Mmp14 (matrix metallopeptidase 14) - Rat Genome Database

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Gene: Mmp14 (matrix metallopeptidase 14) Rattus norvegicus
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Symbol: Mmp14
Name: matrix metallopeptidase 14
RGD ID: 620198
Description: Enables integrin binding activity. Involved in several processes, including cellular response to genistein; gonad development; and negative regulation of focal adhesion assembly. Predicted to be located in macropinosome and nucleus. Predicted to be active in extracellular space and plasma membrane. Used to study ischemia. Biomarker of IgA glomerulonephritis; anti-basement membrane glomerulonephritis; artery disease (multiple); cerebrovascular disease (multiple); and congestive heart failure. Human ortholog(s) of this gene implicated in Winchester syndrome; esophagus adenocarcinoma; and myocardial infarction. Orthologous to human MMP14 (matrix metallopeptidase 14); PARTICIPATES IN hypoxia inducible factor pathway; gonadotropin-releasing hormone signaling pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,3,4,7,8-Pentachlorodibenzofuran; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: matrix metallopeptidase 14 (membrane-inserted); matrix metalloproteinase 14 (membrane-inserted); matrix metalloproteinase 14 membrane-inserted; matrix metalloproteinase 14, membrane-inserted; matrix metalloproteinase-14; membrane type 1-matrix metalloproteinase; membrane-type matrix metalloproteinase 1; membrane-type-1 matrix metalloproteinase; MMP-14; MT-MMP 1; Mt1-mmp; MT1MMP; MTMMP1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81531,857,824 - 31,867,049 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1531,857,546 - 31,869,893 (+)EnsemblGRCr8
mRatBN7.21527,887,795 - 27,897,020 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1527,887,727 - 27,899,864 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1529,727,071 - 29,736,290 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01530,874,288 - 30,883,507 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01529,124,651 - 29,133,873 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01533,074,441 - 33,083,666 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1533,074,441 - 33,083,655 (+)Ensemblrn6Rnor6.0
Rnor_5.01536,960,282 - 36,969,507 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41532,493,852 - 32,503,077 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1527,470,861 - 27,480,086 (+)NCBICelera
RGSC_v3.11532,509,551 - 32,518,777 (+)NCBI
Cytogenetic Map15p13NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (ISO)
2,3,4,7,8-Pentachlorodibenzofuran  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
2,4-dinitrotoluene  (EXP)
2-butoxyethanol  (ISO)
2-hydroxypropanoic acid  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-Nerolidylcatechol  (ISO)
4-vinylcyclohexene dioxide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (EXP)
6-propyl-2-thiouracil  (EXP)
7,12-dimethyltetraphene  (EXP)
acetamide  (EXP)
acrolein  (ISO)
acrylamide  (EXP)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
ageladine A  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
aminoguanidine  (EXP)
ammonium chloride  (EXP)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
aristolochic acid A  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (EXP,ISO)
Azoxymethane  (ISO)
barium(0)  (ISO)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
berberine  (EXP)
beta-aminopropionitrile  (ISO)
beta-lapachone  (ISO)
beta-naphthoflavone  (EXP)
bexarotene  (EXP)
biochanin A  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisdemethoxycurcumin  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
Butylbenzyl phthalate  (ISO)
cadmium dichloride  (ISO)
capsaicin  (ISO)
carbon nanotube  (ISO)
carbonyl sulfide  (EXP)
carvone  (ISO)
CGP 52608  (ISO)
CGS-21680  (ISO)
chrysene  (ISO)
ciguatoxin CTX1B  (ISO)
cisplatin  (ISO)
clozapine  (ISO)
cobalt dichloride  (EXP,ISO)
cocaine  (EXP)
copper(II) chloride  (ISO)
cumene  (ISO)
Cuprizon  (EXP)
curcumin  (EXP,ISO)
cyclosporin A  (ISO)
cysteamine  (ISO)
D-glucose  (ISO)
DDE  (ISO)
decabromodiphenyl ether  (EXP)
demethoxycurcumin  (ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (EXP,ISO)
dibutyl phthalate  (EXP,ISO)
dichlorine  (EXP)
diethyl phthalate  (ISO)
diethylstilbestrol  (EXP)
dihydroartemisinin  (ISO)
diisobutyl phthalate  (ISO)
diisononyl phthalate  (ISO)
dimethylarsinic acid  (ISO)
dioxygen  (EXP,ISO)
diuron  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
endosulfan  (EXP)
erlotinib hydrochloride  (ISO)
ethanol  (ISO)
ethylparaben  (ISO)
finasteride  (EXP)
flutamide  (EXP)
folic acid  (ISO)
folpet  (ISO)
furan  (EXP)
gadolinium trichloride  (EXP)
Geniposide pentaacetate  (EXP)
genistein  (ISO)
gentamycin  (EXP)
glucose  (ISO)
glycidyl methacrylate  (ISO)
graphene oxide  (ISO)
heparin  (ISO)
hydrogen cyanide  (ISO)
hydroquinone  (ISO)
indole-3-methanol  (EXP)
indometacin  (EXP)
inulin  (ISO)
Isoangustone A  (ISO)
isoprenaline  (ISO)
ivermectin  (ISO)
ketamine  (EXP)
ketoconazole  (EXP)
lead diacetate  (EXP,ISO)
lipopolysaccharide  (ISO)
LY294002  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (EXP,ISO)
melatonin  (EXP)
mercury dibromide  (ISO)
metformin  (ISO)
methoxychlor  (ISO)
methylmercury chloride  (ISO)
methylphenidate  (EXP)
microcystin-LR  (ISO)
mifepristone  (ISO)
mitomycin C  (ISO)
N-methyl-4-phenylpyridinium  (EXP)
N-nitrosodiethylamine  (EXP)
N-nitrosodimethylamine  (EXP)
naled  (ISO)
nickel sulfate  (ISO)
omeprazole  (EXP)
oxaliplatin  (EXP)
ozone  (EXP,ISO)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
pentane-2,3-dione  (EXP)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
phenobarbital  (EXP,ISO)
phenylmercury acetate  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
piperine  (ISO)
pirinixic acid  (EXP)
potassium cyanide  (ISO)
potassium dichromate  (ISO)
pravastatin  (EXP)
pregnenolone 16alpha-carbonitrile  (EXP)
progesterone  (ISO)
propiconazole  (ISO)
rac-lactic acid  (ISO)
resveratrol  (ISO)
rotenone  (EXP)
Rutecarpine  (ISO)
Salinomycin  (ISO)
SB 431542  (ISO)
selenium atom  (ISO)
serpentine asbestos  (ISO)
silibinin  (ISO)
silicon dioxide  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sotorasib  (ISO)
sulindac  (EXP)
sunitinib  (ISO)
tamoxifen  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
tetraphene  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (EXP,ISO)
topotecan  (EXP)
trametinib  (ISO)
Trapidil  (EXP)
trichostatin A  (ISO)
triphenyl phosphate  (EXP,ISO)
triptonide  (ISO)
triticonazole  (EXP)
tyrphostin AG 1478  (ISO)
valproic acid  (ISO)
vanadium atom  (ISO)
vanadium(0)  (ISO)
vorinostat  (ISO)
wortmannin  (ISO)
Y-27632  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
angiogenesis  (IEP)
astrocyte cell migration  (IEP)
bone development  (ISO)
branching morphogenesis of an epithelial tube  (ISO)
cell migration  (ISO)
cell motility  (IEA)
cell population proliferation  (IEA)
cellular response to genistein  (IEP)
chondrocyte proliferation  (ISO)
collagen catabolic process  (IBA,ISO)
craniofacial suture morphogenesis  (ISO)
embryonic cranial skeleton morphogenesis  (ISO)
endochondral ossification  (ISO)
endodermal cell differentiation  (IEA,ISO)
endothelial cell proliferation  (IEP)
extracellular matrix organization  (IBA)
head development  (ISO)
lung development  (ISO)
male gonad development  (IEP)
negative regulation of focal adhesion assembly  (IDA)
negative regulation of GDF15-GFRAL signaling pathway  (IEA,ISO)
negative regulation of Notch signaling pathway  (IEA,ISO,ISS)
ossification  (IEA,IEP,ISO)
ovarian follicle development  (IEP)
positive regulation of B cell differentiation  (IEA,ISO,ISS)
positive regulation of cell growth  (IEA,ISO)
positive regulation of cell migration  (IEA,ISO)
positive regulation of macrophage migration  (IEA,ISO)
positive regulation of myotube differentiation  (IEA,ISO,ISS)
positive regulation of protein processing  (IMP)
protein catabolic process  (IEA,ISO)
proteolysis  (IEA,ISO)
regulation of protein localization to plasma membrane  (IEA,ISO)
response to estrogen  (IEP)
response to hormone  (IDA)
response to hypoxia  (IEP)
response to mechanical stimulus  (IEP)
response to odorant  (IEP)
response to oxidative stress  (IEP)
skeletal system development  (IBA,IEA,ISO)
tissue remodeling  (IDA)
tube morphogenesis  (IEA)
zymogen activation  (IBA,IEA,ISO)

Cellular Component
cytoplasm  (IEA,ISO)
cytoplasmic vesicle  (IEA,ISO)
extracellular matrix  (IEA)
extracellular space  (IBA,IEA,ISO)
macropinosome  (IEA,ISO)
melanosome  (IEA)
nucleus  (IEA,ISO)
plasma membrane  (IBA,IEA,ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Up-regulation of matrix metalloproteinase-2 and membrane-type 1-matrix metalloproteinase were coupled with that of type I procollagen in granulation tissue response after the onset of aortic dissection. Akiyama M, etal., Virchows Arch. 2006 Jun;448(6):811-21. Epub 2006 Apr 12.
2. Expression patterns of matrix metalloproteinases and vascular endothelial growth factor during epiphyseal ossification. Alvarez J, etal., J Bone Miner Res. 2005 Jun;20(6):1011-21. Epub 2005 Feb 7.
3. Differential regulation of matrix metalloproteinase activities in abdominal aortic aneurysms. Annabi B, etal., J Vasc Surg. 2002 Mar;35(3):539-46.
4. Upregulated expression and activation of membrane‑associated proteases in esophageal squamous cell carcinoma. Augoff K, etal., Oncol Rep. 2014 Jun;31(6):2820-6. doi: 10.3892/or.2014.3162. Epub 2014 Apr 29.
5. Vascular extracellular matrix remodeling in cerebral aneurysms. Bruno G, etal., J Neurosurg. 1998 Sep;89(3):431-40.
6. Identification of new therapeutic targets by genome-wide analysis of gene expression in the ipsilateral cortex of aged rats after stroke. Buga AM, etal., PLoS One. 2012;7(12):e50985. doi: 10.1371/journal.pone.0050985. Epub 2012 Dec 12.
7. Upregulation of extracellular matrix metalloproteinase inducer (EMMPRIN) and gelatinases in human atherosclerosis infected with Chlamydia pneumoniae: the potential role of Chlamydia pneumoniae infection in the progression of atherosclerosis. Choi EY, etal., Exp Mol Med. 2002 Dec 31;34(6):391-400.
8. Gubernaculum as icebreaker: do matrix metalloproteinases in rodent gubernaculum and inguinal fat pad permit testicular descent? Churchill JA, etal., J Pediatr Surg. 2011 Dec;46(12):2353-7. doi: 10.1016/j.jpedsurg.2011.09.025.
9. Ischemia-induced cleavage of cadherins in NRK cells requires MT1-MMP (MMP-14). Covington MD, etal., Am J Physiol Renal Physiol. 2006 Jan;290(1):F43-51. Epub 2005 Aug 2.
10. Differential transcriptional activation of matrix metalloproteinase-2 and membrane type-1 matrix metalloproteinase by experimental deep venous thrombosis and thrombin. Dahi S, etal., J Vasc Surg. 2005 Sep;42(3):539-45.
11. MT1-matrix metalloproteinase directs arterial wall invasion and neointima formation by vascular smooth muscle cells. Filippov S, etal., J Exp Med. 2005 Sep 5;202(5):663-71.
12. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
13. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
14. Enhanced expression of membrane type-1 matrix metalloproteinase in mesangial proliferative glomerulonephritis. Hayashi K, etal., J Am Soc Nephrol. 1998 Dec;9(12):2262-71.
15. Macrophage-derived MT1-MMP and increased MMP-2 activity are associated with glomerular damage in crescentic glomerulonephritis. Hayashi K, etal., J Pathol. 2000 Jul;191(3):299-305.
16. Induction of Matrix Metalloproteinase-2 Enhances Systemic Vasoconstriction after Hypoxia. He JZ, etal., Am J Physiol Heart Circ Physiol. 2006 Sep 15;.
17. Angiotensin type 1 receptor blockage improves ischemic injury following transient focal cerebral ischemia. Hosomi N, etal., Neuroscience. 2005;134(1):225-31.
18. Expression of matrix metalloproteinases and endogenous inhibitors within ascending aortic aneurysms of patients with Marfan syndrome. Ikonomidis JS, etal., Circulation. 2006 Jul 4;114(1 Suppl):I365-70.
19. Novel odors affect gene expression for cytokines and proteinases in the rat amygdala and hippocampus. Irwin LN and Byers DM, Brain Res. 2012 Dec 13;1489:1-7. doi: 10.1016/j.brainres.2012.10.034. Epub 2012 Oct 26.
20. Membrane type 1-matrix metalloproteinase (MMP)-associated MMP-2 activation increases in the rat ovary in response to an ovulatory dose of human chorionic gonadotropin. Jo M, etal., Biol Reprod. 2004 Apr;70(4):1024-32. Epub 2003 Dec 10.
21. Matrix metalloproteinases are down-regulated in rat lenses exposed to oxidative stress. John M, etal., Exp Eye Res. 2004 Dec;79(6):839-46.
22. Combination of tumor necrosis factor-alpha ablation and matrix metalloproteinase inhibition prevents heart failure after pressure overload in tissue inhibitor of metalloproteinase-3 knock-out mice. Kassiri Z, etal., Circ Res. 2005 Aug 19;97(4):380-90. Epub 2005 Jul 21.
23. Expression of matrix metalloproteinases and their inhibitors by rat NK cells: inhibition of their expression by genistein. Kim MH, etal., In Vivo. 2000 Sep-Oct;14(5):557-64.
24. Expression and tissue localization of membrane-types 1, 2, and 3 matrix metalloproteinases in human urothelial carcinomas. Kitagawa Y, etal., J Urol. 1998 Oct;160(4):1540-5.
25. Membrane-type matrix metalloproteinase-1 (MT1-MMP) is down-regulated in estrogen-deficient rat osteoblast in vivo. Liao EY, etal., J Endocrinol Invest. 2004 Jan;27(1):1-5.
26. Coordinated elevation of membrane type 1-matrix metalloproteinase and matrix metalloproteinase-2 expression in rat uterus during postpartum involution. Manase K, etal., Reprod Biol Endocrinol. 2006 Jun 2;4:32.
27. Role of MT1-MMP in the osteogenic differentiation. Manduca P, etal., Bone. 2009 Feb;44(2):251-65. Epub 2008 Nov 5.
28. Basal membrane remodeling during follicle histogenesis in the rat ovary: contribution of proteinases of the MMP and PA families. Mazaud S, etal., Dev Biol. 2005 Jan 15;277(2):403-16.
29. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
30. Decreased vascular matrix metalloproteinase abundance in diabetic patients with symptomatic macroangiopathy. Mondy JS, etal., Ethn Dis. 2002 Fall;12(4):S3-18-22.
31. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
32. The role of proteases in fibronectin matrix remodeling in thyroid epithelial cell monolayer cultures. Nezi L, etal., Biol Chem 2002 Jan;383(1):167-76.
33. Elevated expression of extracellular matrix metalloproteinase inducer (CD147) and membrane-type matrix metalloproteinases in venous leg ulcers. Norgauer J, etal., Br J Dermatol. 2002 Dec;147(6):1180-6.
34. Membrane-type matrix metalloproteinase (MT-MMP) gene is expressed in stromal cells of human colon, breast, and head and neck carcinomas. Okada A, etal., Proc Natl Acad Sci U S A 1995 Mar 28;92(7):2730-4.
35. Increased expression and activity of matrix metalloproteinases characterize embolic cardiac myxomas. Orlandi A, etal., Am J Pathol. 2005 Jun;166(6):1619-28.
36. Evolution of matrix metalloprotease and tissue inhibitor expression during heart failure progression in the infarcted rat. Peterson JT, etal., Cardiovasc Res. 2000 May;46(2):307-15.
37. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
38. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
39. GOA pipeline RGD automated data pipeline
40. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
41. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
42. Extracellular matrix metalloproteinase inducer regulates matrix metalloproteinase activity in cardiovascular cells: implications in acute myocardial infarction. Schmidt R, etal., Circulation. 2006 Feb 14;113(6):834-41. Epub 2006 Feb 6.
43. Cleavage of focal adhesion kinase in vascular smooth muscle cells overexpressing membrane-type matrix metalloproteinases. Shofuda T, etal., Arterioscler Thromb Vasc Biol. 2004 May;24(5):839-44. Epub 2004 Mar 25.
44. Early MT-1 MMP expression following elastase exposure is associated with increased cleaved MMP-2 activity in experimental rodent aortic aneurysms. Sinha I, etal., Surgery. 2004 Aug;136(2):176-82.
45. Expression of matrix metalloproteases (MMP-2, MT1 -MMP) and their tissue inhibitor (TIMP-2) by rat sertoli cells in culture: implications for spermatogenesis. Slongo ML, etal., Biol Chem 2002 Jan;383(1):235-9.
46. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
47. Role of intracellular S100A4 for migration of rat astrocytes. Takenaga K and Kozlova EN, Glia. 2006 Feb;53(3):313-21.
48. Expression and tissue localization of membrane-types 1, 2, and 3 matrix metalloproteinases in human invasive breast carcinomas. Ueno H, etal., Cancer Res. 1997 May 15;57(10):2055-60.
49. Impaired angiogenesis in SHR is associated with decreased KDR and MT1-MMP expression. Wang H, etal., Biochem Biophys Res Commun. 2004 Mar 5;315(2):363-8.
50. Angiotensin II signals mechanical stretch-induced cardiac matrix metalloproteinase expression via JAK-STAT pathway. Wang TL, etal., J Mol Cell Cardiol. 2004 Sep;37(3):785-94.
51. Association between polymorphisms in cancer-related genes and early onset of esophageal adenocarcinoma. Wu IC, etal., Neoplasia. 2011 Apr;13(4):386-92. doi: 10.1593/neo.101722.
Additional References at PubMed
PMID:12747454   PMID:12970340   PMID:14729674   PMID:15351710   PMID:15358140   PMID:15509661   PMID:15572153   PMID:15863497   PMID:16541018   PMID:17644578   PMID:17684756   PMID:18022611  
PMID:18286538   PMID:18436234   PMID:18562481   PMID:18668563   PMID:20666777   PMID:20683769   PMID:20857180   PMID:20945382   PMID:21385940   PMID:21414971   PMID:21423176   PMID:21572390  
PMID:21826658   PMID:21909755   PMID:22065321   PMID:22342460   PMID:22974613   PMID:23154389   PMID:23404084   PMID:23683405   PMID:24379181   PMID:24784232   PMID:24859005   PMID:24867951  
PMID:24970228   PMID:24990232   PMID:25028660   PMID:25031710   PMID:25759388   PMID:26234751   PMID:26598508   PMID:26620678   PMID:27640084   PMID:27712978   PMID:29853773   PMID:30035384  
PMID:30659604   PMID:33287916   PMID:34229297  


Genomics

Comparative Map Data
Mmp14
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81531,857,824 - 31,867,049 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1531,857,546 - 31,869,893 (+)EnsemblGRCr8
mRatBN7.21527,887,795 - 27,897,020 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1527,887,727 - 27,899,864 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1529,727,071 - 29,736,290 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01530,874,288 - 30,883,507 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01529,124,651 - 29,133,873 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01533,074,441 - 33,083,666 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1533,074,441 - 33,083,655 (+)Ensemblrn6Rnor6.0
Rnor_5.01536,960,282 - 36,969,507 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41532,493,852 - 32,503,077 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1527,470,861 - 27,480,086 (+)NCBICelera
RGSC_v3.11532,509,551 - 32,518,777 (+)NCBI
Cytogenetic Map15p13NCBI
MMP14
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381422,836,585 - 22,847,758 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1422,836,532 - 22,849,041 (+)Ensemblhg38GRCh38
GRCh371423,305,794 - 23,316,967 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361422,375,633 - 22,386,643 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341422,375,632 - 22,386,642NCBI
Celera143,168,679 - 3,179,688 (+)NCBICelera
Cytogenetic Map14q11.2NCBI
HuRef143,422,922 - 3,433,986 (+)NCBIHuRef
CHM1_11423,304,418 - 23,315,462 (+)NCBICHM1_1
T2T-CHM13v2.01417,034,651 - 17,045,822 (+)NCBIT2T-CHM13v2.0
Mmp14
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391454,669,055 - 54,679,913 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1454,669,069 - 54,682,821 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381454,431,598 - 54,442,456 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1454,431,612 - 54,445,364 (+)Ensemblmm10GRCm38
MGSCv371455,050,441 - 55,060,095 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361453,385,824 - 53,395,458 (+)NCBIMGSCv36mm8
Celera1452,223,646 - 52,233,174 (+)NCBICelera
Cytogenetic Map14C2NCBI
cM Map1427.79NCBI
Mmp14
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540937,440,541 - 37,448,437 (-)Ensembl
ChiLan1.0NW_00495540937,438,924 - 37,448,704 (-)NCBIChiLan1.0ChiLan1.0
MMP14
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21524,266,301 - 24,277,533 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11423,482,405 - 23,494,022 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0143,654,125 - 3,665,158 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11421,753,305 - 21,764,061 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1421,753,305 - 21,764,058 (+)EnsemblpanPan2panpan1.1
MMP14
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.183,183,419 - 3,193,079 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl83,183,606 - 3,194,122 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha83,132,308 - 3,142,668 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.083,291,562 - 3,301,919 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl83,291,310 - 3,301,917 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.182,983,033 - 2,993,386 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.083,044,810 - 3,055,166 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.083,306,779 - 3,317,137 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Mmp14
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864034,931,359 - 34,941,231 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367221,447,335 - 1,457,611 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049367221,447,189 - 1,457,632 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MMP14
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl776,172,971 - 76,185,928 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1776,174,502 - 76,185,931 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2781,413,927 - 81,424,899 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MMP14
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12923,201,425 - 23,212,408 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2923,201,112 - 23,212,679 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366605923,209,848 - 23,220,925 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mmp14
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248209,667,262 - 9,677,774 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248209,667,371 - 9,677,488 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Mmp14
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11270,557,769 - 70,568,324 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Mmp14
14 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:399
Count of miRNA genes:173
Interacting mature miRNAs:198
Transcripts:ENSRNOT00000042938, ENSRNOT00000075610
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1641913Colcr2Colorectal carcinoma resistance QTL 26.570.0197intestine integrity trait (VT:0010554)poorly differentiated malignant colorectal tumor number (CMO:0002076)15231575947315759Rat
5684946Bss98Bone structure and strength QTL 983.90.0026tibia strength trait (VT:1000284)tibia ultimate force (CMO:0001734)15139411584Rat
1641887Alcrsp14Alcohol response QTL 14response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)15144836456Rat
738017Hcas7Hepatocarcinoma susceptibility QTL 72.91liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)15231575953331089Rat
152025253Hrtrt24Heart rate QTL 243.82heart pumping trait (VT:2000009)153185580392671517Rat
10755503Bp391Blood pressure QTL 3912.37arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)152272835342072050Rat
10054130Srcrt8Stress Responsive Cort QTL 82.180.0085blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)152852773273527732Rat
1578646Bmd18Bone mineral density QTL 185.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)1525285835104695021Rat
2324620Coatc3Coat color QTL 3coat/hair pigmentation trait (VT:0010463)pigmented coat/hair area to total coat/hair area ratio (CMO:0001810)152233635152597086Rat
1578647Bmd17Bone mineral density QTL 174femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)1525285835104695021Rat
61424Scl1Serum cholesterol level QTL 17.70.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)151915576287086765Rat
10401805Kidm51Kidney mass QTL 51kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)15278592347785923Rat
1354657Despr13Despair related QTL 130.0022locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)15132342855Rat
2317750Glom26Glomerulus QTL 264.3urine protein amount (VT:0005160)urine protein level (CMO:0000591)151492659471614418Rat
631550Bw7Body weight QTL 73.6body mass (VT:0001259)body weight (CMO:0000012)152233635167336351Rat
5685002Bss103Bone structure and strength QTL 1032.8tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)151691152132439851Rat
1578660Bss19Bone structure and strength QTL 194.3femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)1525285835104695021Rat

Markers in Region
RH91125  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21527,896,772 - 27,896,928 (+)MAPPERmRatBN7.2
Rnor_6.01533,083,419 - 33,083,574NCBIRnor6.0
Rnor_5.01536,969,260 - 36,969,415UniSTSRnor5.0
RGSC_v3.41532,502,830 - 32,502,985UniSTSRGSC3.4
Celera1527,479,839 - 27,479,994UniSTS
Cytogenetic Map15p13UniSTS
BI286324  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21527,896,812 - 27,896,979 (+)MAPPERmRatBN7.2
Rnor_6.01533,083,459 - 33,083,625NCBIRnor6.0
Rnor_5.01536,969,300 - 36,969,466UniSTSRnor5.0
RGSC_v3.41532,502,870 - 32,503,036UniSTSRGSC3.4
Celera1527,479,879 - 27,480,045UniSTS
Cytogenetic Map15p13UniSTS
AI325305  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21527,896,211 - 27,896,319 (+)MAPPERmRatBN7.2
Rnor_6.01533,082,858 - 33,082,965NCBIRnor6.0
Rnor_5.01536,968,699 - 36,968,806UniSTSRnor5.0
RGSC_v3.41532,502,269 - 32,502,376UniSTSRGSC3.4
Celera1527,479,278 - 27,479,385UniSTS
Cytogenetic Map15p13UniSTS
Mmp14  
Rat AssemblyChrPosition (strand)SourceJBrowse
RGSC_v3.410103,730,181 - 103,730,256UniSTSRGSC3.4
RGSC_v3.41532,500,938 - 32,502,522UniSTSRGSC3.4
Celera1527,477,947 - 27,479,531UniSTS
Celera1097,735,660 - 97,735,735UniSTS
MARC_9867-9868:996688667:1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21527,895,200 - 27,896,218 (+)MAPPERmRatBN7.2
Rnor_6.01533,081,847 - 33,082,864NCBIRnor6.0
Rnor_5.01536,967,688 - 36,968,705UniSTSRnor5.0
RGSC_v3.41532,501,258 - 32,502,275UniSTSRGSC3.4
Celera1527,478,267 - 27,479,284UniSTS
Cytogenetic Map15p13UniSTS
Mmp14  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_5.01536,967,368 - 36,968,952UniSTSRnor5.0
RGSC_v3.41532,500,938 - 32,502,522UniSTSRGSC3.4
Celera1527,477,947 - 27,479,531UniSTS
Cytogenetic Map15p13UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 160 91 90 59 51 59 6 315 151 11 139 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000075610   ⟹   ENSRNOP00000065434
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1531,857,725 - 31,867,038 (+)Ensembl
mRatBN7.2 Ensembl1527,887,764 - 27,897,009 (+)Ensembl
Rnor_6.0 Ensembl1533,074,441 - 33,083,655 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000096630   ⟹   ENSRNOP00000081148
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1531,860,875 - 31,867,038 (+)Ensembl
mRatBN7.2 Ensembl1527,890,846 - 27,897,009 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000118043   ⟹   ENSRNOP00000086712
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1531,857,546 - 31,869,893 (+)Ensembl
mRatBN7.2 Ensembl1527,887,727 - 27,899,864 (+)Ensembl
RefSeq Acc Id: NM_031056   ⟹   NP_112318
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81531,857,824 - 31,867,049 (+)NCBI
mRatBN7.21527,887,795 - 27,897,020 (+)NCBI
Rnor_6.01533,074,441 - 33,083,666 (+)NCBI
Rnor_5.01536,960,282 - 36,969,507 (+)NCBI
RGSC_v3.41532,493,852 - 32,503,077 (+)RGD
Celera1527,470,861 - 27,480,086 (+)RGD
Sequence:
RefSeq Acc Id: NP_112318   ⟸   NM_031056
- Peptide Label: precursor
- UniProtKB: Q6IN06 (UniProtKB/Swiss-Prot),   Q10739 (UniProtKB/Swiss-Prot),   A6KGU1 (UniProtKB/TrEMBL),   A0A8I5ZRB7 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000065434   ⟸   ENSRNOT00000075610
Ensembl Acc Id: ENSRNOP00000086712   ⟸   ENSRNOT00000118043
Ensembl Acc Id: ENSRNOP00000081148   ⟸   ENSRNOT00000096630
Protein Domains
Peptidase metallopeptidase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q10739-F1-model_v2 AlphaFold Q10739 1-582 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699650
Promoter ID:EPDNEW_R10173
Type:initiation region
Name:Mmp14_1
Description:matrix metallopeptidase 14
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01533,074,386 - 33,074,446EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620198 AgrOrtholog
BioCyc Gene G2FUF-13802 BioCyc
Ensembl Genes ENSRNOG00000010947 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000075610 ENTREZGENE
  ENSRNOT00000075610.3 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.101.10 UniProtKB/Swiss-Prot
  2.110.10.10 UniProtKB/Swiss-Prot
  3.40.390.10 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7103279 IMAGE-MGC_LOAD
InterPro Hemopexin-like_dom UniProtKB/Swiss-Prot
  Hemopexin-like_dom_sf UniProtKB/Swiss-Prot
  Hemopexin-like_repeat UniProtKB/Swiss-Prot
  Hemopexin_CS UniProtKB/Swiss-Prot
  M10A_MMP UniProtKB/Swiss-Prot
  MetalloPept_cat_dom_sf UniProtKB/Swiss-Prot
  Pept_M10_metallopeptidase UniProtKB/Swiss-Prot
  Pept_M10A UniProtKB/Swiss-Prot
  Pept_M10A_metallopeptidase_C UniProtKB/Swiss-Prot
  Pept_M10A_Zn_BS UniProtKB/Swiss-Prot
  Peptidase_Metallo UniProtKB/Swiss-Prot
  Peptidoglycan-bd-like UniProtKB/Swiss-Prot
  PGBD-like_sf UniProtKB/Swiss-Prot
  PGBDSf UniProtKB/Swiss-Prot
KEGG Report rno:81707 UniProtKB/Swiss-Prot
MGC_CLONE MGC:91652 IMAGE-MGC_LOAD
NCBI Gene 81707 ENTREZGENE
PANTHER MATRIX METALLOPROTEINASE UniProtKB/Swiss-Prot
  MATRIX METALLOPROTEINASE-14 UniProtKB/Swiss-Prot
Pfam DUF3377 UniProtKB/Swiss-Prot
  Hemopexin UniProtKB/Swiss-Prot
  Peptidase_M10 UniProtKB/Swiss-Prot
  PG_binding_1 UniProtKB/Swiss-Prot
PhenoGen Mmp14 PhenoGen
PIRSF Peptidase_M10A_matrix UniProtKB/Swiss-Prot
PRINTS MATRIXIN UniProtKB/Swiss-Prot
PROSITE CYSTEINE_SWITCH UniProtKB/Swiss-Prot
  HEMOPEXIN UniProtKB/Swiss-Prot
  HEMOPEXIN_2 UniProtKB/Swiss-Prot
  ZINC_PROTEASE UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000010947 RatGTEx
SMART SM00120 UniProtKB/Swiss-Prot
  ZnMc UniProtKB/Swiss-Prot
Superfamily-SCOP Metalloproteases ('zincins'), catalytic domain UniProtKB/Swiss-Prot
  SSF47090 UniProtKB/Swiss-Prot
  SSF50923 UniProtKB/Swiss-Prot
UniProt A0A8I5ZRB7 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6A4B9_RAT UniProtKB/TrEMBL
  A6KGT9_RAT UniProtKB/TrEMBL
  A6KGU1 ENTREZGENE, UniProtKB/TrEMBL
  MMP14_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q6IN06 ENTREZGENE
UniProt Secondary Q6IN06 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-12-23 Mmp14  matrix metallopeptidase 14  Mmp14  matrix metallopeptidase 14 (membrane-inserted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Mmp14  matrix metallopeptidase 14 (membrane-inserted)    matrix metalloproteinase 14 (membrane-inserted)  Name updated 1299863 APPROVED
2004-09-10 Mmp14  matrix metalloproteinase 14 (membrane-inserted)    matrix metalloproteinase 14, membrane-inserted  Name updated 1299863 APPROVED
2002-08-07 Mmp14  matrix metalloproteinase 14, membrane-inserted      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_process may have a critical role in tumor progression 729349