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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621065
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Csf2
Name: colony stimulating factor 2
Acc ID: CHEBI:28177
Term: theophylline
Definition: A dimethylxanthine having the two methyl groups located at positions 1 and 3. It is structurally similar to caffeine and is found in green and black tea.
Chemical ID: MESH:D013806
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Csf2decreases expressionISOCSF2 (Homo sapiens)6480464CTDTheophylline results in decreased expression of CSF2 mRNAPMID:10596698
Csf2multiple interactionsISOCSF2 (Homo sapiens)6480464CTD[Theophylline co-treated with Dexamethasone] inhibits the reaction [IL1B protein results in increased secretion of CSF2 protein]; Theophylline inhibits the reaction [CSF2 protein results in increased expression of EDN1 mRNA]; Theophylline promotes the reaction [IL1B protein results in increased secretion of CSF2 protein]; trichostatin A inhibits the reaction [[Theophylline co-treated with Dexamethasone] inhibits the reaction [IL1B protein results in increased secretion of CSF2 protein]]PMID:10374451 PMID:12070353
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