RGD Reference Report - The transforming growth factor-beta superfamily of receptors. - Rat Genome Database

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The transforming growth factor-beta superfamily of receptors.

Authors: De Caestecker, M 
Citation: de Caestecker M Cytokine Growth Factor Rev. 2004 Feb;15(1):1-11.
RGD ID: 1559168
Pubmed: PMID:14746809   (View Abstract at PubMed)

The transforming growth factor-beta (TGF-beta) superfamily of receptors comprises two groups of transmembrane serine-threonine kinase receptors, so called type I, and type II receptors, that are activated following engagement by members of the TGF-beta superfamily of ligands. These events specify diverse downstream responses that are differentially regulated by controlling access and activation of the ligands, their receptors and downstream substrates in different cell types. The purpose of this review is to describe the biochemical properties of these receptors, focusing specifically on the mechanisms regulating receptor/ligand interactions and activation in mammalian cells.

Objects referenced in this article
Gene Acvr1 activin A receptor type 1 Rattus norvegicus
Gene Acvr1b activin A receptor type 1B Rattus norvegicus
Gene Acvr2b activin A receptor type 2B Rattus norvegicus
Gene Acvrl1 activin A receptor like type 1 Rattus norvegicus

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