RGD Reference Report - Cross-talk of the related bioactivity mediators in serum after injection of soluble TNF-alpha receptor on silicosis model of rats. - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

Cross-talk of the related bioactivity mediators in serum after injection of soluble TNF-alpha receptor on silicosis model of rats.

Authors: Gao, HS  Rong, XUE  Peng, DING  Chen, NF  Bing, MENG  Zhao, HB  Zhen, YANG  Wang, SX 
Citation: Gao HS, etal., Toxicol Ind Health. 2011 Aug;27(7):607-16. doi: 10.1177/0748233710393778. Epub 2011 Apr 19.
RGD ID: 10450467
Pubmed: PMID:21505002   (View Abstract at PubMed)
DOI: DOI:10.1177/0748233710393778   (Journal Full-text)

This study investigates cross-talk of the related bioactivity mediators in silica-induced pulmonary inflammatory and fibrosis on rats, which contributes to the preventive and therapeutic effect of soluble TNF-alpha receptor. Wistar rats received saline or 50 mg of quartz by intratracheal instillation. Rats in drug-treated groups were given soluble tumor necrosis factor-alpha (TNF-alpha) receptor (500 mug) by hypodermic injection on days 1, 5 and 8 after operation. At 7 days or 14 days after instillation, rats were killed to observe the degree of injury and expression of the related bioactivity mediators including nuclear factor KB (NF-KB), nitric oxide, interleukin-1beta, interleukin-10, transforming growth factor beta 1 (TGF-beta1), TNF-alpha, interferon-Y (IFN-Y) and granulocyte macrophage colony-stimulating factor (GM-CSF). The area percentages of type I and III collagens in intervention group were lower than those in silica group. The expression of NF-kappaB, TGF-beta1, and COL I were lower in intervention group than in silica group(p < 0.05) and GM-CSF was significantly higher (p < 0.05) at 7 days after instillation, however, NF-kappaB, TGF-beta1, and COL I were identically lower in intervention group than in silica group, and TNF-alpha, IFN-gamma, and GM-CSF were higher at 14 days after instillation. It may be concluded that soluble TNF-alpha receptor upregulating or downregulating the expression of the related bioactivity mediators results in decreasing lung injury induced by silica.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
silicosis  ISOCsf2 (Rattus norvegicus)10450467; 10450467protein:increased expression:serum:RGD 
silicosis  IEP 10450467protein:increased expression:serum:RGD 

Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
response to silicon dioxide  IEP 10450467 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Csf2  (colony stimulating factor 2)

Genes (Mus musculus)
Csf2  (colony stimulating factor 2 (granulocyte-macrophage))

Genes (Homo sapiens)
CSF2  (colony stimulating factor 2)


Additional Information