Abcc6 (ATP binding cassette subfamily C member 6) - Rat Genome Database

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Gene: Abcc6 (ATP binding cassette subfamily C member 6) Rattus norvegicus
Analyze
Symbol: Abcc6
Name: ATP binding cassette subfamily C member 6
RGD ID: 620268
Description: Enables several functions, including ATP binding activity; ATP hydrolysis activity; and inorganic diphosphate transmembrane transporter activity. Involved in several processes, including inorganic diphosphate transport; intracellular phosphate ion homeostasis; and xenobiotic transmembrane transport. Located in apical plasma membrane; basolateral plasma membrane; and lateral plasma membrane. Used to study pseudoxanthoma elasticum. Human ortholog(s) of this gene implicated in arterial calcification of infancy; coronary artery disease; and pseudoxanthoma elasticum. Orthologous to human ABCC6 (ATP binding cassette subfamily C member 6); PARTICIPATES IN multidrug resistance-associated protein mediated transport pathway; INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: ATP-binding cassette sub-family C member 6; ATP-binding cassette, sub-family C (CFTR/MRP), member 6; ATP-binding cassette, subfamily C (CFTR/MRP), member 6; liver multidrug resistance-associated protein 6; MLP-1; MRP-like protein 1; Mrp6; multidrug resistance-associated protein 6
RGD Orthologs
Human
Mouse
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: Abcc6em1Qlju ; Abcc6em2Qlju ; Abcc6em3Qlju ; Abcc6em4Qlju ; Abcc6em5Qlju
Genetic Models: SD-Abcc6em4Qlju-/- ; SD-Abcc6em2Qlju-/- ; SD-Abcc6em2Qlju+/- ; SD-Abcc6em1Qlju-/- ; SD-Abcc6em3Qlju-/- ; SD-Abcc6em5Qlju-/-
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81105,583,681 - 105,637,895 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1105,583,682 - 105,637,895 (-)EnsemblGRCr8
mRatBN7.2196,447,224 - 96,501,464 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl196,447,251 - 96,501,464 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1101,833,395 - 101,887,602 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01110,305,383 - 110,359,590 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01103,595,749 - 103,649,961 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01101,954,786 - 102,013,252 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1101,959,540 - 102,013,243 (-)Ensemblrn6Rnor6.0
Rnor_5.01103,042,723 - 103,096,453 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4196,448,588 - 96,524,655 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera190,699,816 - 90,752,348 (-)NCBICelera
RGSC_v3.1196,526,698 - 96,602,766 (-)NCBI
Cytogenetic Map1q22NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
17beta-estradiol  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
5-fluorouracil  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (EXP)
6-propyl-2-thiouracil  (EXP,ISO)
7,12-dimethyltetraphene  (ISO)
9-cis-retinoic acid  (ISO)
acrylamide  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
allyl alcohol  (ISO)
amiodarone  (EXP)
ammonium chloride  (EXP)
arsenous acid  (ISO)
ATP  (ISO)
Azoxymethane  (ISO)
belinostat  (ISO)
benzbromarone  (EXP,ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
beryllium difluoride  (EXP)
beta-naphthoflavone  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
butanal  (ISO)
butylated hydroxyanisole  (ISO)
Butylbenzyl phthalate  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
calcein  (ISO)
calcein am  (ISO)
carbon nanotube  (ISO)
clofibrate  (EXP)
clofibric acid  (EXP)
cobalt atom  (EXP)
copper(II) sulfate  (ISO)
cyclosporin A  (ISO)
dexamethasone  (EXP)
dextran sulfate  (ISO)
diallyl disulfide  (ISO)
diallyl trisulfide  (ISO)
diarsenic trioxide  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP,ISO)
diiodine  (ISO)
doxorubicin  (ISO)
emodin  (EXP)
endosulfan  (EXP)
epoxiconazole  (ISO)
ethoxyquin  (ISO)
flutamide  (EXP)
furan  (EXP)
genistein  (ISO)
glutathione  (ISO)
glyphosate  (EXP)
GW 4064  (ISO)
Heliotrine  (ISO)
heptachlor  (EXP)
indometacin  (ISO)
inulin  (ISO)
isoniazide  (EXP)
kojic acid  (EXP,ISO)
L-ethionine  (EXP)
leukotriene C4  (ISO)
lipopolysaccharide  (EXP)
lithocholic acid  (ISO)
magnesium atom  (ISO)
magnesium dichloride  (EXP)
manganese atom  (EXP)
manganese(0)  (EXP)
methamphetamine  (EXP,ISO)
methylmercury chloride  (ISO)
mirex  (EXP)
mono(2-ethylhexyl) phthalate  (ISO)
N-Ethylmaleimide-S-glutathione  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
N-Nitrosopyrrolidine  (ISO)
nefazodone  (EXP)
nickel atom  (EXP,ISO)
O-methyleugenol  (ISO)
okadaic acid  (ISO)
oltipraz  (ISO)
omeprazole  (EXP)
paracetamol  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (EXP)
phenobarbital  (EXP,ISO)
pirinixic acid  (EXP,ISO)
probenecid  (ISO)
progesterone  (ISO)
propanal  (ISO)
propiconazole  (ISO)
quercetin  (ISO)
rifampicin  (ISO)
rotenone  (EXP)
S-nitrosoglutathione  (ISO)
SCH 23390  (EXP)
senecionine  (ISO)
Senkirkine  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP)
soybean oil  (EXP)
streptozocin  (ISO)
sunitinib  (ISO)
tetrachloroethene  (ISO)
tetrachloromethane  (EXP,ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
triclosan  (ISO)
triphenyl phosphate  (ISO)
troglitazone  (ISO)
urethane  (ISO)
valproic acid  (ISO)
verapamil  (ISO)
vincristine  (ISO)
warfarin  (ISO)
zidovudine  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. The genetic association database. Becker KG, etal., Nat Genet. 2004 May;36(5):431-2.
2. Characterization of the drug resistance and transport properties of multidrug resistance protein 6 (MRP6, ABCC6). Belinsky MG, etal., Cancer Res 2002 Nov 1;62(21):6172-7.
3. Mutations in ABCC6 cause pseudoxanthoma elasticum. Bergen AA, etal., Nat Genet 2000 Jun;25(2):228-31.
4. Nucleotide binding and nucleotide hydrolysis properties of the ABC transporter MRP6 (ABCC6). Cai J, etal., Biochemistry 2002 Jun 25;41(25):8058-67.
5. A novel Q378X mutation exists in the transmembrane transporter protein ABCC6 and its pseudogene: implications for mutation analysis in pseudoxanthoma elasticum. Cai L, etal., J Mol Med (Berl). 2001 Sep;79(9):536-46.
6. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
7. ABCC6 mutations in Italian families affected by pseudoxanthoma elasticum (PXE). Gheduzzi D, etal., Hum Mutat. 2004 Nov;24(5):438-9.
8. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
9. Transport of xenobiotics across the blood-brain barrier. Hagenbuch B, etal., News Physiol Sci 2002 Dec;17:231-4.
10. Effect of inflammation on molecular targets and drug transporters. Hanafy S, etal., J Pharm Pharm Sci. 2012;15(3):361-75.
11. Hepatic expression of multidrug resistance-associated protein-like proteins maintained in eisai hyperbilirubinemic rats. Hirohashi T, etal., Mol Pharmacol 1998 Jun;53(6):1068-75.
12. Analysis of the frequent R1141X mutation in the ABCC6 gene in pseudoxanthoma elasticum. Hu X, etal., Invest Ophthalmol Vis Sci. 2003 May;44(5):1824-9.
13. Targeted ablation of the abcc6 gene results in ectopic mineralization of connective tissues. Klement JF, etal., Mol Cell Biol. 2005 Sep;25(18):8299-310.
14. Abcc6 Knockout Rat Model Highlights the Role of Liver in PPi Homeostasis in Pseudoxanthoma Elasticum. Li Q, etal., J Invest Dermatol. 2017 May;137(5):1025-1032. doi: 10.1016/j.jid.2016.11.042. Epub 2017 Jan 19.
15. Transport function and hepatocellular localization of mrp6 in rat liver. Madon J, etal., Mol Pharmacol 2000 Mar;57(3):634-41.
16. A mouse model of beta-thalassemia shows a liver-specific down-regulation of Abcc6 expression. Martin L, etal., Am J Pathol. 2011 Feb;178(2):774-83. doi: 10.1016/j.ajpath.2010.10.004.
17. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
18. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
19. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
20. Mutation detection in the ABCC6 gene and genotype-phenotype analysis in a large international case series affected by pseudoxanthoma elasticum. Pfendner EG, etal., J Med Genet. 2007 Oct;44(10):621-8. Epub 2007 Jul 6.
21. GOA pipeline RGD automated data pipeline
22. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
23. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
24. Comprehensive gene review and curation RGD comprehensive gene curation
25. Molecular genetics of pseudoxanthoma elasticum. Ringpfeil F, etal., Exp Dermatol 2001 Aug;10(4):221-8.
26. Novel mutations in the ABCC6 gene of German patients with pseudoxanthoma elasticum. Schulz V, etal., Hum Biol. 2005 Jun;77(3):367-84.
27. Mutational analysis of the ABCC6 gene and the proximal ABCC6 gene promoter in German patients with pseudoxanthoma elasticum (PXE). Schulz V, etal., Hum Mutat. 2006 Aug;27(8):831.
28. Generation of fully functional fluorescent fusion proteins to gain insights into ABCC6 biology. Szeri F, etal., FEBS Lett. 2020 Oct 15. doi: 10.1002/1873-3468.13957.
29. Frequent mutation in the ABCC6 gene (R1141X) is associated with a strong increase in the prevalence of coronary artery disease. Trip MD, etal., Circulation. 2002 Aug 13;106(7):773-5.
Additional References at PubMed
PMID:24969777   PMID:24994603  


Genomics

Comparative Map Data
Abcc6
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81105,583,681 - 105,637,895 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1105,583,682 - 105,637,895 (-)EnsemblGRCr8
mRatBN7.2196,447,224 - 96,501,464 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl196,447,251 - 96,501,464 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1101,833,395 - 101,887,602 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01110,305,383 - 110,359,590 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01103,595,749 - 103,649,961 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01101,954,786 - 102,013,252 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1101,959,540 - 102,013,243 (-)Ensemblrn6Rnor6.0
Rnor_5.01103,042,723 - 103,096,453 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4196,448,588 - 96,524,655 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera190,699,816 - 90,752,348 (-)NCBICelera
RGSC_v3.1196,526,698 - 96,602,766 (-)NCBI
Cytogenetic Map1q22NCBI
ABCC6
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381616,149,565 - 16,223,494 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1616,149,565 - 16,223,637 (-)Ensemblhg38GRCh38
GRCh371616,243,422 - 16,317,351 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361616,150,923 - 16,224,838 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341616,151,490 - 16,224,815NCBI
Celera1615,923,582 - 15,972,084 (-)NCBICelera
Cytogenetic Map16p13.11NCBI
HuRef1615,637,406 - 15,701,476 (-)NCBIHuRef
HuRef1617,226,645 - 17,228,924 (+)NCBIHuRef
CHM1_11616,327,717 - 16,401,692 (-)NCBICHM1_1
T2T-CHM13v2.01616,154,422 - 16,229,003 (-)NCBIT2T-CHM13v2.0
Abcc6
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39745,625,804 - 45,679,915 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl745,616,979 - 45,679,726 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38745,974,110 - 46,030,491 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl745,967,555 - 46,030,302 (-)Ensemblmm10GRCm38
MGSCv37753,231,750 - 53,285,656 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36745,844,422 - 45,898,327 (-)NCBIMGSCv36mm8
MGSCv36735,552,479 - 35,606,515 (-)NCBIMGSCv36mm8
Celera741,445,055 - 41,502,729 (-)NCBICelera
Cytogenetic Map7B3NCBI
cM Map729.64NCBI
Abcc6
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955442865,238 - 922,221 (-)Ensembl
ChiLan1.0NW_004955442865,292 - 921,739 (-)NCBIChiLan1.0ChiLan1.0
ABCC6
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1627,800,060 - 27,849,170 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl627,798,835 - 27,848,689 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha629,163,710 - 29,212,774 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0627,963,339 - 28,012,220 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl627,963,425 - 28,011,739 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1627,766,376 - 27,815,441 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0627,656,383 - 27,705,374 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0628,061,767 - 28,110,633 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Abcc6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344115,372,021 - 115,412,095 (-)NCBIHiC_Itri_2
SpeTri2.0NW_0049365013,469,928 - 3,508,577 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ABCC6
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl328,261,214 - 28,356,706 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1328,260,935 - 28,356,706 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2328,960,801 - 29,063,405 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ABCC6
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1515,169,725 - 15,243,731 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl515,168,156 - 15,242,811 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366606814,739,120 - 14,812,929 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Abcc6
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624782594,511 - 640,180 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_004624782590,174 - 640,576 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Abcc6
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v12153,492,676 - 153,545,901 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Abcc6
331 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:353
Count of miRNA genes:208
Interacting mature miRNAs:238
Transcripts:ENSRNOT00000042115
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1582234Gluco18Glucose level QTL 183.40.0003blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)187889942132889942Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)151941022208479811Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)139728272132889942Rat
1331793Bp200Blood pressure QTL 2003.71601arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1102780511182384005Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)151940904168768703Rat
2300324Fetw1Fetal weight QTL 112.10.005fetal growth trait (VT:0004201)fetal body weight (CMO:0002080)192963855109494029Rat
1554320Bmd1Bone mineral density QTL 112.20.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1101228864146228864Rat
1331800Scl25Serum cholesterol level QTL 253.013blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)187785026142582336Rat
7421628Bp361Blood pressure QTL 3610.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183019780128019780Rat
631495Bp96Blood pressure QTL 964.52arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)166404680111404680Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134184556172281316Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)166009857160501508Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134565911208798288Rat
631519Pia11Pristane induced arthritis QTL 115.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)193903998191260518Rat
1302788Scl19Serum cholesterol QTL 194.60.001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)166400974132889942Rat
1549903Bp267Blood pressure QTL 267arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)184107164115183752Rat
2313083Bmd74Bone mineral density QTL 7440.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)191302413136302413Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)151511344153680016Rat
724567Tcas6Tongue tumor susceptibility QTL 66.85tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)1102359314153680016Rat
724521Uae1Urinary albumin excretion QTL 13.80.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)199645382182701046Rat
1358902Bw47Body weight QTL 471.67body mass (VT:0001259)body weight (CMO:0000012)199645382221502378Rat
1358192Ept13Estrogen-induced pituitary tumorigenesis QTL 133.4pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)186622262131622262Rat
2300164Bmd44Bone mineral density QTL 445.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)166077886111077886Rat
731168Bp154Blood pressure QTL 1543.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1103779152223964440Rat
631205Bp196Blood pressure QTL 19640.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)198879955208479939Rat
738022Anxrr13Anxiety related response QTL 134.60.00039locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of, or within a discrete space in an open field apparatus (CMO:0001514)192683681137683681Rat
10054135Gmadr2Adrenal mass QTL 21.970.0129adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)186993904131993904Rat
152025249Scl82Serum cholesterol level QTL 824.77blood cholesterol amount (VT:0000180)152891222109116986Rat
1331749Hrtrt11Heart rate QTL 112.973heart pumping trait (VT:2000009)heart rate (CMO:0000002)192683681137683681Rat
7411712Strs4Sensitivity to stroke QTL 48.7cerebrum integrity trait (VT:0010549)percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)187558587132558587Rat
737977Bp160Blood pressure QTL 1600.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)197582336142582336Rat
2293142Bp314Blood pressure QTL 314arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1101594089146594089Rat
61433Cia2Collagen induced arthritis QTL 25joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1100345976145345976Rat
724529Cm16Cardiac mass QTL 162.7heart mass (VT:0007028)calculated heart weight (CMO:0000073)196717367160111531Rat

Markers in Region
D1Got95  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2196,497,036 - 96,497,167 (+)MAPPERmRatBN7.2
Rnor_6.01102,008,816 - 102,008,946NCBIRnor6.0
Rnor_5.01103,092,026 - 103,092,156UniSTSRnor5.0
RGSC_v3.4196,520,228 - 96,520,358UniSTSRGSC3.4
RGSC_v3.4196,520,227 - 96,520,358RGDRGSC3.4
Celera190,747,921 - 90,748,051UniSTS
RGSC_v3.1196,598,339 - 96,598,469RGD
RH 3.4 Map1908.1UniSTS
RH 3.4 Map1908.1RGD
Cytogenetic Map1q22UniSTS
RH134844  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2196,447,444 - 96,447,633 (+)MAPPERmRatBN7.2
Rnor_6.01101,959,734 - 101,959,922NCBIRnor6.0
Rnor_5.01103,042,944 - 103,043,132UniSTSRnor5.0
RGSC_v3.4196,448,782 - 96,448,970UniSTSRGSC3.4
Celera190,700,010 - 90,700,198UniSTS
RH 3.4 Map1908.2UniSTS
Cytogenetic Map1q22UniSTS


Genetic Models
This gene Abcc6 is modified in the following models/strains:
SD-Abcc6em4Qlju-/-     SD-Abcc6em2Qlju-/-     SD-Abcc6em2Qlju+/-     SD-Abcc6em1Qlju-/-     SD-Abcc6em3Qlju-/-     SD-Abcc6em5Qlju-/-    


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 11 42 146 90 89 59 27 59 6 261 97 6 124 81 92 30 10 10

Sequence


Ensembl Acc Id: ENSRNOT00000042115   ⟹   ENSRNOP00000051412
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1105,583,682 - 105,637,895 (-)Ensembl
mRatBN7.2 Ensembl196,447,251 - 96,501,464 (-)Ensembl
Rnor_6.0 Ensembl1101,959,540 - 102,013,243 (-)Ensembl
RefSeq Acc Id: NM_031013   ⟹   NP_112275
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81105,583,682 - 105,637,895 (-)NCBI
mRatBN7.2196,447,251 - 96,501,464 (-)NCBI
Rnor_6.01101,959,540 - 102,013,243 (-)NCBI
Rnor_5.01103,042,723 - 103,096,453 (-)NCBI
RGSC_v3.4196,448,588 - 96,524,655 (-)RGD
Celera190,699,816 - 90,752,348 (-)RGD
Sequence:
RefSeq Acc Id: XM_017589770   ⟹   XP_017445259
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81105,583,681 - 105,624,924 (-)NCBI
mRatBN7.2196,447,224 - 96,488,482 (-)NCBI
Rnor_6.01101,959,513 - 102,000,289 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039092093   ⟹   XP_038948021
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81105,583,681 - 105,633,339 (-)NCBI
mRatBN7.2196,447,224 - 96,496,901 (-)NCBI
RefSeq Acc Id: XM_039092100   ⟹   XP_038948028
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81105,583,681 - 105,633,339 (-)NCBI
mRatBN7.2196,447,224 - 96,496,901 (-)NCBI
RefSeq Acc Id: XM_039092116   ⟹   XP_038948044
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81105,583,681 - 105,613,338 (-)NCBI
mRatBN7.2196,447,224 - 96,476,909 (-)NCBI
RefSeq Acc Id: XM_063275135   ⟹   XP_063131205
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81105,583,681 - 105,624,924 (-)NCBI
RefSeq Acc Id: NP_112275   ⟸   NM_031013
- UniProtKB: O88269 (UniProtKB/Swiss-Prot),   A6JBA8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017445259   ⟸   XM_017589770
- Peptide Label: isoform X3
- UniProtKB: A6JBA8 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000051412   ⟸   ENSRNOT00000042115
RefSeq Acc Id: XP_038948028   ⟸   XM_039092100
- Peptide Label: isoform X2
- UniProtKB: A6JBA8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038948021   ⟸   XM_039092093
- Peptide Label: isoform X1
- UniProtKB: A6JBA8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038948044   ⟸   XM_039092116
- Peptide Label: isoform X4
RefSeq Acc Id: XP_063131205   ⟸   XM_063275135
- Peptide Label: isoform X3
- UniProtKB: A6JBA8 (UniProtKB/TrEMBL)
Protein Domains
ABC transmembrane type-1   ABC transporter

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O88269-F1-model_v2 AlphaFold O88269 1-1502 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13690058
Promoter ID:EPDNEW_R583
Type:multiple initiation site
Name:Abcc6_1
Description:ATP binding cassette subfamily C member 6
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01102,013,178 - 102,013,238EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620268 AgrOrtholog
BioCyc Gene G2FUF-59637 BioCyc
Ensembl Genes ENSRNOG00000028781 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000042115 ENTREZGENE
  ENSRNOT00000042115.2 UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.1560.10 UniProtKB/Swiss-Prot
  3.40.50.300 UniProtKB/Swiss-Prot
InterPro AAA+_ATPase UniProtKB/Swiss-Prot
  ABC1_TM_dom UniProtKB/Swiss-Prot
  ABC1_TM_sf UniProtKB/Swiss-Prot
  ABC_transporter-like UniProtKB/Swiss-Prot
  ABC_transporter_C UniProtKB/Swiss-Prot
  ABC_transporter_CS UniProtKB/Swiss-Prot
  Multidrug-R_assoc UniProtKB/Swiss-Prot
  P-loop_NTPase UniProtKB/Swiss-Prot
KEGG Report rno:81642 UniProtKB/Swiss-Prot
NCBI Gene 81642 ENTREZGENE
PANTHER ATP-BINDING CASSETTE SUB-FAMILY C UniProtKB/Swiss-Prot
  PTHR24223:SF339 UniProtKB/Swiss-Prot
Pfam ABC_membrane UniProtKB/Swiss-Prot
  ABC_tran UniProtKB/Swiss-Prot
PharmGKB ABCC6 RGD
PhenoGen Abcc6 PhenoGen
PROSITE ABC_TM1F UniProtKB/Swiss-Prot
  ABC_TRANSPORTER_1 UniProtKB/Swiss-Prot
  ABC_TRANSPORTER_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000028781 RatGTEx
SMART AAA UniProtKB/Swiss-Prot
Superfamily-SCOP SSF52540 UniProtKB/Swiss-Prot
  SSF90123 UniProtKB/Swiss-Prot
UniProt A6JBA4_RAT UniProtKB/TrEMBL
  A6JBA5_RAT UniProtKB/TrEMBL
  A6JBA6_RAT UniProtKB/TrEMBL
  A6JBA7_RAT UniProtKB/TrEMBL
  A6JBA8 ENTREZGENE, UniProtKB/TrEMBL
  MRP6_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-11-25 Abcc6  ATP binding cassette subfamily C member 6  Abcc6  ATP-binding cassette, subfamily C (CFTR/MRP), member 6  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2010-11-16 Abcc6  ATP-binding cassette, subfamily C (CFTR/MRP), member 6  Abcc6  ATP-binding cassette, sub-family C (CFTR/MRP), member 6  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Abcc6  ATP-binding cassette, sub-family C (CFTR/MRP), member 6    liver multidrug resistance-associated protein 6  Name updated 1299863 APPROVED
2002-08-07 Abcc6  liver multidrug resistance-associated protein 6      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_disease mutation of the human homolog is detected in patients with pseudoxanthoma elasticum (PXE), which affects elastic fibers in the skin, retina, and blood vessels 728121
gene_process may participate directly in the active transport of drugs into subcellular organelles or influence drug distribution indirectly 724707