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Gene-Chemical Interaction AnnotationsGene-Chemical Interaction Annotations
Gene-Chemical Interaction AnnotationsTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | 1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane | increases expression | ISO | RGD:1552250 | 6480464 | 2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane results in increased expression of AXIN1 mRNA | CTD | PMID:20826375 | 17beta-estradiol | increases expression | ISO | RGD:1552250 | 6480464 | Estradiol results in increased expression of AXIN1 mRNA | CTD | PMID:20826375 | 2,4-dinitrotoluene | affects expression | EXP | | 6480464 | 2,4-dinitrotoluene affects the expression of AXIN1 mRNA | CTD | PMID:21346803 | 2-methylcholine | affects expression | ISO | RGD:736564 | 6480464 | beta-methylcholine affects the expression of AXIN1 mRNA | CTD | PMID:21179406 | all-trans-retinoic acid | increases expression | ISO | RGD:736564 | 6480464 | Tretinoin results in increased expression of AXIN1 mRNA | CTD | PMID:15498508 | ammonium chloride | affects expression | EXP | | 6480464 | Ammonium Chloride affects the expression of AXIN1 mRNA | CTD | PMID:16483693 | benzo[a]pyrene | multiple interactions | ISO | RGD:1552250 | 6480464 | [Benzo(a)pyrene co-treated with XPA gene mutant form co-treated with TRP53 gene mutant form] results in decreased expression of AXIN1 mRNA | CTD | PMID:21715664 | bisphenol A | increases expression | ISO | RGD:1552250 | 6480464 | bisphenol A results in increased expression of AXIN1 mRNA | CTD | PMID:20826375 | calcium atom | affects expression | EXP | | 6480464 | Calcium affects the expression of AXIN1 mRNA | CTD | PMID:15913539 | calcium(0) | affects expression | EXP | | 6480464 | Calcium affects the expression of AXIN1 mRNA | CTD | PMID:15913539 | choline | multiple interactions | ISO | RGD:1552250 | 6480464 | [Folic Acid co-treated with Vitamin B 12 co-treated with Betaine co-treated with Choline] results in increased methylation of AXIN1 gene | CTD | PMID:16868943 | cyanocob(III)alamin | multiple interactions | ISO | RGD:1552250 | 6480464 | [Folic Acid co-treated with Vitamin B 12 co-treated with Betaine co-treated with Choline] results in increased methylation of AXIN1 gene | CTD | PMID:16868943 | dibenzo[a,l]pyrene | decreases expression | ISO | RGD:736564 | 6480464 | dibenzo(a,l)pyrene results in decreased expression of AXIN1 mRNA | CTD | PMID:16269432 | dibutyl phthalate | decreases expression | EXP | | 6480464 | Dibutyl Phthalate results in decreased expression of AXIN1 mRNA | CTD | PMID:21266533 | disodium selenite | increases expression | ISO | RGD:736564 | 6480464 | Sodium Selenite results in increased expression of AXIN1 mRNA | CTD | PMID:18175754 | doxorubicin | multiple interactions | ISO | RGD:1552250 | 6480464 | [[MT1 protein co-treated with MT2 protein] affects the susceptibility to Doxorubicin] which affects the expression of AXIN1 mRNA | CTD | PMID:21040762 | folic acid | multiple interactions | ISO | RGD:1552250 | 6480464 | [Folic Acid co-treated with Vitamin B 12 co-treated with Betaine co-treated with Choline] results in increased methylation of AXIN1 gene | CTD | PMID:16868943 | glycine betaine | multiple interactions | ISO | RGD:1552250 | 6480464 | [Folic Acid co-treated with Vitamin B 12 co-treated with Betaine co-treated with Choline] results in increased methylation of AXIN1 gene | CTD | PMID:16868943 | paracetamol | affects expression | ISO | RGD:1552250 | 6480464 | Acetaminophen affects the expression of AXIN1 mRNA | CTD | PMID:17562736 | phenobarbital | affects expression | ISO | RGD:736564 | 6480464 | Phenobarbital affects the expression of AXIN1 mRNA | CTD | PMID:19159669 | progesterone | affects expression | ISO | RGD:1552250 | 6480464 | Progesterone affects the expression of AXIN1 mRNA | CTD | PMID:17251523 | progesterone | increases expression | EXP | | 6480464 | Progesterone results in increased expression of AXIN1 mRNA | CTD | PMID:17170212 | tamibarotene | increases expression | ISO | RGD:736564 | 6480464 | Am 80 results in increased expression of AXIN1 mRNA; more ... | CTD | PMID:15498508 | valproic acid | decreases expression | ISO | RGD:1552250 | 6480464 | Valproic Acid results in decreased expression of AXIN1 mRNA | CTD | PMID:19136453 | | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Gene Ontology AnnotationsMolecular Pathway AnnotationsDisease Annotations
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Gene-Chemical Interaction Annotations
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Gene Ontology Annotations
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Molecular Pathway Annotations
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| External Database Links | |
| KEGG Pathway | Basal cell carcinoma |
| Colorectal cancer | |
| Endometrial cancer | |
| Hippo signaling pathway | |
| Pathways in cancer | |
| Wnt signaling pathway | |
| Pathway Interaction Database | C-MYC pathway (PID:200111) |
| Canonical Wnt signaling pathway (PID:200077) | |
| Degradation of beta catenin (PID:200024) | |
| N-cadherin signaling events (PID:200209) | |
| Presenilin action in Notch and Wnt signaling (PID:200063) | |
| TGF-beta receptor signaling (PID:200227) | |
References - curated| 1. |
GOA data from the GO Consortium |
| 2. |
Hirabayashi S, etal., J Neurochem 2004 Jul;90(2):332-9. |
| 3. |
Ikeda S, etal., EMBO J 1998 Mar 2;17(5):1371-84. |
| 4. |
Kadoya T, etal., J Biol Chem 2000 Nov 24;275(47):37030-7. |
| 5. |
Kim SI, etal., Biochem Biophys Res Commun 2004 Apr 30;317(2):478-83. |
| 6. |
Kishida S, etal., Mol Cell Biol. 1999 Jun;19(6):4414-22. |
| 7. |
Klaus A and Birchmeier W, Nat Rev Cancer. 2008 May;8(5):387-98. |
| 8. |
MGD data from the GO Consortium |
| 9. |
NCBI rat LocusLink and RefSeq merged data July 26, 2002 |
| 10. |
Pipeline to import KEGG annotations from KEGG into RGD Pathway Ontology |
| 11. |
Pipeline to import Pathway Interaction Database annotations from NCI into RGD |
| 12. |
RGD automated data pipeline |
| 13. |
RGD automated import pipeline for gene-chemical interactions |
| 14. |
RGD Automated Pipelines |
| 15. |
Satoh S, etal., Nat Genet 2000 Mar;24(3):245-50. |
References - uncuratedRGD Disease Portals| Axin1 has been annotated in the following RGD Disease Portals. |
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Comparative Map Data| Axin1 (Rattus norvegicus) |
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| AXIN1 (Homo sapiens) |
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| Axin1 (Mus musculus) |
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Position Markers| PMC134648P1 |
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| RH144513 |
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| RH140789 |
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QTLs in Region (RGSC Genome Assembly v3.4)| The following QTLs overlap with this region. |  | Full Report | | CSV | | TAB | | Printer | | Gviewer |
Nucleotide Sequences| Nucleotide RefSeqs | NM_024405 | (Get FASTA) | Search GEO for Microarray Profiles |
| GenBank Nucleotide | AABR06063030 | (Get FASTA) | Search GEO for Microarray Profiles |
| AAHX01062953 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01062954 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01062955 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AF017756 | (Get FASTA) | Search GEO for Microarray Profiles | |
| CH473948 | (Get FASTA) | Search GEO for Microarray Profiles |
| RefSeq Acc Id: | NM_024405 | ||||||||||||||||||||
| RefSeq Status: | PROVISIONAL | ||||||||||||||||||||
| Type: | CODING | ||||||||||||||||||||
| Protein Acc Id: | NP_077381 | ||||||||||||||||||||
| Position: |
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Protein Sequences| Protein RefSeqs | NP_077381 | (Get FASTA) |
| GenBank Protein | AAC40066 | (Get FASTA) |
| EDM03995 | (Get FASTA) | |
| EDM03996 | (Get FASTA) | |
| EDM03997 | (Get FASTA) | |
| O70239 | (Get FASTA) |
Strain Sequence Variants
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External Database Links| Database | Acc Id | Source(s) |
| Ensembl Genes | ENSRNOG00000020414 | ENTREZGENE, UniProtKB/Swiss-Prot |
| Ensembl Protein | ENSRNOP00000027705 | ENTREZGENE, UniProtKB/Swiss-Prot |
| Ensembl Transcript | ENSRNOT00000027705 | ENTREZGENE, UniProtKB/Swiss-Prot |
| Entrez Gene | 79257 | ENTREZGENE |
| Gene3D-CATH | G3DSA:1.10.196.10 | UniProtKB/Swiss-Prot |
| Germonline | ENSRNOG00000020414 | UniProtKB/Swiss-Prot |
| HomoloGene Group ID | 2614 | ENTREZGENE |
| InterPro | Axin_b-cat_bd | UniProtKB/Swiss-Prot |
| DIX | UniProtKB/Swiss-Prot | |
| Regulat_G_prot_signal | UniProtKB/Swiss-Prot | |
| Regulat_G_prot_signal_dom1 | UniProtKB/Swiss-Prot | |
| Regulat_G_prot_signal_superfam | UniProtKB/Swiss-Prot | |
| IPI | IPI00231576 | UniProtKB/Swiss-Prot |
| KEGG Report | rno:79257 | ENTREZGENE, UniProtKB/Swiss-Prot |
| Pfam | Axin_b-cat_bind | UniProtKB/Swiss-Prot |
| DIX | UniProtKB/Swiss-Prot | |
| RGS | UniProtKB/Swiss-Prot | |
| PRINTS | RGSPROTEIN | UniProtKB/Swiss-Prot |
| PROSITE | DIX | UniProtKB/Swiss-Prot |
| RGS | UniProtKB/Swiss-Prot | |
| SMART | DAX | UniProtKB/Swiss-Prot |
| RGS | UniProtKB/Swiss-Prot | |
| Superfamily-SCOP | Regulat_G_prot_signal_superfam | UniProtKB/Swiss-Prot |
| UniGene | Rn.31781 | ENTREZGENE |
| UniProt | AXN1_RAT | UniProtKB/Swiss-Prot |
Nomenclature History| Date | Current Symbol | Current Name | Previous Symbol | Previous Name | Description | Reference | Status |
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| 2004-12-14 | Axin1 | axin 1 | Axin | GSK-3beta interacting protein rAxin | Symbol and Name updated | 10779 | APPROVED |
| 2002-08-07 | Axin | GSK-3beta interacting protein rAxin | Symbol and Name status set to provisional | 1724 | PROVISIONAL |
RGD Curation Notes| Note Type | Note | Reference |
|---|---|---|
| gene_domains | contains Regulators of G protein Signaling (RGS) and dishevelled (Dsh) homologous domains in its N- and C-terminals, respectively | 632259 |
| gene_homology | amino acid level shows 94% identity to mouse Axin | 632259 |
| gene_physical_interaction | forms a complex with synaptic scaffolding molecule S-SCAM and beta-catenin | 1304344 |
| gene_protein | 832 amino acids | 632259 |
| More on Axin1 | |
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Entrez Gene |
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Ensembl Gene |
| Genome Browser |
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NCBI Map Viewer |
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Vista |
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Vista + UCSC |
| RGD Object Information | |
| RGD ID: | 620859 |
| Created: | 2002-08-06 |
| Species: | Rattus norvegicus |
| Last Modified: | 2013-04-16 |
| Status: | ACTIVE |
© Bioinformatics Program, HMGC at the Medical College of Wisconsin
RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.