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Gene-Chemical Interaction Annotations
Gene-Chemical Interaction AnnotationsTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | 17beta-estradiol | multiple interactions | EXP | | 6480464 | ABCC8 protein promotes the reaction [Estradiol results in increased activity of CASP3 protein]; more ... | CTD | PMID:19095654 | 17beta-estradiol | affects binding | EXP | | 6480464 | Estradiol binds to ABCC8 protein mutant form | CTD | PMID:19095654 | 17beta-estradiol | increases response to substance | EXP | | 6480464 | ABCC8 protein mutant form results in increased susceptibility to Estradiol; more ... | CTD | PMID:19095654 | 17beta-estradiol | multiple interactions | ISO | RGD:736889 | 6480464 | Estradiol binds to and affects the activity of ABCC8 protein | CTD | PMID:19095654 | 17beta-estradiol | decreases response to substance | EXP | | 6480464 | ABCC8 protein mutant form results in decreased susceptibility to Estradiol | CTD | PMID:19095654 | 17beta-estradiol | affects response to substance | ISO | RGD:736889 | 6480464 | ABCC8 protein affects the susceptibility to Estradiol | CTD | PMID:19095654 | 2,3,7,8-tetrachlorodibenzodioxine | multiple interactions | EXP | | 6480464 | AHR protein alternative form affects the reaction [Tetrachlorodibenzodioxin results in decreased expression of ABCC8 mRNA] | CTD | PMID:21215274 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of ABCC8 mRNA | CTD | PMID:21215274 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | EXP | | 6480464 | Tetrachlorodibenzodioxin affects the expression of ABCC8 mRNA | CTD | PMID:22298810 | 2,4-dinitrotoluene | affects expression | EXP | | 6480464 | 2,4-dinitrotoluene affects the expression of ABCC8 mRNA | CTD | PMID:21346803 | acetylcholine | multiple interactions | EXP | | 6480464 | ABCC8 protein inhibits the reaction [Acetylcholine promotes the reaction [KCNJ8 protein results in increased transport of Potassium]] | CTD | PMID:15894309 | ammonium chloride | affects expression | EXP | | 6480464 | Ammonium Chloride affects the expression of ABCC8 mRNA | CTD | PMID:16483693 | ATP | multiple interactions | EXP | | 6480464 | Adenosine Triphosphate deficiency inhibits the reaction [Estradiol inhibits the reaction [Glyburide binds to ABCC8 protein]] | CTD | PMID:19095654 | benzo[a]pyrene | multiple interactions | ISO | RGD:736889 | 6480464 | Benzo(a)pyrene promotes the reaction [AHR protein binds to ABCC8 promoter] | CTD | PMID:19654925 | beryllium difluoride | decreases activity | ISO | RGD:733938 | 6480464 | beryllium fluoride results in decreased activity of ABCC8 protein | CTD | PMID:18025464 | beryllium difluoride | decreases activity | EXP | | 6480464 | beryllium fluoride results in decreased activity of ABCC8 protein | CTD | PMID:17561960 | bisphenol A | affects expression | EXP | | 6480464 | bisphenol A affects the expression of ABCC8 mRNA | CTD | PMID:23328667 | bromobenzene | decreases expression | EXP | | 6480464 | bromobenzene results in decreased expression of ABCC8 mRNA | CTD | PMID:15976192 | chlorpropamide | multiple interactions | ISO | RGD:733938 | 6480464 | [KCNJ11 mutant form co-treated with ABCC8 mutant form] results in decreased susceptibility to Chlorpropamide | CTD | PMID:22209866 | cisplatin | affects response to substance | ISO | RGD:733938 | 6480464 | ABCC8 mRNA affects the susceptibility to Cisplatin | CTD | PMID:18610736 | diethylstilbestrol | decreases expression | EXP | | 6480464 | Diethylstilbestrol results in decreased expression of ABCC8 mRNA | CTD | PMID:21658437 | estrone | increases response to substance | EXP | | 6480464 | ABCC8 protein results in increased susceptibility to Estrone | CTD | PMID:19095654 | gliclazide | multiple interactions | ISO | RGD:733938 | 6480464 | [KCNJ11 mutant form co-treated with ABCC8 mutant form] results in increased susceptibility to Gliclazide | CTD | PMID:22209866 | glimepiride | multiple interactions | ISO | RGD:733938 | 6480464 | [KCNJ11 mutant form co-treated with ABCC8 mutant form] results in decreased susceptibility to glimepiride | CTD | PMID:22209866 | glyburide | increases response to substance | EXP | | 6480464 | ABCC8 protein results in increased susceptibility to Glyburide | CTD | PMID:19095654 | glyburide | multiple interactions | EXP | | 6480464 | resveratrol inhibits the reaction [Glyburide binds to ABCC8 protein] | CTD | PMID:17138562 | glyburide | affects binding | EXP | | 6480464 | Glyburide binds to ABCC8 protein; more ... | CTD | PMID:19095654 | glyburide | multiple interactions | EXP | | 6480464 | Adenosine Triphosphate deficiency inhibits the reaction [Estradiol inhibits the reaction [Glyburide binds to ABCC8 protein]]; more ... | CTD | PMID:19095654 | mercaptopurine | decreases expression | EXP | | 6480464 | 6-Mercaptopurine results in decreased expression of ABCC8 mRNA | CTD | PMID:23358152 | mifepristone | decreases expression | ISO | RGD:733938 | 6480464 | Mifepristone results in decreased expression of ABCC8 mRNA | CTD | PMID:17584828 | N-nitrosodimethylamine | decreases expression | EXP | | 6480464 | Dimethylnitrosamine results in decreased expression of ABCC8 mRNA | CTD | PMID:15976192 | paracetamol | decreases expression | EXP | | 6480464 | Acetaminophen results in decreased expression of ABCC8 mRNA | CTD | PMID:15976192 | phenobarbital | decreases expression | EXP | | 6480464 | Phenobarbital results in decreased expression of ABCC8 mRNA | CTD | PMID:19162173 | potassium atom | increases transport | ISO | RGD:736889 | 6480464 | ABCC8 protein results in increased transport of Potassium | CTD | PMID:10022826 | potassium atom | multiple interactions | EXP | | 6480464 | ABCC8 protein inhibits the reaction [Acetylcholine promotes the reaction [KCNJ8 protein results in increased transport of Potassium]] | CTD | PMID:15894309 | purine-6-thiol | decreases expression | EXP | | 6480464 | 6-Mercaptopurine results in decreased expression of ABCC8 mRNA | CTD | PMID:23358152 | resveratrol | increases response to substance | EXP | | 6480464 | ABCC8 protein results in increased susceptibility to resveratrol | CTD | PMID:19095654 | resveratrol | multiple interactions | EXP | | 6480464 | resveratrol inhibits the reaction [Glyburide binds to ABCC8 protein] | CTD | PMID:17138562 | resveratrol | affects binding | EXP | | 6480464 | resveratrol binds to ABCC8 protein | CTD | PMID:17138562 | riddelliine | decreases expression | EXP | | 6480464 | riddelliine results in decreased expression of ABCC8 mRNA | CTD | PMID:18047727 PMID:18047722 | riddelliine | decreases expression | EXP | | 6480464 | riddelliine results in decreased expression of ABCC8 mRNA | CTD | PMID:18047722 PMID:18047727 | sirolimus | decreases expression | EXP | | 6480464 | Sirolimus results in decreased expression of ABCC8 mRNA | CTD | PMID:21865292 | tetrachloromethane | decreases expression | EXP | | 6480464 | Carbon Tetrachloride results in decreased expression of ABCC8 mRNA | CTD | PMID:15976192 | tetrachloromethane | decreases expression | EXP | | 6480464 | Carbon Tetrachloride results in decreased expression of ABCC8 protein | CTD | PMID:17544377 | thioacetamide | decreases expression | EXP | | 6480464 | Thioacetamide results in decreased expression of ABCC8 mRNA | CTD | PMID:15976192 | tolbutamide | multiple interactions | ISO | RGD:733938 | 6480464 | [KCNJ11 mutant form co-treated with ABCC8 mutant form] results in decreased susceptibility to Tolbutamide | CTD | PMID:22209866 | tolbutamide | multiple interactions | ISO | RGD:733938 | 6480464 | ABCC8 gene SNP inhibits the reaction [Tolbutamide results in increased secretion of INS protein] | CTD | PMID:9568693 | tolbutamide | multiple interactions | ISO | RGD:733938 | 6480464 | Tolbutamide inhibits the reaction [ABCC8 protein mutant form results in increased activity of KCNJ11 protein] | CTD | PMID:18025464 | trans-resveratrol | increases response to substance | EXP | | 6480464 | ABCC8 protein results in increased susceptibility to resveratrol | CTD | PMID:19095654 | trans-resveratrol | multiple interactions | EXP | | 6480464 | resveratrol inhibits the reaction [Glyburide binds to ABCC8 protein] | CTD | PMID:17138562 | trans-resveratrol | affects binding | EXP | | 6480464 | resveratrol binds to ABCC8 protein | CTD | PMID:17138562 | troglitazone | decreases expression | EXP | | 6480464 | troglitazone results in decreased expression of ABCC8 mRNA | CTD | PMID:21515302 | uranium atom | affects expression | ISO | RGD:733938 | 6480464 | Uranium affects the expression of ABCC8 mRNA | CTD | PMID:15672453 | | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Gene Ontology Annotations
Molecular Pathway Annotations| External Database Links | |
| KEGG Pathway | ABC transporters |
| Insulin secretion | |
| Type II diabetes mellitus | |
| Pathway Interaction Database | FOXA2 and FOXA3 transcription factor networks (PID:200087) |
Phenotype Annotations
Disease Annotations
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Gene-Chemical Interaction Annotations
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Gene Ontology Annotations
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Molecular Pathway Annotations
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| External Database Links | |
| KEGG Pathway | ABC transporters |
| Insulin secretion | |
| Type II diabetes mellitus | |
| Pathway Interaction Database | FOXA2 and FOXA3 transcription factor networks (PID:200087) |
Phenotype Annotations
References - curated| 1. |
Bancila V, etal., J Biol Chem. 2005 Mar 11;280(10):8793-9. Epub 2004 Dec 21. |
| 2. |
Cao K, etal., Biochem Biophys Res Commun 2002 Aug 16;296(2):463-9. |
| 3. |
Cartier EA, etal., J Biol Chem 2003 Feb 28;278(9):7081-90. |
| 4. |
Darendeliler F, etal., J Pediatr Endocrinol Metab. 2002 Jul-Aug;15(7):993-1000. |
| 5. |
de Wet H, etal., Proc Natl Acad Sci U S A. 2007 Nov 27;104(48):18988-92. Epub 2007 Nov 19. |
| 6. |
Dorschner H, etal., Mol Pharmacol. 1999 Jun;55(6):1060-6. |
| 7. |
Elrod JW, etal., Circulation. 2008 Mar 18;117(11):1405-13. Epub 2008 Mar 3. |
| 8. |
Fan X, etal., Diabetes. 2008 Sep 5. |
| 9. |
Feng Y, etal., Diabetes Care. 2008 Oct;31(10):1939-44. Epub 2008 Jul 3. |
| 10. |
Florez JC, etal., Diabetes. 2007 Feb;56(2):531-6. |
| 11. |
Gloyn AL, etal., Hum Mutat. 2006 Mar;27(3):220-31. |
| 12. |
GOA data from the GO Consortium |
| 13. |
Gros L, etal., Br J Pharmacol 2002 Sep;137(1):98-106. |
| 14. |
He YY, etal., Acta Pharmacol Sin. 2008 Aug;29(8):983-9. |
| 15. |
Heemskerk S, etal., Pflugers Arch. 2007 May;454(2):321-34. Epub 2007 Feb 7. |
| 16. |
Hiriart M and Aguilar-Bryan L, Am J Physiol Endocrinol Metab. 2008 Dec;295(6):E1298-306. Epub 2008 Oct 21. |
| 17. |
Hirohashi T, etal., Mol Pharmacol 1998 Jun;53(6):1068-75. |
| 18. |
Jiang K, etal., Neuropathology. 2007 Dec;27(6):531-8. |
| 19. |
Kunte H, etal., Stroke. 2007 Sep;38(9):2526-30. Epub 2007 Aug 2. |
| 20. |
Laukkanen O, etal., J Clin Endocrinol Metab. 2004 Dec;89(12):6286-90. |
| 21. |
Lohmueller KE, etal., Nat Genet 2003 Feb;33(2):177-82. |
| 22. |
MGD data from the GO Consortium |
| 23. |
Moritz W, etal., Endocrinology 2001 Jan;142(1):129-38. |
| 24. |
Morrissey A, etal., BMC Physiol. 2005 Jan 12;5(1):1. |
| 25. |
NCBI rat LocusLink and RefSeq merged data July 26, 2002 |
| 26. |
Ota M, etal., Neurosci Lett. 2007 Feb 2;412(3):254-8. Epub 2006 Dec 15. |
| 27. |
Pasyk EA, etal., J Biol Chem 2004 Feb 6;279(6):4234-40. Epub 2003 Nov 25. |
| 28. |
Pipeline to import KEGG annotations from KEGG into RGD Pathway Ontology |
| 29. |
Pipeline to import Pathway Interaction Database annotations from NCI into RGD |
| 30. |
Reis AF, etal., Hum Genet 2000 Aug;107(2):138-44. |
| 31. |
RGD automated data pipeline |
| 32. |
RGD automated import pipeline for gene-chemical interactions |
| 33. |
RGD Automated Pipelines |
| 34. |
Simard JM, etal., J Clin Invest. 2007 Aug;117(8):2105-13. |
| 35. |
Simard JM, etal., Nat Med. 2006 Apr;12(4):433-40. Epub 2006 Mar 19. |
| 36. |
Tagmose TM, etal., J Med Chem. 2004 Jun 3;47(12):3202-11. |
| 37. |
Tammaro P, etal., EMBO J. 2005 Jul 6;24(13):2318-30. Epub 2005 Jun 16. |
| 38. |
Tarasov AI, etal., Diabetes. 2008 Jun;57(6):1595-604. Epub 2008 Mar 17. |
| 39. |
Thomas PM, etal., Science 1995 Apr 21;268(5209):426-9. |
| 40. |
Vavaiya KV and Briski KP, J Mol Neurosci. 2008 Feb;34(2):121-9. Epub 2007 Dec 15. |
| 41. |
Verkarre V, etal., J Clin Invest. 1998 Oct 1;102(7):1286-91. |
| 42. |
Wang S, etal., Neuropharmacology. 2005 Jun;48(7):984-92. |
References - uncurated| PubMed | 12627323 |
| 15485808 | |
| 16308567 | |
| 17311891 | |
| 17395632 | |
| 17561960 | |
| 17584766 | |
| 17593344 | |
| 17656102 | |
| 17889836 | |
| 19151370 | |
| 19604096 | |
| 19933268 | |
| 20410530 | |
| 20456845 | |
| 20598356 | |
| 21173146 | |
| 21527399 | |
| 21540180 | |
| 22144717 | |
| 22165413 | |
| 23255597 | |
| 7716547 | |
| 8942641 |
RGD Disease Portals| Abcc8 has been annotated in the following RGD Disease Portals. |
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Candidate Gene Status
Comparative Map Data| Abcc8 (Rattus norvegicus) |
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| ABCC8 (Homo sapiens) |
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| Abcc8 (Mus musculus) |
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Position Markers| D1Rat379 |
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| BF388506 |
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| BE110066 |
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| Abcc8 |
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QTLs in Region (RGSC Genome Assembly v3.4)| The following QTLs overlap with this region. | ![]() | Full Report | ![]() | CSV | ![]() | TAB | ![]() | Printer | ![]() | Gviewer |
Nucleotide Sequences| Nucleotide RefSeqs | NM_013039 | (Get FASTA) | Search GEO for Microarray Profiles |
| GenBank Nucleotide | AABR06004833 | (Get FASTA) | Search GEO for Microarray Profiles |
| AABR06004834 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01005052 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01005053 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01005054 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01005055 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01005056 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AB052294 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AF039595 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AJ511272 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AJ511273 | (Get FASTA) | Search GEO for Microarray Profiles | |
| CH473979 | (Get FASTA) | Search GEO for Microarray Profiles | |
| X97279 | (Get FASTA) | Search GEO for Microarray Profiles |
| RefSeq Acc Id: | NM_013039 | ||||||||||||||||||||
| RefSeq Status: | PROVISIONAL | ||||||||||||||||||||
| Type: | CODING | ||||||||||||||||||||
| Protein Acc Id: | NP_037171 | ||||||||||||||||||||
| Position: |
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Protein Sequences| Protein RefSeqs | NP_037171 | (Get FASTA) |
| GenBank Protein | AAB96684 | (Get FASTA) |
| BAB19011 | (Get FASTA) | |
| CAA65934 | (Get FASTA) | |
| CAD54072 | (Get FASTA) | |
| CAD54073 | (Get FASTA) | |
| EDM07269 | (Get FASTA) | |
| EDM07270 | (Get FASTA) | |
| EDM07271 | (Get FASTA) | |
| Q09429 | (Get FASTA) |
Strain Sequence Variants
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External Database Links| Database | Acc Id | Source(s) |
| Ensembl Genes | ENSRNOG00000021130 | ENTREZGENE, UniProtKB/TrEMBL |
| Ensembl Protein | ENSRNOP00000028696 | ENTREZGENE, UniProtKB/TrEMBL |
| ENSRNOP00000035010 | UniProtKB/TrEMBL | |
| Ensembl Transcript | ENSRNOT00000028696 | ENTREZGENE, UniProtKB/TrEMBL |
| ENSRNOT00000038798 | UniProtKB/TrEMBL | |
| Entrez Gene | 25559 | ENTREZGENE |
| Germonline | ENSRNOG00000021130 | UniProtKB/Swiss-Prot |
| HomoloGene Group ID | 68048 | ENTREZGENE |
| InterPro | ABC_transporter-like | UniProtKB/Swiss-Prot |
| ABC_transporter_CS | UniProtKB/Swiss-Prot | |
| ABC_transporter_type1 | UniProtKB/Swiss-Prot | |
| ABC_transptr_TM_dom | UniProtKB/Swiss-Prot | |
| ABC_transptrTM_dom_typ1 | UniProtKB/Swiss-Prot | |
| ATPase_AAA+_core | UniProtKB/Swiss-Prot | |
| Sulphorea_rcpt_N | UniProtKB/Swiss-Prot | |
| Surea_rcpt_1_N | UniProtKB/Swiss-Prot | |
| IPI | IPI00204427 | UniProtKB/Swiss-Prot |
| IPI00476240 | UniProtKB/Swiss-Prot | |
| IPI00851131 | UniProtKB/Swiss-Prot | |
| IPI00959623 | UniProtKB/TrEMBL | |
| KEGG Report | rno:25559 | ENTREZGENE, UniProtKB/Swiss-Prot |
| Pfam | ABC_membrane | UniProtKB/Swiss-Prot |
| ABC_tran | UniProtKB/Swiss-Prot | |
| PharmGKB | ABCC8 | RGD |
| PRINTS | SULFNYLUR1 | UniProtKB/Swiss-Prot |
| SULFNYLUREAR | UniProtKB/Swiss-Prot | |
| PROSITE | ABC_TM1F | UniProtKB/Swiss-Prot |
| ABC_TRANSPORTER_1 | UniProtKB/Swiss-Prot | |
| ABC_TRANSPORTER_2 | UniProtKB/Swiss-Prot | |
| SMART | AAA | UniProtKB/Swiss-Prot |
| Superfamily-SCOP | ABC_TM_1 | UniProtKB/Swiss-Prot |
| UniGene | Rn.11187 | ENTREZGENE |
| UniProt | ABCC8_RAT | UniProtKB/Swiss-Prot |
| D4A3L6_RAT | UniProtKB/TrEMBL | |
| F1LS70_RAT | UniProtKB/TrEMBL | |
| Q70X90_RAT | UniProtKB/TrEMBL |
Nomenclature History| Date | Current Symbol | Current Name | Previous Symbol | Previous Name | Description | Reference | Status |
|---|---|---|---|---|---|---|---|
| 2010-11-16 | Abcc8 | ATP-binding cassette, subfamily C (CFTR/MRP), member 8 | Abcc8 | ATP-binding cassette, sub-family C (CFTR/MRP), member 8 | Nomenclature updated to reflect human and mouse nomenclature | 10779 | APPROVED |
| 2004-09-10 | Abcc8 | ATP-binding cassette, sub-family C (CFTR/MRP), member 8 | ATP-binding cassette, subfamily C (CFTR/MRP), member 8 | Name updated | 10779 | APPROVED | |
| 2002-06-10 | Abcc8 | ATP-binding cassette, subfamily C (CFTR/MRP), member 8 | Symbol and Name status set to approved | 1490 | APPROVED | ||
| 2002-01-14 | Abcc8 | ATP-binding cassette, subfamily C (CFTR/MRP), member 8 | Symbol and Name updated to reflect Human and Mouse nomenclature | 915 | APPROVED |
RGD Curation Notes| Note Type | Note | Reference |
|---|---|---|
| gene_disease | mutation of the human homolog is detected in patients with familial persistent hyperinsulinemic hypoglycemia of infancy (PHHI) | 728122 |
| gene_function | putative subunit of the beta-cell ATP-sensitive potassium channel (KATP) | 724707 |
| gene_process | regulator of ATP-sensitive K+ channels and insulin release | 724707 |
| More on Abcc8 | |
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Entrez Gene |
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Ensembl Gene |
![]() | Genome Browser |
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NCBI Map Viewer |
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Vista |
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Vista + UCSC |
| RGD Object Information | |
| RGD ID: | 3786 |
| Created: | 2000-05-25 |
| Species: | Rattus norvegicus |
| Last Modified: | 2013-04-16 |
| Status: | ACTIVE |
© Bioinformatics Program, HMGC at the Medical College of Wisconsin
RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.




