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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621065
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Csf2
Name: colony stimulating factor 2
Acc ID: CHEBI:17747
Term: bis(2-ethylhexyl) phthalate
Definition: A phthalate ester that is the bis(2-ethylhexyl) ester of benzene-1,2-dicarboxylic acid.
Chemical ID: MESH:D004051
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Csf2increases expressionISOCsf2 (Mus musculus)6480464CTDDiethylhexyl Phthalate results in increased expression of CSF2 mRNAPMID:36583613
Csf2multiple interactionsISOCsf2 (Mus musculus)6480464CTD[Diethylhexyl Phthalate co-treated with CSF2] results in increased expression of IFNG protein; [Diethylhexyl Phthalate co-treated with CSF2] results in increased expression of IL10 protein; [Diethylhexyl Phthalate co-treated with CSF2] results in increased expression of IL4 protein; Diethylhexyl Phthalate inhibits the reaction [[CSF2 protein co-treated with IL4 protein] results in increased expression of CD40 protein]; Diethylhexyl Phthalate inhibits the reaction [[CSF2 protein co-treated with IL4 protein] results in increased expression of CD80 protein]; Diethylhexyl Phthalate inhibits the reaction [[CSF2 protein co-treated with IL4 protein] results in increased expression of CD86 protein]; Diethylhexyl Phthalate inhibits the reaction [[CSF2 protein co-treated with IL4 protein] results in increased expression of ITGAX protein]; Diethylhexyl Phthalate inhibits the reaction [[CSF2 protein co-treated with IL4 protein] results in increased expression of LY75 protein]; Diethylhexyl Phthalate inhibits the reaction [[CSF2 protein co-treated with IL4 protein] results in increased expression of SELL protein]; Fulvestrant inhibits the reaction [Diethylhexyl Phthalate inhibits the reaction [[CSF2 protein co-treated with IL4 protein] results in increased expression of CD86 protein]]; Fulvestrant inhibits the reaction [Diethylhexyl Phthalate inhibits the reaction [[CSF2 protein co-treated with IL4 protein] results in increased expression of LY75 protein]]; Lycopene inhibits the reaction [Diethylhexyl Phthalate results in increased expression of CSF2 mRNA]PMID:19428943 PMID:21538406 PMID:36583613
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