Gene:	Sos2 ( Rattus norvegicus ) son of sevenless homolog 2 (Drosophila)
Description:	mRNA expression increases after chronic clozapine treatment in the prefrontal cortex; may play a role in synaptic function
Synonyms:	son of sevenless 1; Sos1;
ArrayIDs:	6666198; 5846912; 1376489_at; 6538160; 5669318; rc_AI044857_at; rc_AI228913_at; 6102364; 6619927; 6675227; 5733721; A_43_P15943; 6387302; 6614356; 5779018; 6411076; 5733211; 5620092; 6327956; 6149465; 6678437; 6182966; 6491977; 5710881; 6359467; 6392445; 6137128; 6251626; 6658235; 6251526; A_42_P559085; 5793239; 5802691;  (details...)
Gene Type:	protein-coding
Additional Data
Homologs
Comparative Map Data Species Symbol Map Name Chr. Position Rattus norvegicus Sos2 Rat Celera Assembly 6 86538140 - 86650990     Cytogenetic 6 q24     genome assembly 3.1 6 91671060 - 91684551   View comparative maps:
Genome
View:
Browsers:	Select a browser to viewGene (GBrowse)Gene and SNPs (GBrowse)UCSCVCMAPEnsemblNCBIECRVISTAVISTA+UCSC
Annotation
Molecular Function	Gene Ontology protein binding,  Rho guanyl-nucleotide exchange factor activity,  DNA binding (details...)
Biological Process	Gene Ontology small GTPase mediated signal transduction,  regulation of Rho protein signal transduction (details...)
Cellular Component	Gene Ontology intracellular,  cytosol (details...)
Pathway	Ontology insulin signaling pathway (details...)
External Links
Databases	DATABASE ID SOURCE SMART: RasGEF IPI SMART: PH IPI SMART: RasGEFN IPI SMART: RhoGEF IPI PROSITE: DH_2 IPI PROSITE: RASGEF_NTER IPI PROSITE: RASGEF_CAT IPI PROSITE: RASGEF IPI PROSITE: PH_DOMAIN IPI UNIPARC: UPI0000506EEC IPI KEGG Report: rno:85384 ENTREZGENE Germonline: 620435 Pfam: Histone IPI Pfam: PH IPI Pfam: RasGEF_N IPI Pfam: RhoGEF IPI Pfam: RasGEF IPI KEGG Pathway: 04660 ENTREZGENE KEGG Pathway: 05211 ENTREZGENE KEGG Pathway: 04810 ENTREZGENE KEGG Pathway: 05215 ENTREZGENE KEGG Pathway: 05223 ENTREZGENE KEGG Pathway: 04650 ENTREZGENE KEGG Pathway: 04010 ENTREZGENE KEGG Pathway: 04630 ENTREZGENE KEGG Pathway: 04910 ENTREZGENE KEGG Pathway: 04912 ENTREZGENE KEGG Pathway: 05214 ENTREZGENE KEGG Pathway: 04540 ENTREZGENE KEGG Pathway: 04510 ENTREZGENE KEGG Pathway: 04664 ENTREZGENE KEGG Pathway: 04012 ENTREZGENE KEGG Pathway: 05213 ENTREZGENE KEGG Pathway: 04320 ENTREZGENE KEGG Pathway: 05220 ENTREZGENE KEGG Pathway: 05210 ENTREZGENE InterPro: Ras_G-nucl-exch_fac_CS. IPI InterPro: Histone-fold. IPI InterPro: DH-domain. IPI InterPro: PH_type. IPI InterPro: Pleckstrin_homology. IPI InterPro: Ras-like_Gua-exchang_fac_N. IPI InterPro: Ras_GEF. IPI InterPro: RasGRF_CDC25. IPI InterPro: Sos. IPI InterPro: Histone_core_D. IPI IPI: IPI00367392 IPI Ensembl Protein: ENSRNOP00000006425 IPI Gene3D-CATH: PH_type IPI Gene3D-CATH: RhoGEF IPI Gene3D-CATH: Histone-fold IPI Gene3D-CATH: RasGRF_CDC25 IPI Entrez Gene: Sos2 ENTREZGENE UniProt: Q9Z1I1_RAT IPI Ensembl Genes: ENSRNOG00000004826 IPI Superfamily-SCOP: DH-domain IPI Superfamily-SCOP: Histone-fold IPI Superfamily-SCOP: Ras_GEF IPI PANTHER: Ras_GEF IPI PANTHER: Sos IPI
Sequences	Nucleotide: D83014 Get FASTA Search GEO Profiles Nucleotide: NM_001135561 Get FASTA Search GEO Profiles Nucleotide: XM_001080400 Get FASTA Search GEO Profiles (View all 3 Nucleotide Accessions) Protein: Q9Z1I1 Get FASTA Protein: XP_001080400 Get FASTA Protein: NP_001129033 Get FASTA Protein: BAA74949 Get FASTA (View all 4 Protein Accessions)
Clusters	UniGene: 4226
References
Curated References	8 references in RGD related to Sos2
Other References	3 other references at PubMed related to Sos2
Database Information
RGD ID	620435
History	Date Current Symbol Current Name Previous Symbol Previous name Status Description Reference 15-DEC-04: Sos2 son of sevenless homolog 2 (Drosophila) Sos1 son of sevenless 1 APPROVED Symbol and Name updated to reflect Human and Mouse nomenclature 1299863 07-AUG-02: Sos1 son of sevenless 1 PROVISIONAL Symbol and Name status set to provisional 70820