
neomycin  (ISO)
nickel atom  (EXP)
nickel dichloride  (ISO)
nicotine  (ISO)
nitrates  (EXP)
nitric oxide  (EXP,ISO)
nitro blue tetrazolium dichloride  (ISO)
nitrogen dioxide  (ISO)
nocodazole  (ISO)
octadecanoic acid  (ISO)
okadaic acid  (ISO)
oroxylin A  (ISO)
ozone  (EXP,ISO)
paracetamol  (ISO)
paraoxon  (EXP)
paraquat  (ISO)
parathion  (EXP)
pentachlorophenol  (ISO)
pentanal  (ISO)
peptidoglycan  (ISO)
permethrin  (EXP)
phenethyl isothiocyanate  (ISO)
Phomenone  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
pimecrolimus  (ISO)
piperine  (ISO)
poly(ethylene)  (ISO)
poly(I:C)  (ISO)
polymyxin B2  (ISO)
pomalidomide  (ISO)
procyanidin B3  (ISO)
propan-2-ol  (ISO)
prostaglandin E2  (ISO)
Psi-tectorigenin  (ISO)
Pyridostigmine bromide  (EXP)
quartz  (ISO)
quercetin  (ISO)
raloxifene  (ISO)
reactive oxygen species  (ISO)
resveratrol  (ISO)
rutin  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
Salmeterol xinafoate  (ISO)
SB 203580  (ISO)
scopolamine  (ISO)
serpentine asbestos  (ISO)
silicon dioxide  (ISO)
sirolimus  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (ISO)
sodium dodecyl sulfate  (ISO)
spironolactone  (ISO)
staurosporine  (ISO)
sulfasalazine  (ISO)
sulforaphane  (ISO)
sumatriptan  (EXP)
sunitinib  (ISO)
tacrolimus hydrate  (ISO)
tamoxifen  (ISO)
taurocholic acid  (ISO)
temozolomide  (ISO)
terameprocol  (ISO)
testosterone  (ISO)
tetracyclines  (ISO)
thalidomide  (ISO)
theophylline  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
thymidine  (ISO)
tipifarnib  (ISO)
titanium dioxide  (ISO)
toluene 2,4-diisocyanate  (ISO)
triamcinolone acetonide  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
triclosan  (ISO)
triptonide  (ISO)
troglitazone  (ISO)
tubocurarine  (ISO)
tungsten  (EXP)
tyrphostin AG 1478  (ISO)
U-73122  (ISO)
urethane  (ISO)
usnic acid  (ISO)
vanadyl sulfate  (ISO)
vancomycin  (ISO)
vincristine  (ISO)
vitamin K  (EXP)
wortmannin  (ISO)
zearalenone  (ISO)
zidovudine  (ISO)
zinc atom  (ISO)
zinc dichloride  (ISO)
zinc oxide  (ISO)
zinc(0)  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
cell surface receptor signaling pathway via JAK-STAT  (IEA,ISO)
cell surface receptor signaling pathway via STAT  (IEA,ISO)
cellular response to granulocyte macrophage colony-stimulating factor stimulus  (IEA,ISO)
cellular response to lipopolysaccharide  (IEP)
dendritic cell differentiation  (IDA,IEA,ISO)
embryonic placenta development  (ISO)
epithelial cell proliferation  (TAS)
epithelial fluid transport  (IDA)
granulocyte-macrophage colony-stimulating factor signaling pathway  (IEA,ISO)
histamine secretion  (IDA)
immune response  (IEA)
macrophage differentiation  (IEA,ISO)
monocyte differentiation  (ISO)
myeloid cell differentiation  (IBA)
myeloid dendritic cell differentiation  (IEA,ISO)
negative regulation of DNA-templated transcription  (IEA,ISO)
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand  (IEA,ISO)
neutrophil differentiation  (ISO)
positive regulation of cell migration  (IMP)
positive regulation of cell population proliferation  (IEA,ISO)
positive regulation of ERK1 and ERK2 cascade  (ISO)
positive regulation of gene expression  (IEA,ISO)
positive regulation of interleukin-23 production  (IEA,ISO)
positive regulation of leukocyte proliferation  (IEA,ISO)
positive regulation of macrophage derived foam cell differentiation  (IEA,ISO)
positive regulation of macrophage differentiation  (TAS)
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (ISO)
positive regulation of podosome assembly  (IEA,ISO)
positive regulation of trophectodermal cell proliferation  (ISO)
regulation of cell population proliferation  (ISO)
regulation of circadian sleep/wake cycle, sleep  (IMP)
regulation of gene expression  (ISO)
response to fluid shear stress  (IEP)
response to silicon dioxide  (IEP)
TOR signaling  (ISO)

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Early granulocyte-macrophage colony-stimulating factor expression by alveolar inflammatory cells during bleomycin-induced rat lung fibrosis. Andreutti D, etal., Lab Invest. 1998 Dec;78(12):1493-502.
2. Recombinant human granulocyte-macrophage colony-stimulating factor reverses neutropenia and reduces secondary infections in visceral leishmaniasis. Badaro R, etal., J Infect Dis. 1994 Aug;170(2):413-8.
3. Protection against gram-negative bacteremia in neutropenic mice with recombinant granulocyte-macrophage colony-stimulating factor. Bermudez LE, etal., Cytokine. 1990 Jul;2(4):287-93.
4. Azithromycin and clarithromycin inhibit lipopolysaccharide-induced murine pulmonary neutrophilia mainly through effects on macrophage-derived granulocyte-macrophage colony-stimulating factor and interleukin-1beta. Bosnar M, etal., J Pharmacol Exp Ther. 2009 Oct;331(1):104-13. Epub 2009 Jul 24.
5. Simultaneous administration of granulocyte-macrophage colony-stimulating factor and cytosine arabinoside for the treatment of relapsed acute myeloid leukemia. Cannistra SA, etal., Leukemia. 1991 Mar;5(3):230-8.
6. Bone marrow and splenic granulocyte-macrophage colony-stimulating factor and transforming growth factor-beta mRNA levels in irradiated mice. Chang CM, etal., Blood. 1995 Sep 15;86(6):2130-6.
7. The role of TNF-alpha in eosinophilic inflammation associated with RSV bronchiolitis. Choi J, etal., Pediatr Allergy Immunol. 2010 May;21(3):474-9. Epub 2009 Jan 14.
8. Therapeutic efficacy of intranasally delivered mesenchymal stem cells in a rat model of Parkinson disease. Danielyan L, etal., Rejuvenation Res. 2011 Feb;14(1):3-16. Epub 2011 Feb 3.
9. A dual role for the immune response in a mouse model of inflammation-associated lung cancer. Dougan M, etal., J Clin Invest. 2011 Jun 1;121(6):2436-46. doi: 10.1172/JCI44796. Epub 2011 May 2.
10. The ability of recombinant murine granulocyte-macrophage colony-stimulating factor to protect neonatal rats from septic death due to Staphylococcus aureus. Frenck RW, etal., J Infect Dis. 1990 Jul;162(1):109-14.
11. Cross-talk of the related bioactivity mediators in serum after injection of soluble TNF-alpha receptor on silicosis model of rats. Gao HS, etal., Toxicol Ind Health. 2011 Aug;27(7):607-16. doi: 10.1177/0748233710393778. Epub 2011 Apr 19.
12. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
13. Chronic cough resembles asthma with IL-5 and granulocyte-macrophage colony-stimulating factor gene expression in bronchoalveolar cells. Gibson PG, etal., J Allergy Clin Immunol. 1998 Mar;101(3):320-6.
14. Role of granulocyte-macrophage colony-stimulating factor in preventing apoptosis and improving functional outcome in experimental spinal cord contusion injury. Ha Y, etal., J Neurosurg Spine. 2005 Jan;2(1):55-61.
15. Biologically active recombinant rat granulocyte macrophage colony-stimulating factor produced in Escherichia coli. Holowachuk EW and Ruhoff MS, Protein Expr Purif. 1995 Oct;6(5):588-96.
16. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Huang C, etal., Lancet. 2020 Feb 15;395(10223):497-506. doi: 10.1016/S0140-6736(20)30183-5. Epub 2020 Jan 24.
17. GM-CSF in the Lung Protects Against Lethal Influenza Infection. Huang FF, etal., Am J Respir Crit Care Med. 2011 Apr 7.
18. Protective effects of recombinant human granulocyte macrophage colony stimulating factor on H1N1 influenza virus-induced pneumonia in mice. Huang H, etal., Cytokine. 2010 Aug;51(2):151-7. Epub 2010 Apr 27.
19. Inhibition of granulocyte-macrophage colony-stimulating factor prevents dissemination and induces remission of juvenile myelomonocytic leukemia in engrafted immunodeficient mice. Iversen PO, etal., Blood. 1997 Dec 15;90(12):4910-7.
20. Propofol pretreatment attenuates LPS-induced granulocyte-macrophage colony-stimulating factor production in cultured hepatocytes by suppressing MAPK/ERK activity and NF-kappaB translocation. Jawan B, etal., Toxicol Appl Pharmacol. 2008 Jun 15;229(3):362-73. Epub 2008 Feb 21.
21. Cytokine-mediated deployment of SDF-1 induces revascularization through recruitment of CXCR4+ hemangiocytes. Jin DK, etal., Nat Med. 2006 May;12(5):557-67. Epub 2006 Apr 30.
22. Plasma concentrations of granulocyte-macrophage colony-stimulating factor and interleukin-6 in septic and healthy preterms. Kantar M, etal., Eur J Pediatr. 2000 Mar;159(3):156-7.
23. Genetic kininogen deficiency contributes to aortic aneurysm formation but not to atherosclerosis. Kaschina E, etal., Physiol Genomics 2004 Sep 16;19(1):41-9. Epub 2004 Jul 06.
24. An Open-Label Trial of Rituximab Therapy in Pulmonary Alveolar Proteinosis. Kavuru MS, etal., Eur Respir J. 2011 Apr 8.
25. Antibody to Granulocyte-Macrophage Colony-Stimulating Factor Reduces the Number of Activated Tissue Macrophages and Improves Left Ventricular Function Following Myocardial Infarction in a Rat Coronary-Artery Ligation Model. Kellar RS, etal., J Cardiovasc Pharmacol. 2011 Feb 12.
26. Involvement of granulocyte-macrophage colony-stimulating factor (GM-CSF) in pregnancy-enhanced sleep. Kimura M and Inoue S, Psychiatry Clin Neurosci. 2002 Jun;56(3):337-8.
27. Effects of decreased calmodulin protein on the survival mechanisms of alveolar macrophages during Pneumocystis pneumonia. Lasbury ME, etal., Infect Immun. 2009 Aug;77(8):3344-54. Epub 2009 Jun 1.
28. Antitumoral vaccination with granulocyte-macrophage colony-stimulating factor or interleukin-12-expressing DHD/K12 colon adenocarcinoma cells. Lechanteur C, etal., Cancer Gene Ther. 2000 May;7(5):676-82.
29. Compartmentalized transgene expression of granulocyte-macrophage colony-stimulating factor (GM-CSF) in mouse lung enhances allergic airways inflammation. Lei XF, etal., Clin Exp Immunol. 1998 Aug;113(2):157-65.
30. Chronic aspiration of gastric fluid induces the development of obliterative bronchiolitis in rat lung transplants. Li B, etal., Am J Transplant. 2008 Aug;8(8):1614-21. Epub 2008 Jun 28.
31. In vivo disruption of TGF-beta signaling by Smad7 in airway epithelium alleviates allergic asthma but aggravates lung carcinogenesis in mouse. Luo X, etal., PLoS One. 2010 Apr 13;5(4):e10149.
32. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
33. In vitro proliferation of axotomized rat facial nucleus-derived activated microglia in an autocrine fashion. Nakajima K, etal., J Neurosci Res. 2006 Aug 1;84(2):348-59. doi: 10.1002/jnr.20882.
34. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
35. Subcutaneous injection containing IL-3 and GM-CSF ameliorates stab wound-induced brain injury in rats. Nishihara T, etal., Exp Neurol. 2011 Jun;229(2):507-16. Epub 2011 Apr 16.
36. Cytokine gene expression in the marrow stromal cells of patients with giant cell arteritis. Orphanos V, etal., Clin Exp Rheumatol. 1998 Nov-Dec;16(6):683-8.
37. Granulocyte-macrophage colony stimulating factor (GM-CSF) treatment improves alveolar epithelial barrier function in the alcoholic rat lung. Pelaez A, etal., Am J Physiol Lung Cell Mol Physiol 2004 Jan;286(1):L106-11. Epub 2003 Sep 22.
38. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
39. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
40. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
41. Granulocyte macrophage-colony stimulating factor (GM-CSF) in neonatal neutropenia. Ray M, etal., Indian J Pediatr. 2000 Jan;67(1):67-8.
42. GOA pipeline RGD automated data pipeline
43. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
44. Granulocyte-macrophage colony-stimulating factor expression in induced sputum and bronchial mucosa in asthma and COPD. Saha S, etal., Thorax. 2009 Aug;64(8):671-6. Epub 2009 Feb 12.
45. Correlation of measurable serum markers of inflammation with lung levels following bilateral femur fracture in a rat model. Sears BW, etal., J Inflamm Res. 2010 Aug 1;2010(3):105-114.
46. Therapeutic efficacy of granulocyte-macrophage colony-stimulating factor in patients with idiopathic acquired alveolar proteinosis. Seymour JF, etal., Am J Respir Crit Care Med. 2001 Feb;163(2):524-31.
47. Attenuated hematopoietic response to granulocyte-macrophage colony-stimulating factor in patients with acquired pulmonary alveolar proteinosis. Seymour JF, etal., Blood. 1998 Oct 15;92(8):2657-67.
48. Identification of histamine-production-increasing factor produced by stimulated RBL-2H3 rat basophilic leukemia cells as granulocyte-macrophage colony-stimulating factor. Shiraishi M, etal., Biochim Biophys Acta. 1998 Jul 24;1403(3):273-80.
49. Hemodynamic forces regulate mural macrophage infiltration in experimental aortic aneurysms. Sho E, etal., Exp Mol Pathol. 2004 Apr;76(2):108-16.
50. Multiplex analysis of urinary cytokine levels in rat model of cyclophosphamide-induced cystitis. Smaldone MC, etal., Urology. 2009 Feb;73(2):421-6. Epub 2008 Oct 9.
51. Nucleotide sequence of the Lewis rat granulocyte-macrophage colony stimulating factor. Smith LR, etal., Immunogenetics 1994;39(1):80.
52. Concurrent delivery of GM-CSF and endostatin genes by a single adenoviral vector provides a synergistic effect on the treatment of orthotopic liver tumors. Tai KF, etal., J Gene Med. 2003 May;5(5):386-98.
53. Idiotype/granulocyte-macrophage colony-stimulating factor fusion protein as a vaccine for B-cell lymphoma. Tao MH and Levy R, Nature. 1993 Apr 22;362(6422):755-8.
54. Macrophage colony-stimulating factor release and receptor expression in bone cells. Weir EC, etal., J Bone Miner Res. 1993 Dec;8(12):1507-18. doi: 10.1002/jbmr.5650081214.
55. Technical Advance: The rat aorta contains resident mononuclear phagocytes with proliferative capacity and proangiogenic properties. Zorzi P, etal., J Leukoc Biol. 2010 Nov;88(5):1051-9. Epub 2010 Jul 13.
Additional References at PubMed
PMID:1350248   PMID:3925454   PMID:7690439   PMID:9697835   PMID:9722506   PMID:10652277   PMID:10666185   PMID:10678181   PMID:12021780   PMID:12071442   PMID:14557677   PMID:14651956  
PMID:15220135   PMID:15958400   PMID:16116184   PMID:16276414   PMID:16606666   PMID:16792532   PMID:16877635   PMID:17457367   PMID:17478029   PMID:17953750   PMID:18832728   PMID:19022682  
PMID:19032770   PMID:19109256   PMID:19228596   PMID:19560459   PMID:20027291   PMID:21148126   PMID:21149635   PMID:21932404   PMID:24520418   PMID:24942581   PMID:25677907   PMID:27364613  
PMID:28550897   PMID:28898718  


Genomics

Comparative Map Data
Csf2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81038,887,692 - 38,889,673 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1038,887,692 - 38,890,031 (-)EnsemblGRCr8
mRatBN7.21038,386,945 - 38,388,926 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1038,386,945 - 38,389,199 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1043,071,621 - 43,073,600 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01042,561,720 - 42,563,699 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01038,065,426 - 38,067,405 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01039,602,089 - 39,604,070 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1039,602,089 - 39,604,070 (-)Ensemblrn6Rnor6.0
Rnor_5.01039,379,120 - 39,381,430 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41039,665,850 - 39,667,831 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1037,727,629 - 37,729,611 (-)NCBICelera
RGSC_v3.11039,679,472 - 39,681,403 (-)NCBI
Cytogenetic Map10q22NCBI
CSF2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385132,073,789 - 132,076,170 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5132,073,789 - 132,076,170 (+)Ensemblhg38GRCh38
GRCh375131,409,482 - 131,411,863 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 365131,437,384 - 131,439,758 (+)NCBIBuild 36Build 36hg18NCBI36
Build 345131,437,383 - 131,439,758NCBI
Celera5127,539,561 - 127,541,935 (+)NCBICelera
Cytogenetic Map5q31.1NCBI
HuRef5126,601,846 - 126,604,224 (+)NCBIHuRef
CHM1_15130,842,312 - 130,844,690 (+)NCBICHM1_1
T2T-CHM13v2.05132,593,659 - 132,596,040 (+)NCBIT2T-CHM13v2.0
Csf2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391154,138,096 - 54,140,725 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1154,138,097 - 54,140,493 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381154,247,270 - 54,249,899 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1154,247,271 - 54,249,667 (-)Ensemblmm10GRCm38
MGSCv371154,060,772 - 54,063,401 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361154,090,687 - 54,093,065 (-)NCBIMGSCv36mm8
Celera1158,835,805 - 58,838,455 (-)NCBICelera
Cytogenetic Map11B1.3NCBI
cM Map1132.13NCBI
Csf2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554083,451,965 - 3,454,312 (+)Ensembl
ChiLan1.0NW_0049554083,452,009 - 3,454,255 (+)NCBIChiLan1.0ChiLan1.0
CSF2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v24127,392,221 - 127,394,601 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan15125,531,784 - 125,534,164 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v05127,496,951 - 127,499,325 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.15133,660,775 - 133,663,146 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5133,660,775 - 133,663,146 (+)EnsemblpanPan2panpan1.1
CSF2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11120,342,880 - 20,346,959 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1120,344,648 - 20,346,959 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1119,140,218 - 19,142,512 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01121,128,373 - 21,132,476 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1121,129,967 - 21,132,524 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11119,849,460 - 19,851,754 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01119,697,439 - 19,699,733 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01120,339,024 - 20,341,318 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Csf2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213116,079,008 - 116,081,102 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366473,081,896 - 3,083,864 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049366473,081,896 - 3,083,864 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CSF2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl2134,354,724 - 134,357,155 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.12134,354,724 - 134,357,155 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.22139,706,386 - 139,708,817 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CSF2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12334,906,987 - 34,911,252 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2334,908,911 - 34,911,140 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366603443,046,561 - 43,048,998 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Csf2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473340,039,414 - 40,041,294 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462473340,039,127 - 40,041,294 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Csf2
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1936,705,511 - 36,707,674 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Csf2
13 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:92
Count of miRNA genes:77
Interacting mature miRNAs:91
Transcripts:ENSRNOT00000032333
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61441Btemp1Thermal response to stress QTL 14body temperature trait (VT:0005535)core body temperature (CMO:0001036)103589345164140567Rat
152025229Scl83Serum cholesterol level QTL 834.33blood cholesterol amount (VT:0000180)103621155669161158Rat
1578779Tcas10Tongue tumor susceptibility QTL 103.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)103179628176796281Rat
631564Apr3Acute phase response QTL 33.9blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)101577675460776754Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102702353598502431Rat
2293669Bmd33Bone mineral density QTL 334.50.0001femur strength trait (VT:0010010)femoral neck polar moment of inertia (CMO:0001670)102744378772443787Rat
631552Vetf2Vascular elastic tissue fragility QTL 24.50.0002aorta elastic tissue integrity trait (VT:0010556)artery internal elastic lamina non-tumorous lesion count (CMO:0001913)103550938391417879Rat
631554Bp133Blood pressure QTL 1330.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)10125055464349221Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
2293679Bmd30Bone mineral density QTL 303.50.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)102744378772443787Rat
1578761Stresp21Stress response QTL 213.3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)10687714251877142Rat
2298544Neuinf9Neuroinflammation QTL 94.6nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)101993920764939207Rat
61332Eau3Experimental allergic uveoretinitis QTL 30.004uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)101803578263035782Rat
10401803Kidm50Kidney mass QTL 50kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1092219745922197Rat
2317754Glom25Glomerulus QTL 253.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)10210370847103708Rat
1598852Anxrr19Anxiety related response QTL 195.07body movement coordination trait (VT:0005424)number of rearing movements in an experimental apparatus (CMO:0001752)101866841963668419Rat
1581497Esta1Estrogen-induced thymic atrophy QTL 1thymus mass (VT:0004954)thymus wet weight (CMO:0000855)102183375861843633Rat
2313095Bss62Bone structure and strength QTL 621.50.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)10589381150893811Rat
724527Bp148Blood pressure QTL 1480.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102895035373950353Rat
1358897Stresp6Stress response QTL 64.170.022blood norepinephrine amount (VT:0005663)plasma norepinephrine level (CMO:0001010)103589326364653589Rat
1331762Rf40Renal function QTL 403.873kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)102980091064653589Rat
2300171Bmd58Bone mineral density QTL 584.90.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)102744378772443787Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
2301967Cm73Cardiac mass QTL 734.55heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)101499153586964295Rat
2313104Bss61Bone structure and strength QTL 610.90.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)10589381150893811Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014991535107556066Rat
2293652Bmd22Bone mineral density QTL 224.90.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)102744378772443787Rat
724556Pur2Proteinuria QTL 25.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)102293137391127454Rat
8662860Vetf10Vascular elastic tissue fragility QTL 10artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)10666092373950353Rat
2313066Bss63Bone structure and strength QTL 631.40.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)10589381150893811Rat
2313064Bmd71Bone mineral density QTL 710.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)10589381150893811Rat
70223Bp57Blood pressure QTL 575arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)101465354159653541Rat
1354587Kidm21Kidney mass QTL 213.3kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)101553301273695498Rat
634329Pia15Pristane induced arthritis QTL 153.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)102466212373695339Rat
70224Eae3Experimental allergic encephalomyelitis QTL 34.1nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)102702353561843633Rat
2298480Eau7Experimental allergic uveoretinitis QTL 70.0049uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)103550938380509383Rat
2313081Bss64Bone structure and strength QTL 641.30.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)10589381150893811Rat
1331791Cm31Cardiac mass QTL 313.84606heart mass (VT:0007028)heart wet weight (CMO:0000069)102980091091417879Rat
2298495Eae23Experimental allergic encephalomyelitis QTL 2316.93nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis duration (CMO:0001424)101617552561175525Rat
2313087Bmd80Bone mineral density QTL 803.20.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)102011061465110614Rat
1354614Hpcl1Hepatic cholesterol level QTL 13.3liver cholesterol amount (VT:0010498)liver cholesterol level (CMO:0001597)103589326352293000Rat
631530Tls3T-lymphoma susceptibility QTL 300.0001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)102758722696099902Rat
2289985Bp305Blood pressure QTL 305arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102907697874076978Rat
631532Cm50Cardiac mass QTL 506.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)101803578263035782Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
2293705Bmd25Bone mineral density QTL 257.10.0001femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)102744378772443787Rat
1600371Mcs21Mammary carcinoma susceptibility QTL 213mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)102937704652699134Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014991535107713808Rat
1576311Pia26Pristane induced arthritis QTL 26joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)103112911376129113Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10686461896620484Rat
6893342Cm78Cardiac mass QTL 780.10.88heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)103550938388177745Rat
2313055Bw96Body weight QTL 963.60.0001body mass (VT:0001259)body weight (CMO:0000012)102011061465110614Rat
631542Bp82Blood pressure QTL 826.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102702353599451848Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
13 1 17 15 28 43 14 28 14 5 85 48 12 9 40 29 1 1

Sequence


Ensembl Acc Id: ENSRNOT00000032333   ⟹   ENSRNOP00000034235
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1038,887,692 - 38,890,031 (-)Ensembl
mRatBN7.2 Ensembl1038,386,945 - 38,389,199 (-)Ensembl
Rnor_6.0 Ensembl1039,602,089 - 39,604,070 (-)Ensembl
RefSeq Acc Id: NM_053852   ⟹   NP_446304
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81038,887,692 - 38,889,673 (-)NCBI
mRatBN7.21038,386,945 - 38,388,926 (-)NCBI
Rnor_6.01039,602,089 - 39,604,070 (-)NCBI
Rnor_5.01039,379,120 - 39,381,430 (-)NCBI
Celera1037,727,629 - 37,729,611 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_446304 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA18281 (Get FASTA)   NCBI Sequence Viewer  
  EDM04426 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000034235
  ENSRNOP00000034235.3
GenBank Protein P48750 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_446304   ⟸   NM_053852
- Peptide Label: precursor
- UniProtKB: P48750 (UniProtKB/Swiss-Prot),   A6HEH1 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000034235   ⟸   ENSRNOT00000032333

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P48750-F1-model_v2 AlphaFold P48750 1-144 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13697187
Promoter ID:EPDNEW_R7711
Type:single initiation site
Name:Csf2_1
Description:colony stimulating factor 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01039,604,102 - 39,604,162EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621065 AgrOrtholog
BioCyc Gene G2FUF-25118 BioCyc
Ensembl Genes ENSRNOG00000026805 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000032333 ENTREZGENE
  ENSRNOT00000032333.4 UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.1250.10 UniProtKB/Swiss-Prot
InterPro 4_helix_cytokine-like_core UniProtKB/Swiss-Prot
  GM_colony-stim-fac UniProtKB/Swiss-Prot
KEGG Report rno:116630 UniProtKB/Swiss-Prot
NCBI Gene 116630 ENTREZGENE
PANTHER GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR UniProtKB/Swiss-Prot
  PTHR10059 UniProtKB/Swiss-Prot
Pfam GM_CSF UniProtKB/Swiss-Prot
PhenoGen Csf2 PhenoGen
PRINTS GMCSFACTOR UniProtKB/Swiss-Prot
PROSITE GM_CSF UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000026805 RatGTEx
SMART CSF2 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF47266 UniProtKB/Swiss-Prot
UniProt A6HEH1 ENTREZGENE, UniProtKB/TrEMBL
  CSF2_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-01-20 Csf2  colony stimulating factor 2  Csf2  colony stimulating factor 2 (granulocyte-macrophage)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Csf2  colony stimulating factor 2 (granulocyte-macrophage)      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Csf2  colony stimulating factor 2 (granulocyte-macrophage)      Symbol and Name status set to provisional 70820 PROVISIONAL