Gene: AXIN1 (axin 1)  Homo sapiens

Symbol: AXIN1
Name: axin 1
Description: This gene encodes a cytoplasmic protein which contains a regulation of G-protein signaling (RGS) domain and a dishevelled and axin (DIX) domain. The encoded protein interacts with adenomatosis polyposis coli, catenin beta-1, glycogen synthase kinase 3 beta, protein phosphate 2, and itself. This protein functions as a negative regulator of the wingless-type MMTV integration site family, member 1 (WNT) signaling pathway and can induce apoptosis. The crystal structure of a portion of this protein, alone and in a complex with other proteins, has been resolved. Mutations in this gene have been associated with hepatocellular carcinoma, hepatoblastomas, ovarian endometriod adenocarcinomas, and medullablastomas. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Dec 2010]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: AXIN; axin-1; axis inhibition protein 1; axis inhibitor 1; fused, mouse, homolog of; gsk-3beta interacting protein raxin; hAxin; MGC52315; OTTHUMP00000067405; OTTHUMP00000067406; PPP1R49; protein phosphatase 1, regulatory subunit 49
Orthologs: Mus musculus : Axin1 (axin 1)  MGI
Rattus norvegicus : Axin1 (axin 1)
Latest Assembly: Human Genome Assembly GRCh37
Position:
MapChrPositionStrandSource
Human Alternate Assembly CHM1_116276,306 - 364,897-NCBI
Human Genome Assembly HuRef16255,743 - 344,360-NCBI
Human Genome Assembly GRCh3716337,440 - 402,676-NCBI
Human Genome Assembly Build 3616277,441 - 342,465-NCBI
Human Cytogenetic Map16p13.3 NCBI
Human Genome Assembly16277,440 - 342,465 NCBI
Model

Launch Genome Browser (GBrowse) : build 36 (hg18) build 37 (hg19)


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated
RGD Disease Portals

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Human Genome Assembly GRCh37)

Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
Nomenclature History
 
More on AXIN1
Entrez Gene
Ensembl Gene
Genome Browser: (hg18) (hg19)
HGNC Report
NCBI Map Viewer
Vista
Vista + UCSC

RGD Object Information
RGD ID: 736564
Created: 2004-02-06
Species: Homo sapiens
Last Modified: 2013-05-14
Status: ACTIVE