Sos2 (SOS Ras/Rho guanine nucleotide exchange factor 2) - Rat Genome Database

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Gene: Sos2 (SOS Ras/Rho guanine nucleotide exchange factor 2) Rattus norvegicus
Analyze
Symbol: Sos2
Name: SOS Ras/Rho guanine nucleotide exchange factor 2
RGD ID: 620435
Description: Predicted to enable guanyl-nucleotide exchange factor activity. Involved in positive regulation of small GTPase mediated signal transduction. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in Noonan syndrome 9. Orthologous to human SOS2 (SOS Ras/Rho guanine nucleotide exchange factor 2); PARTICIPATES IN insulin signaling pathway; epidermal growth factor/neuregulin signaling pathway; interleukin-6 signaling pathway; INTERACTS WITH 1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile; 2,3,7,8-tetrachlorodibenzodioxine; 2,6-dinitrotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: son of sevenless 1; son of sevenless homolog 2; son of sevenless homolog 2 (Drosophila); Sos1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8693,778,971 - 93,892,161 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl693,778,971 - 93,892,811 (-)EnsemblGRCr8
mRatBN7.2688,042,966 - 88,156,140 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl688,042,966 - 88,156,692 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx688,441,868 - 88,554,726 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0688,741,318 - 88,854,178 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0688,181,063 - 88,293,917 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0691,885,292 - 92,008,059 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl691,883,425 - 92,007,957 (-)Ensemblrn6Rnor6.0
Rnor_5.06101,337,035 - 101,457,580 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4691,609,463 - 91,722,481 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera686,538,138 - 86,650,990 (-)NCBICelera
RGSC_v3.1691,671,060 - 91,684,551 (-)NCBI
Cytogenetic Map6q24NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
(1->4)-beta-D-glucan  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile  (EXP)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
2,6-dinitrotoluene  (EXP)
acrylamide  (EXP)
aflatoxin B1  (ISO)
ammonium chloride  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
benzene  (EXP)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP,ISO)
butanal  (ISO)
butyric acid  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
calcitriol  (ISO)
cannabidiol  (ISO)
carbamazepine  (ISO)
chromium(6+)  (ISO)
citalopram  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
DDE  (ISO)
Dibutyl phosphate  (ISO)
diclofenac  (ISO)
diuron  (EXP)
doxorubicin  (ISO)
entinostat  (ISO)
epoxiconazole  (ISO)
escitalopram  (EXP)
ethyl methanesulfonate  (ISO)
fluvastatin  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
fulvestrant  (ISO)
geldanamycin  (ISO)
lead(0)  (ISO)
leflunomide  (ISO)
methoxychlor  (EXP)
methyl methanesulfonate  (ISO)
methylmercury(1+)  (EXP)
ochratoxin A  (ISO)
ouabain  (ISO)
oxaliplatin  (EXP)
perfluorooctane-1-sulfonic acid  (ISO)
phenobarbital  (ISO)
potassium chromate  (ISO)
sodium arsenite  (ISO)
sunitinib  (ISO)
testosterone enanthate  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
topotecan  (EXP)
trichloroethene  (EXP)
trichostatin A  (ISO)
triptonide  (ISO)
tungsten  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vorinostat  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. EGF-ERBB signalling: towards the systems level. Citri A and Yarden Y, Nat Rev Mol Cell Biol. 2006 Jul;7(7):505-16.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Insulin signaling through insulin receptor substrate 1 and 2 in normal liver development. Khamzina L, etal., Gastroenterology 2003 Aug;125(2):572-85.
5. Effect of long-term exercise on gene expression of insulin signaling pathway intermediates in skeletal muscle. Kim YB, etal., Biochem Biophys Res Commun 1999 Jan 27;254(3):720-7.
6. Antipsychotic drug treatment induces differential gene expression in the rat cortex. Kontkanen O, etal., J Neurochem 2002 Dec;83(5):1043-53.
7. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
8. IL-6/IL-6 receptor system and its role in physiological and pathological conditions. Mihara M, etal., Clin Sci (Lond). 2012 Feb;122(4):143-59. doi: 10.1042/CS20110340.
9. Sam68 associates with the SH3 domains of Grb2 recruiting GAP to the Grb2-SOS complex in insulin receptor signaling. Najib S and Sanchez-Margalet V, J Cell Biochem 2002;86(1):99-106.
10. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
11. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
12. GOA pipeline RGD automated data pipeline
13. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
14. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
15. Comprehensive gene review and curation RGD comprehensive gene curation
16. Src-dependent TrkA transactivation is required for pituitary adenylate cyclase-activating polypeptide 38-mediated Rit activation and neuronal differentiation. Shi GX, etal., Mol Biol Cell. 2010 May 1;21(9):1597-608. Epub 2010 Mar 10.
Additional References at PubMed
PMID:8316835   PMID:14712229   PMID:15728722   PMID:24043312  


Genomics

Comparative Map Data
Sos2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8693,778,971 - 93,892,161 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl693,778,971 - 93,892,811 (-)EnsemblGRCr8
mRatBN7.2688,042,966 - 88,156,140 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl688,042,966 - 88,156,692 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx688,441,868 - 88,554,726 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0688,741,318 - 88,854,178 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0688,181,063 - 88,293,917 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0691,885,292 - 92,008,059 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl691,883,425 - 92,007,957 (-)Ensemblrn6Rnor6.0
Rnor_5.06101,337,035 - 101,457,580 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4691,609,463 - 91,722,481 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera686,538,138 - 86,650,990 (-)NCBICelera
RGSC_v3.1691,671,060 - 91,684,551 (-)NCBI
Cytogenetic Map6q24NCBI
SOS2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381450,117,130 - 50,231,882 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1450,117,130 - 50,231,906 (-)Ensemblhg38GRCh38
GRCh371450,583,848 - 50,698,296 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361449,653,596 - 49,767,849 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341449,654,811 - 49,767,751NCBI
Celera1430,450,982 - 30,565,239 (-)NCBICelera
Cytogenetic Map14q21.3NCBI
HuRef1430,709,316 - 30,823,581 (-)NCBIHuRef
CHM1_11450,522,549 - 50,636,772 (-)NCBICHM1_1
T2T-CHM13v2.01444,323,369 - 44,437,823 (-)NCBIT2T-CHM13v2.0
Sos2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391269,630,535 - 69,728,626 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1269,630,536 - 69,728,626 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381269,583,761 - 69,681,852 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1269,583,762 - 69,681,852 (-)Ensemblmm10GRCm38
MGSCv371270,684,748 - 70,782,839 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361270,502,366 - 70,604,506 (-)NCBIMGSCv36mm8
Celera1270,672,614 - 70,748,402 (-)NCBICelera
Cytogenetic Map12C2NCBI
cM Map1228.93NCBI
Sos2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540912,542,401 - 12,620,971 (+)Ensembl
ChiLan1.0NW_00495540912,542,353 - 12,622,165 (+)NCBIChiLan1.0ChiLan1.0
SOS2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21551,258,304 - 51,371,362 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11450,473,416 - 50,587,987 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01430,707,477 - 30,822,029 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11449,013,565 - 49,125,554 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1449,014,782 - 49,101,764 (-)EnsemblpanPan2panpan1.1
SOS2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1826,636,849 - 26,698,837 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl826,637,895 - 26,717,781 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha826,390,439 - 26,470,730 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0826,814,649 - 26,894,950 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl826,815,329 - 26,894,886 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1826,469,577 - 26,549,895 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0826,542,070 - 26,622,344 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0826,860,723 - 26,941,080 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Sos2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864058,809,388 - 58,905,175 (-)NCBIHiC_Itri_2
SpeTri2.0NW_00493649515,286,524 - 15,365,598 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SOS2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1179,907,590 - 180,015,220 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11179,907,578 - 180,014,941 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21200,269,189 - 200,355,926 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SOS2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12427,183,571 - 27,302,201 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2427,182,991 - 27,302,141 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366605315,512,960 - 15,627,378 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Sos2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473118,601,651 - 18,695,603 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462473118,601,652 - 18,694,593 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Sos2
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1783,229,601 - 83,341,505 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Sos2
641 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:219
Count of miRNA genes:153
Interacting mature miRNAs:181
Transcripts:ENSRNOT00000006425
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2293088Iddm28Insulin dependent diabetes mellitus QTL 285.21blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)668767270135411972Rat
1331799Bp211Blood pressure QTL 2113.66407arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)688019181136741135Rat
4889933Bss88Bone structure and strength QTL 883.8tibia size trait (VT:0100001)tibia total bone volume (CMO:0001724)65368492198684921Rat
61329Eae9Experimental allergic encephalomyelitis QTL 93.7body mass (VT:0001259)change in body weight (CMO:0002045)684490437129490437Rat
5684992Bmd83Bone mineral density QTL 824.8tibia mineral mass (VT:1000283)bone mineral content (CMO:0001554)65368492198684921Rat
1331789Rf37Renal function QTL 373.224kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)686494122112380234Rat
4145119Mcs25Mammary carcinoma susceptibility QTL 250.0001mammary gland integrity trait (VT:0010552)ratio of deaths to total study population during a period of time (CMO:0001023)671278722116278722Rat
70176Mcsm1Mammary carcinoma susceptibility modifier QTL 1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)664367996109367996Rat
10054138Gmadr3Adrenal mass QTL 33.680.00045adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)690871046135871046Rat
1581563Uae33Urinary albumin excretion QTL 33urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)693560258136550638Rat
1558641Cm47Cardiac mass QTL 472.90.001heart mass (VT:0007028)heart wet weight (CMO:0000069)66345744194939581Rat
724524Uae2Urinary albumin excretion QTL 22.70.0005urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)679198463144254945Rat
737827Hcar11Hepatocarcinoma resistance QTL 114.4liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)646050607116278722Rat
2303624Vencon5Ventilatory control QTL 54.45respiration trait (VT:0001943)minute ventilation (CMO:0000132)693778632138778632Rat
1576309Emca7Estrogen-induced mammary cancer QTL 74mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)620859430113082285Rat
2293837Kiddil1Kidney dilation QTL 13.7kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)686867923110125012Rat
2293842Kiddil3Kidney dilation QTL 34.3kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)686867923110125012Rat
4889848Pur25Proteinuria QTL 25140.003urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)66303731995934232Rat
10054123Srcrt6Stress Responsive Cort QTL 62.50.0043blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)690871046135871046Rat
724536Uae7Urinary albumin excretion QTL 73.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)693560258136550638Rat
5684963Bss99Bone structure and strength QTL 993.1tibia area (VT:1000281)tibia area measurement (CMO:0001382)65368492198684921Rat
1576302Schws4Schwannoma susceptibility QTL 40.0078nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)678204640123204640Rat
1581550Pur8Proteinuria QTL 8urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)693560258136550638Rat
1300075Glom7Glomerulus QTL 75.60.0000002kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)676937178121937178Rat
6893332Cm74Cardiac mass QTL 740.40.64heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)66345744194939581Rat

Markers in Region
D6Rat197  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8693,848,633 - 93,848,847 (+)Marker Load Pipeline
mRatBN7.2688,112,631 - 88,112,845 (+)MAPPERmRatBN7.2
Rnor_6.0691,953,739 - 91,953,952NCBIRnor6.0
Rnor_5.06101,405,482 - 101,405,695UniSTSRnor5.0
RGSC_v3.4691,679,125 - 91,679,339RGDRGSC3.4
RGSC_v3.4691,679,126 - 91,679,339UniSTSRGSC3.4
Celera686,607,537 - 86,607,750UniSTS
RGSC_v3.1691,682,581 - 91,682,795RGD
SHRSP x BN Map653.3798UniSTS
SHRSP x BN Map653.3798RGD
Cytogenetic Map6q24UniSTS
BI288574  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8693,782,168 - 93,782,321 (+)Marker Load Pipeline
mRatBN7.2688,046,163 - 88,046,316 (+)MAPPERmRatBN7.2
Rnor_6.0691,888,490 - 91,888,642NCBIRnor6.0
Rnor_5.06101,340,233 - 101,340,385UniSTSRnor5.0
RGSC_v3.4691,612,661 - 91,612,813UniSTSRGSC3.4
Celera686,541,336 - 86,541,488UniSTS
RH 3.4 Map6629.5UniSTS
Cytogenetic Map6q24UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 164 91 90 59 92 59 6 356 192 11 143 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000006425   ⟹   ENSRNOP00000006425
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl693,778,971 - 93,890,645 (-)Ensembl
mRatBN7.2 Ensembl688,042,966 - 88,156,692 (-)Ensembl
Rnor_6.0 Ensembl691,885,298 - 92,007,917 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000089891   ⟹   ENSRNOP00000069620
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl693,778,971 - 93,892,188 (-)Ensembl
mRatBN7.2 Ensembl688,042,966 - 88,156,692 (-)Ensembl
Rnor_6.0 Ensembl691,883,425 - 92,007,957 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000134978   ⟹   ENSRNOP00000101962
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl693,778,971 - 93,892,188 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000140868   ⟹   ENSRNOP00000098665
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl693,778,971 - 93,892,188 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000161465   ⟹   ENSRNOP00000111358
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl693,778,971 - 93,883,253 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000163764   ⟹   ENSRNOP00000108907
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl693,778,971 - 93,892,188 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000164115   ⟹   ENSRNOP00000111985
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl693,778,971 - 93,892,811 (-)Ensembl
RefSeq Acc Id: NM_001135561   ⟹   NP_001129033
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8693,778,971 - 93,891,989 (-)NCBI
mRatBN7.2688,042,966 - 88,155,991 (-)NCBI
Rnor_6.0691,885,292 - 92,007,917 (-)NCBI
Rnor_5.06101,337,035 - 101,457,580 (-)NCBI
RGSC_v3.4691,609,463 - 91,722,481 (-)RGD
Celera686,538,138 - 86,650,990 (-)RGD
Sequence:
RefSeq Acc Id: XM_006240184   ⟹   XP_006240246
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8693,778,973 - 93,848,973 (-)NCBI
mRatBN7.2688,042,966 - 88,112,972 (-)NCBI
Rnor_6.0691,885,294 - 91,952,846 (-)NCBI
Rnor_5.06101,337,035 - 101,457,580 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008764721   ⟹   XP_008762943
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8693,778,973 - 93,892,161 (-)NCBI
mRatBN7.2688,042,966 - 88,156,140 (-)NCBI
Rnor_6.0691,885,294 - 92,008,059 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039113012   ⟹   XP_038968940
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8693,778,973 - 93,892,161 (-)NCBI
mRatBN7.2688,042,966 - 88,156,140 (-)NCBI
RefSeq Acc Id: XM_039113013   ⟹   XP_038968941
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8693,778,973 - 93,892,161 (-)NCBI
mRatBN7.2688,042,966 - 88,156,140 (-)NCBI
RefSeq Acc Id: XM_063262560   ⟹   XP_063118630
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8693,778,973 - 93,876,385 (-)NCBI
RefSeq Acc Id: NP_001129033   ⟸   NM_001135561
- UniProtKB: F1MAI3 (UniProtKB/TrEMBL),   A6HBX0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006240246   ⟸   XM_006240184
- Peptide Label: isoform X5
- UniProtKB: A6HBX0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008762943   ⟸   XM_008764721
- Peptide Label: isoform X3
- UniProtKB: A0A0G2JVU2 (UniProtKB/TrEMBL),   A6HBX0 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000006425   ⟸   ENSRNOT00000006425
Ensembl Acc Id: ENSRNOP00000069620   ⟸   ENSRNOT00000089891
RefSeq Acc Id: XP_038968940   ⟸   XM_039113012
- Peptide Label: isoform X1
- UniProtKB: A6HBX0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038968941   ⟸   XM_039113013
- Peptide Label: isoform X2
- UniProtKB: A6HBX0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063118630   ⟸   XM_063262560
- Peptide Label: isoform X4
- UniProtKB: A6HBX0 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000111985   ⟸   ENSRNOT00000164115
Ensembl Acc Id: ENSRNOP00000108907   ⟸   ENSRNOT00000163764
Ensembl Acc Id: ENSRNOP00000111358   ⟸   ENSRNOT00000161465
Ensembl Acc Id: ENSRNOP00000101962   ⟸   ENSRNOT00000134978
Ensembl Acc Id: ENSRNOP00000098665   ⟸   ENSRNOT00000140868
Protein Domains
DH   N-terminal Ras-GEF   PH   Ras-GEF

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F1MAI3-F1-model_v2 AlphaFold F1MAI3 1-1333 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620435 AgrOrtholog
BioCyc Gene G2FUF-37230 BioCyc
Ensembl Genes ENSRNOG00000004826 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000006425.7 UniProtKB/TrEMBL
  ENSRNOT00000089891 ENTREZGENE
  ENSRNOT00000089891.3 UniProtKB/TrEMBL
  ENSRNOT00000134978 ENTREZGENE
  ENSRNOT00000134978.1 UniProtKB/TrEMBL
  ENSRNOT00000140868 ENTREZGENE
  ENSRNOT00000140868.1 UniProtKB/TrEMBL
  ENSRNOT00000161465.1 UniProtKB/TrEMBL
  ENSRNOT00000163764.1 UniProtKB/TrEMBL
  ENSRNOT00000164115.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.20.10 UniProtKB/TrEMBL
  1.10.840.10 UniProtKB/TrEMBL
  1.20.900.10 UniProtKB/TrEMBL
  2.30.29.30 UniProtKB/TrEMBL
  6.10.250.3060 UniProtKB/TrEMBL
  Son of sevenless (SoS) protein Chain: S domain 1 UniProtKB/TrEMBL
InterPro DBL_dom_sf UniProtKB/TrEMBL
  DH-domain UniProtKB/TrEMBL
  Histone-fold UniProtKB/TrEMBL
  PH_like_dom UniProtKB/TrEMBL
  Pleckstrin_homology UniProtKB/TrEMBL
  Ras-like_GEF UniProtKB/TrEMBL
  Ras-like_Gua-exchang_fac_N UniProtKB/TrEMBL
  Ras_G-nucl-exch_fac_CS UniProtKB/TrEMBL
  Ras_GEF_dom UniProtKB/TrEMBL
  RASGEF_cat_dom_sf UniProtKB/TrEMBL
  RasGRF_CDC25 UniProtKB/TrEMBL
  SOS1_NGEF_PH UniProtKB/TrEMBL
KEGG Report rno:85384 UniProtKB/TrEMBL
NCBI Gene 85384 ENTREZGENE
PANTHER PTHR23113 UniProtKB/TrEMBL
  SON OF SEVENLESS HOMOLOG 2 UniProtKB/TrEMBL
Pfam RasGEF UniProtKB/TrEMBL
  RasGEF_N UniProtKB/TrEMBL
  RhoGEF UniProtKB/TrEMBL
  SOS1_NGEF_PH UniProtKB/TrEMBL
PhenoGen Sos2 PhenoGen
PROSITE DH_2 UniProtKB/TrEMBL
  PH_DOMAIN UniProtKB/TrEMBL
  RASGEF UniProtKB/TrEMBL
  RASGEF_CAT UniProtKB/TrEMBL
  RASGEF_NTER UniProtKB/TrEMBL
RatGTEx ENSRNOG00000004826 RatGTEx
SMART RasGEF UniProtKB/TrEMBL
  RasGEFN UniProtKB/TrEMBL
  RhoGEF UniProtKB/TrEMBL
  SM00233 UniProtKB/TrEMBL
Superfamily-SCOP DH-domain UniProtKB/TrEMBL
  Histone-fold UniProtKB/TrEMBL
  PH domain-like UniProtKB/TrEMBL
  Ras_GEF UniProtKB/TrEMBL
UniProt A0A0G2JVU2 ENTREZGENE, UniProtKB/TrEMBL
  A0ABK0L131_RAT UniProtKB/TrEMBL
  A0ABK0L4Y3_RAT UniProtKB/TrEMBL
  A0ABK0LE02_RAT UniProtKB/TrEMBL
  A0ABK0LKC8_RAT UniProtKB/TrEMBL
  A0ABK0M1M3_RAT UniProtKB/TrEMBL
  A6HBX0 ENTREZGENE, UniProtKB/TrEMBL
  F1MAI3 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-11-20 Sos2  SOS Ras/Rho guanine nucleotide exchange factor 2  Sos2  son of sevenless homolog 2 (Drosophila)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-12-15 Sos2  son of sevenless homolog 2 (Drosophila)  Sos1  son of sevenless 1  Symbol and Name updated to reflect Human and Mouse nomenclature 1299863 APPROVED
2002-08-07 Sos1  son of sevenless 1      Symbol and Name status set to provisional 70820 PROVISIONAL