Imported Disease Annotations - CTDTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | Noonan syndrome 9 | | ISO | SOS2 (Homo sapiens) | 11554173 | CTD Direct Evidence: marker/mechanism | CTD | | |
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Imported Disease Annotations - CTDTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | Noonan syndrome 9 | | ISO | SOS2 (Homo sapiens) | 11554173 | CTD Direct Evidence: marker/mechanism | CTD | | |
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# | Reference Title | Reference Citation |
1. | EGF-ERBB signalling: towards the systems level. | Citri A and Yarden Y, Nat Rev Mol Cell Biol. 2006 Jul;7(7):505-16. |
2. | Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. | Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27. |
3. | Rat ISS GO annotations from GOA human gene data--August 2006 | GOA data from the GO Consortium |
4. | Insulin signaling through insulin receptor substrate 1 and 2 in normal liver development. | Khamzina L, etal., Gastroenterology 2003 Aug;125(2):572-85. |
5. | Effect of long-term exercise on gene expression of insulin signaling pathway intermediates in skeletal muscle. | Kim YB, etal., Biochem Biophys Res Commun 1999 Jan 27;254(3):720-7. |
6. | Antipsychotic drug treatment induces differential gene expression in the rat cortex. | Kontkanen O, etal., J Neurochem 2002 Dec;83(5):1043-53. |
7. | Rat ISS GO annotations from MGI mouse gene data--August 2006 | MGD data from the GO Consortium |
8. | IL-6/IL-6 receptor system and its role in physiological and pathological conditions. | Mihara M, etal., Clin Sci (Lond). 2012 Feb;122(4):143-59. doi: 10.1042/CS20110340. |
9. | Sam68 associates with the SH3 domains of Grb2 recruiting GAP to the Grb2-SOS complex in insulin receptor signaling. | Najib S and Sanchez-Margalet V, J Cell Biochem 2002;86(1):99-106. |
10. | Electronic Transfer of LocusLink and RefSeq Data | NCBI rat LocusLink and RefSeq merged data July 26, 2002 |
11. | KEGG Annotation Import Pipeline | Pipeline to import KEGG annotations from KEGG into RGD |
12. | GOA pipeline | RGD automated data pipeline |
13. | ClinVar Automated Import and Annotation Pipeline | RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations |
14. | Data Import for Chemical-Gene Interactions | RGD automated import pipeline for gene-chemical interactions |
15. | Comprehensive gene review and curation | RGD comprehensive gene curation |
16. | Src-dependent TrkA transactivation is required for pituitary adenylate cyclase-activating polypeptide 38-mediated Rit activation and neuronal differentiation. | Shi GX, etal., Mol Biol Cell. 2010 May 1;21(9):1597-608. Epub 2010 Mar 10. |
Sos2 (Rattus norvegicus - Norway rat) |
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SOS2 (Homo sapiens - human) |
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Sos2 (Mus musculus - house mouse) |
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Sos2 (Chinchilla lanigera - long-tailed chinchilla) |
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SOS2 (Pan paniscus - bonobo/pygmy chimpanzee) |
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SOS2 (Canis lupus familiaris - dog) |
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Sos2 (Ictidomys tridecemlineatus - thirteen-lined ground squirrel) |
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SOS2 (Sus scrofa - pig) |
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SOS2 (Chlorocebus sabaeus - green monkey) |
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Sos2 (Heterocephalus glaber - naked mole-rat) |
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Variants in Sos2
944 total Variants |
The detailed report is available here: | Full Report | CSV | TAB | Printer | ||||
miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/). For more information about miRGate, see PMID:25858286 or access the full paper here. |
The following QTLs overlap with this region. | Full Report | CSV | TAB | Printer | Gviewer |
D6Rat197 |
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BI288574 |
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alimentary part of gastrointestinal system | circulatory system | endocrine system | exocrine system | hemolymphoid system | hepatobiliary system | integumental system | musculoskeletal system | nervous system | renal system | reproductive system | respiratory system | appendage | |
High | |||||||||||||
Medium | 3 | 29 | 16 | 6 | 13 | 6 | 8 | 10 | 74 | 35 | 36 | 11 | 8 |
Low | 14 | 41 | 35 | 6 | 35 | 1 | 5 | ||||||
Below cutoff |
RefSeq Transcripts | NM_001135561 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles |
XM_006240184 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
XM_008764721 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
XM_039113012 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
XM_039113013 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
XM_063262560 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
GenBank Nucleotide | D83014 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles |
FQ221289 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
JAXUCZ010000006 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles |
RefSeq Acc Id: | ENSRNOT00000006425 ⟹ ENSRNOP00000006425 | ||||||||||||
Type: | CODING | ||||||||||||
Position: |
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RefSeq Acc Id: | ENSRNOT00000089891 ⟹ ENSRNOP00000069620 | ||||||||||||
Type: | CODING | ||||||||||||
Position: |
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RefSeq Acc Id: | NM_001135561 ⟹ NP_001129033 | ||||||||||||||||||||||||||||
RefSeq Status: | VALIDATED | ||||||||||||||||||||||||||||
Type: | CODING | ||||||||||||||||||||||||||||
Position: |
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Sequence: |
RefSeq Acc Id: | XM_006240184 ⟹ XP_006240246 | ||||||||||||||||||||
Type: | CODING | ||||||||||||||||||||
Position: |
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Sequence: |
RefSeq Acc Id: | XM_008764721 ⟹ XP_008762943 | ||||||||||||||||
Type: | CODING | ||||||||||||||||
Position: |
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Sequence: |
RefSeq Acc Id: | XM_039113012 ⟹ XP_038968940 | ||||||||||||
Type: | CODING | ||||||||||||
Position: |
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RefSeq Acc Id: | XM_039113013 ⟹ XP_038968941 | ||||||||||||
Type: | CODING | ||||||||||||
Position: |
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RefSeq Acc Id: | XM_063262560 ⟹ XP_063118630 | ||||||||
Type: | CODING | ||||||||
Position: |
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Protein RefSeqs | NP_001129033 | (Get FASTA) | NCBI Sequence Viewer |
XP_006240246 | (Get FASTA) | NCBI Sequence Viewer | |
XP_008762943 | (Get FASTA) | NCBI Sequence Viewer | |
XP_038968940 | (Get FASTA) | NCBI Sequence Viewer | |
XP_038968941 | (Get FASTA) | NCBI Sequence Viewer | |
XP_063118630 | (Get FASTA) | NCBI Sequence Viewer | |
GenBank Protein | BAA74949 | (Get FASTA) | NCBI Sequence Viewer |
Ensembl Protein | ENSRNOP00000006425 | ||
ENSRNOP00000006425.4 | |||
ENSRNOP00000069620 | |||
ENSRNOP00000069620.2 |
RefSeq Acc Id: | NP_001129033 ⟸ NM_001135561 |
- UniProtKB: | F1MAI3 (UniProtKB/TrEMBL), A6HBX0 (UniProtKB/TrEMBL) |
- Sequence: |
RefSeq Acc Id: | XP_006240246 ⟸ XM_006240184 |
- Peptide Label: | isoform X5 |
- UniProtKB: | A6HBX0 (UniProtKB/TrEMBL) |
- Sequence: |
RefSeq Acc Id: | XP_008762943 ⟸ XM_008764721 |
- Peptide Label: | isoform X3 |
- UniProtKB: | A0A0G2JVU2 (UniProtKB/TrEMBL), A6HBX0 (UniProtKB/TrEMBL) |
- Sequence: |
RefSeq Acc Id: | ENSRNOP00000006425 ⟸ ENSRNOT00000006425 |
RefSeq Acc Id: | ENSRNOP00000069620 ⟸ ENSRNOT00000089891 |
RefSeq Acc Id: | XP_038968940 ⟸ XM_039113012 |
- Peptide Label: | isoform X1 |
- UniProtKB: | A6HBX0 (UniProtKB/TrEMBL) |
RefSeq Acc Id: | XP_038968941 ⟸ XM_039113013 |
- Peptide Label: | isoform X2 |
- UniProtKB: | A6HBX0 (UniProtKB/TrEMBL) |
RefSeq Acc Id: | XP_063118630 ⟸ XM_063262560 |
- Peptide Label: | isoform X4 |
Name | Modeler | Protein Id | AA Range | Protein Structure |
AF-F1MAI3-F1-model_v2 | AlphaFold | F1MAI3 | 1-1333 | view protein structure |
eQTL | View at Phenogen | |
WGCNA | View at Phenogen | |
Tissue/Strain Expression | View at Phenogen |
Database | Acc Id | Source(s) |
AGR Gene | RGD:620435 | AgrOrtholog |
BioCyc Gene | G2FUF-37230 | BioCyc |
Ensembl Genes | ENSRNOG00000004826 | Ensembl, ENTREZGENE, UniProtKB/TrEMBL |
Ensembl Transcript | ENSRNOT00000006425 | ENTREZGENE |
ENSRNOT00000006425.6 | UniProtKB/TrEMBL | |
ENSRNOT00000089891.2 | UniProtKB/TrEMBL | |
Gene3D-CATH | 1.10.20.10 | UniProtKB/TrEMBL |
1.10.840.10 | UniProtKB/TrEMBL | |
1.20.900.10 | UniProtKB/TrEMBL | |
2.30.29.30 | UniProtKB/TrEMBL | |
6.10.250.3060 | UniProtKB/TrEMBL | |
Son of sevenless (SoS) protein Chain: S domain 1 | UniProtKB/TrEMBL | |
InterPro | DBL_dom_sf | UniProtKB/TrEMBL |
DH-domain | UniProtKB/TrEMBL | |
Histone-fold | UniProtKB/TrEMBL | |
PH_like_dom | UniProtKB/TrEMBL | |
Pleckstrin_homology | UniProtKB/TrEMBL | |
Ras-like_GEF | UniProtKB/TrEMBL | |
Ras-like_Gua-exchang_fac_N | UniProtKB/TrEMBL | |
Ras_G-nucl-exch_fac_CS | UniProtKB/TrEMBL | |
Ras_GEF_dom | UniProtKB/TrEMBL | |
RASGEF_cat_dom_sf | UniProtKB/TrEMBL | |
RasGRF_CDC25 | UniProtKB/TrEMBL | |
KEGG Report | rno:85384 | UniProtKB/TrEMBL |
NCBI Gene | 85384 | ENTREZGENE |
PANTHER | PTHR23113 | UniProtKB/TrEMBL |
SON OF SEVENLESS HOMOLOG 2 | UniProtKB/TrEMBL | |
Pfam | PF00169 | UniProtKB/TrEMBL |
RasGEF | UniProtKB/TrEMBL | |
RasGEF_N | UniProtKB/TrEMBL | |
RhoGEF | UniProtKB/TrEMBL | |
PhenoGen | Sos2 | PhenoGen |
PROSITE | DH_2 | UniProtKB/TrEMBL |
PH_DOMAIN | UniProtKB/TrEMBL | |
RASGEF | UniProtKB/TrEMBL | |
RASGEF_CAT | UniProtKB/TrEMBL | |
RASGEF_NTER | UniProtKB/TrEMBL | |
RatGTEx | ENSRNOG00000004826 | RatGTEx |
SMART | RasGEF | UniProtKB/TrEMBL |
RasGEFN | UniProtKB/TrEMBL | |
RhoGEF | UniProtKB/TrEMBL | |
SM00233 | UniProtKB/TrEMBL | |
Superfamily-SCOP | DH-domain | UniProtKB/TrEMBL |
Histone-fold | UniProtKB/TrEMBL | |
PH domain-like | UniProtKB/TrEMBL | |
Ras_GEF | UniProtKB/TrEMBL | |
UniProt | A0A0G2JVU2 | ENTREZGENE, UniProtKB/TrEMBL |
A6HBX0 | ENTREZGENE, UniProtKB/TrEMBL | |
F1MAI3 | ENTREZGENE, UniProtKB/TrEMBL |
Date | Current Symbol | Current Name | Previous Symbol | Previous Name | Description | Reference | Status |
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2015-11-20 | Sos2 | SOS Ras/Rho guanine nucleotide exchange factor 2 | Sos2 | son of sevenless homolog 2 (Drosophila) | Nomenclature updated to reflect human and mouse nomenclature | 1299863 | APPROVED |
2004-12-15 | Sos2 | son of sevenless homolog 2 (Drosophila) | Sos1 | son of sevenless 1 | Symbol and Name updated to reflect Human and Mouse nomenclature | 1299863 | APPROVED |
2002-08-07 | Sos1 | son of sevenless 1 | Symbol and Name status set to provisional | 70820 | PROVISIONAL |