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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620268
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Abcc6
Name: ATP binding cassette subfamily C member 6
Acc ID: CHEBI:33216
Term: bisphenol A
Definition: A bisphenol that is 4,4'-methanediyldiphenol in which the methylene hydrogens are replaced by two methyl groups.
Chemical ID: MESH:C006780
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Abcc6decreases expressionEXP 6480464CTDbisphenol A results in decreased expression of ABCC6 mRNAPMID:25181051 PMID:30816183 PMID:32145629 PMID:32528016
Abcc6increases expressionEXP 6480464CTDbisphenol A results in increased expression of ABCC6 mRNAPMID:35192832
Abcc6multiple interactionsEXP 6480464CTD[bisphenol A co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate] affects the methylation of ABCC6 promoterPMID:23359474
Abcc6affects expressionISOABCC6 (Homo sapiens)6480464CTDbisphenol A affects the expression of ABCC6 mRNAPMID:30903817
Abcc6increases expressionISOAbcc6 (Mus musculus)6480464CTDbisphenol A results in increased expression of ABCC6 mRNAPMID:33221593
Abcc6multiple interactionsISOAbcc6 (Mus musculus)6480464CTD[Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in decreased expression of ABCC6 mRNAPMID:28433925
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