Gene:	Axin1 ( Rattus norvegicus ) axin 1
Description:	plays a role in synaptic organization and function
Synonyms:	GSK-3beta interacting protein rAxin; Axin;
ArrayIDs:	5788984; rc_AI639478_at; 5765760; 5842114; GE1292484; A_43_P12444; 1392798_at; 5703074; 1387056_at; 6465460; AF017756_at; 6683034; 6612433; 5660496; 6540671; 6368108; 6407648; 5925732; 6182986; 5805145; 5624662; 5920310; 5948320; 6245943; 6442248; 6103433; 5739732; 6262204; 6247069; 5891441; GE13190; A_44_P154049; 6591949; 6394841;  (details...)
Gene Type:	protein-coding
Additional Data
Homologs
Homo sapiens: AXIN1     See the Human gene in context in:     UCSC     NCBI MapViewer
Mus musculus: Axin1     See the Mouse gene in context in:     UCSC     NCBI MapViewer
Comparative Map Data Species Symbol Map Name Chr. Position Rattus norvegicus Axin1 genome assembly 3.1 10 15410421 - 15463774     Rat Celera Assembly 10 14831660 - 14883421     RGSC genome assembly v3.4 10 15409372 - 15462726     Cytogenetic 10 q12 Mus musculus Axin1 Mouse genome assembly build 36.1 17 26275679 - 26332756     Cytogenetic 17 17 A3.3 Homo sapiens AXIN1 human genome assembly 16 277440 - 342465     Human genome assembly build 36.2 16 277441 - 342465     Cytogenetic 16 p13.3   View comparative maps:      NCBI MapViewer
Genome
View:
Browsers:	Select a browser to viewGene (GBrowse)Gene and SNPs (GBrowse)UCSCVCMAPEnsemblNCBIECRVISTAVISTA+UCSC
Annotation
Molecular Function	Gene Ontology signal transducer activity,  armadillo repeat domain binding,  protein binding ...  (details...)
Biological Process	Gene Ontology multicellular organismal development,  Wnt receptor signaling pathway through beta-catenin,  positive regulation of peptidyl-serine phosphorylation ...  (details...)
Cellular Component	Gene Ontology synapse,  nucleus,  cytoplasm ...  (details...)
Disease	Ontology Carcinoma, Hepatocellular,  Colorectal Neoplasms (details...)
Pathway	Ontology altered canonical Wnt signaling pathway,  colorectal cancer pathway,  canonical Wnt signaling pathway (details...)
Protein	Note Reference 832 amino acids 632259
Domain	Note Reference contains Regulators of G protein Signaling (RGS) and dishevelled (Dsh) homologous domains in its N- and C-terminals, respectively 632259
Physical interaction	Note Reference forms a complex with synaptic scaffolding molecule S-SCAM and beta-catenin 1304344
Homology	Note Reference amino acid level shows 94% identity to mouse Axin 632259
External Links
Databases	DATABASE ID SOURCE SMART: RGS IPI SMART: DAX IPI PROSITE: DIX IPI PROSITE: RGS IPI UNIPARC: UPI00001679D2 IPI UNIPARC: UPI000021D79A IPI KEGG Report: rno:79257 ENTREZGENE HomoloGene Group ID: 2614 ENTREZGENE Germonline: 620859 Pfam: RGS IPI Pfam: DIX IPI Pfam: Axin_b-cat_bind IPI KEGG Pathway: 05213 ENTREZGENE KEGG Pathway: 05210 ENTREZGENE KEGG Pathway: 05217 ENTREZGENE KEGG Pathway: 04310 ENTREZGENE InterPro: DIX. IPI InterPro: Regulat_G_prot_signal. IPI InterPro: Regulat_G_prot_signal_superfam. IPI InterPro: Axin_b-cat_bd. IPI IPI: IPI00231576 IPI IPI: IPI00204189 IPI Ensembl Protein: ENSRNOP00000027705 IPI Ensembl Protein: ENSRNOP00000044336 IPI Entrez Gene: Axin1 ENTREZGENE UniProt: AXN1_RAT IPI Ensembl Genes: ENSRNOG00000020414 IPI Superfamily-SCOP: Regulat_G_prot_signal_superfam IPI PRINTS: RGSPROTEIN. IPI
Sequences	Nucleotide: CH473948 Get FASTA Search GEO Profiles Nucleotide: NM_024405 Get FASTA Search GEO Profiles Nucleotide: AF017756 Get FASTA Search GEO Profiles (View all 3 Nucleotide Accessions) Protein: EDM03996 Get FASTA Protein: EDM03995 Get FASTA Protein: AAC40066 Get FASTA Protein: EDM03997 Get FASTA Protein: NP_077381 Get FASTA Protein: O70239 Get FASTA (View all 6 Protein Accessions)
Clusters	UniGene: 31781
References
Curated References	9 references in RGD related to Axin1
Other References	6 other references at PubMed related to Axin1
Database Information
RGD ID	620859
History	Date Current Symbol Current Name Previous Symbol Previous name Status Description Reference 14-DEC-04: Axin1 axin 1 Axin GSK-3beta interacting protein rAxin APPROVED Symbol and Name updated 1299863 07-AUG-02: Axin GSK-3beta interacting protein rAxin PROVISIONAL Symbol and Name status set to provisional 70820