Becn1 (beclin 1) - Rat Genome Database

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Gene: Becn1 (beclin 1) Rattus norvegicus
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Symbol: Becn1
Name: beclin 1
RGD ID: 620190
Description: Enables ubiquitin protein ligase binding activity. Involved in several processes, including intracellular signaling cassette; regulation of apoptotic process; and regulation of organelle organization. Located in dendrite and trans-Golgi network. Used to study brain ischemia and middle cerebral artery infarction. Biomarker of several diseases, including Barrett's esophagus; acute necrotizing pancreatitis; artery disease (multiple); brain disease (multiple); and neuropathy (multiple). Human ortholog(s) of this gene implicated in Machado-Joseph disease and breast cancer. Orthologous to human BECN1 (beclin 1); PARTICIPATES IN autophagy pathway; inositol metabolic pathway; mitochondrial autophagy pathway; INTERACTS WITH (+)-pilocarpine; (+)-taxifolin; (-)-anisomycin.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: beclin 1 (coiled-coil, myosin-like BCL2-interacting protein); beclin 1, autophagy related; beclin-1; Beclin1; coiled-coil myosin-like BCL2-interacting protein
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81086,731,649 - 86,747,002 (-)NCBIGRCr8
mRatBN7.21086,231,387 - 86,246,742 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1086,231,388 - 86,246,742 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1091,269,132 - 91,284,493 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01090,743,662 - 90,759,021 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01086,136,830 - 86,152,190 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01089,209,944 - 89,225,297 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1089,209,940 - 89,225,297 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01089,008,975 - 89,024,328 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41090,317,957 - 90,333,329 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11090,332,322 - 90,347,231 (-)NCBI
Celera1084,949,343 - 84,964,691 (-)NCBICelera
Cytogenetic Map10q31NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


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Original Reference(s)
Becn1RatAcute Experimental Pancreatitis treatmentISOBecn1 (Mus musculus)11560530 RGD 
Becn1Ratacute necrotizing pancreatitis  IEP 6483068protein:increased expression:pancreasRGD 
Becn1Ratalcoholic cardiomyopathy treatmentISOBecn1 (Mus musculus)407532638 RGD 
Becn1Ratalcoholic hepatitis  ISOBecn1 (Mus musculus)407445926protein:increased expression:liverRGD 
Becn1RatAlcoholic Liver Diseases  ISOBecn1 (Mus musculus)407445926protein:increased expression:liverRGD 
Becn1RatAlzheimer's disease  ISOBecn1 (Mus musculus)6483102 RGD 
Becn1RatAlzheimer's disease  ISOBECN1 (Homo sapiens)6483101protein:decreased expression:gray matterRGD 
Becn1Ratamyotrophic lateral sclerosis  ISOBecn1 (Mus musculus)11561951mRNA:increased expression:spinal cordRGD 
Becn1Ratanterior ischemic optic neuropathy  IEP 6483070protein:decreased expression:retinaRGD 
Becn1RatBarrett's esophagus  IEP 11561943 RGD 
Becn1RatBarrett's esophagus disease_progressionISOBECN1 (Homo sapiens)11561943 RGD 
Becn1RatBrain Hypoxia-Ischemia  IEP 6483050protein:increased expression:cerebral cortexRGD 
Becn1RatBrain Hypoxia-Ischemia  IEP 11558017protein:increased expression:brainRGD 
Becn1Ratbrain infarction  IEP 6483057protein:increased expression:brainRGD 
Becn1RatBrain Injuries  IEP 6483098protein:increased expression:neuron and astrocyteRGD 
Becn1RatBrain Injuries  IEP 11558018protein:increased expression:hippocampusRGD 
Becn1RatBrain Injuries  ISOBecn1 (Mus musculus)6483314protein:increased expression:brainRGD 
Becn1Ratbrain ischemia  IEP 6483313protein:increased expression:hippocampus and frontal cortexRGD 
Becn1Ratbrain ischemia  IMP 6483094 RGD 
Becn1Ratbreast cancer disease_progressionISOBECN1 (Homo sapiens)155641236 RGD 
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Original Reference(s)
Becn1RatBrain Injuries  ISOBECN1 (Homo sapiens)11554173CTD Direct Evidence: therapeuticCTDPMID:34929507
Becn1RatColonic Neoplasms  ISOBECN1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:20876807
Becn1RatLewy body dementia  ISOBECN1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:19628769
Becn1RatLung Neoplasms  ISOBECN1 (Homo sapiens)11554173CTD Direct Evidence: therapeuticCTDPMID:22481206 and PMID:23790316
Becn1Ratmyocardial infarction  ISOBECN1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:20079142
Becn1RatSpinal Cord Injuries  ISOBECN1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:29793971
Becn1Ratstatus epilepticus  ISOBECN1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:19138675
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Original Reference(s)
Becn1Ratsystemic lupus erythematosus  ISSBecn1 (Mus musculus)13592920OMIM:152700 more ...MouseDO 

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Becn1Rat(+)-pilocarpine multiple interactionsEXP 6480464Vitamin E inhibits the reaction [Pilocarpine results in increased expression of BECN1 mRNA] and Vitamin E inhibits the reaction [Pilocarpine results in increased expression of BECN1 protein]CTDPMID:19138675
Becn1Rat(+)-pilocarpine increases expressionEXP 6480464Pilocarpine results in increased expression of BECN1 mRNA and Pilocarpine results in increased expression of BECN1 proteinCTDPMID:17971868 and PMID:19138675
Becn1Rat(+)-taxifolin multiple interactionsEXP 6480464alogliptin promotes the reaction [taxifolin inhibits the reaction [[Diethylnitrosamine co-treated with Carbon Tetrachloride] results in decreased expression of BECN1 protein]] more ...CTDPMID:33840231 more ...
Becn1Rat(+)-Tetrandrine increases expressionISOBECN1 (Homo sapiens)6480464tetrandrine results in increased expression of BECN1 proteinCTDPMID:26822499 and PMID:30123091
Becn1Rat(+)-Tetrandrine multiple interactionsISOBECN1 (Homo sapiens)6480464[sodium arsenite co-treated with tetrandrine] results in increased expression of BECN1 proteinCTDPMID:30123091
Becn1Rat(+)-Tetrandrine decreases expressionISOBECN1 (Homo sapiens)6480464tetrandrine results in decreased expression of BECN1 proteinCTDPMID:25266202
Becn1Rat(-)-alpha-phellandrene increases phosphorylationISOBECN1 (Homo sapiens)6480464alpha phellandrene results in increased phosphorylation of BECN1 proteinCTDPMID:25649747
Becn1Rat(-)-anisomycin multiple interactionsEXP 6480464Anisomycin promotes the reaction [Colistin results in increased expression of BECN1 protein]CTDPMID:28842171
Becn1Rat(-)-citrinin increases expressionISOBecn1 (Mus musculus)6480464Citrinin results in increased expression of BECN1 mRNACTDPMID:22771370
Becn1Rat(-)-epigallocatechin 3-gallate increases expressionISOBECN1 (Homo sapiens)6480464epigallocatechin gallate results in increased expression of BECN1 proteinCTDPMID:32512070
Becn1Rat(-)-epigallocatechin 3-gallate multiple interactionsISOBecn1 (Mus musculus)6480464epigallocatechin gallate inhibits the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in increased expression of BECN1 protein] and epigallocatechin gallate inhibits the reaction [Hydrogen Peroxide results in increased expression of BECN1 protein]CTDPMID:34740634
Becn1Rat(1->4)-beta-D-glucan multiple interactionsISOBecn1 (Mus musculus)6480464[perfluorooctane sulfonic acid co-treated with Cellulose] results in decreased expression of BECN1 mRNACTDPMID:36331819
Becn1Rat(20S)-ginsenoside Rg3 multiple interactionsISOBECN1 (Homo sapiens)64804643-methyladenine inhibits the reaction [ginsenoside Rg3 inhibits the reaction [Cisplatin results in decreased expression of BECN1 protein]] and ginsenoside Rg3 inhibits the reaction [Cisplatin results in decreased expression of BECN1 protein]CTDPMID:34423507
Becn1Rat(20S)-ginsenoside Rg3 multiple interactionsISOBecn1 (Mus musculus)6480464ginsenoside Rg3 inhibits the reaction [Cisplatin results in decreased expression of BECN1 protein]CTDPMID:34423507
Becn1Rat(S)-nicotine increases expressionISOBecn1 (Mus musculus)6480464Nicotine results in increased expression of BECN1 mRNACTDPMID:30605750
Becn1Rat(S)-nicotine multiple interactionsISOBecn1 (Mus musculus)6480464Nicotine promotes the reaction [Dextran Sulfate results in increased expression of BECN1 protein]CTDPMID:31926917
Becn1Rat(S)-nicotine multiple interactionsISOBECN1 (Homo sapiens)6480464dorsomorphin inhibits the reaction [Nicotine promotes the reaction [Dextran Sulfate results in increased expression of BECN1 protein]] and Nicotine promotes the reaction [Dextran Sulfate results in increased expression of BECN1 protein]CTDPMID:31926917
Becn1Rat(S)-ropivacaine increases expressionISOBECN1 (Homo sapiens)6480464Ropivacaine results in increased expression of BECN1 proteinCTDPMID:36193553
Becn1Rat(S)-ropivacaine multiple interactionsISOBECN1 (Homo sapiens)6480464Ropivacaine inhibits the reaction [3-methyladenine results in decreased expression of BECN1 protein]CTDPMID:36193553
Becn1Rat1,2-dimethylhydrazine multiple interactionsISOBecn1 (Mus musculus)6480464[1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of BECN1 mRNACTDPMID:22206623

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Biological Process
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Original Reference(s)
Becn1Ratamyloid-beta metabolic process acts_upstream_of_or_withinISOBecn1 (Mus musculus)1624291MGI:2683696 PMID:18497889RGDPMID:18497889
Becn1Ratamyloid-beta metabolic process acts_upstream_of_or_withinIEAUniProtKB:O88597 and ensembl:ENSMUSP000001193691600115GO_REF:0000107EnsemblGO_REF:0000107
Becn1Ratapoptotic process involved_inIEAUniProtKB-KW:KW-00531600115GO_REF:0000043UniProtGO_REF:0000043
Becn1Ratautophagosome assembly  IMP 1643189 RGD 
Becn1Ratautophagosome assembly involved_inIBAMGI:1891828 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Becn1Ratautophagosome assembly involved_inIEAUniProtKB:O88597 and ensembl:ENSMUSP000001193691600115GO_REF:0000107EnsemblGO_REF:0000107
Becn1Ratautophagosome assembly involved_inIEAUniProtKB:Q14457 and ensembl:ENSP000004653641600115GO_REF:0000107EnsemblGO_REF:0000107
Becn1Ratautophagosome assembly involved_inISOBECN1 (Homo sapiens)1624291 PMID:25891078RGDPMID:25891078
Becn1Ratautophagosome assembly involved_inISSUniProtKB:O885971600115GO_REF:0000024UniProtGO_REF:0000024
Becn1Ratautophagosome assembly involved_inISOBecn1 (Mus musculus)1624291 PMID:23332761RGDPMID:23332761
Becn1Ratautophagosome maturation involved_inISOBECN1 (Homo sapiens)1624291 PMID:10625637RGDPMID:10625637
Becn1Ratautophagosome maturation involved_inIEAUniProtKB:Q14457 and ensembl:ENSP000004653641600115GO_REF:0000107EnsemblGO_REF:0000107
Becn1Ratautophagy  IMP 1643194 RGD 
Becn1Ratautophagy involved_inIEAUniProtKB:Q14457 and ensembl:ENSP000004653641600115GO_REF:0000107EnsemblGO_REF:0000107
Becn1Ratautophagy involved_inIEAInterPro:IPR0072431600115GO_REF:0000002InterProGO_REF:0000002
Becn1Ratautophagy acts_upstream_of_or_withinIEAUniProtKB:O88597 and ensembl:ENSMUSP000001193691600115GO_REF:0000107EnsemblGO_REF:0000107
Becn1Ratautophagy acts_upstream_of_or_withinISOBecn1 (Mus musculus)1624291 PMID:12372286 and PMID:17589504RGDPMID:12372286 and PMID:17589504
Becn1Ratautophagy involved_inIEAUniProtKB-KW:KW-00721600115GO_REF:0000043UniProtGO_REF:0000043
Becn1Ratautophagy involved_inISOBecn1 (Mus musculus)1624291 PMID:23364696 more ...RGDPMID:23364696 more ...
Becn1Ratautophagy involved_inISOBECN1 (Homo sapiens)1624291 PMID:23184933 more ...RGDPMID:23184933 more ...
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Cellular Component
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Becn1Ratautophagosome located_inISOBecn1 (Mus musculus)1624291 PMID:23798385RGDPMID:23798385
Becn1Ratautophagosome located_inIEAUniProtKB-SubCell:SL-00231600115GO_REF:0000044UniProtGO_REF:0000044
Becn1Ratautophagosome located_inIEAUniProtKB:O88597 and ensembl:ENSMUSP000001193691600115GO_REF:0000107EnsemblGO_REF:0000107
Becn1Ratcytoplasm is_active_inISOBecn1 (Mus musculus)1624291 PMID:22498477RGDPMID:22498477
Becn1Ratcytoplasm located_inIEAUniProtKB:O88597 and ensembl:ENSMUSP000001193691600115GO_REF:0000107EnsemblGO_REF:0000107
Becn1Ratcytoplasm located_inIEAUniProtKB-KW:KW-09631600115GO_REF:0000043UniProtGO_REF:0000043
Becn1Ratcytoplasm located_inIEAUniProtKB-SubCell:SL-00861600115GO_REF:0000044UniProtGO_REF:0000044
Becn1Ratcytoplasm located_inIEAUniProtKB:Q14457 and ensembl:ENSP000004653641600115GO_REF:0000107EnsemblGO_REF:0000107
Becn1Ratcytoplasm located_inISOBecn1 (Mus musculus)1624291 PMID:17589504RGDPMID:17589504
Becn1Ratcytoplasm located_inISOBECN1 (Homo sapiens)1624291 PMID:22498477RGDPMID:22498477
Becn1Ratcytoplasmic side of mitochondrial outer membrane located_inISOBECN1 (Homo sapiens)1624291 PMID:23878393RGDPMID:23878393
Becn1Ratcytoplasmic side of mitochondrial outer membrane located_inIEAUniProtKB:Q14457 and ensembl:ENSP000004653641600115GO_REF:0000107EnsemblGO_REF:0000107
Becn1Ratcytoplasmic vesicle located_inISOBecn1 (Mus musculus)1624291 PMID:12372286RGDPMID:12372286
Becn1Ratcytoplasmic vesicle located_inIEAUniProtKB-KW:KW-09681600115GO_REF:0000043UniProtGO_REF:0000043
Becn1Ratcytoplasmic vesicle located_inIEAUniProtKB:O88597 and ensembl:ENSMUSP000001193691600115GO_REF:0000107EnsemblGO_REF:0000107
Becn1Ratcytosol located_inIEAUniProtKB:Q14457 and ensembl:ENSP000004653641600115GO_REF:0000107EnsemblGO_REF:0000107
Becn1Ratcytosol located_inISOBECN1 (Homo sapiens)1624291 RGDGO_REF:0000052
Becn1Ratcytosol located_inIEAUniProtKB:A0A024R1X5 and ensembl:ENSP000004653641600115GO_REF:0000107EnsemblGO_REF:0000107
Becn1Ratdendrite  IDA 6483070 RGD 
Becn1Ratendoplasmic reticulum located_inIEAUniProtKB-KW:KW-02561600115GO_REF:0000043UniProtGO_REF:0000043
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Molecular Function
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Becn1RatGTPase binding enablesISOBECN1 (Homo sapiens)1624291UniProtKB:A1A4Y4 and PMID:25891078RGDPMID:25891078
Becn1RatGTPase binding enablesIEAUniProtKB:Q14457 and ensembl:ENSP000004653641600115GO_REF:0000107EnsemblGO_REF:0000107
Becn1Ratidentical protein binding enablesISOBecn1 (Mus musculus)1624291PR:O88597 PMID:27994061RGDPMID:27994061
Becn1Ratidentical protein binding enablesIEAUniProtKB:O88597 and ensembl:ENSMUSP000001193691600115GO_REF:0000107EnsemblGO_REF:0000107
Becn1Ratmolecular adaptor activity enablesISOBECN1 (Homo sapiens)1624291 PMID:34796041RGDPMID:34796041
Becn1Ratmolecular adaptor activity enablesIEAUniProtKB:Q14457 and ensembl:ENSP000004653641600115GO_REF:0000107EnsemblGO_REF:0000107
Becn1Ratphosphatidylinositol 3-kinase binding enablesISOBECN1 (Homo sapiens)1624291UniProtKB:Q8NEB9 and PMID:23878393RGDPMID:23878393
Becn1Ratphosphatidylinositol 3-kinase binding enablesIBAPANTHER:PTN000298965 and UniProtKB:Q144571600115GO_REF:0000033GO_CentralGO_REF:0000033
Becn1Ratphosphatidylinositol 3-kinase binding enablesIEAUniProtKB:Q14457 and ensembl:ENSP000004653641600115GO_REF:0000107EnsemblGO_REF:0000107
Becn1Ratprotein binding  IPIAmbra1 (Rattus norvegicus)11552604 RGD 
Becn1Ratprotein binding enablesISOBECN1 (Homo sapiens)1624291UniProtKB:A8K0Z3 more ...RGDPMID:16417406 more ...
Becn1Ratprotein binding enablesISOBecn1 (Mus musculus)1624291PR:A2AH22 more ...RGDPMID:12372286 more ...
Becn1Ratprotein binding enablesIPIUniProtKB:P4995014390051PMID:27031958UniProt 
Becn1Ratprotein kinase binding enablesISOBECN1 (Homo sapiens)1624291UniProtKB:Q13464 and PMID:27853422RGDPMID:27853422
Becn1Ratprotein kinase binding enablesIEAUniProtKB:Q14457 and ensembl:ENSP000004653641600115GO_REF:0000107EnsemblGO_REF:0000107
Becn1Ratprotein-macromolecule adaptor activity enablesIBAMGI:1891828 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Becn1Ratprotein-macromolecule adaptor activity enablesIEAUniProtKB:O88597 and ensembl:ENSMUSP000001193691600115GO_REF:0000107EnsemblGO_REF:0000107
Becn1Ratprotein-macromolecule adaptor activity enablesIEAUniProtKB:Q14457 and ensembl:ENSP000004653641600115GO_REF:0000107EnsemblGO_REF:0000107
Becn1Ratprotein-macromolecule adaptor activity enablesISOBecn1 (Mus musculus)1624291 PMID:25275521RGDPMID:25275521
Becn1Ratprotein-macromolecule adaptor activity enablesISOBECN1 (Homo sapiens)1624291 PMID:25891078RGDPMID:25891078
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RGD Manual Annotations


  
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Original Reference(s)
Becn1Ratautophagy pathway   ISOXPNPEP1 (Homo sapiens)1643329 RGD 
Becn1Ratautophagy pathway   ISOXPNPEP1 (Homo sapiens)4889529 RGD 
Becn1Ratautophagy pathway   IMP 1643194 RGD 
Becn1Ratmitochondrial autophagy pathway   ISOBECN1 (Homo sapiens)10401098 RGD 

Imported Annotations - SMPDB

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Original Reference(s)
Becn1Ratinositol metabolic pathway  ISOBECN1 (Homo sapiens)10402751 SMPDBSMP:00011
Becn1Ratphosphoinositide metabolic pathway  ISOBECN1 (Homo sapiens)10402751 SMPDBSMP:00463

Imported Annotations - KEGG (archival)

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Original Reference(s)
Becn1Ratautophagy pathway   IEA 6907045 KEGGrno:04140

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Reference Title
Reference Citation
1. Dysregulated Autophagy and Lysosome Function Are Linked to Exosome Production by Micro-RNA 155 in Alcoholic Liver Disease. Babuta M, etal., Hepatology. 2019 Dec;70(6):2123-2141. doi: 10.1002/hep.30766. Epub 2019 Jun 24.
2. Hypoxia-inducible factor-1alpha (HIF-1alpha) and autophagy in polycystic kidney disease (PKD). Belibi F, etal., Am J Physiol Renal Physiol. 2011 May;300(5):F1235-43. Epub 2011 Jan 26.
3. High Beclin-1 and ARID1A expression corelates with poor survival and high recurrence in intrahepatic cholangiocarcinoma: a histopathological retrospective study. Bi C, etal., BMC Cancer. 2019 Mar 8;19(1):213. doi: 10.1186/s12885-019-5429-3.
4. Nupr1/Chop signal axis is involved in mitochondrion-related endothelial cell apoptosis induced by methamphetamine. Cai D, etal., Cell Death Dis. 2016 Mar 31;7:e2161. doi: 10.1038/cddis.2016.67.
5. Autophagy is upregulated in rats with status epilepticus and partly inhibited by Vitamin E. Cao L, etal., Biochem Biophys Res Commun. 2009 Feb 20;379(4):949-53. Epub 2009 Jan 10.
6. Noggin attenuates cerulein-induced acute pancreatitis and impaired autophagy. Cao Y, etal., Pancreas. 2013 Mar;42(2):301-7. doi: 10.1097/MPA.0b013e31825b9f2c.
7. Autophagy is a protective mechanism in normal cartilage, and its aging-related loss is linked with cell death and osteoarthritis. Carames B, etal., Arthritis Rheum. 2010 Mar;62(3):791-801.
8. Trehalose delays the progression of amyotrophic lateral sclerosis by enhancing autophagy in motoneurons. Castillo K, etal., Autophagy. 2013 Sep;9(9):1308-20. doi: 10.4161/auto.25188. Epub 2013 Jun 6.
9. Induction of autophagic cell death in the rat brain caused by iron. Chen G, etal., Am J Med Sci. 2013 May;345(5):369-74. doi: 10.1097/MAJ.0b013e318271c031.
10. Cold ischemia-induced autophagy in rat lung tissue. Chen X, etal., Mol Med Rep. 2015 Apr;11(4):2513-9. doi: 10.3892/mmr.2014.2999. Epub 2014 Nov 26.
11. BECN1 is involved in the initiation of mitophagy: it facilitates PARK2 translocation to mitochondria. Choubey V, etal., Autophagy. 2014 Jun;10(6):1105-19. doi: 10.4161/auto.28615.
12. Propofol prevents autophagic cell death following oxygen and glucose deprivation in PC12 cells and cerebral ischemia-reperfusion injury in rats. Cui D, etal., PLoS One. 2012;7(4):e35324. doi: 10.1371/journal.pone.0035324. Epub 2012 Apr 11.
13. Closed head injury induces upregulation of Beclin 1 at the cortical site of injury. Diskin T, etal., J Neurotrauma. 2005 Jul;22(7):750-62.
14. Ascorbic acid ameliorates seizures and brain damage in rats through inhibiting autophagy. Dong Y, etal., Brain Res. 2013 Oct 16;1535:115-23. doi: 10.1016/j.brainres.2013.08.039. Epub 2013 Aug 28.
15. Neurodegeneration induces upregulation of Beclin 1. Erlich S, etal., Autophagy. 2006 Jan-Mar;2(1):49-51. Epub 2006 Jan 8.
16. Mitochondrial impairment in the five-sixth nephrectomy model of chronic renal failure: proteomic approach. Fedorova LV, etal., BMC Nephrol. 2013 Oct 4;14:209. doi: 10.1186/1471-2369-14-209.
17. Paraplegia increases skeletal muscle autophagy. Fry CS, etal., Muscle Nerve. 2012 Nov;46(5):793-8. doi: 10.1002/mus.23423.
18. Association of FKBP51 with priming of autophagy pathways and mediation of antidepressant treatment response: evidence in cells, mice, and humans. Gassen NC, etal., PLoS Med. 2014 Nov 11;11(11):e1001755. doi: 10.1371/journal.pmed.1001755. eCollection 2014 Nov.
19. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
20. Involvement of autophagy in hypoxic-excitotoxic neuronal death. Ginet V, etal., Autophagy. 2014 May;10(5):846-60. doi: 10.4161/auto.28264. Epub 2014 Mar 11.
1 to 20 of 106 rows
PMID:9765397   PMID:12372286   PMID:14657337   PMID:17330750   PMID:17468177   PMID:17589504   PMID:17891140   PMID:19273585   PMID:19335206   PMID:19520853   PMID:19901551   PMID:20190558  
PMID:20208530   PMID:20643123   PMID:21646862   PMID:22328594   PMID:22393062   PMID:22493499   PMID:22543707   PMID:22917477   PMID:23184933   PMID:23332761   PMID:23364696   PMID:23392707  
PMID:23478334   PMID:23590156   PMID:23629966   PMID:23798385   PMID:23868341   PMID:23878393   PMID:24056303   PMID:24324270   PMID:24579466   PMID:24872334   PMID:25046113   PMID:25127057  
PMID:25215947   PMID:25816157   PMID:25891078   PMID:26386349   PMID:26647915   PMID:26783301   PMID:26822891   PMID:27472881   PMID:27853422   PMID:27994061   PMID:28340591   PMID:28383560  
PMID:28428545   PMID:28578340   PMID:28893091   PMID:28964771   PMID:29157081   PMID:29196028   PMID:29797121   PMID:30951836   PMID:31140414   PMID:31168983   PMID:31583941   PMID:31707369  
PMID:32016995   PMID:33167086   PMID:34046789   PMID:34217716   PMID:34830430   PMID:35266018   PMID:35818233   PMID:38261732  



Becn1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81086,731,649 - 86,747,002 (-)NCBIGRCr8
mRatBN7.21086,231,387 - 86,246,742 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1086,231,388 - 86,246,742 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1091,269,132 - 91,284,493 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01090,743,662 - 90,759,021 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01086,136,830 - 86,152,190 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01089,209,944 - 89,225,297 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1089,209,940 - 89,225,297 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01089,008,975 - 89,024,328 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41090,317,957 - 90,333,329 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11090,332,322 - 90,347,231 (-)NCBI
Celera1084,949,343 - 84,964,691 (-)NCBICelera
Cytogenetic Map10q31NCBI
BECN1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381742,810,132 - 42,824,282 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1742,810,134 - 42,833,350 (-)EnsemblGRCh38hg38GRCh38
GRCh371740,962,150 - 40,976,300 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361738,215,678 - 38,229,807 (-)NCBINCBI36Build 36hg18NCBI36
Build 341738,215,677 - 38,229,807NCBI
Celera1737,618,135 - 37,632,364 (-)NCBICelera
Cytogenetic Map17q21.31NCBI
HuRef1736,726,539 - 36,740,774 (-)NCBIHuRef
CHM1_11741,197,767 - 41,211,922 (-)NCBICHM1_1
T2T-CHM13v2.01743,667,271 - 43,682,705 (-)NCBIT2T-CHM13v2.0
Becn1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3911101,179,084 - 101,193,112 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl11101,176,778 - 101,193,112 (-)EnsemblGRCm39 Ensembl
GRCm3811101,288,258 - 101,302,286 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11101,285,952 - 101,302,286 (-)EnsemblGRCm38mm10GRCm38
MGSCv3711101,149,581 - 101,163,581 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3611102,067,439 - 102,081,397 (-)NCBIMGSCv36mm8
MGSCv3611101,104,357 - 101,118,357 (-)NCBIMGSCv36mm8
Cytogenetic Map11DNCBI
cM Map1164.58NCBI
Becn1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545116,616,595 - 16,625,730 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495545116,616,595 - 16,625,731 (-)NCBIChiLan1.0ChiLan1.0
BECN1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21922,152,390 - 22,175,667 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11724,042,657 - 24,065,785 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01714,493,619 - 14,507,809 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11714,719,781 - 14,733,286 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1714,719,781 - 14,733,286 (+)Ensemblpanpan1.1panPan2
BECN1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1920,204,203 - 20,215,081 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl920,204,220 - 20,214,236 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha919,665,517 - 19,676,150 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0920,922,592 - 20,933,221 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl920,922,586 - 20,933,212 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1919,707,479 - 19,718,113 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0919,973,720 - 19,984,352 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0920,076,426 - 20,087,053 (+)NCBIUU_Cfam_GSD_1.0
Becn1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560219,544,014 - 19,557,039 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493649017,517,751 - 17,531,151 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493649017,518,100 - 17,531,126 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
BECN1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1220,041,956 - 20,054,373 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11220,041,914 - 20,054,249 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21220,256,871 - 20,268,928 (+)NCBISscrofa10.2Sscrofa10.2susScr3
BECN1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11663,469,187 - 63,482,627 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1663,469,192 - 63,485,322 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607734,260,316 - 34,273,836 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Becn1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247951,385,756 - 1,405,714 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247951,386,154 - 1,406,314 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

.

.
Variants in Becn1
31 total Variants

Predicted Target Of
Summary Value
Count of predictions:322
Count of miRNA genes:210
Interacting mature miRNAs:246
Transcripts:ENSRNOT00000027868
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 78 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
1549846Scl47Serum cholesterol level QTL 473.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)105057470795574707Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102652195798003205Rat
61449Ciaa2CIA Autoantibody QTL 27.1blood autoantibody amount (VT:0003725)calculated serum anti-type 2 collagen antibody titer (CMO:0001279)1063221094107211142Rat
631555Bp134Blood pressure QTL 1340.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)108051528791230079Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
1298078Stresp5Stress response QTL 52.990.00025blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1042045676104670812Rat
1549831Bss6Bone structure and strength QTL 64lumbar vertebra strength trait (VT:0010574)vertebra ultimate force (CMO:0001678)1057576521102576521Rat
70164Bw21Body weight QTL 214.360.00005body mass (VT:0001259)body weight (CMO:0000012)105379749498952626Rat
4889948Bss91Bone structure and strength QTL 914tibia area (VT:1000281)tibia midshaft total cross-sectional area (CMO:0001715)108256485692369470Rat
61463Bp12Blood pressure QTL 126.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104133325886333258Rat

1 to 10 of 78 rows
RH127824  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81086,731,825 - 86,732,029 (+)Marker Load Pipeline
mRatBN7.21086,231,563 - 86,231,767 (+)MAPPERmRatBN7.2
Rnor_6.01089,210,121 - 89,210,324NCBIRnor6.0
Rnor_5.01089,009,152 - 89,009,355UniSTSRnor5.0
RGSC_v3.41090,318,134 - 90,318,337UniSTSRGSC3.4
Celera1084,949,520 - 84,949,723UniSTS
RH 3.4 Map10877.09UniSTS
Cytogenetic Map10q32.1UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31



Ensembl Acc Id: ENSRNOT00000027868   ⟹   ENSRNOP00000027868
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1086,231,399 - 86,246,681 (-)Ensembl
Rnor_6.0 Ensembl1089,209,944 - 89,225,297 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000075886
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1086,239,364 - 86,246,742 (-)Ensembl
Rnor_6.0 Ensembl1089,217,566 - 89,225,222 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000076146
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1089,212,680 - 89,215,849 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000076489
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1089,209,940 - 89,212,536 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000077048
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1089,215,499 - 89,217,147 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000082010   ⟹   ENSRNOP00000071966
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1086,231,388 - 86,246,742 (-)Ensembl
Rnor_6.0 Ensembl1089,209,945 - 89,225,297 (-)Ensembl
RefSeq Acc Id: NM_001034117   ⟹   NP_001029289
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81086,731,649 - 86,747,002 (-)NCBI
mRatBN7.21086,231,387 - 86,246,742 (-)NCBI
Rnor_6.01089,209,944 - 89,225,297 (-)NCBI
Rnor_5.01089,008,975 - 89,024,328 (-)NCBI
RGSC_v3.41090,317,957 - 90,333,329 (-)RGD
Celera1084,949,343 - 84,964,691 (-)RGD
Sequence:
RefSeq Acc Id: NM_053739   ⟹   NP_446191
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81086,731,649 - 86,747,002 (-)NCBI
mRatBN7.21086,231,387 - 86,246,742 (-)NCBI
Rnor_6.01089,209,944 - 89,225,297 (-)NCBI
Rnor_5.01089,008,975 - 89,024,328 (-)NCBI
RGSC_v3.41090,317,957 - 90,333,329 (-)RGD
Celera1084,949,343 - 84,964,691 (-)RGD
Sequence:
RefSeq Acc Id: XM_039085040   ⟹   XP_038940968
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81086,731,649 - 86,738,510 (-)NCBI
mRatBN7.21086,231,387 - 86,238,249 (-)NCBI
RefSeq Acc Id: NP_001029289   ⟸   NM_001034117
- UniProtKB: Q91XJ1 (UniProtKB/Swiss-Prot),   A6HJA4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_446191   ⟸   NM_053739
- UniProtKB: Q91XJ1 (UniProtKB/Swiss-Prot),   A6HJA4 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000071966   ⟸   ENSRNOT00000082010
Ensembl Acc Id: ENSRNOP00000027868   ⟸   ENSRNOT00000027868
RefSeq Acc Id: XP_038940968   ⟸   XM_039085040
- Peptide Label: isoform X1
Atg6 BARA   Atg6/beclin coiled-coil   Beclin-1 BH3

Name Modeler Protein Id AA Range Protein Structure
AF-Q91XJ1-F1-model_v2 AlphaFold Q91XJ1 1-448 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13697758
Promoter ID:EPDNEW_R8277
Type:initiation region
Name:Becn1_1
Description:beclin 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01089,225,222 - 89,225,282EPDNEW


1 to 28 of 28 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-23183 BioCyc
Ensembl Genes ENSRNOG00000020513 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000082010 ENTREZGENE
  ENSRNOT00000082010.2 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.418.40 UniProtKB/Swiss-Prot
  6.10.250.3110 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7100185 IMAGE-MGC_LOAD
InterPro Atg6/Beclin UniProtKB/Swiss-Prot
  Atg6/Beclin_C_sf UniProtKB/Swiss-Prot
  Atg6/beclin_CC UniProtKB/Swiss-Prot
  Atg6_BARA UniProtKB/Swiss-Prot
  BH3_dom UniProtKB/Swiss-Prot
KEGG Report rno:114558 UniProtKB/Swiss-Prot
MGC_CLONE MGC:91559 IMAGE-MGC_LOAD
NCBI Gene 114558 ENTREZGENE
PANTHER PTHR12768 UniProtKB/Swiss-Prot
  PTHR12768:SF6 UniProtKB/Swiss-Prot
Pfam APG6 UniProtKB/Swiss-Prot
  APG6_N UniProtKB/Swiss-Prot
  BH3 UniProtKB/Swiss-Prot
PhenoGen Becn1 PhenoGen
RatGTEx ENSRNOG00000020513 RatGTEx
UniProt A0A8I6GIY1_RAT UniProtKB/TrEMBL
  A0A8L2UKH5_RAT UniProtKB/TrEMBL
  A6HJA4 ENTREZGENE, UniProtKB/TrEMBL
  A6HJA5_RAT UniProtKB/TrEMBL
  A6HJA7_RAT UniProtKB/TrEMBL
  BECN1_RAT UniProtKB/Swiss-Prot, ENTREZGENE
1 to 28 of 28 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-05-04 Becn1  beclin 1  Becn1  beclin 1, autophagy related  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-22 Becn1  beclin 1, autophagy related  Becn1  beclin 1 (coiled-coil, myosin-like BCL2-interacting protein)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-02-26 Becn1  beclin 1 (coiled-coil, myosin-like BCL2-interacting protein)      Symbol and Name status set to approved 625702 APPROVED
2002-08-07 Becn1  beclin 1 (coiled-coil, myosin-like BCL2-interacting protein)      Symbol and Name status set to provisional 70820 PROVISIONAL