TRPM4 (transient receptor potential cation channel subfamily M member 4) - Rat Genome Database

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Pathways
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Gene: TRPM4 (transient receptor potential cation channel subfamily M member 4) Chlorocebus sabaeus
Analyze
Symbol: TRPM4
Name: transient receptor potential cation channel subfamily M member 4
RGD ID: 18361432
Description: ENCODES a protein that exhibits identical protein binding (ortholog); INVOLVED IN calcium ion transport (ortholog); long-term memory (ortholog); negative regulation of bone mineralization (ortholog); ASSOCIATED WITH arrhythmogenic right ventricular cardiomyopathy (ortholog); atrioventricular block (ortholog); Bradycardia (ortholog); FOUND IN neuronal cell body (ortholog)
Type: protein-coding
RefSeq Status: MODEL
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1642,379,534 - 42,424,721 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl642,379,659 - 42,424,146 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607322,272,664 - 22,341,345 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
calcium ion transmembrane transport  (IEA)
calcium ion transport  (IEA,ISO)
calcium-mediated signaling  (IEA)
cellular response to ATP  (IEA)
dendritic cell chemotaxis  (IEA)
inorganic cation transmembrane transport  (IEA)
long-term memory  (ISO)
membrane depolarization during AV node cell action potential  (IEA)
membrane depolarization during bundle of His cell action potential  (IEA)
membrane depolarization during Purkinje myocyte cell action potential  (IEA)
monoatomic ion transmembrane transport  (IEA)
monoatomic ion transport  (IEA)
negative regulation of bone mineralization  (ISO)
negative regulation of osteoblast differentiation  (ISO)
positive regulation of adipose tissue development  (ISO)
positive regulation of atrial cardiac muscle cell action potential  (ISO)
positive regulation of canonical Wnt signaling pathway  (IEA)
positive regulation of cell population proliferation  (IEA)
positive regulation of cytosolic calcium ion concentration  (ISO)
positive regulation of fat cell differentiation  (ISO)
positive regulation of heart rate  (ISO)
positive regulation of insulin secretion involved in cellular response to glucose stimulus  (ISO)
positive regulation of regulation of vascular associated smooth muscle cell membrane depolarization  (ISO)
positive regulation of vasoconstriction  (ISO)
protein homotetramerization  (IEA)
protein sumoylation  (IEA)
regulation of heart rate by cardiac conduction  (IEA)
regulation of T cell cytokine production  (IEA)
regulation of ventricular cardiac muscle cell action potential  (IEA)
sodium ion import across plasma membrane  (IEA)
transmembrane transport  (IEA)

Cellular Component

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
TRPM4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1642,379,534 - 42,424,721 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl642,379,659 - 42,424,146 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607322,272,664 - 22,341,345 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
TRPM4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381949,157,792 - 49,211,836 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1949,157,741 - 49,211,836 (+)EnsemblGRCh38hg38GRCh38
GRCh371949,661,049 - 49,715,093 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361954,352,864 - 54,406,905 (+)NCBINCBI36Build 36hg18NCBI36
Build 341954,352,863 - 54,406,903NCBI
Celera1946,527,963 - 46,581,978 (+)NCBICelera
Cytogenetic Map19q13.33NCBI
HuRef1946,037,071 - 46,092,109 (+)NCBIHuRef
CHM1_11949,662,673 - 49,716,555 (+)NCBICHM1_1
T2T-CHM13v2.01952,152,347 - 52,209,191 (+)NCBIT2T-CHM13v2.0
Trpm4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39744,952,579 - 44,983,495 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl744,952,056 - 44,983,204 (-)EnsemblGRCm39 Ensembl
GRCm38745,303,155 - 45,334,071 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl745,302,632 - 45,333,780 (-)EnsemblGRCm38mm10GRCm38
MGSCv37752,558,525 - 52,589,150 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36745,170,674 - 45,201,784 (-)NCBIMGSCv36mm8
Celera740,759,067 - 40,790,038 (-)NCBICelera
Cytogenetic Map7B3NCBI
cM Map729.24NCBI
Trpm4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81104,918,462 - 104,949,453 (-)NCBIGRCr8
mRatBN7.2195,781,805 - 95,812,095 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl195,782,000 - 95,812,532 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1101,167,413 - 101,197,191 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01109,640,086 - 109,669,864 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01102,930,482 - 102,960,268 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01101,293,300 - 101,323,484 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1101,293,409 - 101,323,960 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01102,357,043 - 102,387,010 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4195,773,485 - 95,803,542 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1195,851,812 - 95,863,602 (-)NCBI
Celera190,039,848 - 90,063,911 (-)NCBICelera
Cytogenetic Map1q22NCBI
Trpm4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555591,546,365 - 1,581,712 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555591,539,036 - 1,581,800 (-)NCBIChiLan1.0ChiLan1.0
TRPM4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22055,272,183 - 55,328,155 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11957,191,713 - 57,248,153 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01946,168,301 - 46,224,726 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11955,095,029 - 55,150,464 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1955,095,029 - 55,150,464 (+)Ensemblpanpan1.1panPan2
TRPM4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11107,261,760 - 107,304,157 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1107,261,756 - 107,303,346 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1106,849,462 - 106,891,183 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01107,786,342 - 107,828,325 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1107,678,345 - 107,828,249 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11107,454,730 - 107,496,450 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01107,100,989 - 107,142,706 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01107,938,110 - 107,978,274 (-)NCBIUU_Cfam_GSD_1.0
Trpm4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934921,474,889 - 21,506,283 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366643,093,367 - 3,124,117 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366643,093,258 - 3,124,473 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TRPM4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl654,342,784 - 54,377,155 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1654,342,774 - 54,377,557 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2649,975,735 - 49,985,615 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Trpm4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248324,902,659 - 4,936,926 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248324,902,335 - 4,937,806 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

endocrine system hemolymphoid system nervous system
High
Medium 31 26
Low 5 16 34
Below cutoff 4

Sequence


Reference Sequences
RefSeq Acc Id: ENSCSAT00000000673   ⟹   ENSCSAP00000015390
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl642,379,659 - 42,424,146 (+)Ensembl
RefSeq Acc Id: XM_037991903   ⟹   XP_037847831
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_02366607322,273,185 - 22,341,345 (+)NCBI
RefSeq Acc Id: XM_037991904   ⟹   XP_037847832
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_02366607322,272,664 - 22,341,345 (+)NCBI
RefSeq Acc Id: XM_037991905   ⟹   XP_037847833
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_02366607322,273,248 - 22,341,345 (+)NCBI
RefSeq Acc Id: XM_037991906   ⟹   XP_037847834
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_02366607322,307,583 - 22,341,345 (+)NCBI
Protein Sequences
Protein RefSeqs XP_037847831 (Get FASTA)   NCBI Sequence Viewer  
  XP_037847832 (Get FASTA)   NCBI Sequence Viewer  
  XP_037847833 (Get FASTA)   NCBI Sequence Viewer  
  XP_037847834 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCSAP00000015390.1
Reference Protein Sequences
RefSeq Acc Id: ENSCSAP00000015390   ⟸   ENSCSAT00000000673
RefSeq Acc Id: XP_037847832   ⟸   XM_037991904
- Peptide Label: isoform X1
- UniProtKB: A0A0D9S3F1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_037847831   ⟸   XM_037991903
- Peptide Label: isoform X1
- UniProtKB: A0A0D9S3F1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_037847833   ⟸   XM_037991905
- Peptide Label: isoform X2
- UniProtKB: A0A0D9S3F1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_037847834   ⟸   XM_037991906
- Peptide Label: isoform X3


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000002727 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000000673.1 UniProtKB/TrEMBL
InterPro Ion_trans_dom UniProtKB/TrEMBL
  TRPM_SLOG UniProtKB/TrEMBL
NCBI Gene TRPM4 ENTREZGENE
PANTHER PTHR13800:SF6 UniProtKB/TrEMBL
  TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL, SUBFAMILY M, MEMBER 6 UniProtKB/TrEMBL
Pfam Ion_trans UniProtKB/TrEMBL
  LSDAT_euk UniProtKB/TrEMBL
Superfamily-SCOP Pseudo ankyrin repeat-like UniProtKB/TrEMBL
UniProt A0A0D9S3F1 ENTREZGENE, UniProtKB/TrEMBL