Trpm4 (transient receptor potential cation channel, subfamily M, member 4) - Rat Genome Database

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Gene: Trpm4 (transient receptor potential cation channel, subfamily M, member 4) Rattus norvegicus
Analyze
Symbol: Trpm4
Name: transient receptor potential cation channel, subfamily M, member 4
RGD ID: 620244
Description: Enables calcium-activated cation channel activity. Involved in several processes, including long-term memory; negative regulation of osteoblast differentiation; and regulation of blood circulation. Located in several cellular components, including Golgi apparatus; endoplasmic reticulum; and neuronal cell body. Biomarker of cardiac arrest. Human ortholog(s) of this gene implicated in erythrokeratodermia variabilis et progressiva 6 and progressive familial heart block type IB. Orthologous to human TRPM4 (transient receptor potential cation channel subfamily M member 4); INTERACTS WITH (+)-schisandrin B; 1-naphthyl isothiocyanate; 17beta-estradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: calcium-activated non-selective cation channel 1; long transient receptor potential channel 4; LTrpC-4; LTrpC4; melastatin like 2 protein; melastatin-like 2; Mls2s; transient receptor potential cation channel subfamily M member 4
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81104,918,462 - 104,949,453 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1104,918,462 - 104,948,653 (-)EnsemblGRCr8
mRatBN7.2195,781,805 - 95,812,095 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl195,782,000 - 95,812,532 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1101,167,413 - 101,197,191 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01109,640,086 - 109,669,864 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01102,930,482 - 102,960,268 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01101,293,300 - 101,323,484 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1101,293,409 - 101,323,960 (-)Ensemblrn6Rnor6.0
Rnor_5.01102,357,043 - 102,387,010 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4195,773,485 - 95,803,542 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera190,039,848 - 90,063,911 (-)NCBICelera
RGSC_v3.1195,851,812 - 95,863,602 (-)NCBI
Cytogenetic Map1q22NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(1->4)-beta-D-glucan  (ISO)
1,2-dimethylhydrazine  (ISO)
1,4-dithiothreitol  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
1-naphthyl isothiocyanate  (EXP)
17beta-estradiol  (EXP)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,6-dimethoxyphenol  (ISO)
2,6-dinitrotoluene  (EXP)
3,4-methylenedioxymethamphetamine  (ISO)
4-hydroxy-TEMPO  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
9-phenanthrol  (ISO)
acetylsalicylic acid  (ISO)
aflatoxin B1  (EXP,ISO)
Aflatoxin B2 alpha  (ISO)
aldosterone  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
aristolochic acid A  (ISO)
arsenous acid  (ISO)
ATP  (EXP,ISO)
atrazine  (ISO)
Azoxymethane  (ISO)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP)
Bufotalin  (ISO)
Butylbenzyl phthalate  (ISO)
C60 fullerene  (EXP)
cadmium dichloride  (ISO)
calcium atom  (EXP,ISO)
calcium(0)  (EXP,ISO)
chlordecone  (ISO)
choline  (ISO)
chromium(6+)  (ISO)
clofibric acid  (EXP)
cyclosporin A  (ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
diazinon  (ISO)
dichloroacetic acid  (ISO)
Dichloroacetonitrile  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
entinostat  (ISO)
ethanol  (ISO)
flufenamic acid  (EXP,ISO)
folic acid  (ISO)
furan  (EXP)
furfural  (ISO)
genistein  (EXP)
glyburide  (EXP,ISO)
hydrogen peroxide  (ISO)
indole-3-methanol  (EXP)
inulin  (ISO)
ionomycin  (ISO)
ivermectin  (ISO)
L-1,4-dithiothreitol  (ISO)
L-glutamic acid  (ISO)
L-methionine  (ISO)
leflunomide  (ISO)
lipopolysaccharide  (EXP,ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
methapyrilene  (ISO)
N-ethyl-N-nitrosourea  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
niclosamide  (ISO)
okadaic acid  (ISO)
paracetamol  (EXP)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenylmercury acetate  (ISO)
piperonyl butoxide  (ISO)
pirinixic acid  (ISO)
potassium atom  (EXP,ISO)
progesterone  (ISO)
resveratrol  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sodium atom  (EXP,ISO)
sodium chloride  (ISO)
streptozocin  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP)
titanium dioxide  (ISO)
tributylstannane  (ISO)
trichloroethene  (EXP)
triclosan  (ISO)
triphenyl phosphate  (ISO)
tris(2-butoxyethyl) phosphate  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adaptive immune response  (IEA)
calcium ion transmembrane transport  (IEA)
calcium ion transport  (ISO)
calcium-mediated signaling  (IEA,ISO)
cellular response to ATP  (IEA,ISO)
dendritic cell chemotaxis  (IEA,ISO,ISS)
immune system process  (IEA)
long-term memory  (IMP)
membrane depolarization during AV node cell action potential  (IEA,ISO)
membrane depolarization during bundle of His cell action potential  (IEA,ISO)
membrane depolarization during Purkinje myocyte cell action potential  (IEA,ISO)
metal ion transport  (IBA)
monoatomic cation transmembrane transport  (IBA,IEA)
monoatomic ion transmembrane transport  (IEA)
monoatomic ion transport  (IEA)
negative regulation of bone mineralization  (IMP)
negative regulation of osteoblast differentiation  (IMP)
positive regulation of adipose tissue development  (IMP)
positive regulation of atrial cardiac muscle cell action potential  (IMP)
positive regulation of canonical Wnt signaling pathway  (IEA,ISO,ISS)
positive regulation of cell population proliferation  (IEA,ISO,ISS)
positive regulation of cytosolic calcium ion concentration  (IMP)
positive regulation of fat cell differentiation  (IMP)
positive regulation of heart rate  (IMP)
positive regulation of insulin secretion involved in cellular response to glucose stimulus  (IMP)
positive regulation of regulation of vascular associated smooth muscle cell membrane depolarization  (IMP)
positive regulation of vasoconstriction  (IMP)
protein homotetramerization  (IEA,ISO,ISS)
protein sumoylation  (IEA,ISO,ISS)
regulation of heart rate by cardiac conduction  (IEA,ISO)
regulation of T cell cytokine production  (IEA,ISO,ISS)
regulation of ventricular cardiac muscle cell action potential  (IEA,ISO)
sodium ion import across plasma membrane  (IEA,ISO)
transmembrane transport  (IEA,ISO,ISS)

Cellular Component
endoplasmic reticulum  (IDA,IEA,ISO)
Golgi apparatus  (IDA,IEA,ISO)
membrane  (IEA,ISO)
neuronal cell body  (IDA)
plasma membrane  (IBA,IDA,IEA,ISO,ISS)
sodium channel complex  (IEA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Disentangling the role of TRPM4 in hippocampus-dependent plasticity and learning: an electrophysiological, behavioral and FMRI approach. Bovet-Carmona M, etal., Brain Struct Funct. 2018 Nov;223(8):3557-3576. doi: 10.1007/s00429-018-1706-1. Epub 2018 Jul 3.
2. TRPM4 controls insulin secretion in pancreatic beta-cells. Cheng H, etal., Cell Calcium. 2007 Jan;41(1):51-61. Epub 2006 Jun 27.
3. Vasoconstriction resulting from dynamic membrane trafficking of TRPM4 in vascular smooth muscle cells. Crnich R, etal., Am J Physiol Cell Physiol. 2010 Sep;299(3):C682-94. doi: 10.1152/ajpcell.00101.2010. Epub 2010 Jul 7.
4. Critical role for transient receptor potential channel TRPM4 in myogenic constriction of cerebral arteries. Earley S, etal., Circ Res. 2004 Oct 29;95(9):922-9. Epub 2004 Oct 7.
5. Basal protein kinase Cdelta activity is required for membrane localization and activity of TRPM4 channels in cerebral artery smooth muscle cells. Garcia ZI, etal., Channels (Austin). 2011 May-Jun;5(3):210-4. Epub 2011 May 1.
6. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
7. De novo expression of Trpm4 initiates secondary hemorrhage in spinal cord injury. Gerzanich V, etal., Nat Med. 2009 Feb;15(2):185-91. doi: 10.1038/nm.1899. Epub 2009 Jan 25.
8. Pharmacological inhibition of TRPM4 hyperpolarizes vascular smooth muscle. Gonzales AL, etal., Am J Physiol Cell Physiol. 2010 Nov;299(5):C1195-202. doi: 10.1152/ajpcell.00269.2010. Epub 2010 Sep 8.
9. Functional expression of the TRPM4 cationic current in ventricular cardiomyocytes from spontaneously hypertensive rats. Guinamard R, etal., Hypertension. 2006 Oct;48(4):587-94. Epub 2006 Sep 11.
10. Implication of the TRPM4 nonselective cation channel in mammalian sinus rhythm. Hof T, etal., Heart Rhythm. 2013 Nov;10(11):1683-9. doi: 10.1016/j.hrthm.2013.08.014. Epub 2013 Aug 14.
11. Glibenclamide Improves Survival and Neurologic Outcome After Cardiac Arrest in Rats. Huang K, etal., Crit Care Med. 2015 Sep;43(9):e341-9. doi: 10.1097/CCM.0000000000001093.
12. 17ß-estradiol inhibits MMP-9 and SUR1/TrpM4 expression and activation and thereby attenuates BSCB disruption/hemorrhage after spinal cord injury in male rats. Lee JY, etal., Endocrinology. 2015 May;156(5):1838-50. doi: 10.1210/en.2014-1832. Epub 2015 Mar 12.
13. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
14. Identification and characterization of the murine TRPM4 channel. Murakami M, etal., Biochem Biophys Res Commun 2003 Aug 1;307(3):522-8.
15. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
16. Transient receptor potential melastatin 4 channel controls calcium signals and dental follicle stem cell differentiation. Nelson P, etal., Stem Cells. 2013 Jan;31(1):167-77. doi: 10.1002/stem.1264.
17. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
18. GOA pipeline RGD automated data pipeline
19. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
20. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
21. Information Derived from GenBank Report RGD, Sept. 2003
22. Transient receptor potential channel m4 and m5 in magnocellular cells in rat supraoptic and paraventricular nuclei. Teruyama R, etal., J Neuroendocrinol. 2011 Dec;23(12):1204-13. doi: 10.1111/j.1365-2826.2011.02211.x.
23. Inhibition of the Sur1-Trpm4 channel reduces neuroinflammation and cognitive impairment in subarachnoid hemorrhage. Tosun C, etal., Stroke. 2013 Dec;44(12):3522-8. doi: 10.1161/STROKEAHA.113.002904. Epub 2013 Oct 10.
24. Cloning and characterization of rat transient receptor potential-melastatin 4 (TRPM4). Yoo JC, etal., Biochem Biophys Res Commun. 2010 Jan 1;391(1):806-11. doi: 10.1016/j.bbrc.2009.11.142. Epub 2009 Nov 27.
Additional References at PubMed
PMID:15030426   PMID:15057822   PMID:17188667   PMID:17293488   PMID:17585083   PMID:17712480   PMID:18758465   PMID:19063936   PMID:19726882   PMID:20427713   PMID:20625999   PMID:20656926  
PMID:22153976   PMID:23255597   PMID:23283997   PMID:24391909   PMID:25099756   PMID:25261791   PMID:25378404   PMID:25836769   PMID:26172285   PMID:27207958   PMID:28758259   PMID:29211714  
PMID:29211723   PMID:29217581   PMID:29390943   PMID:29435486   PMID:29569041   PMID:30553915   PMID:31022885   PMID:31664513   PMID:32147520   PMID:32619565   PMID:34144257   PMID:35099165  
PMID:35163382   PMID:37404129  


Genomics

Comparative Map Data
Trpm4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81104,918,462 - 104,949,453 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1104,918,462 - 104,948,653 (-)EnsemblGRCr8
mRatBN7.2195,781,805 - 95,812,095 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl195,782,000 - 95,812,532 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1101,167,413 - 101,197,191 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01109,640,086 - 109,669,864 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01102,930,482 - 102,960,268 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01101,293,300 - 101,323,484 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1101,293,409 - 101,323,960 (-)Ensemblrn6Rnor6.0
Rnor_5.01102,357,043 - 102,387,010 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4195,773,485 - 95,803,542 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera190,039,848 - 90,063,911 (-)NCBICelera
RGSC_v3.1195,851,812 - 95,863,602 (-)NCBI
Cytogenetic Map1q22NCBI
TRPM4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381949,157,792 - 49,211,836 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1949,157,741 - 49,211,836 (+)Ensemblhg38GRCh38
GRCh371949,661,049 - 49,715,093 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361954,352,864 - 54,406,905 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341954,352,863 - 54,406,903NCBI
Celera1946,527,963 - 46,581,978 (+)NCBICelera
Cytogenetic Map19q13.33NCBI
HuRef1946,037,071 - 46,092,109 (+)NCBIHuRef
CHM1_11949,662,673 - 49,716,555 (+)NCBICHM1_1
T2T-CHM13v2.01952,152,347 - 52,209,191 (+)NCBIT2T-CHM13v2.0
Trpm4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39744,952,579 - 44,983,495 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl744,952,056 - 44,983,204 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38745,303,155 - 45,334,071 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl745,302,632 - 45,333,780 (-)Ensemblmm10GRCm38
MGSCv37752,558,525 - 52,589,150 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36745,170,674 - 45,201,784 (-)NCBIMGSCv36mm8
Celera740,759,067 - 40,790,038 (-)NCBICelera
Cytogenetic Map7B3NCBI
cM Map729.24NCBI
Trpm4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555591,546,365 - 1,581,712 (-)Ensembl
ChiLan1.0NW_0049555591,539,036 - 1,581,800 (-)NCBIChiLan1.0ChiLan1.0
TRPM4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22055,272,183 - 55,328,155 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11957,191,713 - 57,248,153 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01946,168,301 - 46,224,726 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11955,095,029 - 55,150,464 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1955,095,029 - 55,150,464 (+)EnsemblpanPan2panpan1.1
TRPM4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11107,261,760 - 107,304,157 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1107,261,756 - 107,303,346 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1106,849,462 - 106,891,183 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01107,786,342 - 107,828,325 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1107,678,345 - 107,828,249 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11107,454,730 - 107,496,450 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01107,100,989 - 107,142,706 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01107,938,110 - 107,978,274 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Trpm4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934921,474,889 - 21,506,283 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366643,093,367 - 3,124,117 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049366643,093,258 - 3,124,473 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TRPM4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl654,342,784 - 54,377,155 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1654,342,774 - 54,377,557 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2649,975,735 - 49,985,615 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TRPM4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1642,379,534 - 42,424,721 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl642,379,659 - 42,424,146 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366607322,272,664 - 22,341,345 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Trpm4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248324,902,659 - 4,936,926 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248324,902,335 - 4,937,806 (-)NCBIHetGla 1.0HetGla 1.0hetGla2

Variants

.
Variants in Trpm4
400 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:463
Count of miRNA genes:232
Interacting mature miRNAs:276
Transcripts:ENSRNOT00000041513
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1582234Gluco18Glucose level QTL 183.40.0003blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)187889942132889942Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)151941022208479811Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)139728272132889942Rat
1331793Bp200Blood pressure QTL 2003.71601arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1102780511182384005Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)151940904168768703Rat
2300324Fetw1Fetal weight QTL 112.10.005fetal growth trait (VT:0004201)fetal body weight (CMO:0002080)192963855109494029Rat
1554320Bmd1Bone mineral density QTL 112.20.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1101228864146228864Rat
1331800Scl25Serum cholesterol level QTL 253.013blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)187785026142582336Rat
7421628Bp361Blood pressure QTL 3610.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183019780128019780Rat
631495Bp96Blood pressure QTL 964.52arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)166404680111404680Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134184556172281316Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)166009857160501508Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134565911208798288Rat
631519Pia11Pristane induced arthritis QTL 115.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)193903998191260518Rat
1302788Scl19Serum cholesterol QTL 194.60.001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)166400974132889942Rat
1549903Bp267Blood pressure QTL 267arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)184107164115183752Rat
2313083Bmd74Bone mineral density QTL 7440.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)191302413136302413Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)151511344153680016Rat
724567Tcas6Tongue tumor susceptibility QTL 66.85tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)1102359314153680016Rat
724521Uae1Urinary albumin excretion QTL 13.80.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)199645382182701046Rat
1358902Bw47Body weight QTL 471.67body mass (VT:0001259)body weight (CMO:0000012)199645382221502378Rat
1358192Ept13Estrogen-induced pituitary tumorigenesis QTL 133.4pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)186622262131622262Rat
2300164Bmd44Bone mineral density QTL 445.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)166077886111077886Rat
731168Bp154Blood pressure QTL 1543.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1103779152223964440Rat
631205Bp196Blood pressure QTL 19640.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)198879955208479939Rat
738022Anxrr13Anxiety related response QTL 134.60.00039locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of, or within a discrete space in an open field apparatus (CMO:0001514)192683681137683681Rat
10054135Gmadr2Adrenal mass QTL 21.970.0129adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)186993904131993904Rat
152025249Scl82Serum cholesterol level QTL 824.77blood cholesterol amount (VT:0000180)152891222109116986Rat
1331749Hrtrt11Heart rate QTL 112.973heart pumping trait (VT:2000009)heart rate (CMO:0000002)192683681137683681Rat
7411712Strs4Sensitivity to stroke QTL 48.7cerebrum integrity trait (VT:0010549)percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)187558587132558587Rat
737977Bp160Blood pressure QTL 1600.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)197582336142582336Rat
2293142Bp314Blood pressure QTL 314arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1101594089146594089Rat
61433Cia2Collagen induced arthritis QTL 25joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1100345976145345976Rat
724529Cm16Cardiac mass QTL 162.7heart mass (VT:0007028)calculated heart weight (CMO:0000073)196717367160111531Rat

Markers in Region
RH133941  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2195,803,951 - 95,804,147 (+)MAPPERmRatBN7.2
Rnor_6.01101,315,365 - 101,315,560NCBIRnor6.0
Rnor_5.01102,378,888 - 102,379,083UniSTSRnor5.0
RGSC_v3.4195,795,720 - 95,795,915UniSTSRGSC3.4
Celera190,061,722 - 90,061,917UniSTS
RH 3.4 Map1910.1UniSTS
Cytogenetic Map1q22UniSTS
AI234615  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2195,782,252 - 95,782,461 (+)MAPPERmRatBN7.2
Rnor_6.01101,293,553 - 101,293,761NCBIRnor6.0
Rnor_5.01102,357,296 - 102,357,504UniSTSRnor5.0
RGSC_v3.4195,773,738 - 95,773,946UniSTSRGSC3.4
Celera190,040,101 - 90,040,309UniSTS
RH 3.4 Map1908.89UniSTS
Cytogenetic Map1q22UniSTS
Trpm4  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2195,782,428 - 95,782,510 (+)MAPPERmRatBN7.2
Rnor_6.01101,293,729 - 101,293,810NCBIRnor6.0
Rnor_5.01102,357,472 - 102,357,553UniSTSRnor5.0
Celera190,040,277 - 90,040,358UniSTS
Cytogenetic Map1q22UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 83 59 6 347 183 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000041513   ⟹   ENSRNOP00000041387
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1104,918,462 - 104,948,564 (-)Ensembl
mRatBN7.2 Ensembl195,782,000 - 95,812,532 (-)Ensembl
Rnor_6.0 Ensembl1101,293,409 - 101,323,960 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000099429   ⟹   ENSRNOP00000082333
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1104,919,185 - 104,948,236 (-)Ensembl
mRatBN7.2 Ensembl195,782,211 - 95,812,532 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000100339   ⟹   ENSRNOP00000089776
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl195,782,211 - 95,812,532 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000107811   ⟹   ENSRNOP00000082706
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1104,919,278 - 104,948,653 (-)Ensembl
mRatBN7.2 Ensembl195,782,723 - 95,812,532 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000113541   ⟹   ENSRNOP00000090318
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1104,918,462 - 104,948,304 (-)Ensembl
mRatBN7.2 Ensembl195,782,000 - 95,811,382 (-)Ensembl
RefSeq Acc Id: NM_001136229   ⟹   NP_001129701
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81104,918,462 - 104,948,236 (-)NCBI
mRatBN7.2195,782,000 - 95,811,746 (-)NCBI
Rnor_6.01101,293,300 - 101,323,187 (-)NCBI
Rnor_5.01102,357,043 - 102,387,010 (-)NCBI
RGSC_v3.4195,773,485 - 95,803,542 (-)RGD
Celera190,039,848 - 90,063,911 (-)RGD
Sequence:
RefSeq Acc Id: XM_039088263   ⟹   XP_038944191
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81104,925,950 - 104,949,453 (-)NCBI
mRatBN7.2195,789,489 - 95,812,095 (-)NCBI
RefSeq Acc Id: XR_001835352
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81104,918,672 - 104,949,431 (-)NCBI
mRatBN7.2195,781,805 - 95,812,094 (-)NCBI
Rnor_6.01101,293,513 - 101,323,484 (-)NCBI
Sequence:
RefSeq Acc Id: XR_005491008
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81104,918,672 - 104,948,244 (-)NCBI
mRatBN7.2195,781,805 - 95,811,754 (-)NCBI
RefSeq Acc Id: XR_005491011
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81104,918,672 - 104,942,567 (-)NCBI
mRatBN7.2195,781,805 - 95,806,104 (-)NCBI
RefSeq Acc Id: XR_005491013
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81104,923,746 - 104,949,441 (-)NCBI
mRatBN7.2195,787,280 - 95,812,094 (-)NCBI
RefSeq Acc Id: XR_005491016
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81104,918,672 - 104,937,066 (-)NCBI
mRatBN7.2195,781,805 - 95,800,604 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001129701 (Get FASTA)   NCBI Sequence Viewer  
  XP_038944191 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein ABS12239 (Get FASTA)   NCBI Sequence Viewer  
  BAB15808 (Get FASTA)   NCBI Sequence Viewer  
  EDM07378 (Get FASTA)   NCBI Sequence Viewer  
  EDM07379 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000041387
GenBank Protein Q9ESQ5 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001129701   ⟸   NM_001136229
- UniProtKB: Q9ESQ5 (UniProtKB/Swiss-Prot),   A0A0H2UHX0 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000041387   ⟸   ENSRNOT00000041513
RefSeq Acc Id: XP_038944191   ⟸   XM_039088263
- Peptide Label: isoform X1
Ensembl Acc Id: ENSRNOP00000082706   ⟸   ENSRNOT00000107811
Ensembl Acc Id: ENSRNOP00000089776   ⟸   ENSRNOT00000100339
Ensembl Acc Id: ENSRNOP00000082333   ⟸   ENSRNOT00000099429
Ensembl Acc Id: ENSRNOP00000090318   ⟸   ENSRNOT00000113541
Protein Domains
Ion transport   TRPM SLOG   TRPM-like

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9ESQ5-F1-model_v2 AlphaFold Q9ESQ5 1-1208 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13690033
Promoter ID:EPDNEW_R558
Type:single initiation site
Name:Trpm4_1
Description:transient receptor potential cation channel, subfamily M, member4
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01101,323,972 - 101,324,032EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620244 AgrOrtholog
BioCyc Gene G2FUF-59695 BioCyc
Ensembl Genes ENSRNOG00000020714 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000041513 ENTREZGENE
InterPro Ion_trans_dom UniProtKB/Swiss-Prot
  TRPM UniProtKB/Swiss-Prot
  TRPM_SLOG UniProtKB/Swiss-Prot
KEGG Report rno:171143 UniProtKB/Swiss-Prot
NCBI Gene 171143 ENTREZGENE
PANTHER PTHR13800:SF6 UniProtKB/Swiss-Prot
  TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL, SUBFAMILY M, MEMBER 6 UniProtKB/Swiss-Prot
Pfam Ion_trans UniProtKB/Swiss-Prot
  LSDAT_euk UniProtKB/Swiss-Prot
  TRPM2 UniProtKB/Swiss-Prot
PhenoGen Trpm4 PhenoGen
RatGTEx ENSRNOG00000020714 RatGTEx
Superfamily-SCOP Pseudo ankyrin repeat-like UniProtKB/Swiss-Prot
UniProt A0A0H2UHX0 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZVE9_RAT UniProtKB/TrEMBL
  A0A8I5ZWN0_RAT UniProtKB/TrEMBL
  A0A8I6AAJ1_RAT UniProtKB/TrEMBL
  A6JB05_RAT UniProtKB/TrEMBL
  A6JB06_RAT UniProtKB/TrEMBL
  A7L639_RAT UniProtKB/TrEMBL
  Q9ESQ5 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-09-10 Trpm4  transient receptor potential cation channel, subfamily M, member 4  Mls2s  melastatin like 2 protein  Symbol and Name updated 1299863 APPROVED
2002-08-07 Mls2s  melastatin like 2 protein      Symbol and Name status set to provisional 70820 PROVISIONAL