Acvr1 (activin A receptor type 1) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Behavioral & Substance Use Disorder Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Acvr1 (activin A receptor type 1) Rattus norvegicus
Analyze
Symbol: Acvr1
Name: activin A receptor type 1
RGD ID: 620200
Description: Enables activin receptor activity, type I. Involved in cellular response to glucocorticoid stimulus; regulation of skeletal muscle tissue development; and transforming growth factor beta receptor signaling pathway. Acts upstream of or within urogenital system development. Part of activin receptor complex. Human ortholog(s) of this gene implicated in exfoliation syndrome; fibrodysplasia ossificans progressiva; primary angle-closure glaucoma; and primary open angle glaucoma. Orthologous to human ACVR1 (activin A receptor type 1); PARTICIPATES IN activin signaling pathway; cytokine mediated signaling pathway; transforming growth factor-beta superfamily mediated signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3,3',4,4',5-pentachlorobiphenyl; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: activin A receptor, type 1; activin A receptor, type I; activin receptor type I; activin receptor type-1; activin type I receptor; ACTR-I; ALK2-B; serine/threonine-protein kinase receptor R1; SKR1; TGF-B superfamily receptor type I; TSR-I
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8363,387,378 - 63,506,980 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl363,387,381 - 63,477,884 (-)EnsemblGRCr8
mRatBN7.2342,978,558 - 43,097,892 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl342,978,561 - 43,098,241 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx346,318,305 - 46,385,863 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0354,907,442 - 54,974,813 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0352,686,046 - 52,753,663 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0344,432,476 - 44,539,680 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl344,432,471 - 44,522,930 (-)Ensemblrn6Rnor6.0
Rnor_5.0349,551,411 - 49,641,517 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4340,191,727 - 40,260,488 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera341,046,965 - 41,113,654 (-)NCBICelera
RGSC_v3.1340,088,098 - 40,156,860 (-)NCBI
Cytogenetic Map3q21NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
2,2'-Methylenebis(4-methyl-6-tert-butylphenol)  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-hydroxypropanoic acid  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
aflatoxin B1  (ISO)
aristolochic acid A  (ISO)
arsenite(3-)  (ISO)
Azoxymethane  (ISO)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP,ISO)
butanal  (ISO)
Butylbenzyl phthalate  (ISO)
calciol  (ISO)
carbamazepine  (ISO)
CGP 52608  (ISO)
chlorpyrifos  (ISO)
cisplatin  (ISO)
copper(II) sulfate  (ISO)
coumestrol  (ISO)
cyclosporin A  (ISO)
dextran sulfate  (ISO)
Dibutyl phosphate  (ISO)
dichlorine  (EXP)
diclofenac  (ISO)
ethanol  (ISO)
folic acid  (ISO)
furan  (EXP)
gamma-hexachlorocyclohexane  (EXP)
genistein  (EXP)
gentamycin  (EXP)
geraniol  (ISO)
glyphosate  (EXP,ISO)
lead(0)  (ISO)
leflunomide  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
methimazole  (EXP)
N,N-diethyl-m-toluamide  (EXP)
nickel sulfate  (ISO)
oxaliplatin  (EXP)
ozone  (EXP)
paraquat  (EXP)
permethrin  (EXP)
phenobarbital  (ISO)
pinostrobin  (ISO)
pirinixic acid  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
progesterone  (ISO)
propiconazole  (ISO)
rac-lactic acid  (ISO)
sodium arsenite  (ISO)
Soman  (EXP)
soybean oil  (ISO)
temozolomide  (ISO)
testosterone  (ISO)
thapsigargin  (ISO)
thiram  (ISO)
titanium dioxide  (ISO)
toluene  (EXP)
topotecan  (EXP)
tranilast  (EXP)
triphenyl phosphate  (ISO)
tunicamycin  (ISO)
urethane  (ISO)
valproic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activin receptor signaling pathway  (IEA,ISO)
acute inflammatory response  (IEA,ISO)
atrial septum primum morphogenesis  (IEA,ISO)
atrioventricular valve morphogenesis  (IEA,ISO)
BMP signaling pathway  (IBA,IEA,ISO)
branching involved in blood vessel morphogenesis  (ISO)
cardiac muscle cell fate commitment  (IEA,ISO)
cell differentiation  (IBA)
cell surface receptor protein serine/threonine kinase signaling pathway  (IEA)
cellular response to BMP stimulus  (IEA,ISO)
cellular response to glucocorticoid stimulus  (IEP)
cellular response to growth factor stimulus  (IBA)
determination of left/right symmetry  (ISO)
dorsal/ventral pattern formation  (IBA)
embryonic heart tube morphogenesis  (IEA,ISO)
endocardial cushion cell fate commitment  (IEA,ISO)
endocardial cushion formation  (IEA,ISO)
endocardial cushion fusion  (IEA,ISO)
gastrulation  (ISO)
gastrulation with mouth forming second  (ISO)
germ cell development  (ISO)
heart development  (IBA,ISO)
in utero embryonic development  (ISO)
mesoderm development  (ISO)
mesoderm formation  (ISO)
mitral valve morphogenesis  (IEA,ISO)
negative regulation of activin receptor signaling pathway  (IEA,ISO)
negative regulation of extrinsic apoptotic signaling pathway  (IEA,ISO)
negative regulation of G1/S transition of mitotic cell cycle  (IEA,ISO)
negative regulation of signal transduction  (IEA,ISO)
neural crest cell migration  (ISO)
osteoblast differentiation  (IEA,ISO)
outflow tract septum morphogenesis  (ISO)
pharyngeal system development  (ISO)
positive regulation of bone mineralization  (IEA,ISO)
positive regulation of cardiac epithelial to mesenchymal transition  (IEA,ISO)
positive regulation of cell migration  (IEA,ISO)
positive regulation of determination of dorsal identity  (IEA,ISO)
positive regulation of DNA-templated transcription  (IEA,ISO)
positive regulation of intracellular signal transduction  (IEA,ISO)
positive regulation of osteoblast differentiation  (IEA,ISO)
positive regulation of SMAD protein signal transduction  (IEA,ISO)
positive regulation of transcription by RNA polymerase II  (IEA,ISO)
protein phosphorylation  (TAS)
regulation of developmental process  (IEA)
regulation of ossification  (IEA,ISO)
regulation of skeletal muscle tissue development  (IEP)
smooth muscle cell differentiation  (ISO)
system development  (IEA)
transforming growth factor beta receptor signaling pathway  (IBA,IEA,IMP,ISO)
urogenital system development  (IMP)
ventricular septum morphogenesis  (IEA,ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. The transforming growth factor-beta superfamily of receptors. de Caestecker M Cytokine Growth Factor Rev. 2004 Feb;15(1):1-11.
2. Ovarian follicle populations of the rat express TGF-beta signalling pathways. Drummond AE, etal., Mol Cell Endocrinol. 2003 Apr 28;202(1-2):53-7.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. Regulatory roles of bone morphogenetic proteins and glucocorticoids in catecholamine production by rat pheochromocytoma cells. Kano Y, etal., Endocrinology. 2005 Dec;146(12):5332-40. Epub 2005 Sep 8.
6. Multi-system involvement in a severe variant of fibrodysplasia ossificans progressiva (ACVR1 c.772G>A; R258G): A report of two patients. Kaplan FS, etal., Am J Med Genet A. 2015 Oct;167A(10):2265-71. doi: 10.1002/ajmg.a.37205. Epub 2015 Jun 11.
7. Concomitant over-expression of activin/inhibin beta subunits and their receptors in human pancreatic cancer. Kleeff J, etal., Int J Cancer. 1998 Sep 11;77(6):860-8.
8. Association analysis of polymorphisms rs12997 in ACVR1 and rs1043784 in BMP6 genes involved in bone morphogenic protein signaling pathway in primary angle-closure and pseudoexfoliation glaucoma patients of Saudi origin. Kondkar AA, etal., BMC Med Genet. 2020 Jul 8;21(1):145. doi: 10.1186/s12881-020-01076-0.
9. Association of rs12997 variant in the ACVR1 gene: a member of bone morphogenic protein signaling pathway with primary open-angle glaucoma in a Saudi cohort. Kondkar AA, etal., J Investig Med. 2021 Feb;69(2):402-407. doi: 10.1136/jim-2020-001596. Epub 2020 Dec 21.
10. Patients with ACVR1R206H mutations have an increased prevalence of cardiac conduction abnormalities on electrocardiogram in a natural history study of Fibrodysplasia Ossificans Progressiva. Kou S, etal., Orphanet J Rare Dis. 2020 Jul 29;15(1):193. doi: 10.1186/s13023-020-01465-x.
11. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
12. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
13. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
14. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
15. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
16. GOA pipeline RGD automated data pipeline
17. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
18. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
19. AcvR1-mediated BMP signaling in second heart field is required for arterial pole development: implications for myocardial differentiation and regional identity. Thomas PS, etal., Dev Biol. 2014 Jun 15;390(2):191-207. doi: 10.1016/j.ydbio.2014.03.008. Epub 2014 Mar 27.
20. Deficient signaling via Alk2 (Acvr1) leads to bicuspid aortic valve development. Thomas PS, etal., PLoS One. 2012;7(4):e35539. doi: 10.1371/journal.pone.0035539. Epub 2012 Apr 19.
21. Cloning and characterization of a transmembrane serine kinase that acts as an activin type I receptor. Tsuchida K, etal., Proc Natl Acad Sci U S A 1993 Dec 1;90(23):11242-6.
22. The serine/threonine transmembrane receptor ALK2 mediates Mullerian inhibiting substance signaling. Visser JA, etal., Mol Endocrinol. 2001 Jun;15(6):936-45.
23. Activin signal transduction in the fetal rat adrenal gland and in human H295R cells. Wang EY, etal., J Endocrinol 2003 Jul;178(1):137-48.
24. Loss of tubular bone morphogenetic protein-7 in diabetic nephropathy. Wang SN, etal., J Am Soc Nephrol. 2001 Nov;12(11):2392-9.
25. Inhibitory effects of tranilast on expression of transforming growth factor-beta isoforms and receptors in injured arteries. Ward MR, etal., Atherosclerosis. 1998 Apr;137(2):267-75. doi: 10.1016/s0021-9150(97)00275-x.
26. The tumor suppressor gene Trp53 protects the mouse lens against posterior subcapsular cataracts and the BMP receptor Acvr1 acts as a tumor suppressor in the lens. Wiley LA, etal., Dis Model Mech. 2011 Jul;4(4):484-95. doi: 10.1242/dmm.006593. Epub 2011 Apr 18.
27. Increased decidual mRNA expression levels of candidate maternal pre-eclampsia susceptibility genes are associated with clinical severity. Yong HE, etal., Placenta. 2014 Feb;35(2):117-24. doi: 10.1016/j.placenta.2013.11.008. Epub 2013 Nov 25.
28. ALK2 functions as a BMP type I receptor and induces Indian hedgehog in chondrocytes during skeletal development. Zhang D, etal., J Bone Miner Res. 2003 Sep;18(9):1593-604.
29. Activin A improves the neurological outcome after ischemic stroke in mice by promoting oligodendroglial ACVR1B-mediated white matter remyelination. Zheng J, etal., Exp Neurol. 2021 Mar;337:113574. doi: 10.1016/j.expneurol.2020.113574. Epub 2020 Dec 18.
Additional References at PubMed
PMID:1646080   PMID:7577669   PMID:8242742   PMID:8388127   PMID:8395914   PMID:9884026   PMID:10226013   PMID:10479450   PMID:10704880   PMID:11290335   PMID:12054694   PMID:12065756  
PMID:12151307   PMID:12477932   PMID:14729481   PMID:14993131   PMID:15037318   PMID:15226263   PMID:15289457   PMID:15531373   PMID:16140292   PMID:16420278   PMID:16642017   PMID:17078885  
PMID:17117439   PMID:18326817   PMID:18436533   PMID:19506109   PMID:19736306   PMID:22871113   PMID:26598555   PMID:26873969  


Genomics

Comparative Map Data
Acvr1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8363,387,378 - 63,506,980 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl363,387,381 - 63,477,884 (-)EnsemblGRCr8
mRatBN7.2342,978,558 - 43,097,892 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl342,978,561 - 43,098,241 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx346,318,305 - 46,385,863 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0354,907,442 - 54,974,813 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0352,686,046 - 52,753,663 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0344,432,476 - 44,539,680 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl344,432,471 - 44,522,930 (-)Ensemblrn6Rnor6.0
Rnor_5.0349,551,411 - 49,641,517 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4340,191,727 - 40,260,488 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera341,046,965 - 41,113,654 (-)NCBICelera
RGSC_v3.1340,088,098 - 40,156,860 (-)NCBI
Cytogenetic Map3q21NCBI
ACVR1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382157,736,446 - 157,876,330 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2157,736,249 - 157,876,347 (-)Ensemblhg38GRCh38
GRCh372158,592,958 - 158,732,842 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362158,301,207 - 158,403,036 (-)NCBIBuild 36Build 36hg18NCBI36
Build 342158,418,468 - 158,520,298NCBI
Celera2152,206,070 - 152,344,336 (-)NCBICelera
Cytogenetic Map2q24.1NCBI
HuRef2150,478,249 - 150,616,526 (-)NCBIHuRef
CHM1_12158,598,894 - 158,738,243 (-)NCBICHM1_1
T2T-CHM13v2.02158,189,880 - 158,329,404 (-)NCBIT2T-CHM13v2.0
Acvr1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39258,336,450 - 58,456,840 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl258,278,656 - 58,457,169 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38258,446,438 - 58,566,828 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl258,388,644 - 58,567,157 (-)Ensemblmm10GRCm38
MGSCv37258,298,849 - 58,419,239 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36258,261,824 - 58,331,545 (-)NCBIMGSCv36mm8
Celera260,202,316 - 60,294,260 (-)NCBICelera
Cytogenetic Map2C1.1NCBI
cM Map233.05NCBI
Acvr1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544915,640,230 - 15,708,694 (+)Ensembl
ChiLan1.0NW_00495544915,587,958 - 15,706,432 (+)NCBIChiLan1.0ChiLan1.0
ACVR1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21360,399,806 - 60,481,894 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B60,414,781 - 60,553,730 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B44,994,175 - 45,133,490 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B162,234,823 - 162,372,533 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B162,234,823 - 162,297,805 (-)EnsemblpanPan2panpan1.1
ACVR1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1363,743,257 - 3,818,659 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl363,744,163 - 3,818,652 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha363,880,162 - 4,006,562 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0363,865,484 - 3,991,973 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl363,865,493 - 3,946,584 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1363,867,397 - 3,993,826 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0363,927,214 - 4,053,637 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0363,965,356 - 4,091,837 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Acvr1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303120,806,153 - 120,874,529 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493646920,743,213 - 20,811,569 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493646920,743,195 - 20,811,567 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ACVR1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1564,750,796 - 64,891,544 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11564,749,478 - 64,891,653 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21571,681,467 - 71,823,490 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ACVR1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11043,139,396 - 43,281,024 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1043,139,528 - 43,281,177 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666040156,293,920 - 156,435,319 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Acvr1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247327,929,583 - 8,005,072 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247327,929,997 - 8,004,235 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Acvr1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1536,235,075 - 36,304,642 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Acvr1
796 total Variants
miRNA Target Status (No longer updated)

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
Mir130arno-miR-130a-3pMirtarbaseexternal_infoMicroarrayFunctional MTI (Weak)18258830

Predicted Target Of
Summary Value
Count of predictions:701
Count of miRNA genes:261
Interacting mature miRNAs:322
Transcripts:ENSRNOT00000006963
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10401810Kidm53Kidney mass QTL 53kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)32862533967641995Rat
2298542Neuinf11Neuroinflammation QTL 113.9nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)33540319997383526Rat
1358362Srcrt2Stress Responsive Cort QTL 22.78blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)358601291153936591Rat
737818Hcar12Hepatocarcinoma resistance QTL 122.6liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)349872657138829559Rat
631832Sach1Saccharin preference QTL 12.70.02consumption behavior trait (VT:0002069)calculated saccharin drink intake volume (CMO:0001600)34790417292904172Rat
9590286Uminl1Urine mineral level QTL 13.50.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)34865774493657744Rat
10450816Scl75Serum cholesterol level QTL 754.40.001blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)35860129171157804Rat
4889966Bss95Bone structure and strength QTL 954.4tibia area (VT:1000281)tibia-fibula cross-sectional area (CMO:0001718)33779691982796919Rat
2313093Bmd77Bone mineral density QTL 772.20.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)34790417270710963Rat
12879852Cm93Cardiac mass QTL 930.001heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)33870893167641995Rat
12879853Am5Aortic mass QTL 50.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)33870893167641995Rat
12879854Kidm63Kidney mass QTL 630.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)33870893167641995Rat
61356Bp37Blood pressure QTL 373blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)35109256196092561Rat
1358905Hrtrt17Heart rate QTL 175.90.000014heart pumping trait (VT:2000009)heart rate (CMO:0000002)336721849110333156Rat
12879849Bw180Body weight QTL 1800.037body mass (VT:0001259)body weight (CMO:0000012)33870893167641995Rat
2313101Bmd76Bone mineral density QTL 763.60.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)34790417270710963Rat
12879850Cm91Cardiac mass QTL 910.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)33870893167641995Rat
731172Bp151Blood pressure QTL 1510.04arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)33870893167641995Rat
12879851Cm92Cardiac mass QTL 920.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)33870893167641995Rat
8694196Abfw2Abdominal fat weight QTL 216.580.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)34865774493657744Rat
1358885Bp251Blood pressure QTL 2513.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)31141509147Rat
2290452Scl56Serum cholesterol level QTL 562.26blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)33610140381101403Rat
10450852Stl33Serum triglyceride level QTL 333.40.05blood LDL triglyceride amount (VT:0010699)blood lipoprotein triglyceride level (CMO:0002685)35860129171157804Rat
1358888Bp264Blood pressure QTL 2644.43arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)35675975141509147Rat
4889975Bmd81Bone mineral density QTL 814.3tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)35911940270710963Rat
1300178Hrtrt4Heart rate QTL 43.74heart pumping trait (VT:2000009)heart rate (CMO:0000002)351490129111359995Rat
634317Bw117Body weight QTL 1173.58abdominal fat pad mass (VT:1000711)abdominal fat pad weight to body weight ratio (CMO:0000095)35986366373704481Rat
1331795Rf30Renal function QTL 303.708urine potassium amount (VT:0010539)urine potassium level (CMO:0000128)35986366387321459Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)351581665184004958Rat
1354589Bw31Body weight QTL 313.3body mass (VT:0001259)body weight (CMO:0000012)35365182698651826Rat
2303593Gluco46Glucose level QTL 463blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)34887661993876619Rat
1354590Despr11Despair related QTL 110.000031locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)34887661993876619Rat
2313079Bss73Bone structure and strength QTL 731.5tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)34790417270710963Rat
1331777Bw24Body weight QTL 243.503body mass (VT:0001259)body weight (CMO:0000012)35986366387321459Rat
631647Bp122Blood pressure QTL 1226.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)35109256196092561Rat
2313076Bss74Bone structure and strength QTL 7420.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)34790417270710963Rat
1300169Bp177Blood pressure QTL 1772.96arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)33642511681425116Rat
10450813Scl74Serum cholesterol level QTL 745.80.001blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)35860129171157804Rat
2302276Bw82Body weight QTL 824.32body mass (VT:0001259)body weight (CMO:0000012)35986366383358329Rat
738019Anxrr10Anxiety related response QTL 103.9exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)358925062103925062Rat
9590136Scort3Serum corticosterone level QTL 323.370.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)34865774493657744Rat
61419Cia11Collagen induced arthritis QTL 115.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)35076614595766145Rat
1558650Cm48Cardiac mass QTL 4840.0001heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)35076614595766145Rat
1354597Kidm13Kidney mass QTL 132.9kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)342158111124558371Rat
2325840Bp345Blood pressure QTL 3450.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)33870893183708931Rat
8552950Pigfal12Plasma insulin-like growth factor 1 level QTL 127.3blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)34865774493657744Rat
631676Cm8Cardiac mass QTL 87.030.0001aorta mass (VT:0002845)aorta weight (CMO:0000076)33736373482363734Rat
8694386Bw159Body weight QTL 1594.520.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)34865774493657744Rat
1354604Bw36Body weight QTL 362.9body mass (VT:0001259)body weight (CMO:0000012)342158111124558371Rat
2313049Bss72Bone structure and strength QTL 722.60.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)34790417270710963Rat

Markers in Region
BF401349  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2343,037,901 - 43,038,048 (+)MAPPERmRatBN7.2
Rnor_6.0344,491,716 - 44,491,862NCBIRnor6.0
Rnor_5.0349,610,697 - 49,610,843UniSTSRnor5.0
RGSC_v3.4340,250,254 - 40,250,400UniSTSRGSC3.4
Celera341,104,894 - 41,105,040UniSTS
RH 3.4 Map16742.8UniSTS
Cytogenetic Map3q21UniSTS
RH138112  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2342,982,660 - 42,982,786 (+)MAPPERmRatBN7.2
Rnor_6.0344,436,580 - 44,436,705NCBIRnor6.0
Rnor_5.0349,555,515 - 49,555,640UniSTSRnor5.0
RGSC_v3.4340,194,784 - 40,194,909UniSTSRGSC3.4
Celera341,050,022 - 41,050,147UniSTS
RH 3.4 Map3554.0UniSTS
Cytogenetic Map3q21UniSTS
Acvr1  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8363,388,629 - 63,389,369 (+)Marker Load Pipeline
mRatBN7.2342,979,809 - 42,980,549 (+)MAPPERmRatBN7.2
Rnor_6.0344,433,728 - 44,434,467NCBIRnor6.0
Rnor_5.0349,552,663 - 49,553,402UniSTSRnor5.0
RGSC_v3.4340,191,932 - 40,192,671UniSTSRGSC3.4
Celera341,047,170 - 41,047,909UniSTS
Cytogenetic Map3q21UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 84 59 6 348 184 11 144 81 92 31 17 17

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001431445 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001431446 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_024486 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006234214 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008761864 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008761867 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039105896 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039105898 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039105899 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039105902 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039105904 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039105906 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063284608 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063284609 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063284610 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AY693390 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC167754 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473983 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FB745997 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000003 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L19341 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000006963   ⟹   ENSRNOP00000006963
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl363,387,381 - 63,477,884 (-)Ensembl
mRatBN7.2 Ensembl342,978,561 - 43,054,154 (-)Ensembl
Rnor_6.0 Ensembl344,432,479 - 44,522,930 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000087071   ⟹   ENSRNOP00000072326
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl363,387,381 - 63,456,148 (-)Ensembl
mRatBN7.2 Ensembl342,978,561 - 43,098,241 (-)Ensembl
Rnor_6.0 Ensembl344,432,471 - 44,501,115 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000137840   ⟹   ENSRNOP00000112797
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl363,387,381 - 63,456,148 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000160344   ⟹   ENSRNOP00000102110
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl363,387,381 - 63,456,148 (-)Ensembl
RefSeq Acc Id: NM_024486   ⟹   NP_077812
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8363,388,425 - 63,456,016 (-)NCBI
mRatBN7.2342,979,605 - 43,047,200 (-)NCBI
Rnor_6.0344,433,523 - 44,500,986 (-)NCBI
Rnor_5.0349,551,411 - 49,641,517 (-)NCBI
RGSC_v3.4340,191,727 - 40,260,488 (-)RGD
Celera341,046,965 - 41,113,654 (-)RGD
Sequence:
RefSeq Acc Id: XM_008761867   ⟹   XP_008760089
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8363,387,378 - 63,506,980 (-)NCBI
mRatBN7.2342,978,558 - 43,097,892 (-)NCBI
Rnor_6.0344,432,476 - 44,478,216 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039105896   ⟹   XP_038961824
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8363,387,378 - 63,506,980 (-)NCBI
mRatBN7.2342,978,558 - 43,097,892 (-)NCBI
RefSeq Acc Id: XM_039105898   ⟹   XP_038961826
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8363,387,378 - 63,493,149 (-)NCBI
mRatBN7.2342,978,558 - 43,082,359 (-)NCBI
RefSeq Acc Id: XM_039105899   ⟹   XP_038961827
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8363,387,378 - 63,506,980 (-)NCBI
mRatBN7.2342,978,558 - 43,097,892 (-)NCBI
RefSeq Acc Id: XM_039105902   ⟹   XP_038961830
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8363,387,378 - 63,493,149 (-)NCBI
mRatBN7.2342,978,558 - 43,082,359 (-)NCBI
RefSeq Acc Id: XM_039105904   ⟹   XP_038961832
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8363,387,378 - 63,506,980 (-)NCBI
mRatBN7.2342,978,558 - 43,097,892 (-)NCBI
RefSeq Acc Id: XM_039105906   ⟹   XP_038961834
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8363,387,378 - 63,506,980 (-)NCBI
mRatBN7.2342,978,558 - 43,097,892 (-)NCBI
RefSeq Acc Id: XM_063284608   ⟹   XP_063140678
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8363,387,378 - 63,506,980 (-)NCBI
RefSeq Acc Id: XM_063284609   ⟹   XP_063140679
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8363,387,378 - 63,506,980 (-)NCBI
RefSeq Acc Id: XM_063284610   ⟹   XP_063140680
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8363,387,378 - 63,506,980 (-)NCBI
RefSeq Acc Id: NP_077812   ⟸   NM_024486
- Peptide Label: precursor
- UniProtKB: P80201 (UniProtKB/Swiss-Prot),   B3DM96 (UniProtKB/TrEMBL),   A6JF58 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008760089   ⟸   XM_008761867
- Peptide Label: isoform X2
- UniProtKB: A6JF58 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000072326   ⟸   ENSRNOT00000087071
Ensembl Acc Id: ENSRNOP00000006963   ⟸   ENSRNOT00000006963
RefSeq Acc Id: XP_038961832   ⟸   XM_039105904
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038961824   ⟸   XM_039105896
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038961834   ⟸   XM_039105906
- Peptide Label: isoform X4
- UniProtKB: A6JF58 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038961827   ⟸   XM_039105899
- Peptide Label: isoform X1
- UniProtKB: A0A0G2K2P7 (UniProtKB/TrEMBL),   A6JF58 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038961826   ⟸   XM_039105898
- Peptide Label: isoform X1
- UniProtKB: A0A0G2K2P7 (UniProtKB/TrEMBL),   A6JF58 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038961830   ⟸   XM_039105902
- Peptide Label: isoform X1
- UniProtKB: A0A0G2K2P7 (UniProtKB/TrEMBL),   A6JF58 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063140680   ⟸   XM_063284610
- Peptide Label: isoform X3
RefSeq Acc Id: XP_063140678   ⟸   XM_063284608
- Peptide Label: isoform X1
- UniProtKB: A0A0G2K2P7 (UniProtKB/TrEMBL),   A6JF58 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063140679   ⟸   XM_063284609
- Peptide Label: isoform X1
- UniProtKB: A0A0G2K2P7 (UniProtKB/TrEMBL),   A6JF58 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000102110   ⟸   ENSRNOT00000160344
Ensembl Acc Id: ENSRNOP00000112797   ⟸   ENSRNOT00000137840
Protein Domains
GS   Protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P80201-F1-model_v2 AlphaFold P80201 1-509 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620200 AgrOrtholog
BioCyc Gene G2FUF-49657 BioCyc
Ensembl Genes ENSRNOG00000005033 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000006963 ENTREZGENE
  ENSRNOT00000087071 ENTREZGENE
  ENSRNOT00000137840 ENTREZGENE
  ENSRNOT00000160344 ENTREZGENE
Gene3D-CATH 2.10.60.10 UniProtKB/Swiss-Prot
  Phosphorylase Kinase, domain 1 UniProtKB/Swiss-Prot
  Transferase(Phosphotransferase) domain 1 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:9089038 IMAGE-MGC_LOAD
InterPro Activin_recp UniProtKB/Swiss-Prot
  GS_dom UniProtKB/Swiss-Prot
  Kinase-like_dom_sf UniProtKB/Swiss-Prot
  Prot_kinase_dom UniProtKB/Swiss-Prot
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot
  Ser-Thr/Tyr_kinase_cat_dom UniProtKB/Swiss-Prot
  Ser/Thr_kinase_AS UniProtKB/Swiss-Prot
  Snake_toxin-like_sf UniProtKB/Swiss-Prot
  TGFB_receptor UniProtKB/Swiss-Prot
KEGG Report rno:79558 UniProtKB/Swiss-Prot
MGC_CLONE MGC:187367 IMAGE-MGC_LOAD
NCBI Gene 79558 ENTREZGENE
PANTHER ACTIVIN RECEPTOR TYPE-1 UniProtKB/Swiss-Prot
  PTHR23255 UniProtKB/Swiss-Prot
Pfam Activin_recp UniProtKB/Swiss-Prot
  Pkinase_Tyr UniProtKB/Swiss-Prot
  TGF_beta_GS UniProtKB/Swiss-Prot
PhenoGen Acvr1 PhenoGen
PRINTS ACTIVIN2R UniProtKB/Swiss-Prot
PROSITE PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot
  PROTEIN_KINASE_ST UniProtKB/Swiss-Prot
  PS51256 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000005033 RatGTEx
SMART S_TKc UniProtKB/Swiss-Prot
  SM00467 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF56112 UniProtKB/Swiss-Prot
  SSF57302 UniProtKB/Swiss-Prot
UniProt A0A0G2K2P7 ENTREZGENE, UniProtKB/TrEMBL
  A0A8L2Q2G6_RAT UniProtKB/TrEMBL
  A0ABK0LM51_RAT UniProtKB/TrEMBL
  A0ABK0M1J1_RAT UniProtKB/TrEMBL
  A6JF58 ENTREZGENE, UniProtKB/TrEMBL
  ACVR1_RAT UniProtKB/Swiss-Prot
  B3DM96 ENTREZGENE, UniProtKB/TrEMBL
  P80201 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-15 Acvr1  activin A receptor type 1  Acvr1  activin A receptor, type I  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-09 Acvr1  activin A receptor, type I  Acvr1  activin A receptor, type 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 Acvr1  activin A receptor, type 1    activin type I receptor  Name updated 1299863 APPROVED
2002-08-07 Acvr1  activin type I receptor      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_function receptor for activin 724707
gene_physical_interaction may form a complex with type II activin receptors 724761